PCIDB

KNApSAcK Metabolite C00002367

Metabolite

KNApSAcK Entry

id C00002367
Name Tylophorine
CAS RN 482-20-2
Standard InChI InChI=1S/C24H27NO4/c1-26-21-9-16-15-8-14-6-5-7-25(14)13-20(15)19-12-24(29-4)23(28-3)11-18(19)17(16)10-22(21)27-2/h9-12,14H,5-8,13H2,1-4H3/t14-/m0/s1
Standard InChI (Main Layer) InChI=1S/C24H27NO4/c1-26-21-9-16-15-8-14-6-5-7-25(14)13-20(15)19-12-24(29-4)23(28-3)11-18(19)17(16)10-22(21)27-2/h9-12,14H,5-8,13H2,1-4H3

Cluster

Phytochemical cluster
KCF-S cluster No. 410

Link

ChEMBL

By standard InChI CHEMBL250426
By standard InChI Main Layer CHEMBL250426 CHEMBL258137 CHEMBL493620

KEGG

By LinkDB C10623

CTD

By CAS RN C004218

Human Protein / Gene in interaction

CTD interaction (21)

compound gene gene name gene description interaction interaction type form reference
pmid
C004218 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) tylophorine analog inhibits the reaction [TNF results in increased activity of AKT1 protein] decreases reaction
/ increases activity
protein 19284764
C004218 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) tylophorine analog results in decreased phosphorylation of and results in decreased expression of AKT1 decreases expression
/ decreases phosphorylation
19284764
C004218 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 tylophorine analog results in increased expression of BCL2L1 mRNA increases expression
mRNA 19284764
C004218 890 CCNA2
CCN1
CCNA
cyclin A2 tylophorine analog results in decreased expression of CCNA2 decreases expression
19284764
C004218 891 CCNB1
CCNB
cyclin B1 tylophorine analog results in increased expression of CCNB1 protein increases expression
protein 19284764
C004218 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 tylophorine analog results in increased expression of CCND1 protein increases expression
protein 19284764
C004218 993 CDC25A
CDC25A2
cell division cycle 25A (EC:3.1.3.48) tylophorine analog results in increased expression of CDC25A increases expression
19284764
C004218 8837 CFLAR
CASH
CASP8AP1
CLARP
Casper
FLAME
FLAME-1
FLAME1
FLIP
I-FLICE
MRIT
c-FLIP
c-FLIPL
c-FLIPR
c-FLIPS
CASP8 and FADD-like apoptosis regulator tylophorine analog results in increased expression of CFLAR mRNA increases expression
mRNA 19284764
C004218 1147 CHUK
IKBKA
IKK-alpha
IKK1
IKKA
NFKBIKA
TCF16
conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) tylophorine analog results in increased activity of CHUK protein increases activity
protein 19284764
C004218 3654 IRAK1
IRAK
pelle
interleukin-1 receptor-associated kinase 1 (EC:2.7.11.1) tylophorine analog results in increased expression of IRAK1 mRNA increases expression
mRNA 19284764
C004218 9020 MAP3K14
FTDCR1B
HS
HSNIK
NIK
mitogen-activated protein kinase kinase kinase 14 (EC:2.7.11.25) tylophorine analog results in increased expression of MAP3K14 mRNA increases expression
mRNA 19284764
C004218 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha tylophorine analog results in increased expression of NFKBIA mRNA increases expression
mRNA 19284764
C004218 5293 PIK3CD
P110DELTA
PI3K
p110D
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta (EC:2.7.1.153) tylophorine analog results in increased expression of PIK3CD mRNA increases expression
mRNA 19284764
C004218 5530 PPP3CA
CALN
CALNA
CALNA1
CCN1
CNA1
PPP2B
protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16) tylophorine analog results in increased expression of PPP3CA mRNA increases expression
mRNA 19284764
C004218 5566 PRKACA
PKACA
protein kinase, cAMP-dependent, catalytic, alpha (EC:2.7.11.11) tylophorine analog results in increased expression of PRKACA mRNA increases expression
mRNA 19284764
C004218 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) tylophorine analog inhibits the reaction [TNF results in increased expression of PTGS2 protein] decreases reaction
/ increases expression
protein 19284764
C004218 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A [tylophorine analog co-treated with TNF] results in decreased expression of RELA protein affects cotreatment
/ decreases expression
protein 19284764
C004218 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor [tylophorine analog co-treated with TNF] results in decreased expression of RELA protein affects cotreatment
/ decreases expression
19284764
C004218 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor tylophorine analog inhibits the reaction [TNF results in increased activity of AKT1 protein] decreases reaction
/ increases activity
19284764
C004218 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor tylophorine analog inhibits the reaction [TNF results in increased expression of PTGS2 protein] decreases reaction
/ increases expression
19284764
C004218 8795 TNFRSF10B
CD262
DR5
KILLER
KILLER/DR5
TRAIL-R2
TRAILR2
TRICK2
TRICK2A
TRICK2B
TRICKB
ZTNFR9
tumor necrosis factor receptor superfamily, member 10b tylophorine analog results in increased expression of TNFRSF10B mRNA increases expression
mRNA 19284764