Species

KNApSAcK Entry

Organism name Tabernaemontana rigida
Genus Tabernaemontana
Family Apocynaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Tabernaemontana
Linked NCBI taxonomy ID 52860
Linked level genus

Family

Family in NCBI taxonomy Apocynaceae
ID 4056

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (2)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00025042 External link 512 (-)-16-Epivincamine
/ (-)-cis-Epivincamine
CHEMBL1165342
CHEMBL1361052
CHEMBL1592905
CHEMBL1604925
CHEMBL1728279
27 / 24 / 25 No. 452 No. 4
C00001688 External link 512 Apovincamine
CHEMBL1163488
C063621
No. 502 No. 4

Human Protein / Gene in interactions

27 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00025042 1 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00025042 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00025042 1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00025042 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00025042 0 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00025042 1 / 0
P11473 Vitamin D3 receptor NR1I1 C00025042 2 / 3
P17405 Sphingomyelin phosphodiesterase Enzyme C00025042 2 / 2
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00025042 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00025042 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00025042 7 / 3
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00025042 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00025042 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00025042 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00025042 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00025042 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00025042 0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00025042 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00025042 4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00025042 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00025042 0 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00025042 0 / 0
O00255 Menin Unclassified protein C00025042 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00025042 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00025042 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00025042 1 / 4
Q13148 TAR DNA-binding protein 43 Unclassified protein C00025042 1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (24)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (25)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)