PCIDB

KNApSAcK Metabolite C00002671

Metabolite

KNApSAcK Entry

id C00002671
Name Resorcinol
CAS RN 108-46-3
Standard InChI InChI=1S/C6H6O2/c7-5-2-1-3-6(8)4-5/h1-4,7-8H
Standard InChI (Main Layer) InChI=1S/C6H6O2/c7-5-2-1-3-6(8)4-5/h1-4,7-8H

Cluster

Phytochemical cluster No. 82
KCF-S cluster No. 1590

Link

ChEMBL

By standard InChI CHEMBL24147
By standard InChI Main Layer CHEMBL24147

KEGG

By LinkDB C01751

CTD

By CAS RN C031389

Species

Summary

Plant class

class name count
rosids 1
Spermatophyta 1

Family

family name count
Myrtaceae 1
Pinaceae 1

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Eugenia jambolana 260142 Myrtaceae rosids Viridiplantae
Pinus rigida 164242 Pinaceae Spermatophyta Viridiplantae

Human Protein / Gene in interaction

21 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase CHEMBL24147 CHEMBL992755 (1)
0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase CHEMBL24147 CHEMBL992754 (1)
0 / 0
P43166 Carbonic anhydrase 7 Lyase CHEMBL24147 CHEMBL992757 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL24147 CHEMBL1614544 (1)
11 / 10
P00918 Carbonic anhydrase 2 Lyase CHEMBL24147 CHEMBL933690 (1) CHEMBL991856 (1)
1 / 2
P23280 Carbonic anhydrase 6 Lyase CHEMBL24147 CHEMBL992756 (1)
0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase CHEMBL24147 CHEMBL981174 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL24147 CHEMBL1614458 (1)
0 / 0
O43570 Carbonic anhydrase 12 Lyase CHEMBL24147 CHEMBL992759 (1)
1 / 2
O75496 Geminin Unclassified protein CHEMBL24147 CHEMBL2114780 (1)
0 / 0
P10145 Interleukin-8 Secreted protein CHEMBL24147 CHEMBL2114835 (1)
0 / 0
P00915 Carbonic anhydrase 1 Lyase CHEMBL24147 CHEMBL933689 (1) CHEMBL991855 (1)
0 / 0
P14679 Tyrosinase Oxidoreductase CHEMBL24147 CHEMBL2344047 (1) CHEMBL2344049 (1)
CHEMBL2344051 (1) CHEMBL2344053 (1)
4 / 2
Q16790 Carbonic anhydrase 9 Lyase CHEMBL24147 CHEMBL992758 (1)
0 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL24147 CHEMBL1614227 (1)
3 / 3
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 CHEMBL24147 CHEMBL2114842 (1)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL24147 CHEMBL1614108 (1) CHEMBL1613886 (1)
0 / 1
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL24147 CHEMBL2114890 (1)
0 / 0
P10275 Androgen receptor NR3C4 CHEMBL24147 CHEMBL1794321 (1)
3 / 4
P07451 Carbonic anhydrase 3 Lyase CHEMBL24147 CHEMBL991857 (1)
0 / 0
P22748 Carbonic anhydrase 4 Lyase CHEMBL24147 CHEMBL991858 (1)
1 / 1

CTD interaction (4)

compound gene gene name gene description interaction interaction type form reference
pmid
C031389 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 resorcinol binds to ESR1 protein affects binding
protein 12598185
C031389 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) resorcinol inhibits the reaction [TGFA protein results in increased expression of PTGS2 mRNA] decreases reaction
/ increases expression
mRNA 10783318
C031389 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) resorcinol results in decreased expression of PTGS2 mRNA decreases expression
mRNA 10783318
C031389 7039 TGFA
TFGA
transforming growth factor, alpha resorcinol inhibits the reaction [TGFA protein results in increased expression of PTGS2 mRNA] decreases reaction
/ increases expression
protein 10783318

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (24)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#143860 Hyperchlorhidrosis, isolated O43570
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#275210 Restrictive dermopathy, lethal P02545
#600852 Retinitis pigmentosa 17; rp17 P22748
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275

KEGG DISEASE (25)

KEGG disease name UniProt
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D013959 C031389 Thyroid Diseases marker/mechanism
21800831