PCIDB

KNApSAcK Metabolite C00018753

Metabolite

KNApSAcK Entry

id C00018753
Name MPA / Melbex / NSC 129185 / Lilly 68618 / Mycophenolic acid
CAS RN 24280-93-1
Standard InChI InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
Standard InChI (Main Layer) InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)

Cluster

Phytochemical cluster
KCF-S cluster No. 5526

Link

ChEMBL

By standard InChI CHEMBL866
By standard InChI Main Layer CHEMBL866

KEGG

By LinkDB

CTD

By CAS RN D009173

Species

Summary

Plant class

class name count

Family

family name count
Aspergillaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Penicillium brevicompactum 5074 Aspergillaceae Fungi

Human Protein / Gene in interaction

111 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL866 CHEMBL1741321 (2) CHEMBL1909136 (2)
1 / 0
Q16637 Survival motor neuron protein Unclassified protein CHEMBL866 CHEMBL1614260 (4) CHEMBL1613842 (3)
4 / 2
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme CHEMBL866 CHEMBL1743331 (1) CHEMBL1908087 (1)
CHEMBL1908114 (4)
0 / 0
P20839 Inosine-5'-monophosphate dehydrogenase 1 Oxidoreductase CHEMBL866 CHEMBL699983 (1) CHEMBL697169 (1)
CHEMBL698514 (1) CHEMBL698515 (1)
CHEMBL698516 (1) CHEMBL845493 (1)
CHEMBL865551 (1) CHEMBL865553 (1)
CHEMBL901580 (1) CHEMBL902633 (1)
CHEMBL981157 (1) CHEMBL998516 (1)
CHEMBL1292995 (1) CHEMBL1685945 (1)
2 / 2
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL866 CHEMBL1909139 (2)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL866 CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL866 CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL866 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL866 CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL866 CHEMBL1909201 (2)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL866 CHEMBL1909176 (2)
0 / 0
P29466 Caspase-1 C14 CHEMBL866 CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL866 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL866 CHEMBL1909199 (2)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL866 CHEMBL1909197 (2)
2 / 2
P02545 Prelamin-A/C Unclassified protein CHEMBL866 CHEMBL1614544 (1) CHEMBL1614073 (1)
11 / 10
P37840 Alpha-synuclein Unclassified protein CHEMBL866 CHEMBL2354282 (1)
4 / 2
P12268 Inosine-5'-monophosphate dehydrogenase 2 Oxidoreductase CHEMBL866 CHEMBL699983 (1) CHEMBL699984 (1)
CHEMBL698524 (1) CHEMBL698525 (1)
CHEMBL697550 (1) CHEMBL698781 (1)
CHEMBL699556 (1) CHEMBL699557 (1)
CHEMBL699558 (1) CHEMBL699559 (1)
CHEMBL699561 (1) CHEMBL699564 (1)
CHEMBL699565 (1) CHEMBL865552 (1)
CHEMBL865553 (1) CHEMBL889231 (1)
CHEMBL901581 (1) CHEMBL902634 (1)
CHEMBL981158 (1) CHEMBL998517 (1)
CHEMBL1292996 (1) CHEMBL1685943 (1)
CHEMBL1936596 (1) CHEMBL2020803 (1)
0 / 0
P00918 Carbonic anhydrase 2 Lyase CHEMBL866 CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL866 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL866 CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL866 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL866 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL866 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL866 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL866 CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL866 CHEMBL1909093 (2)
0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL866 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL866 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL866 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL866 CHEMBL1741325 (2) CHEMBL1909135 (2)
0 / 1
Q9HAW7 UDP-glucuronosyltransferase 1-7 Enzyme CHEMBL866 CHEMBL1743328 (1) CHEMBL1908118 (2)
0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL866 CHEMBL1909203 (2)
1 / 11
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL866 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL866 CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL866 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL866 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL866 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL866 CHEMBL1909214 (2)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL866 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL866 CHEMBL1909096 (2)
1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL866 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL866 CHEMBL1909166 (2)
1 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL866 CHEMBL1614458 (2)
0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL866 CHEMBL1909133 (2)
0 / 0
O75496 Geminin Unclassified protein CHEMBL866 CHEMBL2114843 (1)
0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme CHEMBL866 CHEMBL1908120 (2)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL866 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL866 CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL866 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL866 CHEMBL1909101 (2)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL866 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL866 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL866 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL866 CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL866 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL866 CHEMBL1909100 (2)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL866 CHEMBL1909167 (2)
1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL866 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL866 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL866 CHEMBL1909110 (2)
1 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL866 CHEMBL2114788 (1)
0 / 0
P03956 Interstitial collagenase M10A CHEMBL866 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL866 CHEMBL1909119 (2)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL866 CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL866 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL866 CHEMBL1909170 (2)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL866 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL866 CHEMBL1909109 (2)
2 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL866 CHEMBL897826 (1) CHEMBL897827 (1)
CHEMBL897828 (1) CHEMBL897829 (1)
5 / 3
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL866 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL866 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL866 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL866 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL866 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL866 CHEMBL1909108 (2)
0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL866 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL866 CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL866 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL866 CHEMBL1741322 (2) CHEMBL1909132 (2)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL866 CHEMBL1613910 (2) CHEMBL1614227 (1)
3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL866 CHEMBL1614038 (4)
2 / 2
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme CHEMBL866 CHEMBL1743329 (1) CHEMBL1908085 (1)
CHEMBL1908119 (2)
0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL866 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL866 CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL866 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL866 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL866 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL866 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL866 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL866 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL866 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL866 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL866 CHEMBL1909168 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL866 CHEMBL1741323 (2) CHEMBL1909134 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL866 CHEMBL1614108 (2) CHEMBL1613886 (2)
CHEMBL1741324 (2) CHEMBL1909138 (2)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL866 CHEMBL1909137 (2)
0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme CHEMBL866 CHEMBL1908113 (2)
5 / 1
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL866 CHEMBL1738184 (1)
0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL866 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL866 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL866 CHEMBL1909213 (2)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL866 CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL866 CHEMBL1909116 (2)
1 / 1
P06239 Tyrosine-protein kinase Lck Src CHEMBL866 CHEMBL1909206 (2)
0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL866 CHEMBL1909128 (2)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL866 CHEMBL1613914 (4)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL866 CHEMBL1738442 (1)
0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL866 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL866 CHEMBL1613933 (1)
1 / 6
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL866 CHEMBL2354287 (1)
1 / 1

CTD interaction (33)

compound gene gene name gene description interaction interaction type form reference
pmid
D009173 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) Mycophenolic Acid results in increased expression of AKT1 protein increases expression
protein 21396949
D009173 466 ATF1
EWS-ATF1
FUS/ATF-1
TREB36
activating transcription factor 1 Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of ATF1 protein] decreases reaction
/ increases phosphorylation
protein 20302854
D009173 581 BAX
BCL2L4
BCL2-associated X protein [Mycophenolic Acid co-treated with Hypoxanthine] results in increased expression of BAX protein affects cotreatment
/ increases expression
protein 21396949
D009173 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 [Mycophenolic Acid co-treated with Hypoxanthine] results in decreased expression of BCL2 protein affects cotreatment
/ decreases expression
protein 21396949
D009173 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) [Mycophenolic Acid co-treated with Hypoxanthine] results in increased activity of CASP3 protein affects cotreatment
/ increases activity
protein 21396949
D009173 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Mycophenolic Acid results in increased activity of CASP3 protein increases activity
protein 16059982
D009173 1027 CDKN1B
CDKN4
KIP1
MEN1B
MEN4
P27KIP1
cyclin-dependent kinase inhibitor 1B (p27, Kip1) Mycophenolic Acid inhibits the reaction [IL2 protein results in decreased expression of CDKN1B protein] decreases expression
/ decreases reaction
protein 12193749
D009173 1385 CREB1
CREB
cAMP responsive element binding protein 1 Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of CREB1 protein] decreases reaction
/ increases phosphorylation
protein 20302854
D009173 1558 CYP2C8
CPC8
CYPIIC8
MP-12/MP-20
cytochrome P450, family 2, subfamily C, polypeptide 8 (EC:1.14.14.1) CYP2C8 protein results in increased methylation of Mycophenolic Acid increases methylation
protein 15570183
D009173 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) CYP3A4 protein results in increased methylation of Mycophenolic Acid increases methylation
protein 15570183
D009173 1577 CYP3A5
CP35
CYPIIIA5
P450PCN3
PCN3
cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) CYP3A5 protein results in increased methylation of Mycophenolic Acid increases methylation
protein 15570183
D009173 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog Mycophenolic Acid results in increased expression of FOS mRNA increases expression
mRNA 12730611
D009173 2932 GSK3B
glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of GSK3B protein] decreases reaction
/ increases phosphorylation
protein 20302854
D009173 3558 IL2
IL-2
TCGF
lymphokine
interleukin 2 Mycophenolic Acid inhibits the reaction [IL2 protein results in decreased expression of CDKN1B protein] decreases expression
/ decreases reaction
protein 12193749
D009173 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased secretion of IL8 protein] decreases reaction
/ increases secretion
protein 20302854
D009173 22914 KLRK1
CD314
D12S2489E
KLR
NKG2-D
NKG2D
killer cell lectin-like receptor subfamily K, member 1 Mycophenolic Acid results in decreased expression of KLRK1 decreases expression
20736080
D009173 4067 LYN
JTK8
p53Lyn
p56Lyn
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2) [Mycophenolic Acid co-treated with imatinib] results in decreased phosphorylation of LYN protein affects cotreatment
/ decreases phosphorylation
protein 15604220
D009173 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 20302854
D009173 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Mycophenolic Acid results in decreased expression of MAPK1 protein modified form decreases expression
protein 20302854
D009173 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 20302854
D009173 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Mycophenolic Acid results in decreased expression of MAPK3 protein modified form decreases expression
protein 20302854
D009173 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein] decreases reaction
/ increases phosphorylation
protein 20302854
D009173 5601 MAPK9
JNK-55
JNK2
JNK2A
JNK2ALPHA
JNK2B
JNK2BETA
PRKM9
SAPK
SAPK1a
p54a
p54aSAPK
mitogen-activated protein kinase 9 (EC:2.7.11.24) Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein] decreases reaction
/ increases phosphorylation
protein 20302854
D009173 4137 MAPT
DDPAC
FTDP-17
MAPTL
MSTD
MTBT1
MTBT2
PPND
TAU
microtubule-associated protein tau Mycophenolic Acid results in decreased expression of MAPT protein decreases expression
protein 16930453
D009173 9437 NCR1
CD335
LY94
NK-p46
NKP46
natural cytotoxicity triggering receptor 1 Mycophenolic Acid results in decreased expression of NCR1 decreases expression
20736080
D009173 9436 NCR2
CD336
LY95
NK-p44
NKP44
dJ149M18.1
natural cytotoxicity triggering receptor 2 Mycophenolic Acid results in decreased expression of NCR2 decreases expression
20736080
D009173 259197 NCR3
1C7
CD337
LY117
MALS
NKp30
natural cytotoxicity triggering receptor 3 Mycophenolic Acid results in decreased expression of NCR3 decreases expression
20736080
D009173 5578 PRKCA
AAG6
PKC-alpha
PKCA
PRKACA
protein kinase C, alpha (EC:2.7.11.13) Mycophenolic Acid results in increased expression of PRKCA protein increases expression
protein 21396949
D009173 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Mycophenolic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RELA protein] decreases reaction
/ increases phosphorylation
protein 20302854
D009173 6194 RPS6
S6
ribosomal protein S6 [Mycophenolic Acid co-treated with imatinib] results in decreased phosphorylation of RPS6 protein affects cotreatment
/ decreases phosphorylation
protein 15604220
D009173 6776 STAT5A
MGF
STAT5
signal transducer and activator of transcription 5A [Mycophenolic Acid co-treated with imatinib] results in decreased phosphorylation of STAT5A protein affects cotreatment
/ decreases phosphorylation
protein 15604220
D009173 54600 UGT1A9
HLUGP4
LUGP4
UDPGT
UDPGT_1-9
UGT-1I
UGT1-09
UGT1-9
UGT1.9
UGT1AI
UGT1I
UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) UGT1A9 gene SNP affects the metabolism of Mycophenolic Acid affects metabolic processing
gene 18498916
D009173 54600 UGT1A9
HLUGP4
LUGP4
UDPGT
UDPGT_1-9
UGT-1I
UGT1-09
UGT1-9
UGT1.9
UGT1AI
UGT1I
UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) UGT1A9 protein results in increased glucuronidation of Mycophenolic Acid increases glucuronidation
protein 18816295

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (72)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
%606641 Body mass index; bmi P37231
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#218800 Crigler-najjar syndrome, type i P22309
#606785 Crigler-najjar syndrome, type ii P22309
#162800 Cyclic neutropenia P08246
#127750 Dementia, lewy body; dlb P37840
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#143500 Gilbert syndrome P22309
#137800 Glioma susceptibility 1; glm1 P04626
P37231
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#603932 Intervertebral disc disease; idd P14780
#613837 Leber congenital amaurosis 11; lca11 P20839
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
P37231
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#180105 Retinitis pigmentosa 10; rp10 P20839
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (58)

KEGG disease name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00527 Retinitis pigmentosa (RP) P20839 (related)
H00837 Leber congenital amaurosis (LCR) P20839 (related)
H00548 Brunner syndrome P21397 (related)
H00208 Hyperbilirubinemia P22309 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

11 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000740 D009173 Anemia marker/mechanism
17318074
D005767 D009173 Gastrointestinal Diseases marker/mechanism
17318074
D006086 D009173 Graft vs Host Disease therapeutic
20736080
D006526 D009173 Hepatitis C therapeutic
12781720
D007249 D009173 Inflammation marker/mechanism
19818335
D007968 D009173 Leukoencephalopathy, Progressive Multifocal marker/mechanism
20657885
D007970 D009173 Leukopenia marker/mechanism
17318074
D055953 D009173 Microscopic Polyangiitis therapeutic
19184066
D009336 D009173 Necrosis marker/mechanism
19430526
D009421 D009173 Nervous System Malformations marker/mechanism
22914985
D014890 D009173 Wegener Granulomatosis therapeutic
19184066