PCIDB

KNApSAcK Metabolite C00025042

Metabolite

KNApSAcK Entry

id C00025042
Name (-)-16-Epivincamine / (-)-cis-Epivincamine
CAS RN 6835-99-0
Standard InChI InChI=1S/C21H26N2O3/c1-3-20-10-6-11-22-12-9-15-14-7-4-5-8-16(14)23(17(15)18(20)22)21(25,13-20)19(24)26-2/h4-5,7-8,18,25H,3,6,9-13H2,1-2H3/t18-,20+,21-/m1/s1
Standard InChI (Main Layer) InChI=1S/C21H26N2O3/c1-3-20-10-6-11-22-12-9-15-14-7-4-5-8-16(14)23(17(15)18(20)22)21(25,13-20)19(24)26-2/h4-5,7-8,18,25H,3,6,9-13H2,1-2H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 452

Link

ChEMBL

By standard InChI CHEMBL1728279
By standard InChI Main Layer CHEMBL1165342 CHEMBL1361052 CHEMBL1592905 CHEMBL1604925 CHEMBL1728279

KEGG

By LinkDB

CTD

By CAS RN

Human Protein / Gene in interaction

27 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1361052 CHEMBL1614110 (2) CHEMBL1741321 (2)
1 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL1728279 CHEMBL1738312 (1)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL1604925 CHEMBL1614076 (1)
1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL1604925 CHEMBL1794585 (1)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1361052 CHEMBL1741325 (2)
0 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL1604925 CHEMBL1614166 (1)
1 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL1604925 CHEMBL1794311 (1)
2 / 3
P17405 Sphingomyelin phosphodiesterase Enzyme CHEMBL1604925 CHEMBL1794495 (1)
2 / 2
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL1361052 CHEMBL1614456 (1) CHEMBL1613803 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL1361052 CHEMBL1738606 (1)
0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL1165342 CHEMBL2114810 (1)
7 / 3
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein CHEMBL1604925 CHEMBL1614280 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL1361052 CHEMBL1794467 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL1361052 CHEMBL1741322 (2)
0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL1165342 CHEMBL1738588 (1) CHEMBL1738317 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1361052 CHEMBL1741323 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1361052 CHEMBL1592905 CHEMBL1614108 (4) CHEMBL1613886 (4)
CHEMBL1741324 (2)
0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL1604925 CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1604925 CHEMBL1614250 (1) CHEMBL1614421 (1)
CHEMBL1614502 (1)
4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL1604925 CHEMBL1613914 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL1604925 CHEMBL1738442 (1)
0 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme CHEMBL1604925 CHEMBL1963966 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL1604925 CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL1604925 CHEMBL1614531 (1)
1 / 3
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL1604925 CHEMBL1738090 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL1604925 CHEMBL1738090 (1)
1 / 6
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL1728279 CHEMBL2354287 (1)
1 / 1

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (24)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (25)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)