PCIDB

KNApSAcK Metabolite C00002340

Metabolite

KNApSAcK Entry

id C00002340
Name Gliotoxin
CAS RN 67-99-2
Standard InChI InChI=1S/C13H14N2O4S2/c1-14-10(18)12-5-7-3-2-4-8(17)9(7)15(12)11(19)13(14,6-16)21-20-12/h2-4,8-9,16-17H,5-6H2,1H3/t8-,9-,12+,13+/m0/s1
Standard InChI (Main Layer) InChI=1S/C13H14N2O4S2/c1-14-10(18)12-5-7-3-2-4-8(17)9(7)15(12)11(19)13(14,6-16)21-20-12/h2-4,8-9,16-17H,5-6H2,1H3

Cluster

Phytochemical cluster
KCF-S cluster No. 5539

Link

ChEMBL

By standard InChI CHEMBL331627
By standard InChI Main Layer CHEMBL331627 CHEMBL1972524

KEGG

By LinkDB C10595

CTD

By CAS RN D005912

Species

Summary

Plant class

class name count

Family

family name count
Aspergillaceae 2

List (3)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Aspergillus fumigatus 746128 Aspergillaceae Fungi
Gliocladium fimbriatum 62887 Fungi
Penicillium spp. 5073 Aspergillaceae Fungi

Human Protein / Gene in interaction

8 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
O43463 Histone-lysine N-methyltransferase SUV39H1 Enzyme CHEMBL331627 CHEMBL2173370 (1)
0 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL331627 CHEMBL1794311 (1)
2 / 3
Q8WTS6 Histone-lysine N-methyltransferase SETD7 Enzyme CHEMBL331627 CHEMBL1953574 (1)
0 / 0
P06732 Creatine kinase M-type Enzyme CHEMBL331627 CHEMBL664050 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL331627 CHEMBL1953573 (1) CHEMBL2173371 (1)
0 / 0
P49356 Protein farnesyltransferase subunit beta Enzyme CHEMBL331627 CHEMBL680085 (1) CHEMBL682844 (1)
0 / 0
P49354 Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Enzyme CHEMBL331627 CHEMBL680085 (1) CHEMBL682844 (1)
CHEMBL686125 (1)
0 / 0
P53609 Geranylgeranyl transferase type-1 subunit beta Enzyme CHEMBL331627 CHEMBL686125 (1)
0 / 0

CTD interaction (8)

compound gene gene name gene description interaction interaction type form reference
pmid
D005912 330 BIRC3
AIP1
API2
CIAP2
HAIP1
HIAP1
MALT2
MIHC
RNF49
c-IAP2
baculoviral IAP repeat containing 3 Gliotoxin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BIRC3 mRNA] decreases reaction
/ increases expression
mRNA 14527959
D005912 3458 IFNG
IFG
IFI
interferon, gamma Gliotoxin results in decreased expression of IFNG mRNA decreases expression
mRNA 12112629
D005912 3458 IFNG
IFG
IFI
interferon, gamma Gliotoxin results in decreased secretion of IFNG protein decreases secretion
protein 12112629
D005912 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Gliotoxin inhibits the reaction [Zymosan results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 11527995
D005912 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Gliotoxin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [NFKB1 protein binds to RELA protein]] affects binding
/ decreases reaction
/ increases activity
protein 14527959
D005912 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Gliotoxin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [NFKB1 protein binds to RELA protein]] affects binding
/ decreases reaction
/ increases activity
protein 14527959
D005912 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) Gliotoxin inhibits the reaction [Lipopolysaccharides results in increased expression of SOD2 mRNA] decreases reaction
/ increases expression
mRNA 10653605
D005912 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Gliotoxin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] decreases reaction
/ increases expression
mRNA 10653605

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (2)

OMIM preferred title UniProt
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (3)

KEGG disease name UniProt
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D056486 D005912 Drug-Induced Liver Injury therapeutic
19739265