Species

KNApSAcK Entry

Organism name Streptomyces filipinensis NRRL 2437
Genus Streptomyces
Family Streptomycetaceae
Kingdom Bacteria

NCBI taxonomy

Entry

Linked NCBI taxonomy name Streptomyces
Linked NCBI taxonomy ID 1883
Linked level genus

Family

Family in NCBI taxonomy Streptomycetaceae
ID 2062

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Bacteria
ID 2

Plant class

Plant class
ID

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00018790 External link 512 Filipin II
No. 1095
C00018791 External link 512 Filipin III
CHEMBL154669
CHEMBL1562334
CHEMBL1981819
CHEMBL2103755
D005372
5 / 5 / 4 6 / 1 No. 1095
C00018792 External link 512 Filipin IV
CHEMBL154669
CHEMBL1562334
CHEMBL1981819
CHEMBL2103755
5 / 5 / 4 No. 1095

Human Protein / Gene in interactions

5 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P16473 Thyrotropin receptor Glycohormone receptor C00018791 C00018792 3 / 2
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00018791 C00018792 1 / 1
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00018791 C00018792 0 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00018791 C00018792 1 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00018791 C00018792 0 / 0

6 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00018791
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00018791
3716 JAK1, JAK1A, JAK1B, JTK3 Janus kinase 1 (EC:2.7.10.2) C00018791
5621 PRNP, ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30 prion protein C00018791
6714 SRC, ASV, SRC1, c-SRC, p60-Src v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (EC:2.7.10.2) C00018791
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00018791

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (5)

OMIM preferred title UniProt
#609535 Drug metabolism, poor, cyp2c19-related P33261
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#607276 Resting heart rate, variation in P08588

KEGG DISEASE (4)

KEGG name UniProt
H00079 Asthma P07550 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D017096 Prion Diseases C00018791