Species

KNApSAcK Entry

Organism name Vinca minor
Genus Vinca
Family Apocynaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Vinca minor
Linked NCBI taxonomy ID 60093
Linked level species

Family

Family in NCBI taxonomy Apocynaceae
ID 4056

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (13)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005747 External link 512 Myricetin 3-robinobioside-7-rhamnoside
No. 5 No. 15
C00005461 External link 512 Clovin
/ Quercetin 3-robinobioside-7-rhamnoside
No. 5 No. 15
C00002631 External link 512 (+)-Lirioresinol B
/ (+)-Syringaresinol
CHEMBL361362
CHEMBL402653
C042192
1 / 0 / 0 No. 38 No. 21
C00024482 External link 512 11-Methoxyvincadifformine
/ 6,7-Dihydro-11-methoxytabersonine
No. 61 No. 4
C00025069 External link 512 Vincareine
/ (+)-Vincaminine
No. 452 No. 4
C00025042 External link 512 (-)-16-Epivincamine
/ (-)-cis-Epivincamine
CHEMBL1165342
CHEMBL1361052
CHEMBL1592905
CHEMBL1604925
CHEMBL1728279
27 / 24 / 25 No. 452 No. 4
C00025070 External link 512 (+)-Vincinine
No. 452 No. 4
C00025041 External link 512 (-)-11-Methoxyeburnamonine
No. 502 No. 4
C00001714 External link 512 Eburnamonine
CHEMBL1318553
CHEMBL1553441
CHEMBL1733074
CHEMBL1892145
14 / 20 / 16 No. 502 No. 4
C00025061 External link 512 (+)-Eburnamenine
CHEMBL1097688
No. 502 No. 4
C00025062 External link 512 (+)-Isoeburnamine
CHEMBL2104946
No. 502 No. 4
C00024291 External link 512 21-Deoxyvomilenine
No. 523 No. 4
C00024313 External link 512 Vinorine
/ (-)-Vinorine
/ 21-Deoxyvomilenine
No. 523 No. 4

Human Protein / Gene in interactions

36 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001714 C00025042 1 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001714 C00025042 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001714 C00025042 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001714 C00025042 1 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001714 C00025042 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001714 C00025042 0 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00025042 0 / 0
P02545 Prelamin-A/C Unclassified protein C00001714 11 / 10
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00025042 1 / 0
P11387 DNA topoisomerase 1 Isomerase C00002631 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00025042 2 / 3
P17405 Sphingomyelin phosphodiesterase Enzyme C00025042 2 / 2
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00025042 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00025042 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00001714 2 / 0
O75496 Geminin Unclassified protein C00001714 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00001714 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00025042 7 / 3
P16473 Thyrotropin receptor Glycohormone receptor C00001714 3 / 2
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00001714 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00025042 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00025042 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00025042 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00025042 1 / 1
Q99700 Ataxin-2 Unclassified protein C00001714 1 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00025042 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00025042 4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00025042 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00025042 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001714 1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00025042 0 / 0
O00255 Menin Unclassified protein C00025042 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00025042 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00025042 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00025042 1 / 4
Q13148 TAR DNA-binding protein 43 Unclassified protein C00025042 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (42)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (38)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)