PCIDB

KNApSAcK Metabolite C00018791

Metabolite

KNApSAcK Entry

id C00018791
Name Filipin III
CAS RN 480-49-9
Standard InChI InChI=1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14+/t24-,25?,26?,27?,28?,29?,30?,31+,32+,33?,34?/m0/s1
Standard InChI (Main Layer) InChI=1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3

Cluster

Phytochemical cluster
KCF-S cluster No. 1095

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL154669 CHEMBL1562334 CHEMBL1981819 CHEMBL2103755

KEGG

By LinkDB

CTD

By CAS RN D005372

Species

Summary

Plant class

class name count

Family

family name count
Streptomycetaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Streptomyces filipinensis NRRL 2437 1883 Streptomycetaceae Bacteria

Human Protein / Gene in interaction

5 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL1562334 CHEMBL1614361 (1)
3 / 2
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1562334 CHEMBL1613777 (1)
1 / 1
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL154669 CHEMBL650217 (1)
0 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL154669 CHEMBL650217 (1)
1 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL154669 CHEMBL650217 (1)
0 / 0

CTD interaction (7)

compound gene gene name gene description interaction interaction type form reference
pmid
D005372 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) Filipin inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 12614848
D005372 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 Filipin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 19632255
D005372 3716 JAK1
JAK1A
JAK1B
JTK3
Janus kinase 1 (EC:2.7.10.2) Filipin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of JAK1 protein] decreases reaction
/ increases phosphorylation
protein 19632255
D005372 5621 PRNP
ASCR
AltPrP
CD230
CJD
GSS
KURU
PRIP
PrP
PrP27-30
PrP33-35C
PrPc
p27-30
prion protein Filipin inhibits the reaction [Copper Sulfate results in increased uptake of and affects the localization of PRNP protein] affects localization
/ decreases reaction
/ increases uptake
protein 11994310
D005372 5621 PRNP
ASCR
AltPrP
CD230
CJD
GSS
KURU
PRIP
PrP
PrP27-30
PrP33-35C
PrPc
p27-30
prion protein Filipin results in increased secretion of PRNP protein increases secretion
protein 11994310
D005372 6714 SRC
ASV
SRC1
c-SRC
p60-Src
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) Filipin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of SRC protein] decreases reaction
/ increases phosphorylation
protein 19632255
D005372 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 Filipin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 19632255

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (5)

OMIM preferred title UniProt
#609535 Drug metabolism, poor, cyp2c19-related P33261
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#607276 Resting heart rate, variation in P08588

KEGG DISEASE (4)

KEGG disease name UniProt
H00079 Asthma P07550 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D017096 D005372 Prion Diseases therapeutic
11994310