PCIDB

KNApSAcK Metabolite C00023672

Metabolite

KNApSAcK Entry

id C00023672
Name Wortmannin
CAS RN 19545-26-7
Standard InChI InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1
Standard InChI (Main Layer) InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3

Cluster

Phytochemical cluster
KCF-S cluster No. 4941

Link

ChEMBL

By standard InChI CHEMBL428496
By standard InChI Main Layer CHEMBL428496 CHEMBL295038 CHEMBL1418590 CHEMBL1474372

KEGG

By LinkDB C15181

CTD

By CAS RN C009687

Species

Summary

Plant class

class name count

Family

family name count
Aspergillaceae 1

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Myrothecium roridum 62969 Fungi
Penicillium wortmannii 5073 Aspergillaceae Fungi

Human Protein / Gene in interaction

131 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1418590 CHEMBL1741321 (1)
1 / 0
P42345 Serine/threonine-protein kinase mTOR Enzyme CHEMBL428496 CHEMBL872196 (1)
0 / 0
Q02750 Dual specificity mitogen-activated protein kinase kinase 1 Ste7 CHEMBL428496 CHEMBL1062820 (1)
1 / 1
P42338 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Enzyme CHEMBL428496 CHEMBL871586 (1) CHEMBL1646726 (1)
CHEMBL2217264 (1)
0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL1418590 CHEMBL1613992 (1) CHEMBL1613995 (1)
7 / 44
Q9P1W9 Serine/threonine-protein kinase pim-2 Pim CHEMBL428496 CHEMBL1061086 (1)
0 / 0
Q8TDX7 Serine/threonine-protein kinase Nek7 Nek CHEMBL428496 CHEMBL1060151 (1)
0 / 0
Q16637 Survival motor neuron protein Unclassified protein CHEMBL295038 CHEMBL1613842 (1)
4 / 2
Q99700 Ataxin-2 Unclassified protein CHEMBL295038 CHEMBL1794367 (1) CHEMBL2114784 (1)
1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL428496 CHEMBL295038 CHEMBL1794499 (3)
2 / 0
P14618 Pyruvate kinase PKM Enzyme CHEMBL1418590 CHEMBL1614177 (1) CHEMBL1614265 (1)
0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL295038 CHEMBL1794573 (1)
2 / 2
P78527 DNA-dependent protein kinase catalytic subunit Atypical serine/threonine protein kinase PIKK subfamily CHEMBL428496 CHEMBL829682 (1) CHEMBL2183424 (1)
0 / 0
Q15759 Mitogen-activated protein kinase 11 p38 CHEMBL428496 CHEMBL1052111 (1) CHEMBL1249570 (1)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL428496 CHEMBL1063767 (1) CHEMBL1249569 (1)
0 / 0
O15530 3-phosphoinositide-dependent protein kinase 1 Pdk1 CHEMBL428496 CHEMBL1063811 (1)
0 / 0
P41240 Tyrosine-protein kinase CSK Csk CHEMBL428496 CHEMBL1061954 (1)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL295038 CHEMBL1614175 (1)
1 / 1
P42336 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Enzyme CHEMBL428496 CHEMBL829681 (1) CHEMBL866276 (1)
CHEMBL871583 (1) CHEMBL979105 (1)
CHEMBL979106 (1) CHEMBL1064071 (1)
CHEMBL1633056 (1) CHEMBL1646725 (1)
CHEMBL2161901 (1) CHEMBL2217265 (1)
CHEMBL2327633 (1)
9 / 1
P45984 Mitogen-activated protein kinase 9 Jnk CHEMBL428496 CHEMBL1060122 (1)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL428496 CHEMBL1062776 (1) CHEMBL1249578 (1)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL428496 CHEMBL1061959 (1)
0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL428496 CHEMBL1794585 (1)
0 / 0
O14757 Serine/threonine-protein kinase Chk1 Chk1 CHEMBL428496 CHEMBL1051374 (1) CHEMBL1249589 (1)
0 / 0
Q8IWQ3 Serine/threonine-protein kinase BRSK2 CAMK serine/threonine protein kinase BRSK subfamily CHEMBL428496 CHEMBL1051367 (1)
0 / 0
P27448 MAP/microtubule affinity-regulating kinase 3 CAMK serine/threonine protein kinase MARK subfamily CHEMBL428496 CHEMBL1063734 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL295038 CHEMBL1614310 (1) CHEMBL1614544 (1)
11 / 10
P37840 Alpha-synuclein Unclassified protein CHEMBL428496 CHEMBL295038 CHEMBL2354282 (3)
4 / 2
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL428496 CHEMBL295038 CHEMBL1614554 (4) CHEMBL1613776 (4)
3 / 1
Q05513 Protein kinase C zeta type Iota CHEMBL428496 CHEMBL1052114 (1)
0 / 0
P11309 Serine/threonine-protein kinase pim-1 Pim CHEMBL428496 CHEMBL1063736 (1)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1418590 CHEMBL1741325 (1)
0 / 1
P23443 Ribosomal protein S6 kinase beta-1 p70 CHEMBL428496 CHEMBL1052119 (1) CHEMBL1249582 (1)
0 / 0
Q9UQB9 Aurora kinase C Aur CHEMBL428496 CHEMBL1062797 (1)
1 / 1
Q9HBH9 MAP kinase-interacting serine/threonine-protein kinase 2 CAMK serine/threonine protein kinase MNK subfamily CHEMBL428496 CHEMBL1060126 (1)
0 / 0
Q9NQU5 Serine/threonine-protein kinase PAK 6 STE serine/threonine protein kinase PAKB subfamily CHEMBL428496 CHEMBL1063719 (1)
0 / 0
Q16644 MAP kinase-activated protein kinase 3 CAMK serine/threonine protein kinase MAPKAPK CHEMBL428496 CHEMBL1061148 (1)
0 / 0
Q9H422 Homeodomain-interacting protein kinase 3 CMGC dual-specificity kinase HIPK CHEMBL428496 CHEMBL1061964 (1)
0 / 0
Q14680 Maternal embryonic leucine zipper kinase Melk CHEMBL428496 CHEMBL1052104 (1)
0 / 0
Q9NYY3 Serine/threonine-protein kinase PLK2 Plk2 CHEMBL428496 CHEMBL995301 (1)
0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL295038 CHEMBL1614166 (1)
1 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL428496 CHEMBL295038 CHEMBL1418590 CHEMBL1794311 (6)
2 / 3
Q15746 Myosin light chain kinase, smooth muscle Mlck CHEMBL428496 CHEMBL805570 (1) CHEMBL1061945 (1)
CHEMBL1062028 (1) CHEMBL1646347 (1)
1 / 1
Q13188 Serine/threonine-protein kinase 3 STE serine/threonine protein kinase MST subfamily CHEMBL428496 CHEMBL1060209 (1)
0 / 0
P31751 RAC-beta serine/threonine-protein kinase Akt CHEMBL428496 CHEMBL1061917 (1)
2 / 2
O75582 Ribosomal protein S6 kinase alpha-5 CAMK serine/threonine protein kinase MSKB subfamily CHEMBL428496 CHEMBL1062767 (1) CHEMBL1249575 (1)
0 / 0
O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta Other serine/threonine protein kinase CHEMBL428496 CHEMBL1062809 (1)
0 / 0
Q16513 Serine/threonine-protein kinase N2 Pkn CHEMBL428496 CHEMBL1060217 (1)
0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd CHEMBL428496 CHEMBL1062021 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL428496 CHEMBL295038 CHEMBL1418590 CHEMBL1614458 (4)
0 / 0
Q8N5S9 Calcium/calmodulin-dependent protein kinase kinase 1 META serine/threonine protein kinase subfamily CHEMBL428496 CHEMBL1061198 (1)
0 / 0
Q9P286 Serine/threonine-protein kinase PAK 7 STE serine/threonine protein kinase PAKB subfamily CHEMBL428496 CHEMBL1061163 (1)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL1474372 CHEMBL1614456 (1) CHEMBL1613803 (1)
0 / 0
Q96SB4 SRSF protein kinase 1 Srpk CHEMBL428496 CHEMBL1060225 (1)
0 / 0
Q92630 Dual specificity tyrosine-phosphorylation-regulated kinase 2 CMGC dual-specificity kinase DYRK2 CHEMBL428496 CHEMBL1062802 (1)
0 / 0
O43781 Dual specificity tyrosine-phosphorylation-regulated kinase 3 CMGC dual-specificity kinase DYRK2 CHEMBL428496 CHEMBL1061956 (1)
0 / 0
O96013 Serine/threonine-protein kinase PAK 4 STE serine/threonine protein kinase PAKB subfamily CHEMBL428496 CHEMBL1061162 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL295038 CHEMBL1794486 (1)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL428496 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL428496 CHEMBL295038 CHEMBL1613941 (1) CHEMBL2114843 (1)
0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk CHEMBL428496 CHEMBL1060118 (1) CHEMBL1249583 (1)
0 / 0
Q15418 Ribosomal protein S6 kinase alpha-1 Rskb CHEMBL428496 CHEMBL1052116 (1)
0 / 0
O15264 Mitogen-activated protein kinase 13 p38 CHEMBL428496 CHEMBL1060132 (1) CHEMBL1249572 (1)
0 / 0
P53779 Mitogen-activated protein kinase 10 Jnk CHEMBL428496 CHEMBL1060123 (1)
0 / 1
Q9H1R3 Myosin light chain kinase 2, skeletal/cardiac muscle Mlck CHEMBL428496 CHEMBL1249784 (1)
1 / 0
P51955 Serine/threonine-protein kinase Nek2 Nek CHEMBL428496 CHEMBL1062822 (1)
0 / 0
Q96RR4 Calcium/calmodulin-dependent protein kinase kinase 2 META serine/threonine protein kinase subfamily CHEMBL428496 CHEMBL1052080 (1)
0 / 0
Q9H4B4 Serine/threonine-protein kinase PLK3 PLK serine/threonine protein kinase subfamily CHEMBL428496 CHEMBL995295 (1) CHEMBL995297 (1)
CHEMBL995298 (1) CHEMBL995299 (1)
CHEMBL995300 (1)
0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL428496 CHEMBL2114810 (1)
7 / 3
Q9BUB5 MAP kinase-interacting serine/threonine-protein kinase 1 CAMK serine/threonine protein kinase MNK subfamily CHEMBL428496 CHEMBL1063759 (1)
0 / 0
P11308 Transcriptional regulator ERG Unclassified protein CHEMBL428496 CHEMBL2114924 (1)
1 / 2
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL295038 CHEMBL1418590 CHEMBL1614257 (3) CHEMBL1614410 (1)
CHEMBL1614531 (3)
1 / 3
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme CHEMBL428496 CHEMBL1963863 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL295038 CHEMBL1794467 (1)
0 / 0
P48730 Casein kinase I isoform delta Ck1 CHEMBL428496 CHEMBL1062001 (1)
1 / 0
Q96GD4 Aurora kinase B Aur CHEMBL428496 CHEMBL1051365 (1)
0 / 0
P49137 MAP kinase-activated protein kinase 2 CAMK serine/threonine protein kinase MAPKAPK CHEMBL428496 CHEMBL1051342 (1) CHEMBL1249574 (1)
0 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL428496 CHEMBL1418590 CHEMBL1052091 (1) CHEMBL1249567 (1)
CHEMBL1613808 (1)
0 / 0
P45983 Mitogen-activated protein kinase 8 Jnk CHEMBL428496 CHEMBL1061969 (1) CHEMBL1249568 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL1418590 CHEMBL1741322 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL1418590 CHEMBL1474372 CHEMBL1613910 (1) CHEMBL1614227 (2)
3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL295038 CHEMBL1418590 CHEMBL1614038 (2)
2 / 2
Q01453 Peripheral myelin protein 22 Unclassified protein CHEMBL295038 CHEMBL1614171 (1)
5 / 2
P53350 Serine/threonine-protein kinase PLK1 PLK serine/threonine protein kinase subfamily CHEMBL428496 CHEMBL995296 (1) CHEMBL1052115 (1)
CHEMBL1062888 (1) CHEMBL2217230 (1)
0 / 0
Q8IW41 MAP kinase-activated protein kinase 5 CAMK serine/threonine protein kinase MAPKAPK CHEMBL428496 CHEMBL1061101 (1) CHEMBL1249576 (1)
0 / 0
O75116 Rho-associated protein kinase 2 Rock CHEMBL428496 CHEMBL1063671 (1)
0 / 0
O00329 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Enzyme CHEMBL428496 CHEMBL871588 (1) CHEMBL1646729 (1)
CHEMBL2217262 (1)
0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL1418590 CHEMBL1614274 (1) CHEMBL1613823 (1)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL1418590 CHEMBL1614240 (1)
0 / 0
P31749 RAC-alpha serine/threonine-protein kinase Akt CHEMBL428496 CHEMBL1061172 (1) CHEMBL1249580 (1)
4 / 1
Q15118 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial Pdhk CHEMBL428496 CHEMBL1249579 (1)
0 / 0
O00141 Serine/threonine-protein kinase Sgk1 AGC serine/threonine protein kinase SGK subfamily CHEMBL428496 CHEMBL1063673 (1) CHEMBL1249581 (1)
0 / 0
P51812 Ribosomal protein S6 kinase alpha-3 Rskb CHEMBL428496 CHEMBL1063683 (1)
2 / 2
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1418590 CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1418590 CHEMBL1614108 (1) CHEMBL1613886 (1)
CHEMBL1741324 (1)
0 / 1
Q9HC98 Serine/threonine-protein kinase Nek6 Nek CHEMBL428496 CHEMBL1060128 (1)
0 / 0
Q9H2X6 Homeodomain-interacting protein kinase 2 CMGC dual-specificity kinase HIPK CHEMBL428496 CHEMBL1062015 (1)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL428496 CHEMBL295038 CHEMBL1794483 (2)
0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor CHEMBL295038 CHEMBL1614052 (1)
1 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL295038 CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL428496 CHEMBL295038 CHEMBL1418590 CHEMBL1614250 (4) CHEMBL1614421 (4)
CHEMBL1614502 (3)
4 / 3
Q99549 M-phase phosphoprotein 8 Unclassified protein CHEMBL295038 CHEMBL1738402 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL428496 CHEMBL1738184 (1) CHEMBL2114908 (1)
0 / 0
P06239 Tyrosine-protein kinase Lck Src CHEMBL428496 CHEMBL1249588 (1)
0 / 1
O96017 Serine/threonine-protein kinase Chk2 Rad53 CHEMBL428496 CHEMBL1062000 (1)
4 / 1
Q14012 Calcium/calmodulin-dependent protein kinase type 1 Camk1 CHEMBL428496 CHEMBL1051272 (1)
0 / 0
P07900 Heat shock protein HSP 90-alpha Other cytosolic protein CHEMBL428496 CHEMBL1794333 (1)
0 / 0
P48736 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Enzyme CHEMBL428496 CHEMBL871582 (1) CHEMBL902509 (1)
CHEMBL1633057 (1) CHEMBL1646727 (1)
CHEMBL2217263 (1)
0 / 0
P17612 cAMP-dependent protein kinase catalytic subunit alpha Pka CHEMBL428496 CHEMBL1062854 (1)
0 / 0
Q13627 Dual specificity tyrosine-phosphorylation-regulated kinase 1A CMGC dual-specificity kinase DYRK1 CHEMBL428496 CHEMBL1062005 (1)
1 / 0
P53778 Mitogen-activated protein kinase 12 p38 CHEMBL428496 CHEMBL1062773 (1) CHEMBL1249571 (1)
0 / 0
O00418 Eukaryotic elongation factor 2 kinase Atypical serine/threonine protein kinase alpha subfamily CHEMBL428496 CHEMBL1060113 (1)
0 / 0
Q8TD08 Mitogen-activated protein kinase 15 Mapk CHEMBL428496 CHEMBL1062012 (1)
0 / 0
Q86V86 Serine/threonine-protein kinase pim-3 Pim CHEMBL428496 CHEMBL1061912 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL295038 CHEMBL1794536 (2)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL1418590 CHEMBL1613914 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL428496 CHEMBL295038 CHEMBL1418590 CHEMBL1613829 (5)
0 / 0
P40225 Thrombopoietin Unclassified protein CHEMBL1418590 CHEMBL1614086 (1) CHEMBL1614034 (1)
1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL428496 CHEMBL295038 CHEMBL1738442 (5)
0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL428496 CHEMBL295038 CHEMBL2354311 (2)
1 / 0
O00255 Menin Unclassified protein CHEMBL295038 CHEMBL1418590 CHEMBL1614257 (3) CHEMBL1614531 (3)
2 / 5
P20248 Cyclin-A2 Other cytosolic protein CHEMBL428496 CHEMBL1056886 (1)
0 / 0
P78396 Cyclin-A1 Other cytosolic protein CHEMBL428496 CHEMBL1056886 (1)
0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 CHEMBL428496 CHEMBL1056886 (1)
0 / 0
P68400 Casein kinase II subunit alpha Ck2 CHEMBL428496 CHEMBL1061205 (1)
0 / 0
P19784 Casein kinase II subunit alpha' Ck2 CHEMBL428496 CHEMBL1061205 (1)
0 / 0
P67870 Casein kinase II subunit beta REG serine/threonine protein kinase family CHEMBL428496 CHEMBL1061205 (1)
0 / 0
P27986 Phosphatidylinositol 3-kinase regulatory subunit alpha Enzyme CHEMBL428496 CHEMBL866276 (1) CHEMBL2161901 (1)
CHEMBL2327633 (1)
2 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL428496 CHEMBL2114738 (1)
0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme CHEMBL428496 CHEMBL2114796 (1)
2 / 1
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL428496 CHEMBL2354287 (1)
1 / 1

CTD interaction (332)

compound gene gene name gene description interaction interaction type form reference
pmid
C009687 8647 ABCB11
ABC16
BRIC2
BSEP
PFIC-2
PFIC2
PGY4
SPGP
ATP-binding cassette, sub-family B (MDR/TAP), member 11 wortmannin results in decreased activity of ABCB11 protein decreases activity
protein 20829430
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 15050414
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased activity of and results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 19801633
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 11788791
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [C5 protein results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 16116186
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [Caffeine results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 18201823
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [Capsaicin results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 19139269
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [Copper results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 16973122
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [Copper Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 16973122
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15608143
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [Estrone results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 21767602
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [Hexanones results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 14757120
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [Humic Substances results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 19686714
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [Hydrocarbons, Chlorinated results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 14757120
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 16499871
16682453
17520698
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [IL8 results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 21742513
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 17550345
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 16116186
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]] affects cotreatment
/ decreases reaction
/ increases phosphorylation
/ increases reaction
protein 20562903
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]] affects cotreatment
/ decreases reaction
/ increases phosphorylation
/ increases reaction
protein 20562903
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 12482858
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 12614848
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 22556157
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 15980035
17513037
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [Zinc results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 16973122
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 15355987
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 16973122
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin promotes the reaction [evodiamine results in decreased phosphorylation of AKT1 protein] decreases phosphorylation
/ increases reaction
protein 20005289
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin results in decreased activity of AKT1 protein decreases activity
protein 12556562
C009687 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin results in decreased phosphorylation of AKT1 protein decreases phosphorylation
protein 12640124
16059913
23178381
C009687 248 ALPI
IAP
alkaline phosphatase, intestinal (EC:3.1.3.1) wortmannin promotes the reaction [Methotrexate results in increased activity of ALPI protein] increases activity
/ increases reaction
protein 16598758
C009687 248 ALPI
IAP
alkaline phosphatase, intestinal (EC:3.1.3.1) wortmannin results in increased activity of ALPI protein increases activity
protein 16598758
C009687 472 ATM
AT1
ATA
ATC
ATD
ATDC
ATE
TEL1
TELO1
ataxia telangiectasia mutated (EC:2.7.11.1) wortmannin inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]] decreases reaction
/ increases phosphorylation
/ increases reaction
protein 15489221
C009687 472 ATM
AT1
ATA
ATC
ATD
ATDC
ATE
TEL1
TELO1
ataxia telangiectasia mutated (EC:2.7.11.1) wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of ATM protein] decreases reaction
/ increases phosphorylation
protein 22119920
C009687 572 BAD
BBC2
BCL2L8
BCL2-associated agonist of cell death wortmannin inhibits the reaction [Acrolein results in increased phosphorylation of BAD protein] decreases reaction
/ increases phosphorylation
protein 19596284
C009687 572 BAD
BBC2
BCL2L8
BCL2-associated agonist of cell death wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of BAD protein] decreases reaction
/ increases phosphorylation
protein 15608143
C009687 581 BAX
BCL2L4
BCL2-associated X protein wortmannin inhibits the reaction [Leukotriene B4 results in increased expression of BAX protein] decreases reaction
/ increases expression
protein 15970427
C009687 9564 BCAR1
CAS
CAS1
CASS1
CRKAS
P130Cas
breast cancer anti-estrogen resistance 1 Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 10537051
C009687 9564 BCAR1
CAS
CAS1
CASS1
CRKAS
P130Cas
breast cancer anti-estrogen resistance 1 [oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 10537051
C009687 9564 BCAR1
CAS
CAS1
CASS1
CRKAS
P130Cas
breast cancer anti-estrogen resistance 1 wortmannin inhibits the reaction [oxotremorine M results in increased phosphorylation of BCAR1 protein] decreases reaction
/ increases phosphorylation
protein 10537051
C009687 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 wortmannin inhibits the reaction [Ethanol results in increased expression of BCL2 protein] decreases reaction
/ increases expression
protein 21410490
C009687 8678 BECN1
ATG6
VPS30
beclin1
beclin 1, autophagy related wortmannin promotes the reaction [Ethanol results in increased degradation of BECN1 protein] increases degradation
/ increases reaction
protein 21410490
C009687 329 BIRC2
API1
HIAP2
Hiap-2
MIHB
RNF48
c-IAP1
cIAP1
baculoviral IAP repeat containing 2 wortmannin inhibits the reaction [Acrolein results in increased expression of BIRC2 protein] decreases reaction
/ increases expression
protein 19596284
C009687 329 BIRC2
API1
HIAP2
Hiap-2
MIHB
RNF48
c-IAP1
cIAP1
baculoviral IAP repeat containing 2 wortmannin results in decreased expression of BIRC2 mRNA decreases expression
mRNA 15065019
C009687 329 BIRC2
API1
HIAP2
Hiap-2
MIHB
RNF48
c-IAP1
cIAP1
baculoviral IAP repeat containing 2 wortmannin results in decreased expression of BIRC2 protein decreases expression
protein 15065019
C009687 330 BIRC3
AIP1
API2
CIAP2
HAIP1
HIAP1
MALT2
MIHC
RNF49
c-IAP2
baculoviral IAP repeat containing 3 wortmannin inhibits the reaction [Acrolein results in increased expression of BIRC3 protein] decreases reaction
/ increases expression
protein 19596284
C009687 332 BIRC5
API4
EPR-1
baculoviral IAP repeat containing 5 wortmannin results in decreased expression of BIRC5 mRNA decreases expression
mRNA 15065019
C009687 332 BIRC5
API4
EPR-1
baculoviral IAP repeat containing 5 wortmannin results in decreased expression of BIRC5 protein decreases expression
protein 15065019
C009687 727 C5
C5a
C5b
CPAMD4
complement component 5 wortmannin inhibits the reaction [C5 protein results in decreased expression of IL12A mRNA] decreases expression
/ decreases reaction
protein 16116186
C009687 727 C5
C5a
C5b
CPAMD4
complement component 5 wortmannin inhibits the reaction [C5 protein results in decreased expression of [IL12A protein binds to IL12B protein]] affects binding
/ decreases expression
/ decreases reaction
protein 16116186
C009687 727 C5
C5a
C5b
CPAMD4
complement component 5 wortmannin inhibits the reaction [C5 protein results in decreased expression of IL12B mRNA] decreases expression
/ decreases reaction
protein 16116186
C009687 727 C5
C5a
C5b
CPAMD4
complement component 5 wortmannin inhibits the reaction [C5 protein results in decreased expression of IL23A mRNA] decreases expression
/ decreases reaction
protein 16116186
C009687 727 C5
C5a
C5b
CPAMD4
complement component 5 wortmannin inhibits the reaction [C5 protein results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 16116186
C009687 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) ABT-737 promotes the reaction [wortmannin promotes the reaction [celecoxib results in increased cleavage of CASP3 protein]] increases cleavage
/ increases reaction
protein 20104024
C009687 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) wortmannin promotes the reaction [celecoxib results in increased cleavage of CASP3 protein] increases cleavage
/ increases reaction
protein 20104024
C009687 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) wortmannin promotes the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein] increases activity
/ increases cleavage
/ increases reaction
protein 17935137
C009687 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) wortmannin promotes the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP3 protein] increases activity
/ increases cleavage
/ increases reaction
protein 17935137
C009687 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) ABT-737 promotes the reaction [wortmannin promotes the reaction [celecoxib results in increased cleavage of CASP8 protein]] increases cleavage
/ increases reaction
protein 20104024
C009687 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) wortmannin promotes the reaction [celecoxib results in increased cleavage of CASP8 protein] increases cleavage
/ increases reaction
protein 20104024
C009687 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) ABT-737 promotes the reaction [wortmannin promotes the reaction [celecoxib results in increased cleavage of CASP9 protein]] increases cleavage
/ increases reaction
protein 20104024
C009687 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) wortmannin promotes the reaction [celecoxib results in increased cleavage of CASP9 protein] increases cleavage
/ increases reaction
protein 20104024
C009687 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) wortmannin promotes the reaction [Doxorubicin results in increased cleavage of CASP9 protein] increases cleavage
/ increases reaction
protein 17935137
C009687 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) wortmannin promotes the reaction [Etoposide results in increased cleavage of CASP9 protein] increases cleavage
/ increases reaction
protein 17935137
C009687 857 CAV1
BSCL3
CGL3
MSTP085
PPH3
VIP21
CAV
caveolin 1, caveolae protein, 22kDa wortmannin inhibits the reaction [CAV1 protein results in increased susceptibility to Hydrogen Peroxide] decreases reaction
/ increases response to substance
protein 12640124
C009687 857 CAV1
BSCL3
CGL3
MSTP085
PPH3
VIP21
CAV
caveolin 1, caveolae protein, 22kDa wortmannin inhibits the reaction [CAV1 protein results in increased susceptibility to sodium arsenite] decreases reaction
/ increases response to substance
protein 12640124
C009687 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 wortmannin inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CCND1 protein] decreases reaction
/ increases expression
protein 19801633
C009687 894 CCND2
KIAK0002
cyclin D2 wortmannin results in decreased methylation of CCND2 promoter decreases methylation
promoter 14745455
C009687 894 CCND2
KIAK0002
cyclin D2 wortmannin results in increased expression of CCND2 mRNA increases expression
mRNA 14745455
C009687 1232 CCR3
CC-CKR-3
CD193
CKR3
CMKBR3
chemokine (C-C motif) receptor 3 wortmannin inhibits the reaction [IL3 protein results in decreased expression of CCR3 protein] decreases expression
/ decreases reaction
protein 11544337
C009687 948 CD36
BDPLT10
CHDS7
FAT
GP3B
GP4
GPIV
PASIV
SCARB3
CD36 molecule (thrombospondin receptor) wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of CD36 mRNA] decreases reaction
/ increases expression
mRNA 19640849
C009687 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) wortmannin inhibits the reaction [Aspirin results in increased expression of CDKN1A protein] decreases reaction
/ increases expression
protein 21617849
C009687 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) wortmannin inhibits the reaction [docetaxel results in increased expression of CDKN1A protein] decreases reaction
/ increases expression
protein 20878124
C009687 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) wortmannin results in decreased expression of CDKN1A protein decreases expression
protein 22290291
C009687 1027 CDKN1B
CDKN4
KIP1
MEN1B
MEN4
P27KIP1
cyclin-dependent kinase inhibitor 1B (p27, Kip1) wortmannin promotes the reaction [Doxorubicin results in increased expression of CDKN1B protein] increases expression
/ increases reaction
protein 17935137
C009687 1027 CDKN1B
CDKN4
KIP1
MEN1B
MEN4
P27KIP1
cyclin-dependent kinase inhibitor 1B (p27, Kip1) wortmannin promotes the reaction [Etoposide results in increased expression of CDKN1B protein] increases expression
/ increases reaction
protein 17935137
C009687 1080 CFTR
ABC35
ABCC7
CF
CFTR/MRP
MRP7
TNR-CFTR
dJ760C5.1
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) wortmannin inhibits the reaction [CGP 12177 results in increased activity of CFTR protein] decreases reaction
/ increases activity
protein 15563584
C009687 1111 CHEK1
CHK1
checkpoint kinase 1 (EC:2.7.11.1) wortmannin inhibits the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 19261750
C009687 1111 CHEK1
CHK1
checkpoint kinase 1 (EC:2.7.11.1) wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK1 protein] decreases reaction
/ increases phosphorylation
protein 22119920
C009687 1111 CHEK1
CHK1
checkpoint kinase 1 (EC:2.7.11.1) wortmannin results in decreased expression of CHEK1 protein decreases expression
protein 22409540
C009687 11200 CHEK2
CDS1
CHK2
HuCds1
LFS2
PP1425
RAD53
hCds1
checkpoint kinase 2 (EC:2.7.11.1) wortmannin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of CHEK2 protein] decreases reaction
/ increases phosphorylation
protein 19111594
C009687 11200 CHEK2
CDS1
CHK2
HuCds1
LFS2
PP1425
RAD53
hCds1
checkpoint kinase 2 (EC:2.7.11.1) wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK2 protein] decreases reaction
/ increases phosphorylation
protein 22119920
C009687 11200 CHEK2
CDS1
CHK2
HuCds1
LFS2
PP1425
RAD53
hCds1
checkpoint kinase 2 (EC:2.7.11.1) wortmannin results in decreased phosphorylation of CHEK2 protein decreases phosphorylation
protein 22119920
C009687 80781 COL18A1
KNO
KNO1
KS
collagen, type XVIII, alpha 1 wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 mRNA] decreases expression
/ decreases reaction
mRNA 13679210
C009687 80781 COL18A1
KNO
KNO1
KS
collagen, type XVIII, alpha 1 wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 protein] decreases expression
/ decreases reaction
protein 13679210
C009687 1278 COL1A2
OI4
collagen, type I, alpha 2 wortmannin inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] decreases reaction
/ increases expression
mRNA 11343241
C009687 1385 CREB1
CREB
cAMP responsive element binding protein 1 wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of CREB1 protein] decreases reaction
/ increases phosphorylation
protein 15608143
C009687 1499 CTNNB1
CTNNB
MRD19
armadillo
catenin (cadherin-associated protein), beta 1, 88kDa wortmannin results in decreased expression of CTNNB1 protein decreases expression
protein 11739494
C009687 2920 CXCL2
CINC-2a
GRO2
GROb
MGSA-b
MIP-2a
MIP2
MIP2A
SCYB2
chemokine (C-X-C motif) ligand 2 wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15608143
C009687 2920 CXCL2
CINC-2a
GRO2
GROb
MGSA-b
MIP-2a
MIP2
MIP2A
SCYB2
chemokine (C-X-C motif) ligand 2 wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15608143
C009687 2920 CXCL2
CINC-2a
GRO2
GROb
MGSA-b
MIP-2a
MIP2
MIP2A
SCYB2
chemokine (C-X-C motif) ligand 2 wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15608143
C009687 2920 CXCL2
CINC-2a
GRO2
GROb
MGSA-b
MIP-2a
MIP2
MIP2A
SCYB2
chemokine (C-X-C motif) ligand 2 wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of BAD protein] decreases reaction
/ increases phosphorylation
protein 15608143
C009687 2920 CXCL2
CINC-2a
GRO2
GROb
MGSA-b
MIP-2a
MIP2
MIP2A
SCYB2
chemokine (C-X-C motif) ligand 2 wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of CREB1 protein] decreases reaction
/ increases phosphorylation
protein 15608143
C009687 3579 CXCR2
CD182
CDw128b
CMKAR2
IL8R2
IL8RA
IL8RB
chemokine (C-X-C motif) receptor 2 wortmannin inhibits the reaction [IL8 protein results in increased activity of CXCR2 protein] decreases reaction
/ increases activity
protein 12975484
C009687 199974 CYP4Z1
CYP4A20
cytochrome P450, family 4, subfamily Z, polypeptide 1 (EC:1.14.14.1) wortmannin inhibits the reaction [CYP4Z1 protein results in increased expression of TIMP2 mRNA] decreases reaction
/ increases expression
protein 22841774
C009687 199974 CYP4Z1
CYP4A20
cytochrome P450, family 4, subfamily Z, polypeptide 1 (EC:1.14.14.1) wortmannin inhibits the reaction [CYP4Z1 protein results in increased expression of VEGFA mRNA] decreases reaction
/ increases expression
protein 22841774
C009687 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA] decreases reaction
/ increases expression
mRNA 17171638
C009687 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 protein] decreases reaction
/ increases expression
protein 17171638
C009687 1956 EGFR
ERBB
ERBB1
HER1
PIG61
mENA
epidermal growth factor receptor (EC:2.7.10.1) wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C009687 1978 EIF4EBP1
4E-BP1
4EBP1
BP-1
PHAS-I
eukaryotic translation initiation factor 4E binding protein 1 wortmannin inhibits the reaction [IGF1 protein results in increased phosphorylation of EIF4EBP1 protein] decreases reaction
/ increases phosphorylation
protein 12569580
C009687 2057 EPOR
EPO-R
erythropoietin receptor wortmannin inhibits the reaction [testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased expression of EPOR mRNA] decreases reaction
/ increases expression
mRNA 20189893
C009687 2152 F3
CD142
TF
TFA
coagulation factor III (thromboplastin, tissue factor) wortmannin promotes the reaction [Histamine results in increased expression of F3] increases expression
/ increases reaction
16009787
C009687 356 FASLG
ALPS1B
APT1LG1
APTL
CD178
CD95-L
CD95L
FASL
TNFSF6
Fas ligand (TNF superfamily, member 6) wortmannin inhibits the reaction [evodiamine results in increased expression of FASLG protein] decreases reaction
/ increases expression
protein 20005289
C009687 2252 FGF7
HBGF-7
KGF
fibroblast growth factor 7 wortmannin inhibits the reaction [FGF7 protein results in increased expression of PLAC1 mRNA] decreases reaction
/ increases expression
protein 15803460
C009687 2308 FOXO1
FKH1
FKHR
FOXO1A
forkhead box O1 wortmannin inhibits the reaction [Copper affects the localization of FOXO1 protein] affects localization
/ decreases reaction
protein 16973122
C009687 2308 FOXO1
FKH1
FKHR
FOXO1A
forkhead box O1 wortmannin inhibits the reaction [Copper results in increased phosphorylation of FOXO1 protein] decreases reaction
/ increases phosphorylation
protein 16973122
C009687 2308 FOXO1
FKH1
FKHR
FOXO1A
forkhead box O1 wortmannin inhibits the reaction [Copper Sulfate affects the localization of FOXO1 protein] affects localization
/ decreases reaction
protein 16973122
C009687 2308 FOXO1
FKH1
FKHR
FOXO1A
forkhead box O1 wortmannin inhibits the reaction [Copper Sulfate results in increased phosphorylation of FOXO1 protein] decreases reaction
/ increases phosphorylation
protein 16973122
C009687 2308 FOXO1
FKH1
FKHR
FOXO1A
forkhead box O1 wortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of FOXO1 protein] decreases reaction
/ increases phosphorylation
protein 17935137
C009687 2308 FOXO1
FKH1
FKHR
FOXO1A
forkhead box O1 wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of FOXO1 protein] decreases reaction
/ increases phosphorylation
protein 17935137
C009687 2308 FOXO1
FKH1
FKHR
FOXO1A
forkhead box O1 wortmannin inhibits the reaction [Zinc affects the localization of FOXO1 protein] affects localization
/ decreases reaction
protein 16973122
C009687 2308 FOXO1
FKH1
FKHR
FOXO1A
forkhead box O1 wortmannin inhibits the reaction [Zinc results in increased phosphorylation of FOXO1 protein] decreases reaction
/ increases phosphorylation
protein 16973122
C009687 2308 FOXO1
FKH1
FKHR
FOXO1A
forkhead box O1 wortmannin inhibits the reaction [Zinc Sulfate affects the localization of FOXO1 protein] affects localization
/ decreases reaction
protein 16973122
C009687 2308 FOXO1
FKH1
FKHR
FOXO1A
forkhead box O1 wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of FOXO1 protein] decreases reaction
/ increases phosphorylation
protein 16973122
C009687 2309 FOXO3
AF6q21
FKHRL1
FKHRL1P2
FOXO2
FOXO3A
forkhead box O3 wortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of FOXO3 protein] decreases reaction
/ increases phosphorylation
protein 17935137
C009687 2309 FOXO3
AF6q21
FKHRL1
FKHRL1P2
FOXO2
FOXO3A
forkhead box O3 wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of FOXO3 protein] decreases reaction
/ increases phosphorylation
protein 17935137
C009687 4303 FOXO4
AFX
AFX1
MLLT7
forkhead box O4 wortmannin inhibits the reaction [Copper results in increased phosphorylation of FOXO4 protein] decreases reaction
/ increases phosphorylation
protein 16973122
C009687 4303 FOXO4
AFX
AFX1
MLLT7
forkhead box O4 wortmannin inhibits the reaction [Copper Sulfate results in increased phosphorylation of FOXO4 protein] decreases reaction
/ increases phosphorylation
protein 16973122
C009687 4303 FOXO4
AFX
AFX1
MLLT7
forkhead box O4 wortmannin inhibits the reaction [Zinc results in increased phosphorylation of FOXO4 protein] decreases reaction
/ increases phosphorylation
protein 16973122
C009687 4303 FOXO4
AFX
AFX1
MLLT7
forkhead box O4 wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of FOXO4 protein] decreases reaction
/ increases phosphorylation
protein 16973122
C009687 9518 GDF15
GDF-15
MIC-1
MIC1
NAG-1
PDF
PLAB
PTGFB
growth differentiation factor 15 wortmannin results in increased expression of GDF15 protein increases expression
protein 23178381
C009687 2932 GSK3B
glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) wortmannin inhibits the reaction [Estradiol results in increased phosphorylation of GSK3B protein] decreases reaction
/ increases phosphorylation
protein 16076840
C009687 2932 GSK3B
glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of GSK3B protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 12614848
C009687 2932 GSK3B
glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) wortmannin inhibits the reaction [Zinc results in increased phosphorylation of GSK3B protein] decreases reaction
/ increases phosphorylation
protein 17513037
C009687 2932 GSK3B
glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) wortmannin results in decreased phosphorylation of GSK3B protein decreases phosphorylation
protein 20090934
23178381
C009687 3014 H2AFX
H2A.X
H2A/X
H2AX
H2A histone family, member X wortmannin inhibits the reaction [decitabine results in increased expression of H2AFX protein] decreases reaction
/ increases expression
protein 17991895
C009687 3014 H2AFX
H2A.X
H2A/X
H2AX
H2A histone family, member X wortmannin promotes the reaction [docetaxel results in increased expression of H2AFX protein] increases expression
/ increases reaction
protein 20878124
C009687 3014 H2AFX
H2A.X
H2A/X
H2AX
H2A histone family, member X wortmannin promotes the reaction [Soil Pollutants results in increased phosphorylation of H2AFX protein] increases phosphorylation
/ increases reaction
protein 22409540
C009687 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [wortmannin co-treated with U 0126] inhibits the reaction [IGF1 protein promotes the reaction [cobaltous chloride results in increased expression of HIF1A protein]] affects cotreatment
/ decreases reaction
/ increases expression
/ increases reaction
protein 16499871
C009687 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) wortmannin inhibits the reaction [4-hydroxyestradiol results in increased expression of HIF1A protein] decreases reaction
/ increases expression
protein 15050414
C009687 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) wortmannin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein] decreases reaction
/ increases expression
protein 13679210
C009687 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) wortmannin inhibits the reaction [CR 3294 results in decreased expression of HIF1A protein] decreases expression
/ decreases reaction
protein 18927491
C009687 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein] affects binding
/ decreases reaction
/ increases activity
/ increases expression
protein 20335389
C009687 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA] decreases reaction
/ increases expression
mRNA 11424089
19640849
C009687 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) wortmannin results in decreased expression of HIF1A protein decreases expression
protein 14726529
C009687 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) wortmannin inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA] decreases reaction
/ increases expression
mRNA 18048804
C009687 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) wortmannin inhibits the reaction [plumbagin results in increased expression of HMOX1 protein] decreases reaction
/ increases expression
protein 20028456
C009687 3297 HSF1
HSTF1
heat shock transcription factor 1 wortmannin affects the localization of HSF1 protein affects localization
protein 20090934
C009687 3297 HSF1
HSTF1
heat shock transcription factor 1 wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of HSF1 mRNA] decreases reaction
/ increases expression
mRNA 11424089
C009687 692420 wortmannin results in decreased expression of HSP90 protein decreases expression
protein 14726529
C009687 3303 HSPA1A
HSP70-1
HSP70-1A
HSP70I
HSP72
HSPA1
heat shock 70kDa protein 1A wortmannin results in decreased expression of HSPA1A protein decreases expression
protein 20090934
C009687 3303 HSPA1A
HSP70-1
HSP70-1A
HSP70I
HSP72
HSPA1
heat shock 70kDa protein 1A wortmannin results in decreased expression of HSPA1A protein alternative form decreases expression
protein 20090934
C009687 3309 HSPA5
BIP
GRP78
MIF2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) wortmannin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA] decreases reaction
/ increases expression
mRNA 19428936
C009687 3458 IFNG
IFG
IFI
interferon, gamma wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]] affects cotreatment
/ decreases reaction
/ increases abundance
protein 16968468
C009687 3479 IGF1
IGF-I
IGF1A
IGFI
insulin-like growth factor 1 (somatomedin C) [wortmannin co-treated with U 0126] inhibits the reaction [IGF1 protein promotes the reaction [cobaltous chloride results in increased expression of HIF1A protein]] affects cotreatment
/ decreases reaction
/ increases expression
/ increases reaction
protein 16499871
C009687 3479 IGF1
IGF-I
IGF1A
IGFI
insulin-like growth factor 1 (somatomedin C) wortmannin inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein] decreases reaction
/ increases activity
protein 17520698
C009687 3479 IGF1
IGF-I
IGF1A
IGFI
insulin-like growth factor 1 (somatomedin C) wortmannin inhibits the reaction [IGF1 protein results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
protein 16499871
C009687 3479 IGF1
IGF-I
IGF1A
IGFI
insulin-like growth factor 1 (somatomedin C) wortmannin inhibits the reaction [IGF1 protein results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
protein 16499871
C009687 3479 IGF1
IGF-I
IGF1A
IGFI
insulin-like growth factor 1 (somatomedin C) wortmannin inhibits the reaction [IGF1 protein results in increased activity of MTR protein] decreases reaction
/ increases activity
protein 14745455
C009687 3479 IGF1
IGF-I
IGF1A
IGFI
insulin-like growth factor 1 (somatomedin C) wortmannin inhibits the reaction [IGF1 protein results in increased expression of MYCN protein] decreases reaction
/ increases expression
protein 12569580
C009687 3479 IGF1
IGF-I
IGF1A
IGFI
insulin-like growth factor 1 (somatomedin C) wortmannin inhibits the reaction [IGF1 protein results in increased expression of ZNF143 protein] decreases reaction
/ increases expression
protein 20733350
C009687 3479 IGF1
IGF-I
IGF1A
IGFI
insulin-like growth factor 1 (somatomedin C) wortmannin inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 16499871
16682453
17520698
C009687 3479 IGF1
IGF-I
IGF1A
IGFI
insulin-like growth factor 1 (somatomedin C) wortmannin inhibits the reaction [IGF1 protein results in increased phosphorylation of EIF4EBP1 protein] decreases reaction
/ increases phosphorylation
protein 12569580
C009687 3479 IGF1
IGF-I
IGF1A
IGFI
insulin-like growth factor 1 (somatomedin C) wortmannin inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein] decreases reaction
/ increases secretion
protein 16499871
C009687 3592 IL12A
CLMF
IL-12A
NFSK
NKSF1
P35
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) wortmannin inhibits the reaction [C5 protein results in decreased expression of IL12A mRNA] decreases expression
/ decreases reaction
mRNA 16116186
C009687 3592 IL12A
CLMF
IL-12A
NFSK
NKSF1
P35
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) wortmannin inhibits the reaction [C5 protein results in decreased expression of [IL12A protein binds to IL12B protein]] affects binding
/ decreases expression
/ decreases reaction
protein 16116186
C009687 3592 IL12A
CLMF
IL-12A
NFSK
NKSF1
P35
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]] affects binding
/ decreases expression
/ decreases reaction
protein 16116186
C009687 3593 IL12B
CLMF
CLMF2
IL-12B
NKSF
NKSF2
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) wortmannin inhibits the reaction [C5 protein results in decreased expression of [IL12A protein binds to IL12B protein]] affects binding
/ decreases expression
/ decreases reaction
protein 16116186
C009687 3593 IL12B
CLMF
CLMF2
IL-12B
NKSF
NKSF2
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) wortmannin inhibits the reaction [C5 protein results in decreased expression of IL12B mRNA] decreases expression
/ decreases reaction
mRNA 16116186
C009687 3593 IL12B
CLMF
CLMF2
IL-12B
NKSF
NKSF2
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]] affects binding
/ decreases expression
/ decreases reaction
protein 16116186
C009687 3552 IL1A
IL-1A
IL1
IL1-ALPHA
IL1F1
interleukin 1, alpha wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]] affects cotreatment
/ decreases reaction
/ increases abundance
protein 16968468
C009687 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta wortmannin inhibits the reaction [IL1B protein results in increased activity of MMP12 protein] decreases reaction
/ increases activity
protein 16359550
C009687 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta wortmannin inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA] decreases reaction
/ increases expression
protein 16359550
C009687 51561 IL23A
IL-23
IL-23A
IL23P19
P19
SGRF
interleukin 23, alpha subunit p19 wortmannin inhibits the reaction [C5 protein results in decreased expression of IL23A mRNA] decreases expression
/ decreases reaction
mRNA 16116186
C009687 3562 IL3
IL-3
MCGF
MULTI-CSF
interleukin 3 (colony-stimulating factor, multiple) wortmannin inhibits the reaction [IL3 protein results in decreased expression of CCR3 protein] decreases expression
/ decreases reaction
protein 11544337
C009687 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 wortmannin inhibits the reaction [IL8 protein results in increased activity of CXCR2 protein] decreases reaction
/ increases activity
protein 12975484
C009687 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 wortmannin inhibits the reaction [IL8 results in decreased susceptibility to Cisplatin] decreases reaction
/ decreases response to substance
21742513
C009687 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 wortmannin inhibits the reaction [IL8 results in decreased susceptibility to Paclitaxel] decreases reaction
/ decreases response to substance
21742513
C009687 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 wortmannin inhibits the reaction [IL8 results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
21742513
C009687 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 wortmannin inhibits the reaction [nickel subsulfide results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 11978798
C009687 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin [wortmannin co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein] affects cotreatment
/ affects localization
/ decreases reaction
protein 11574405
C009687 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin wortmannin inhibits the reaction [INS protein results in decreased susceptibility to Coumaric Acids] decreases reaction
/ decreases response to substance
protein 20015842
C009687 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin wortmannin inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 17550345
C009687 3685 ITGAV
CD51
MSK8
VNRA
VTNR
integrin, alpha V wortmannin inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]] affects activity
/ affects binding
/ affects localization
/ decreases reaction
protein 15213856
C009687 3689 ITGB2
CD18
LAD
LCAMB
LFA-1
MAC-1
MF17
MFI7
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) wortmannin inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein] decreases reaction
/ increases activity
protein 16963453
C009687 3690 ITGB3
BDPLT16
BDPLT2
CD61
GP3A
GPIIIa
GT
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) wortmannin inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]] affects activity
/ affects binding
/ affects localization
/ decreases reaction
protein 15213856
C009687 3756 KCNH1
EAG
EAG1
Kv10.1
h-eag
potassium voltage-gated channel, subfamily H (eag-related), member 1 wortmannin inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein] decreases reaction
/ increases activity
protein 17520698
C009687 3978 LIG1
ligase I, DNA, ATP-dependent (EC:6.5.1.1) wortmannin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of LIG1 protein] decreases reaction
/ increases phosphorylation
protein 16700562
C009687 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) [bisindolylmaleimide I co-treated with wortmannin] inhibits the reaction [Zinc results in increased phosphorylation of MAPK1 protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 20522546
C009687 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) KN 93 promotes the reaction [wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]] decreases reaction
/ increases phosphorylation
/ increases reaction
protein 15355987
C009687 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) wortmannin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 19477951
C009687 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15608143
C009687 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) wortmannin inhibits the reaction [IGF1 protein results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
protein 16499871
C009687 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C009687 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) wortmannin inhibits the reaction [Zinc results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 20522546
C009687 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 15355987
C009687 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) wortmannin promotes the reaction [KN 93 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]] decreases reaction
/ increases phosphorylation
/ increases reaction
protein 15355987
C009687 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) wortmannin results in increased phosphorylation of MAPK1 protein increases phosphorylation
protein 19139269
C009687 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) [bisindolylmaleimide I co-treated with wortmannin] inhibits the reaction [Zinc results in increased phosphorylation of MAPK3 protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 20522546
C009687 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) KN 93 promotes the reaction [wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]] decreases reaction
/ increases phosphorylation
/ increases reaction
protein 15355987
C009687 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) wortmannin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 19477951
C009687 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15608143
C009687 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) wortmannin inhibits the reaction [IGF1 protein results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
protein 16499871
C009687 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C009687 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) wortmannin inhibits the reaction [Zinc results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 20522546
C009687 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 15355987
C009687 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) wortmannin promotes the reaction [KN 93 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]] decreases reaction
/ increases phosphorylation
/ increases reaction
protein 15355987
C009687 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) wortmannin results in increased phosphorylation of MAPK3 protein increases phosphorylation
protein 19139269
C009687 4170 MCL1
BCL2L3
EAT
MCL1-ES
MCL1L
MCL1S
Mcl-1
TM
bcl2-L-3
mcl1/EAT
myeloid cell leukemia sequence 1 (BCL2-related) wortmannin inhibits the reaction [Leukotriene B4 results in increased expression of MCL1 protein] decreases reaction
/ increases expression
protein 15970427
C009687 4170 MCL1
BCL2L3
EAT
MCL1-ES
MCL1L
MCL1S
Mcl-1
TM
bcl2-L-3
mcl1/EAT
myeloid cell leukemia sequence 1 (BCL2-related) wortmannin promotes the reaction [Doxorubicin results in decreased expression of MCL1 protein] decreases expression
/ increases reaction
protein 17935137
C009687 4170 MCL1
BCL2L3
EAT
MCL1-ES
MCL1L
MCL1S
Mcl-1
TM
bcl2-L-3
mcl1/EAT
myeloid cell leukemia sequence 1 (BCL2-related) wortmannin promotes the reaction [Etoposide results in decreased expression of MCL1 protein] decreases expression
/ increases reaction
protein 17935137
C009687 4193 MDM2
ACTFS
HDMX
hdm2
MDM2 oncogene, E3 ubiquitin protein ligase wortmannin promotes the reaction [Doxorubicin results in increased phosphorylation of MDM2 protein] increases phosphorylation
/ increases reaction
protein 17935137
C009687 4193 MDM2
ACTFS
HDMX
hdm2
MDM2 oncogene, E3 ubiquitin protein ligase wortmannin promotes the reaction [Etoposide results in increased phosphorylation of MDM2 protein] increases phosphorylation
/ increases reaction
protein 17935137
C009687 406991 MIR21
MIRN21
hsa-mir-21
miR-21
miRNA21
microRNA 21 wortmannin inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA] decreases reaction
/ increases expression
mRNA 23052036
C009687 406991 MIR21
MIRN21
hsa-mir-21
miR-21
miRNA21
microRNA 21 wortmannin inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR21 mRNA] decreases reaction
/ increases expression
mRNA 23052036
C009687 4321 MMP12
HME
ME
MME
MMP-12
matrix metallopeptidase 12 (macrophage elastase) (EC:3.4.24.65) wortmannin inhibits the reaction [IL1B protein results in increased activity of MMP12 protein] decreases reaction
/ increases activity
protein 16359550
C009687 4321 MMP12
HME
ME
MME
MMP-12
matrix metallopeptidase 12 (macrophage elastase) (EC:3.4.24.65) wortmannin inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA] decreases reaction
/ increases expression
mRNA 16359550
C009687 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) wortmannin promotes the reaction [ovatodiolide results in decreased activity of MMP9 protein] decreases activity
/ increases reaction
protein 22033475
C009687 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) wortmannin results in decreased activity of MMP9 protein decreases activity
protein 22033475
C009687 4353 MPO
myeloperoxidase (EC:1.11.2.2) wortmannin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of MPO protein] decreases reaction
/ increases secretion
protein 18987595
C009687 4504 MT3
GIF
GIFB
GRIF
ZnMT3
metallothionein 3 wortmannin results in decreased susceptibility to MT3 protein decreases response to substance
protein 19767621
C009687 2475 MTOR
FRAP
FRAP1
FRAP2
RAFT1
RAPT1
mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1) wortmannin inhibits the reaction [Capsaicin results in increased phosphorylation of MTOR protein] decreases reaction
/ increases phosphorylation
protein 19139269
C009687 4548 MTR
HMAG
MS
cblG
5-methyltetrahydrofolate-homocysteine methyltransferase (EC:2.1.1.13) wortmannin inhibits the reaction [Dopamine results in increased activity of MTR protein] decreases reaction
/ increases activity
protein 14745455
C009687 4548 MTR
HMAG
MS
cblG
5-methyltetrahydrofolate-homocysteine methyltransferase (EC:2.1.1.13) wortmannin inhibits the reaction [IGF1 protein results in increased activity of MTR protein] decreases reaction
/ increases activity
protein 14745455
C009687 4613 MYCN
MODED
MYCNOT
N-myc
NMYC
ODED
bHLHe37
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog wortmannin inhibits the reaction [IGF1 protein results in increased expression of MYCN protein] decreases reaction
/ increases expression
protein 12569580
C009687 58498 MYL7
MYL2A
MYLC2A
myosin, light chain 7, regulatory wortmannin inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein] decreases reaction
/ increases phosphorylation
protein 15621049
C009687 58498 MYL7
MYL2A
MYLC2A
myosin, light chain 7, regulatory wortmannin results in decreased phosphorylation of MYL7 protein decreases phosphorylation
protein 15621049
C009687 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha wortmannin inhibits the reaction [Doxorubicin results in increased degradation of NFKBIA protein] decreases reaction
/ increases degradation
protein 17935137
C009687 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha wortmannin inhibits the reaction [Etoposide results in increased degradation of NFKBIA protein] decreases reaction
/ increases degradation
protein 17935137
C009687 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha wortmannin inhibits the reaction [evodiamine results in increased phosphorylation of and results in increased degradation of NFKBIA protein] decreases reaction
/ increases degradation
/ increases phosphorylation
protein 20005289
C009687 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) Fenofibrate inhibits the reaction [wortmannin results in decreased phosphorylation of NOS3 protein] decreases phosphorylation
/ decreases reaction
protein 16442496
C009687 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) wortmannin inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of NOS3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 11788791
C009687 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) wortmannin inhibits the reaction [diallyl disulfide results in increased phosphorylation of NOS3 protein] decreases reaction
/ increases phosphorylation
protein 20229525
C009687 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) wortmannin inhibits the reaction [diallyl trisulfide results in increased phosphorylation of NOS3 protein] decreases reaction
/ increases phosphorylation
protein 20229525
C009687 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]] affects cotreatment
/ decreases reaction
/ increases expression
/ increases phosphorylation
/ increases reaction
protein 20562903
C009687 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) wortmannin inhibits the reaction [Progesterone promotes the reaction [Estradiol results in increased activity of NOS3 protein]] decreases reaction
/ increases activity
/ increases reaction
protein 15358673
C009687 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) wortmannin inhibits the reaction [Progesterone results in increased activity of NOS3 protein] decreases reaction
/ increases activity
protein 15358673
C009687 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) wortmannin inhibits the reaction [Progesterone results in increased phosphorylation of NOS3 protein] decreases reaction
/ increases phosphorylation
protein 18710710
C009687 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) wortmannin inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of NOS3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 18296501
C009687 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) wortmannin inhibits the reaction [rosiglitazone inhibits the reaction [Glucose results in decreased phosphorylation of NOS3 protein]] decreases phosphorylation
/ decreases reaction
protein 19767878
C009687 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) wortmannin inhibits the reaction [rosiglitazone inhibits the reaction [[Glucose results in decreased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]] decreases phosphorylation
/ decreases reaction
/ increases abundance
protein 19767878
C009687 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]] affects cotreatment
/ decreases reaction
/ increases expression
/ increases phosphorylation
/ increases reaction
protein 20562903
C009687 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) wortmannin results in decreased phosphorylation of NOS3 protein decreases phosphorylation
protein 16442496
C009687 1728 NQO1
DHQU
DIA4
DTD
NMOR1
NMORI
QR1
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) wortmannin inhibits the reaction [plumbagin results in increased expression of NQO1 protein] decreases reaction
/ increases expression
protein 20028456
C009687 2516 NR5A1
AD4BP
ELP
FTZ1
FTZF1
POF7
SF-1
SF1
SPGF8
SRXY3
nuclear receptor subfamily 5, group A, member 1 wortmannin inhibits the reaction [Estradiol results in increased activity of NR5A1 protein] decreases reaction
/ increases activity
protein 19549922
C009687 4922 NTS
NMN-125
NN
NT
NT/N
NTS1
neurotensin wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C009687 4922 NTS
NMN-125
NN
NT
NT/N
NTS1
neurotensin wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C009687 4922 NTS
NMN-125
NN
NT
NT/N
NTS1
neurotensin wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C009687 4922 NTS
NMN-125
NN
NT
NT/N
NTS1
neurotensin wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C009687 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) wortmannin promotes the reaction [Doxorubicin results in increased cleavage of PARP1 protein] increases cleavage
/ increases reaction
protein 17935137
C009687 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) wortmannin promotes the reaction [Etoposide results in increased cleavage of PARP1 protein] increases cleavage
/ increases reaction
protein 17935137
C009687 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) wortmannin promotes the reaction [sodium arsenite results in increased degradation of PARP1 protein] increases degradation
/ increases reaction
protein 12614848
C009687 27250 PDCD4
H731
programmed cell death 4 (neoplastic transformation inhibitor) wortmannin results in increased expression of PDCD4 mRNA increases expression
mRNA 17259349
C009687 27250 PDCD4
H731
programmed cell death 4 (neoplastic transformation inhibitor) wortmannin results in increased expression of PDCD4 protein increases expression
protein 17259349
C009687 3651 PDX1
GSF
IDX-1
IPF1
IUF1
MODY4
PDX-1
STF-1
pancreatic and duodenal homeobox 1 [wortmannin co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein] affects cotreatment
/ affects localization
/ decreases reaction
protein 11574405
C009687 3651 PDX1
GSF
IDX-1
IPF1
IUF1
MODY4
PDX-1
STF-1
pancreatic and duodenal homeobox 1 wortmannin inhibits the reaction [Glucose affects the localization of PDX1 protein] affects localization
/ decreases reaction
protein 11574405
C009687 5290 PIK3CA
CLOVE
CWS5
MCAP
MCM
MCMTC
PI3K
p110-alpha
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (EC:2.7.11.1 2.7.1.153) wortmannin inhibits the reaction [Sirolimus results in increased activity of PIK3CA protein] decreases reaction
/ increases activity
protein 16227402
C009687 5290 PIK3CA
CLOVE
CWS5
MCAP
MCM
MCMTC
PI3K
p110-alpha
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (EC:2.7.11.1 2.7.1.153) wortmannin results in decreased activity of PIK3CA protein decreases activity
protein 19036708
C009687 5291 PIK3CB
P110BETA
PI3K
PI3KBETA
PIK3C1
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta (EC:2.7.1.153) wortmannin results in decreased activity of PIK3CB protein decreases activity
protein 11931710
C009687 5295 PIK3R1
AGM7
GRB1
p85
p85-ALPHA
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) wortmannin results in decreased activity of PIK3R1 protein decreases activity
protein 19036708
C009687 10761 PLAC1
CT92
OOSP2L
placenta-specific 1 wortmannin inhibits the reaction [FGF7 protein results in increased expression of PLAC1 mRNA] decreases reaction
/ increases expression
mRNA 15803460
C009687 8493 PPM1D
PP2C-DELTA
WIP1
protein phosphatase, Mg2+/Mn2+ dependent, 1D (EC:3.1.3.16) wortmannin inhibits the reaction [Soil Pollutants results in increased expression of PPM1D protein] decreases reaction
/ increases expression
protein 22409540
C009687 5580 PRKCD
MAY1
PKCD
nPKC-delta
protein kinase C, delta (EC:2.7.10.2 2.7.11.13) wortmannin inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein] decreases reaction
/ increases phosphorylation
protein 17171638
C009687 5580 PRKCD
MAY1
PKCD
nPKC-delta
protein kinase C, delta (EC:2.7.10.2 2.7.11.13) wortmannin inhibits the reaction [Oxygen deficiency results in increased activity of and results in increased localization of PRKCD protein] decreases reaction
/ increases activity
/ increases localization
protein 11424089
C009687 5728 PTEN
10q23del
BZS
CWS1
DEC
GLM2
MHAM
MMAC1
PTEN1
TEP1
phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Doxorubicin] decreases reaction
/ increases response to substance
protein 17935137
C009687 5728 PTEN
10q23del
BZS
CWS1
DEC
GLM2
MHAM
MMAC1
PTEN1
TEP1
phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Etoposide] decreases reaction
/ increases response to substance
protein 17935137
C009687 5731 PTGER1
EP1
prostaglandin E receptor 1 (subtype EP1), 42kDa wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein] affects binding
/ decreases reaction
/ increases activity
/ increases expression
protein 20335389
C009687 5731 PTGER1
EP1
prostaglandin E receptor 1 (subtype EP1), 42kDa wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein] affects binding
/ decreases reaction
/ increases activity
/ increases phosphorylation
protein 20335389
C009687 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) wortmannin inhibits the reaction [PTGS2 protein results in decreased susceptibility to Carboplatin] decreases reaction
/ decreases response to substance
protein 18089846
C009687 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) wortmannin inhibits the reaction [Zinc results in increased expression of PTGS2 mRNA] decreases reaction
/ increases expression
mRNA 15980035
C009687 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) wortmannin inhibits the reaction [Zinc results in increased expression of PTGS2 protein] decreases reaction
/ increases expression
protein 15980035
C009687 5747 PTK2
FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
protein tyrosine kinase 2 (EC:2.7.10.2) Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 10537051
C009687 5747 PTK2
FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
protein tyrosine kinase 2 (EC:2.7.10.2) Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 10537051
C009687 5747 PTK2
FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
protein tyrosine kinase 2 (EC:2.7.10.2) Atropine inhibits the reaction [oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]] affects cotreatment
/ decreases reaction
/ increases phosphorylation
/ increases reaction
protein 10537051
C009687 5747 PTK2
FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
protein tyrosine kinase 2 (EC:2.7.10.2) oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 10537051
C009687 5747 PTK2
FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
protein tyrosine kinase 2 (EC:2.7.10.2) oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 10537051
C009687 5747 PTK2
FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
protein tyrosine kinase 2 (EC:2.7.10.2) oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein] affects cotreatment
/ increases phosphorylation
/ increases reaction
protein 10537051
C009687 5747 PTK2
FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
protein tyrosine kinase 2 (EC:2.7.10.2) [Pilocarpine co-treated with wortmannin] results in increased phosphorylation of PTK2 protein affects cotreatment
/ increases phosphorylation
protein 10537051
C009687 5747 PTK2
FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
protein tyrosine kinase 2 (EC:2.7.10.2) [Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein affects cotreatment
/ increases phosphorylation
protein 10537051
C009687 5747 PTK2
FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
protein tyrosine kinase 2 (EC:2.7.10.2) [wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein affects cotreatment
/ increases phosphorylation
protein 10537051
C009687 5747 PTK2
FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
protein tyrosine kinase 2 (EC:2.7.10.2) [wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein affects cotreatment
/ increases phosphorylation
protein 10537051
C009687 5747 PTK2
FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
protein tyrosine kinase 2 (EC:2.7.10.2) [wortmannin co-treated with Tetradecanoylphorbol Acetate] inhibits the reaction [oxotremorine M results in increased phosphorylation of PTK2 protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 10537051
C009687 5747 PTK2
FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
protein tyrosine kinase 2 (EC:2.7.10.2) wortmannin inhibits the reaction [Testosterone results in increased phosphorylation of PTK2 protein] decreases reaction
/ increases phosphorylation
protein 16038899
C009687 5829 PXN
paxillin Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 10537051
C009687 5829 PXN
paxillin [oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 10537051
C009687 5829 PXN
paxillin wortmannin inhibits the reaction [oxotremorine M results in increased phosphorylation of PXN protein] decreases reaction
/ increases phosphorylation
protein 10537051
C009687 5887 RAD23B
HHR23B
HR23B
P58
RAD23 homolog B (S. cerevisiae) wortmannin inhibits the reaction [Cisplatin results in increased expression of RAD23B protein] decreases reaction
/ increases expression
protein 21742020
C009687 10111 RAD50
NBSLD
RAD502
hRad50
RAD50 homolog (S. cerevisiae) [wortmannin co-treated with docetaxel] results in decreased expression of RAD50 protein affects cotreatment
/ decreases expression
protein 20878124
C009687 5906 RAP1A
KREV-1
KREV1
RAP1
SMGP21
RAP1A, member of RAS oncogene family wortmannin inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein] decreases reaction
/ increases activity
protein 16963453
C009687 6194 RPS6
S6
ribosomal protein S6 wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein] affects binding
/ decreases reaction
/ increases activity
/ increases phosphorylation
protein 20335389
C009687 6199 RPS6KB2
KLS
P70-beta
P70-beta-1
P70-beta-2
S6K-beta2
S6K2
SRK
STK14B
p70(S6K)-beta
p70S6Kb
ribosomal protein S6 kinase, 70kDa, polypeptide 2 (EC:2.7.11.1) wortmannin inhibits the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein] decreases reaction
/ increases activity
protein 12087098
C009687 7857 SCG2
CHGC
EM66
SN
SgII
secretogranin II wortmannin results in decreased activity of SCG2 protein alternative form decreases activity
protein 9473216
C009687 871 SERPINH1
AsTP3
CBP1
CBP2
HSP47
OI10
PPROM
RA-A47
SERPINH2
gp46
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of SERPINH1 mRNA] decreases expression
/ decreases reaction
mRNA 13679210
C009687 871 SERPINH1
AsTP3
CBP1
CBP2
HSP47
OI10
PPROM
RA-A47
SERPINH2
gp46
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of SERPINH1 protein] decreases expression
/ decreases reaction
protein 13679210
C009687 140885 SIRPA
BIT
CD172A
MFR
MYD-1
P84
PTPNS1
SHPS1
SIRP
signal-regulatory protein alpha (EC:3.1.3.48) wortmannin inhibits the reaction [SIRPA protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]] decreases reaction
/ increases secretion
protein 12805067
C009687 23411 SIRT1
SIR2L1
sirtuin 1 wortmannin promotes the reaction [arsenic disulfide results in decreased expression of SIRT1 protein] decreases expression
/ increases reaction
protein 18298901
C009687 6528 SLC5A5
NIS
TDH1
solute carrier family 5 (sodium/iodide cotransporter), member 5 wortmannin inhibits the reaction [Carbamazepine promotes the reaction [Tretinoin results in increased expression of SLC5A5 protein]] decreases reaction
/ increases expression
/ increases reaction
protein 20300827
C009687 6531 SLC6A3
DAT
DAT1
PKDYS
solute carrier family 6 (neurotransmitter transporter), member 3 wortmannin inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine] decreases reaction
/ increases uptake
protein 20875051
C009687 6667 SP1
Sp1 transcription factor wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of SP1 protein] decreases reaction
/ increases phosphorylation
protein 17441964
C009687 412 STS
ARSC
ARSC1
ASC
ES
SSDD
XLI
steroid sulfatase (microsomal), isozyme S (EC:3.1.6.2) wortmannin inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased activity of STS protein] decreases reaction
/ increases activity
protein 16178010
C009687 412 STS
ARSC
ARSC1
ASC
ES
SSDD
XLI
steroid sulfatase (microsomal), isozyme S (EC:3.1.6.2) wortmannin inhibits the reaction [AGN 195183 results in increased activity of STS protein] decreases reaction
/ increases activity
protein 16178010
C009687 412 STS
ARSC
ARSC1
ASC
ES
SSDD
XLI
steroid sulfatase (microsomal), isozyme S (EC:3.1.6.2) wortmannin inhibits the reaction [tazarotene results in increased activity of STS protein] decreases reaction
/ increases activity
protein 16178010
C009687 412 STS
ARSC
ARSC1
ASC
ES
SSDD
XLI
steroid sulfatase (microsomal), isozyme S (EC:3.1.6.2) wortmannin inhibits the reaction [Tretinoin results in increased activity of STS protein] decreases reaction
/ increases activity
protein 16178010
C009687 7077 TIMP2
CSC-21K
DDC8
TIMP metallopeptidase inhibitor 2 wortmannin inhibits the reaction [CYP4Z1 protein results in increased expression of TIMP2 mRNA] decreases reaction
/ increases expression
mRNA 22841774
C009687 7082 TJP1
ZO-1
tight junction protein 1 wortmannin inhibits the reaction [telmisartan affects the localization of TJP1 protein] affects localization
/ decreases reaction
protein 19252288
C009687 7082 TJP1
ZO-1
tight junction protein 1 wortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 mRNA] decreases expression
/ decreases reaction
mRNA 19252288
C009687 7082 TJP1
ZO-1
tight junction protein 1 wortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 protein] decreases expression
/ decreases reaction
protein 19252288
C009687 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]] affects cotreatment
/ decreases reaction
/ increases abundance
protein 16968468
C009687 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor wortmannin inhibits the reaction [SIRPA protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]] decreases reaction
/ increases secretion
protein 12805067
C009687 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor wortmannin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 22556157
C009687 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 wortmannin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of TP53 protein] decreases reaction
/ increases phosphorylation
protein 19111594
C009687 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 wortmannin inhibits the reaction [3,3'-diindolylmethane results in increased phosphorylation of TP53 protein] decreases reaction
/ increases phosphorylation
protein 22290291
C009687 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 wortmannin inhibits the reaction [Asbestos, Serpentine results in increased expression of TP53 protein] decreases reaction
/ increases expression
protein 12676607
C009687 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 wortmannin inhibits the reaction [Asbestos, Serpentine results in increased phosphorylation of TP53 protein] decreases reaction
/ increases phosphorylation
protein 12676607
C009687 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 wortmannin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of TP53 protein] decreases reaction
/ increases phosphorylation
protein 15837074
C009687 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 wortmannin inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]] decreases reaction
/ increases phosphorylation
/ increases reaction
protein 15489221
C009687 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 wortmannin inhibits the reaction [Mustard Gas results in increased expression of TP53 protein] decreases reaction
/ increases expression
protein 22119920
C009687 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of TP53 protein] decreases reaction
/ increases phosphorylation
protein 22119920
C009687 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 wortmannin inhibits the reaction [Nitric Oxide results in increased phosphorylation of TP53 protein] decreases reaction
/ increases phosphorylation
protein 16024610
C009687 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 wortmannin inhibits the reaction [resveratrol results in increased phosphorylation of TP53 protein] decreases reaction
/ increases phosphorylation
protein 17534123
C009687 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 wortmannin inhibits the reaction [spermine nitric oxide complex results in increased phosphorylation of TP53 protein] decreases reaction
/ increases phosphorylation
protein 16024610
C009687 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 wortmannin promotes the reaction [arsenic disulfide results in increased expression of and results in increased phosphorylation of TP53 protein] increases expression
/ increases phosphorylation
/ increases reaction
protein 18298901
C009687 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 wortmannin results in decreased phosphorylation of and results in decreased expression of TP53 protein decreases expression
/ decreases phosphorylation
protein 22290291
C009687 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 wortmannin results in decreased phosphorylation of TP53 protein decreases phosphorylation
protein 22119920
C009687 7161 TP73
P73
tumor protein p73 wortmannin promotes the reaction [Cisplatin results in increased expression of TP73 protein] increases expression
/ increases reaction
protein 21214929
C009687 7161 TP73
P73
tumor protein p73 wortmannin promotes the reaction [Doxorubicin results in increased expression of TP73 protein] increases expression
/ increases reaction
protein 21214929
C009687 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A wortmannin inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein] decreases reaction
/ increases expression
protein 15050414
C009687 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A wortmannin inhibits the reaction [4-tert-octylphenol results in increased secretion of VEGFA protein] decreases reaction
/ increases secretion
protein 18252963
C009687 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A wortmannin inhibits the reaction [butylbenzyl phthalate results in increased secretion of VEGFA protein] decreases reaction
/ increases secretion
protein 18252963
C009687 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A wortmannin inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA] decreases reaction
/ increases expression
mRNA 13679210
C009687 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A wortmannin inhibits the reaction [cobaltous chloride results in increased expression of VEGFA protein] decreases reaction
/ increases expression
protein 13679210
C009687 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A wortmannin inhibits the reaction [CYP4Z1 protein results in increased expression of VEGFA mRNA] decreases reaction
/ increases expression
mRNA 22841774
C009687 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A wortmannin inhibits the reaction [Dieldrin results in increased secretion of VEGFA protein] decreases reaction
/ increases secretion
protein 18252963
C009687 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A wortmannin inhibits the reaction [Estradiol results in increased secretion of VEGFA protein] decreases reaction
/ increases secretion
protein 18252963
C009687 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A wortmannin inhibits the reaction [Genistein results in increased secretion of VEGFA protein] decreases reaction
/ increases secretion
protein 18252963
C009687 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A wortmannin inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein] decreases reaction
/ increases secretion
protein 16499871
C009687 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A wortmannin inhibits the reaction [oxaliplatin results in increased expression of VEGFA protein] decreases reaction
/ increases expression
protein 18790786
C009687 7520 XRCC5
KARP-1
KARP1
KU80
KUB2
Ku86
NFIV
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) [wortmannin co-treated with docetaxel] results in decreased expression of XRCC5 protein affects cotreatment
/ decreases expression
protein 20878124
C009687 2547 XRCC6
CTC75
CTCBF
G22P1
KU70
ML8
TLAA
X-ray repair complementing defective repair in Chinese hamster cells 6 [wortmannin co-treated with docetaxel] results in decreased expression of XRCC6 protein affects cotreatment
/ decreases expression
protein 20878124
C009687 10413 YAP1
YAP
YAP2
YAP65
YKI
Yes-associated protein 1 wortmannin promotes the reaction [Cisplatin results in increased expression of YAP1 protein modified form] increases expression
/ increases reaction
protein 21214929
C009687 10413 YAP1
YAP
YAP2
YAP65
YKI
Yes-associated protein 1 wortmannin promotes the reaction [Doxorubicin results in increased expression of YAP1 protein modified form] increases expression
/ increases reaction
protein 21214929
C009687 7702 ZNF143
SBF
STAF
pHZ-1
zinc finger protein 143 wortmannin inhibits the reaction [IGF1 protein results in increased expression of ZNF143 protein] decreases reaction
/ increases expression
protein 20733350

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (97)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#615224 Advanced sleep phase syndrome, familial, 2; fasps2 P48730
#615214 Agammaglobulinemia 7, autosomal recessive; agm7 P27986
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#613780 Aortic aneurysm, familial thoracic 7; aat7 Q15746
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114480 Breast cancer O96017
P31749
P42336
#615279 Cardiofaciocutaneous syndrome 3; cfc3 Q02750
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#192600 Cardiomyopathy, familial hypertrophic, 1; cmh1 Q9H1R3
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#303600 Coffin-lowry syndrome; cls P51812
#114500 Colorectal cancer; crc P31749
P42336
P84022
Q14191
#612918 Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi P42336
#615108 Cowden syndrome 5; cws5 P42336
#615109 Cowden syndrome 6; cws6 P31749
#127750 Dementia, lewy body; dlb P37840
#125853 Diabetes mellitus, noninsulin-dependent; niddm P31751
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#612219 Ewing sarcoma; es P11308
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#114550 Hepatocellular carcinoma P42336
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#240900 Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh P31751
#182000 Keratosis, seborrheic P42336
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#609265 Li-fraumeni syndrome 2; lfs2 O96017
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#602501 Megalencephaly-capillary malformation-polymicrogyria syndrome; mcap P42336
#603387 Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome; mpph P42336
#614104 Mental retardation, autosomal dominant 7; mrd7 Q13627
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300844 Mental retardation, x-linked 19; mrx19 P51812
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#166350 Osseous heteroplasia, progressive; poh P63092
#259500 Osteogenic sarcoma O96017
#167000 Ovarian cancer P42336
#260500 Papilloma of choroid plexus; cpp P04637
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#176807 Prostate cancer O96017
#176920 Proteus syndrome P31749
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#609620 Short qt syndrome 1; sqt1 Q12809
#269880 Short syndrome P27986
#243060 Spermatogenic failure 5; spgf5 Q9UQB9
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191

KEGG DISEASE (89)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00881 Li-Fraumeni syndrome O96017 (related)
P04637 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P31751 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
P31751 (related)
P42336 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00024 Prostate cancer P11308 (related)
H00035 Ewing's sarcoma P11308 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00480 Non-syndromic X-linked mental retardation P51812 (related)
Q99714 (related)
H00574 Coffin-Lowry syndrome (CLS) P51812 (related)
H00606 Early infantile epileptic encephalopathy P53779 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00523 Noonan syndrome and related disorders Q02750 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00801 Familial thoracic aortic aneurysm and dissection (TAAD) Q15746 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H01282 Spermatogenic failure Q9UQB9 (related)

Diseases related to CTD interactions

11 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000230 C009687 Adenocarcinoma therapeutic
23064031
D001943 C009687 Breast Neoplasms therapeutic
23064031
D005234 C009687 Fatty Liver marker/mechanism
22459179
D006930 C009687 Hyperalgesia therapeutic
16360265
17043245
D009336 C009687 Necrosis marker/mechanism
21410490
D009361 C009687 Neoplasm Invasiveness therapeutic
23064031
D009362 C009687 Neoplasm Metastasis therapeutic
23064031
D010051 C009687 Ovarian Neoplasms therapeutic
17404021
D010146 C009687 Pain therapeutic
17084039
D011041 C009687 Poisoning therapeutic
22155090
D013927 C009687 Thrombosis therapeutic
12606772