KNApSAcK Metabolite C00002725
Metabolite
KNApSAcK Entry
| id | C00002725 |
|---|---|
| Name | Cinnamaldehyde |
| CAS RN | 104-55-2 |
| Standard InChI | InChI=1S/C9H8O/c10-8-4-7-9-5-2-1-3-6-9/h1-8H/b7-4+ |
| Standard InChI (Main Layer) | InChI=1S/C9H8O/c10-8-4-7-9-5-2-1-3-6-9/h1-8H |
Cluster
| Phytochemical cluster | No. 6 |
|---|---|
| KCF-S cluster | No. 2320 |
Link
ChEMBL
| By standard InChI | CHEMBL293492 |
|---|---|
| By standard InChI Main Layer | CHEMBL293492 |
KEGG
| By LinkDB | C00903 |
|---|
CTD
| By CAS RN | C012843 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| Liliopsida | 2 |
| asterids | 2 |
| Magnoliophyta | 1 |
| rosids | 1 |
| eudicotyledons | 1 |
Family
| family name | count |
|---|---|
| Lamiaceae | 2 |
| Lauraceae | 1 |
| Hyacinthaceae | 1 |
| Burseraceae | 1 |
| Amaryllidaceae | 1 |
| Crassulaceae | 1 |
List (7)
* NCBI
Human Protein / Gene in interaction
98 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL293492 |
CHEMBL1909136
(2)
|
1 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | CHEMBL293492 |
CHEMBL1909139
(2)
|
0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | CHEMBL293492 |
CHEMBL1014033
(1)
CHEMBL1014036
(1)
CHEMBL1008495 (1) CHEMBL1909131 (2) |
0 / 3 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | CHEMBL293492 |
CHEMBL1909190
(2)
|
2 / 2 |
| P08246 | Neutrophil elastase | S1A | CHEMBL293492 |
CHEMBL1909195
(2)
|
2 / 1 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | CHEMBL293492 |
CHEMBL1909215
(2)
|
0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | CHEMBL293492 |
CHEMBL1909201
(2)
|
0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | CHEMBL293492 |
CHEMBL1909176
(2)
|
0 / 0 |
| P29466 | Caspase-1 | C14 | CHEMBL293492 |
CHEMBL1909193
(2)
|
0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | CHEMBL293492 |
CHEMBL1909198
(2)
|
0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | CHEMBL293492 |
CHEMBL1909199
(2)
|
0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | CHEMBL293492 |
CHEMBL1909197
(2)
|
2 / 2 |
| P02545 | Prelamin-A/C | Unclassified protein | CHEMBL293492 |
CHEMBL1614544
(1)
|
11 / 10 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | CHEMBL293492 |
CHEMBL2051343
(1)
CHEMBL2051344
(1)
|
1 / 1 |
| P00918 | Carbonic anhydrase 2 | Lyase | CHEMBL293492 |
CHEMBL1909123
(2)
|
1 / 2 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | CHEMBL293492 |
CHEMBL1909092
(2)
|
0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | CHEMBL293492 |
CHEMBL1909169
(2)
|
1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | CHEMBL293492 |
CHEMBL1909157
(2)
|
0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | CHEMBL293492 |
CHEMBL1909156
(2)
|
0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | CHEMBL293492 |
CHEMBL1909143
(2)
|
1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | CHEMBL293492 |
CHEMBL1909174
(2)
|
0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | CHEMBL293492 |
CHEMBL1909090
(2)
|
0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | CHEMBL293492 |
CHEMBL1909093
(2)
|
0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | CHEMBL293492 |
CHEMBL1909127
(2)
|
0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | CHEMBL293492 |
CHEMBL1909204
(2)
|
0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | CHEMBL293492 |
CHEMBL1909202
(2)
|
0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL293492 |
CHEMBL1909135
(2)
|
0 / 1 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | CHEMBL293492 |
CHEMBL1909203
(2)
|
1 / 11 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | CHEMBL293492 |
CHEMBL1909140
(2)
|
2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | CHEMBL293492 |
CHEMBL1909130
(2)
|
0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | CHEMBL293492 |
CHEMBL1909120
(2)
|
0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | CHEMBL293492 |
CHEMBL1909181
(2)
|
0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | CHEMBL293492 |
CHEMBL1909164
(2)
|
0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | CHEMBL293492 |
CHEMBL1909214
(2)
|
0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | CHEMBL293492 |
CHEMBL1909175
(2)
|
0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | CHEMBL293492 |
CHEMBL1909096
(2)
|
1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | CHEMBL293492 |
CHEMBL1909118
(2)
|
0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | CHEMBL293492 |
CHEMBL1909166
(2)
|
1 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL293492 |
CHEMBL1614458
(2)
|
0 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | CHEMBL293492 |
CHEMBL1909133
(2)
|
0 / 0 |
| O75496 | Geminin | Unclassified protein | CHEMBL293492 |
CHEMBL2114780
(1)
|
0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | CHEMBL293492 |
CHEMBL1909158
(2)
|
0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | CHEMBL293492 |
CHEMBL1909088
(2)
|
0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | CHEMBL293492 |
CHEMBL1909142
(2)
|
0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | CHEMBL293492 |
CHEMBL1909101
(2)
|
0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | CHEMBL293492 |
CHEMBL1909141
(2)
|
1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | CHEMBL293492 |
CHEMBL1909180
(2)
|
0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | CHEMBL293492 |
CHEMBL1909146
(2)
|
0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | CHEMBL293492 |
CHEMBL1909104
(2)
|
0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | CHEMBL293492 |
CHEMBL1909144
(2)
|
0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | CHEMBL293492 |
CHEMBL1909100
(2)
|
0 / 0 |
| P10145 | Interleukin-8 | Secreted protein | CHEMBL293492 |
CHEMBL2114835
(2)
|
0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | CHEMBL293492 |
CHEMBL1909167
(2)
|
1 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | CHEMBL293492 |
CHEMBL1909129
(2)
|
0 / 0 |
| P08311 | Cathepsin G | S1A | CHEMBL293492 |
CHEMBL1909194
(2)
|
0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | CHEMBL293492 |
CHEMBL1909110
(2)
|
1 / 0 |
| P03956 | Interstitial collagenase | M10A | CHEMBL293492 |
CHEMBL1909196
(2)
|
0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | CHEMBL293492 |
CHEMBL1909119
(2)
|
0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | CHEMBL293492 |
CHEMBL1909150
(2)
|
0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | CHEMBL293492 |
CHEMBL1909171
(2)
|
2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | CHEMBL293492 |
CHEMBL1909170
(2)
|
0 / 0 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | CHEMBL293492 |
CHEMBL1909122
(2)
|
0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | CHEMBL293492 |
CHEMBL1909109
(2)
|
2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | CHEMBL293492 |
CHEMBL1909205
(2)
|
5 / 10 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | CHEMBL293492 |
CHEMBL1909172
(2)
|
1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | CHEMBL293492 |
CHEMBL1909114
(2)
|
0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | CHEMBL293492 |
CHEMBL1909125
(2)
|
0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | CHEMBL293492 |
CHEMBL1909126
(2)
|
3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | CHEMBL293492 |
CHEMBL1909108
(2)
|
0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | CHEMBL293492 |
CHEMBL1909124
(2)
|
1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | CHEMBL293492 |
CHEMBL1613808
(1)
CHEMBL1909200
(2)
|
0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | CHEMBL293492 |
CHEMBL1909207
(2)
|
2 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL293492 |
CHEMBL1909132
(2)
|
0 / 0 |
| O75762 | Transient receptor potential cation channel subfamily A member 1 | Unclassified protein | CHEMBL293492 |
CHEMBL940160
(1)
CHEMBL1049519
(1)
CHEMBL1118240 (1) CHEMBL1224917 (1) |
1 / 0 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | CHEMBL293492 |
CHEMBL2114842
(1)
|
0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | CHEMBL293492 |
CHEMBL998833
(1)
CHEMBL1909186
(2)
|
0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | CHEMBL293492 |
CHEMBL1909145
(2)
CHEMBL1941568
(1)
CHEMBL1941569 (1) |
1 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | CHEMBL293492 |
CHEMBL1909091
(2)
|
1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | CHEMBL293492 |
CHEMBL1909212
(2)
|
1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | CHEMBL293492 |
CHEMBL1909211
(2)
|
0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | CHEMBL293492 |
CHEMBL1909105
(2)
|
0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | CHEMBL293492 |
CHEMBL1909182
(2)
|
0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | CHEMBL293492 |
CHEMBL1909173
(2)
|
0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | CHEMBL293492 |
CHEMBL1909113
(2)
|
0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | CHEMBL293492 |
CHEMBL1909187
(2)
|
0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | CHEMBL293492 |
CHEMBL1909168
(2)
|
0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL293492 |
CHEMBL1909134
(2)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL293492 |
CHEMBL1909138
(2)
|
0 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | CHEMBL293492 |
CHEMBL1909137
(2)
|
0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL293492 |
CHEMBL2114890
(2)
|
0 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | CHEMBL293492 |
CHEMBL1909094
(2)
|
1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | CHEMBL293492 |
CHEMBL1909087
(2)
|
0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | CHEMBL293492 |
CHEMBL1909213
(2)
|
0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | CHEMBL293492 |
CHEMBL1909089
(2)
|
0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | CHEMBL293492 |
CHEMBL1909116
(2)
|
1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | CHEMBL293492 |
CHEMBL1909206
(2)
|
0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | CHEMBL293492 |
CHEMBL1909128
(2)
|
0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | CHEMBL293492 |
CHEMBL2354311
(1)
|
1 / 0 |
CTD interaction (239)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C012843 | 8714 |
ABCC3
ABC31 EST90757 MLP2 MOAT-D MRP3 cMOAT2 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | cinnamic aldehyde results in increased expression of ABCC3 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 145447 |
ABHD12B
BEM46L3 C14orf29 c14_5314 |
abhydrolase domain containing 12B | cinnamic aldehyde results in increased expression of ABHD12B mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 8745 |
ADAM23
MDC-3 MDC3 |
ADAM metallopeptidase domain 23 | cinnamic aldehyde results in increased expression of ADAM23 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 132 |
ADK
AK |
adenosine kinase (EC:2.7.1.20) | cinnamic aldehyde results in increased expression of ADK mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 133 |
ADM
AM |
adrenomedullin | cinnamic aldehyde results in increased expression of ADM mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 1645 |
AKR1C1
2-ALPHA-HSD 20-ALPHA-HSD C9 DD1 DD1/DD2 DDH DDH1 H-37 HAKRC HBAB MBAB |
aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) | cinnamic aldehyde results in increased expression of AKR1C1 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 1646 |
AKR1C2
AKR1C-pseudo BABP DD DD2 DDH2 HAKRD HBAB MCDR2 SRXY8 |
aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) | cinnamic aldehyde results in increased activity of AKR1C2 promoter |
increases activity
|
promoter |
21195160
|
| C012843 | 207 |
AKT1
AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA |
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | cinnamic aldehyde results in increased phosphorylation of AKT1 protein |
increases phosphorylation
|
protein |
21469739
|
| C012843 | 57679 |
ALS2
ALS2CR6 ALSJ IAHSP PLSJ |
amyotrophic lateral sclerosis 2 (juvenile) | cinnamic aldehyde results in increased expression of ALS2 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 57636 |
ARHGAP23
|
Rho GTPase activating protein 23 | cinnamic aldehyde results in increased expression of ARHGAP23 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 23250 |
ATP11A
ATPIH ATPIS |
ATPase, class VI, type 11A (EC:3.6.3.1) | cinnamic aldehyde results in increased expression of ATP11A mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 581 |
BAX
BCL2L4 |
BCL2-associated X protein | cinnamic aldehyde results in increased expression of BAX protein |
increases expression
|
protein |
15566391
15964311 |
| C012843 | 581 |
BAX
BCL2L4 |
BCL2-associated X protein | Vitamin E inhibits the reaction [cinnamic aldehyde results in increased expression of BAX protein] |
decreases reaction
/ increases expression |
protein |
15566391
|
| C012843 | 55973 |
BCAP29
BAP29 |
B-cell receptor-associated protein 29 | cinnamic aldehyde results in increased expression of BCAP29 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | cinnamic aldehyde analog results in decreased expression of BCL2 protein |
decreases expression
|
protein |
17510524
|
| C012843 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | cinnamic aldehyde results in decreased expression of BCL2 protein |
decreases expression
|
protein |
15566391
15964311 |
| C012843 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | Vitamin E inhibits the reaction [cinnamic aldehyde results in decreased expression of BCL2 protein] |
decreases expression
/ decreases reaction |
protein |
15566391
|
| C012843 | 637 |
BID
FP497 |
BH3 interacting domain death agonist | cinnamic aldehyde results in increased cleavage of BID protein |
increases cleavage
|
protein |
15964311
|
| C012843 | 329 |
BIRC2
API1 HIAP2 Hiap-2 MIHB RNF48 c-IAP1 cIAP1 |
baculoviral IAP repeat containing 2 | cinnamic aldehyde results in decreased expression of BIRC2 protein |
decreases expression
|
protein |
15566391
|
| C012843 | 329 |
BIRC2
API1 HIAP2 Hiap-2 MIHB RNF48 c-IAP1 cIAP1 |
baculoviral IAP repeat containing 2 | Vitamin E inhibits the reaction [cinnamic aldehyde results in decreased expression of BIRC2 protein] |
decreases expression
/ decreases reaction |
protein |
15566391
|
| C012843 | 330 |
BIRC3
AIP1 API2 CIAP2 HAIP1 HIAP1 MALT2 MIHC RNF49 c-IAP2 |
baculoviral IAP repeat containing 3 | cinnamic aldehyde results in decreased expression of BIRC3 protein |
decreases expression
|
protein |
15566391
|
| C012843 | 330 |
BIRC3
AIP1 API2 CIAP2 HAIP1 HIAP1 MALT2 MIHC RNF49 c-IAP2 |
baculoviral IAP repeat containing 3 | Vitamin E inhibits the reaction [cinnamic aldehyde results in decreased expression of BIRC3 protein] |
decreases expression
/ decreases reaction |
protein |
15566391
|
| C012843 | 834 |
CASP1
ICE IL1BC P45 |
caspase 1, apoptosis-related cysteine peptidase (EC:3.4.22.36) | cinnamic aldehyde results in increased expression of CASP1 mRNA |
increases expression
|
mRNA |
19000754
|
| C012843 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | cinnamic aldehyde analog results in increased activity of CASP3 protein |
increases activity
|
protein |
16343908
|
| C012843 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | cinnamic aldehyde analog results in increased expression of CASP3 protein |
increases expression
|
protein |
17510524
|
| C012843 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | cinnamic aldehyde results in increased activity of CASP3 protein |
increases activity
|
protein |
15566391
|
| C012843 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | cinnamic aldehyde results in increased cleavage of CASP3 protein |
increases cleavage
|
protein |
19000754
|
| C012843 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Vitamin E inhibits the reaction [cinnamic aldehyde results in increased activity of CASP3 protein] |
decreases reaction
/ increases activity |
protein |
15566391
|
| C012843 | 841 |
CASP8
ALPS2B CAP4 Casp-8 FLICE MACH MCH5 |
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) | cinnamic aldehyde results in increased activity of CASP8 protein |
increases activity
|
protein |
15964311
|
| C012843 | 91057 |
CCDC34
NY-REN-41 RAMA3 |
coiled-coil domain containing 34 | cinnamic aldehyde results in increased expression of CCDC34 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 6352 |
CCL5
D17S136E RANTES SCYA5 SIS-delta SISd TCP228 eoCP |
chemokine (C-C motif) ligand 5 | cinnamic aldehyde results in increased secretion of CCL5 protein |
increases secretion
|
protein |
20488241
|
| C012843 | 29126 |
CD274
B7-H B7H1 PD-L1 PDCD1L1 PDCD1LG1 PDL1 |
CD274 molecule | cinnamic aldehyde results in increased expression of CD274 protein |
increases expression
|
protein |
20488241
|
| C012843 | 942 |
CD86
B7-2 B7.2 B70 CD28LG2 LAB72 |
CD86 molecule | cinnamic aldehyde results in increased expression of CD86 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 942 |
CD86
B7-2 B7.2 B70 CD28LG2 LAB72 |
CD86 molecule | cinnamic aldehyde results in increased expression of CD86 protein |
increases expression
|
protein |
19665512
20488241 |
| C012843 | 994 |
CDC25B
|
cell division cycle 25B (EC:3.1.3.48) | cinnamic aldehyde analog results in decreased activity of CDC25B protein |
decreases activity
|
protein |
16343908
|
| C012843 | 1026 |
CDKN1A
CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1 |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) | cinnamic aldehyde results in increased expression of CDKN1A mRNA |
increases expression
|
mRNA |
19000754
|
| C012843 | 1026 |
CDKN1A
CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1 |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) | cinnamic aldehyde results in increased expression of CDKN1A protein |
increases expression
|
protein |
19000754
|
| C012843 | 1066 |
CES1
ACAT CE-1 CEH CES2 HMSE HMSE1 PCE-1 REH SES1 TGH hCE-1 |
carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) | cinnamic aldehyde results in increased expression of CES1 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 1196 |
CLK2
hCLK2 |
CDC-like kinase 2 (EC:2.7.12.1) | cinnamic aldehyde results in decreased expression of CLK2 mRNA |
decreases expression
|
mRNA |
17178418
|
| C012843 | 4848 |
CNOT2
CDC36 NOT2 NOT2H |
CCR4-NOT transcription complex, subunit 2 | cinnamic aldehyde results in decreased expression of CNOT2 mRNA |
decreases expression
|
mRNA |
19524605
|
| C012843 | 1294 |
COL7A1
EBD1 EBDCT EBR1 |
collagen, type VII, alpha 1 | cinnamic aldehyde results in increased expression of COL7A1 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 1385 |
CREB1
CREB |
cAMP responsive element binding protein 1 | cinnamic aldehyde results in decreased expression of CREB1 mRNA |
decreases expression
|
mRNA |
20385217
|
| C012843 | 1390 |
CREM
CREM-2 ICER hCREM-2 |
cAMP responsive element modulator | cinnamic aldehyde results in increased expression of CREM mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 51232 |
CRIM1
CRIM-1 S52 |
cysteine rich transmembrane BMP regulator 1 (chordin-like) | cinnamic aldehyde results in increased expression of CRIM1 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 1399 |
CRKL
|
v-crk avian sarcoma virus CT10 oncogene homolog-like | cinnamic aldehyde results in decreased phosphorylation of CRKL protein |
decreases phosphorylation
|
protein |
21729535
|
| C012843 | 1490 |
CTGF
CCN2 HCS24 IGFBP8 NOV2 |
connective tissue growth factor | cinnamic aldehyde results in decreased expression of CTGF mRNA |
decreases expression
|
mRNA |
17178418
|
| C012843 | 54205 |
CYCS
CYC HCS THC4 |
cytochrome c, somatic | cinnamic aldehyde affects the localization of CYCS protein |
affects localization
|
protein |
15566391
|
| C012843 | 54205 |
CYCS
CYC HCS THC4 |
cytochrome c, somatic | Vitamin E inhibits the reaction [cinnamic aldehyde affects the localization of CYCS protein] |
affects localization
/ decreases reaction |
protein |
15566391
|
| C012843 | 1581 |
CYP7A1
CP7A CYP7 CYPVII |
cytochrome P450, family 7, subfamily A, polypeptide 1 (EC:1.14.13.17) | cinnamic aldehyde results in increased expression of CYP7A1 mRNA |
increases expression
|
mRNA |
19000754
|
| C012843 | 1649 |
DDIT3
CEBPZ CHOP CHOP-10 CHOP10 GADD153 |
DNA-damage-inducible transcript 3 | cinnamic aldehyde results in increased expression of DDIT3 mRNA |
increases expression
|
mRNA |
19000754
|
| C012843 | 54541 |
DDIT4
Dig2 REDD-1 REDD1 |
DNA-damage-inducible transcript 4 | cinnamic aldehyde results in decreased expression of DDIT4 mRNA |
decreases expression
|
mRNA |
17178418
|
| C012843 | 56616 |
DIABLO
DFNA64 SMAC |
diablo, IAP-binding mitochondrial protein | cinnamic aldehyde affects the localization of DIABLO protein |
affects localization
|
protein |
15566391
|
| C012843 | 56616 |
DIABLO
DFNA64 SMAC |
diablo, IAP-binding mitochondrial protein | Vitamin E inhibits the reaction [cinnamic aldehyde affects the localization of DIABLO protein] |
affects localization
/ decreases reaction |
protein |
15566391
|
| C012843 | 2039 |
DMTN
DMT EPB49 |
dematin actin binding protein | cinnamic aldehyde results in increased expression of DMTN mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 1789 |
DNMT3B
ICF ICF1 M.HsaIIIB |
DNA (cytosine-5-)-methyltransferase 3 beta (EC:2.1.1.37) | cinnamic aldehyde results in decreased expression of DNMT3B mRNA |
decreases expression
|
mRNA |
17178418
|
| C012843 | 1848 |
DUSP6
HH19 MKP3 PYST1 |
dual specificity phosphatase 6 (EC:3.1.3.16 3.1.3.48) | cinnamic aldehyde results in decreased expression of DUSP6 mRNA |
decreases expression
|
mRNA |
17178418
|
| C012843 | 83658 |
DYNLRB1
BITH BLP DNCL2A DNLC2A ROBLD1 |
dynein, light chain, roadblock-type 1 | cinnamic aldehyde results in increased expression of DYNLRB1 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 55840 |
EAF2
BM040 TRAITS U19 |
ELL associated factor 2 | cinnamic aldehyde results in decreased expression of EAF2 mRNA |
decreases expression
|
mRNA |
19524605
|
| C012843 | 1958 |
EGR1
AT225 G0S30 KROX-24 NGFI-A TIS8 ZIF-268 ZNF225 |
early growth response 1 | cinnamic aldehyde results in increased expression of EGR1 mRNA |
increases expression
|
mRNA |
19000754
|
| C012843 | 2034 |
EPAS1
ECYT4 HIF2A HLF MOP2 PASD2 bHLHe73 |
endothelial PAS domain protein 1 | cinnamic aldehyde results in increased expression of EPAS1 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 2150 |
F2RL1
GPR11 PAR2 |
coagulation factor II (thrombin) receptor-like 1 | edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]] |
decreases reaction
/ increases activity / increases reaction |
protein |
17571167
|
| C012843 | 2150 |
F2RL1
GPR11 PAR2 |
coagulation factor II (thrombin) receptor-like 1 | F2RL1 protein promotes the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein] |
increases activity
/ increases reaction |
protein |
17571167
|
| C012843 | 2213 |
FCGR2B
CD32 CD32B FCG2 FCGR2 IGFR2 |
Fc fragment of IgG, low affinity IIb, receptor (CD32) | cinnamic aldehyde results in increased expression of FCGR2B mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 9103 |
FCGR2C
CD32 CD32C CDW32 FCG2 FCRIIC IGFR2 |
Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) | cinnamic aldehyde results in increased expression of FCGR2C mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 2263 |
FGFR2
BBDS BEK BFR-1 CD332 CEK3 CFD1 ECT1 JWS K-SAM KGFR TK14 TK25 |
fibroblast growth factor receptor 2 (EC:2.7.10.1) | cinnamic aldehyde results in decreased expression of FGFR2 mRNA |
decreases expression
|
mRNA |
17178418
|
| C012843 | 2330 |
FMO5
|
flavin containing monooxygenase 5 (EC:1.14.13.8) | cinnamic aldehyde results in increased expression of FMO5 mRNA |
increases expression
|
mRNA |
19000754
|
| C012843 | 2353 |
FOS
AP-1 C-FOS p55 |
FBJ murine osteosarcoma viral oncogene homolog | cinnamic aldehyde analog results in decreased expression of FOS protein |
decreases expression
|
protein |
17510524
|
| C012843 | 2495 |
FTH1
FHC FTH FTHL6 PIG15 PLIF |
ferritin, heavy polypeptide 1 (EC:1.16.3.1) | cinnamic aldehyde results in increased expression of FTH1 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 2535 |
FZD2
Fz2 fz-2 fzE2 hFz2 |
frizzled family receptor 2 | cinnamic aldehyde results in increased expression of FZD2 mRNA |
increases expression
|
mRNA |
17178418
|
| C012843 | 2539 |
G6PD
G6PD1 |
glucose-6-phosphate dehydrogenase (EC:1.1.1.49) | cinnamic aldehyde results in increased expression of G6PD mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 2729 |
GCLC
GCL GCS GLCL GLCLC |
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cinnamic aldehyde results in increased expression of GCLC protein] |
decreases reaction
/ increases expression |
protein |
21469739
|
| C012843 | 2729 |
GCLC
GCL GCS GLCL GLCLC |
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cinnamic aldehyde results in increased expression of GCLC protein] |
decreases reaction
/ increases expression |
protein |
21469739
|
| C012843 | 2729 |
GCLC
GCL GCS GLCL GLCLC |
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) | anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [cinnamic aldehyde results in increased expression of GCLC protein] |
decreases reaction
/ increases expression |
protein |
21469739
|
| C012843 | 2729 |
GCLC
GCL GCS GLCL GLCLC |
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) | [cinnamic aldehyde results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA |
increases activity
/ increases expression |
mRNA |
20351055
|
| C012843 | 2729 |
GCLC
GCL GCS GLCL GLCLC |
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) | cinnamic aldehyde results in increased expression of GCLC mRNA |
increases expression
|
mRNA |
17178418
|
| C012843 | 2729 |
GCLC
GCL GCS GLCL GLCLC |
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) | cinnamic aldehyde results in increased expression of GCLC protein |
increases expression
|
protein |
21469739
|
| C012843 | 2729 |
GCLC
GCL GCS GLCL GLCLC |
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) | NFE2L2 mRNA affects the reaction [cinnamic aldehyde results in increased expression of GCLC protein] |
affects reaction
/ increases expression |
protein |
21469739
|
| C012843 | 2730 |
GCLM
GLCLR |
glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) | [cinnamic aldehyde results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA |
increases activity
/ increases expression |
mRNA |
20351055
|
| C012843 | 2730 |
GCLM
GLCLR |
glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) | cinnamic aldehyde results in increased expression of GCLM mRNA |
increases expression
|
mRNA |
17178418
|
| C012843 | 2745 |
GLRX
GRX GRX1 |
glutaredoxin (thioltransferase) (EC:1.8.4.1) | [Cadmium Chloride affects the activity of GLRX protein] inhibits the reaction [cinnamic aldehyde results in increased glutathionylation of RELA protein] |
affects activity
/ decreases reaction / increases glutathionylation |
protein |
20351055
|
| C012843 | 2745 |
GLRX
GRX GRX1 |
glutaredoxin (thioltransferase) (EC:1.8.4.1) | cinnamic aldehyde results in increased activity of GLRX protein |
increases activity
|
protein |
20351055
|
| C012843 | 2745 |
GLRX
GRX GRX1 |
glutaredoxin (thioltransferase) (EC:1.8.4.1) | [cinnamic aldehyde results in increased activity of GLRX protein] inhibits the reaction [TNF protein affects the localization of RELA protein] |
affects localization
/ decreases reaction / increases activity |
protein |
20351055
|
| C012843 | 2745 |
GLRX
GRX GRX1 |
glutaredoxin (thioltransferase) (EC:1.8.4.1) | [cinnamic aldehyde results in increased activity of GLRX protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
decreases reaction
/ increases activity / increases expression |
protein |
20351055
|
| C012843 | 2745 |
GLRX
GRX GRX1 |
glutaredoxin (thioltransferase) (EC:1.8.4.1) | [cinnamic aldehyde results in increased activity of GLRX protein] which results in increased glutathionylation of RELA protein |
increases activity
/ increases glutathionylation |
protein |
20351055
|
| C012843 | 2745 |
GLRX
GRX GRX1 |
glutaredoxin (thioltransferase) (EC:1.8.4.1) | cinnamic aldehyde results in increased expression of GLRX mRNA |
increases expression
|
mRNA |
20351055
|
| C012843 | 2844 |
GPR21
|
G protein-coupled receptor 21 | cinnamic aldehyde results in increased expression of GPR21 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 2877 |
GPX2
GI-GPx GPRP GPRP-2 GPx-2 GPx-GI GSHPX-GI GSHPx-2 |
glutathione peroxidase 2 (gastrointestinal) (EC:1.11.1.9) | cinnamic aldehyde results in increased expression of GPX2 mRNA |
increases expression
|
mRNA |
19000754
|
| C012843 | 2936 |
GSR
|
glutathione reductase (EC:1.8.1.7) | cinnamic aldehyde results in increased expression of GSR mRNA |
increases expression
|
mRNA |
19000754
|
| C012843 | 2950 |
GSTP1
DFN7 FAEES3 GST3 GSTP PI |
glutathione S-transferase pi 1 (EC:2.5.1.18) | cinnamic aldehyde binds to and results in decreased activity of GSTP1 protein |
affects binding
/ decreases activity |
protein |
9463521
|
| C012843 | 3077 |
HFE
HFE1 HH HLA-H MVCD7 TFQTL2 |
hemochromatosis | cinnamic aldehyde results in increased expression of HFE mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cinnamic aldehyde results in increased expression of HMOX1 protein] |
decreases reaction
/ increases expression |
protein |
21469739
|
| C012843 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cinnamic aldehyde results in increased expression of HMOX1 protein] |
decreases reaction
/ increases expression |
protein |
21469739
|
| C012843 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [cinnamic aldehyde results in increased expression of HMOX1 protein] |
decreases reaction
/ increases expression |
protein |
21469739
|
| C012843 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | cinnamic aldehyde analog results in increased expression of HMOX1 mRNA |
increases expression
|
mRNA |
18482591
|
| C012843 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | cinnamic aldehyde analog results in increased expression of HMOX1 protein |
increases expression
|
protein |
18482591
|
| C012843 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | cinnamic aldehyde results in increased expression of HMOX1 mRNA |
increases expression
|
mRNA |
17178418
18482591 19000754 19033392 20713136 |
| C012843 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | cinnamic aldehyde results in increased expression of HMOX1 protein |
increases expression
|
protein |
18304597
18482591 21469739 |
| C012843 | 3251 |
HPRT1
HGPRT HPRT |
hypoxanthine phosphoribosyltransferase 1 (EC:2.4.2.8) | cinnamic aldehyde results in decreased mutagenesis of HPRT1 gene |
decreases mutagenesis
|
gene |
17178418
|
| C012843 | 3304 |
HSPA1B
HSP70-1B HSP70-2 |
heat shock 70kDa protein 1B | cinnamic aldehyde results in increased expression of HSPA1B mRNA |
increases expression
|
mRNA |
17178418
|
| C012843 | 10553 |
HTATIP2
CC3 SDR44U1 TIP30 |
HIV-1 Tat interactive protein 2, 30kDa (EC:1.1.1.-) | cinnamic aldehyde results in increased expression of HTATIP2 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 27429 |
HTRA2
OMI PARK13 PRSS25 |
HtrA serine peptidase 2 (EC:3.4.21.108) | cinnamic aldehyde affects the localization of HTRA2 protein |
affects localization
|
protein |
15566391
|
| C012843 | 27429 |
HTRA2
OMI PARK13 PRSS25 |
HtrA serine peptidase 2 (EC:3.4.21.108) | Vitamin E inhibits the reaction [cinnamic aldehyde affects the localization of HTRA2 protein] |
affects localization
/ decreases reaction |
protein |
15566391
|
| C012843 | 3383 |
ICAM1
BB2 CD54 P3.58 |
intercellular adhesion molecule 1 | Buthionine Sulfoximine inhibits the reaction [cinnamic aldehyde inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] |
decreases reaction
/ increases expression |
protein |
20351055
|
| C012843 | 3383 |
ICAM1
BB2 CD54 P3.58 |
intercellular adhesion molecule 1 | cinnamic aldehyde inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
decreases reaction
/ increases expression |
protein |
20351055
|
| C012843 | 3383 |
ICAM1
BB2 CD54 P3.58 |
intercellular adhesion molecule 1 | [cinnamic aldehyde results in increased activity of GLRX protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
decreases reaction
/ increases activity / increases expression |
protein |
20351055
|
| C012843 | 3383 |
ICAM1
BB2 CD54 P3.58 |
intercellular adhesion molecule 1 | [cinnamic aldehyde results in increased activity of NFE2L2 protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
decreases reaction
/ increases activity / increases expression |
protein |
20351055
|
| C012843 | 3429 |
IFI27
FAM14D ISG12 ISG12A P27 |
interferon, alpha-inducible protein 27 | cinnamic aldehyde results in decreased expression of IFI27 mRNA |
decreases expression
|
mRNA |
19524605
|
| C012843 | 10964 |
IFI44L
C1orf29 |
interferon-induced protein 44-like | cinnamic aldehyde results in decreased expression of IFI44L mRNA |
decreases expression
|
mRNA |
19524605
|
| C012843 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | cinnamic aldehyde inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL1B protein] |
affects cotreatment
/ decreases reaction / increases secretion |
protein |
21807015
|
| C012843 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | cinnamic aldehyde results in increased expression of IL1B mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 3575 |
IL7R
CD127 CDW127 IL-7R-alpha IL7RA ILRA |
interleukin 7 receptor | cinnamic aldehyde results in increased expression of IL7R mRNA |
increases expression
|
mRNA |
20713136
|
| C012843 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | Betamethasone inhibits the reaction [cinnamic aldehyde results in increased expression of IL8 mRNA] |
decreases reaction
/ increases expression |
mRNA |
20090409
|
| C012843 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | cinnamic aldehyde results in increased expression of IL8 mRNA |
increases expression
|
mRNA |
19524605
20090409 20713136 21920952 |
| C012843 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | cinnamic aldehyde results in increased secretion of IL8 protein |
increases secretion
|
protein |
18494145
19878716 |
| C012843 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | SB 203580 affects the reaction [cinnamic aldehyde results in increased secretion of IL8 protein] |
affects reaction
/ increases secretion |
protein |
18494145
|
| C012843 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | Tacrolimus inhibits the reaction [cinnamic aldehyde results in increased expression of IL8 mRNA] |
decreases reaction
/ increases expression |
mRNA |
20090409
|
| C012843 | 3638 |
INSIG1
CL-6 CL6 |
insulin induced gene 1 | cinnamic aldehyde results in decreased expression of INSIG1 mRNA |
decreases expression
|
mRNA |
17178418
|
| C012843 | 22801 |
ITGA11
HsT18964 |
integrin, alpha 11 | cinnamic aldehyde results in increased expression of ITGA11 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 3725 |
JUN
AP-1 AP1 c-Jun |
jun proto-oncogene | cinnamic aldehyde analog results in decreased expression of JUN protein |
decreases expression
|
protein |
17510524
|
| C012843 | 3727 |
JUND
AP-1 |
jun D proto-oncogene | cinnamic aldehyde results in decreased expression of JUND mRNA |
decreases expression
|
mRNA |
17178418
|
| C012843 | 9817 |
KEAP1
INrf2 KLHL19 |
kelch-like ECH-associated protein 1 | cinnamic aldehyde results in increased expression of KEAP1 protein |
increases expression
|
protein |
19033392
|
| C012843 | 10186 |
LHFP
|
lipoma HMGIC fusion partner (EC:3.6.5.4) | cinnamic aldehyde results in increased expression of LHFP mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 29995 |
LMCD1
|
LIM and cysteine-rich domains 1 | cinnamic aldehyde results in decreased expression of LMCD1 mRNA |
decreases expression
|
mRNA |
19524605
|
| C012843 | 29967 |
LRP12
ST7 |
low density lipoprotein receptor-related protein 12 | cinnamic aldehyde results in increased expression of LRP12 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 4049 |
LTA
LT TNFB TNFSF1 |
lymphotoxin alpha | cinnamic aldehyde results in increased expression of LTA mRNA |
increases expression
|
mRNA |
19000754
|
| C012843 | 79917 |
MAGIX
JM10 PDZX |
MAGI family member, X-linked | cinnamic aldehyde results in increased expression of MAGIX mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 5605 |
MAP2K2
CFC4 MAPKK2 MEK2 MKK2 PRKMK2 |
mitogen-activated protein kinase kinase 2 (EC:2.7.12.2) | cinnamic aldehyde results in decreased expression of MAP2K2 mRNA |
decreases expression
|
mRNA |
17178418
|
| C012843 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | cinnamic aldehyde results in increased phosphorylation of and results in increased activity of MAPK1 protein |
increases activity
/ increases phosphorylation |
protein |
15964311
|
| C012843 | 1432 |
MAPK14
CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA |
mitogen-activated protein kinase 14 (EC:2.7.11.24) | anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [cinnamic aldehyde results in increased phosphorylation of MAPK14 protein] |
decreases reaction
/ increases phosphorylation |
protein |
15964311
|
| C012843 | 1432 |
MAPK14
CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA |
mitogen-activated protein kinase 14 (EC:2.7.11.24) | cinnamic aldehyde results in increased phosphorylation of and results in increased activity of MAPK14 protein |
increases activity
/ increases phosphorylation |
protein |
15964311
|
| C012843 | 1432 |
MAPK14
CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA |
mitogen-activated protein kinase 14 (EC:2.7.11.24) | SB 203580 inhibits the reaction [cinnamic aldehyde results in increased phosphorylation of MAPK14 protein] |
decreases reaction
/ increases phosphorylation |
protein |
15964311
|
| C012843 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | cinnamic aldehyde results in increased phosphorylation of and results in increased activity of MAPK3 protein |
increases activity
/ increases phosphorylation |
protein |
15964311
|
| C012843 | 5599 |
MAPK8
JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c |
mitogen-activated protein kinase 8 (EC:2.7.11.24) | anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [cinnamic aldehyde results in increased phosphorylation of MAPK8 protein] |
decreases reaction
/ increases phosphorylation |
protein |
15964311
|
| C012843 | 5599 |
MAPK8
JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c |
mitogen-activated protein kinase 8 (EC:2.7.11.24) | cinnamic aldehyde results in increased phosphorylation of and results in increased activity of MAPK8 protein |
increases activity
/ increases phosphorylation |
protein |
15964311
|
| C012843 | 5599 |
MAPK8
JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c |
mitogen-activated protein kinase 8 (EC:2.7.11.24) | cinnamic aldehyde results in increased phosphorylation of MAPK8 protein |
increases phosphorylation
|
protein |
21469739
|
| C012843 | 5599 |
MAPK8
JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c |
mitogen-activated protein kinase 8 (EC:2.7.11.24) | SB 203580 inhibits the reaction [cinnamic aldehyde results in increased phosphorylation of MAPK8 protein] |
decreases reaction
/ increases phosphorylation |
protein |
15964311
|
| C012843 | 8550 |
MAPKAPK5
MAPKAP-K5 MK-5 MK5 PRAK |
mitogen-activated protein kinase-activated protein kinase 5 (EC:2.7.11.1) | cinnamic aldehyde results in increased expression of MAPKAPK5 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 57787 |
MARK4
MARK4L MARK4S MARKL1 MARKL1L PAR-1D |
MAP/microtubule affinity-regulating kinase 4 (EC:2.7.11.1) | cinnamic aldehyde results in decreased expression of MARK4 mRNA |
decreases expression
|
mRNA |
17178418
|
| C012843 | 4170 |
MCL1
BCL2L3 EAT MCL1-ES MCL1L MCL1S Mcl-1 TM bcl2-L-3 mcl1/EAT |
myeloid cell leukemia sequence 1 (BCL2-related) | cinnamic aldehyde results in decreased expression of MCL1 protein |
decreases expression
|
protein |
15964311
|
| C012843 | 4193 |
MDM2
ACTFS HDMX hdm2 |
MDM2 oncogene, E3 ubiquitin protein ligase | cinnamic aldehyde results in increased expression of MDM2 mRNA |
increases expression
|
mRNA |
19000754
|
| C012843 | 4599 |
MX1
IFI-78K IFI78 MX MxA |
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | cinnamic aldehyde results in decreased expression of MX1 mRNA |
decreases expression
|
mRNA |
19524605
|
| C012843 | 4609 |
MYC
MRTL MYCC bHLHe39 c-Myc |
v-myc avian myelocytomatosis viral oncogene homolog | cinnamic aldehyde results in decreased expression of MYC protein |
decreases expression
|
protein |
21729535
|
| C012843 | 100132406 |
NBPF10
AB6 AG1 NBPF9 |
neuroblastoma breakpoint family, member 10 | cinnamic aldehyde results in increased expression of NBPF10 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 653361 |
NCF1
NCF1A NOXO2 SH3PXD1A p47phox |
neutrophil cytosolic factor 1 | cinnamic aldehyde results in increased expression of NCF1 mRNA |
increases expression
|
mRNA |
19000754
|
| C012843 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | cinnamic aldehyde affects the localization of NFE2L2 protein |
affects localization
|
protein |
18304597
21469739 |
| C012843 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | cinnamic aldehyde analog results in increased expression of NFE2L2 protein |
increases expression
|
protein |
18482591
|
| C012843 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | [cinnamic aldehyde results in increased activity of NFE2L2 protein] inhibits the reaction [TNF protein affects the localization of RELA protein] |
affects localization
/ decreases reaction / increases activity |
protein |
20351055
|
| C012843 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | [cinnamic aldehyde results in increased activity of NFE2L2 protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
decreases reaction
/ increases activity / increases expression |
protein |
20351055
|
| C012843 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | [cinnamic aldehyde results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA |
increases activity
/ increases expression |
protein |
20351055
|
| C012843 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | [cinnamic aldehyde results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA |
increases activity
/ increases expression |
protein |
20351055
|
| C012843 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | [cinnamic aldehyde results in increased activity of NFE2L2 protein] which results in increased glutathionylation of RELA protein |
increases activity
/ increases glutathionylation |
protein |
20351055
|
| C012843 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | cinnamic aldehyde results in increased expression of NFE2L2 protein |
increases expression
|
protein |
18482591
19033392 |
| C012843 | 4780 |
NFE2L2
NRF2 |
nuclear factor, erythroid 2-like 2 | NFE2L2 mRNA affects the reaction [cinnamic aldehyde results in increased expression of GCLC protein] |
affects reaction
/ increases expression |
mRNA |
21469739
|
| C012843 | 4790 |
NFKB1
EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | cinnamic aldehyde results in decreased expression of NFKB1 mRNA |
decreases expression
|
mRNA |
20385217
|
| C012843 | 22981 |
NINL
NLP dJ691N24.1 |
ninein-like | cinnamic aldehyde results in increased expression of NINL mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 4854 |
NOTCH3
CADASIL CASIL IMF2 |
notch 3 | cinnamic aldehyde results in increased expression of NOTCH3 mRNA |
increases expression
|
mRNA |
20713136
|
| C012843 | 1728 |
NQO1
DHQU DIA4 DTD NMOR1 NMORI QR1 |
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) | cinnamic aldehyde analog results in increased expression of NQO1 mRNA |
increases expression
|
mRNA |
18482591
|
| C012843 | 1728 |
NQO1
DHQU DIA4 DTD NMOR1 NMORI QR1 |
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) | cinnamic aldehyde results in increased activity of NQO1 protein |
increases activity
|
protein |
18482591
|
| C012843 | 1728 |
NQO1
DHQU DIA4 DTD NMOR1 NMORI QR1 |
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) | cinnamic aldehyde results in increased expression of NQO1 mRNA |
increases expression
|
mRNA |
18482591
19033392 19524605 |
| C012843 | 56666 |
PANX2
PX2 hPANX2 |
pannexin 2 | cinnamic aldehyde results in increased expression of PANX2 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 142 |
PARP1
ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1 |
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) | cinnamic aldehyde analog results in increased cleavage of PARP1 protein |
increases cleavage
|
protein |
16343908
|
| C012843 | 5140 |
PDE3B
HcGIP1 cGIPDE1 |
phosphodiesterase 3B, cGMP-inhibited (EC:3.1.4.17) | cinnamic aldehyde results in increased expression of PDE3B mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 7262 |
PHLDA2
BRW1C BWR1C HLDA2 IPL TSSC3 |
pleckstrin homology-like domain, family A, member 2 | cinnamic aldehyde results in increased expression of PHLDA2 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 8544 |
PIR
|
pirin (iron-binding nuclear protein) (EC:1.13.11.24) | cinnamic aldehyde results in increased expression of PIR mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 5366 |
PMAIP1
APR NOXA |
phorbol-12-myristate-13-acetate-induced protein 1 | cinnamic aldehyde results in increased expression of PMAIP1 mRNA |
increases expression
|
mRNA |
20713136
|
| C012843 | 5447 |
POR
CPR CYPOR P450R |
P450 (cytochrome) oxidoreductase (EC:1.6.2.4) | cinnamic aldehyde results in increased expression of POR mRNA |
increases expression
|
mRNA |
19000754
|
| C012843 | 8496 |
PPFIBP1
L2 SGT2 hSGT2 hSgt2p |
PTPRF interacting protein, binding protein 1 (liprin beta 1) | cinnamic aldehyde results in increased expression of PPFIBP1 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 5514 |
PPP1R10
CAT53 FB19 PNUTS PP1R10 R111 p99 |
protein phosphatase 1, regulatory subunit 10 | cinnamic aldehyde results in decreased expression of PPP1R10 mRNA |
decreases expression
|
mRNA |
17178418
|
| C012843 | 11107 |
PRDM5
BCS2 PFM2 |
PR domain containing 5 | cinnamic aldehyde results in increased expression of PRDM5 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 5743 |
PTGS2
COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2 |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | cinnamic aldehyde inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTGS2 mRNA] |
affects cotreatment
/ decreases reaction / increases expression |
mRNA |
21807015
|
| C012843 | 5743 |
PTGS2
COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2 |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | cinnamic aldehyde inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PTGS2 protein] |
affects cotreatment
/ decreases reaction / increases expression |
protein |
21807015
|
| C012843 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | Buthionine Sulfoximine inhibits the reaction [cinnamic aldehyde inhibits the reaction [TNF protein affects the localization of RELA protein]] |
affects localization
/ decreases reaction |
protein |
20351055
|
| C012843 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [cinnamic aldehyde results in increased glutathionylation of RELA protein] |
decreases abundance
/ decreases reaction / increases glutathionylation |
protein |
20351055
|
| C012843 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | [Cadmium Chloride affects the activity of GLRX protein] inhibits the reaction [cinnamic aldehyde results in increased glutathionylation of RELA protein] |
affects activity
/ decreases reaction / increases glutathionylation |
protein |
20351055
|
| C012843 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | cinnamic aldehyde inhibits the reaction [TNF protein affects the localization of RELA protein] |
affects localization
/ decreases reaction |
protein |
20351055
|
| C012843 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | [cinnamic aldehyde results in increased abundance of Glutathione] which results in increased glutathionylation of RELA protein |
increases abundance
/ increases glutathionylation |
protein |
20351055
|
| C012843 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | [cinnamic aldehyde results in increased abundance of Hydrogen Peroxide] which results in increased glutathionylation of RELA protein |
increases abundance
/ increases glutathionylation |
protein |
20351055
|
| C012843 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | [cinnamic aldehyde results in increased activity of GLRX protein] inhibits the reaction [TNF protein affects the localization of RELA protein] |
affects localization
/ decreases reaction / increases activity |
protein |
20351055
|
| C012843 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | [cinnamic aldehyde results in increased activity of GLRX protein] which results in increased glutathionylation of RELA protein |
increases activity
/ increases glutathionylation |
protein |
20351055
|
| C012843 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | [cinnamic aldehyde results in increased activity of NFE2L2 protein] inhibits the reaction [TNF protein affects the localization of RELA protein] |
affects localization
/ decreases reaction / increases activity |
protein |
20351055
|
| C012843 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | [cinnamic aldehyde results in increased activity of NFE2L2 protein] which results in increased glutathionylation of RELA protein |
increases activity
/ increases glutathionylation |
protein |
20351055
|
| C012843 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | cinnamic aldehyde results in increased glutathionylation of RELA protein |
increases glutathionylation
|
protein |
20351055
|
| C012843 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | Dithiothreitol inhibits the reaction [cinnamic aldehyde results in increased glutathionylation of RELA protein] |
decreases reaction
/ increases glutathionylation |
protein |
20351055
|
| C012843 | 146760 |
RTN4RL1
NGRH2 NgR3 |
reticulon 4 receptor-like 1 | cinnamic aldehyde results in decreased expression of RTN4RL1 mRNA |
decreases expression
|
mRNA |
19524605
|
| C012843 | 5054 |
SERPINE1
PAI PAI-1 PAI1 PLANH1 |
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | cinnamic aldehyde results in increased expression of SERPINE1 mRNA |
increases expression
|
mRNA |
19000754
|
| C012843 | 6444 |
SGCD
35DAG CMD1L DAGD SG-delta SGCDP SGD |
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) | cinnamic aldehyde results in increased expression of SGCD mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 6563 |
SLC14A1
HUT11 HsT1341 JK RACH1 RACH2 UT-B1 UT1 UTE |
solute carrier family 14 (urea transporter), member 1 | cinnamic aldehyde results in increased expression of SLC14A1 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 6506 |
SLC1A2
EAAT2 GLT-1 |
solute carrier family 1 (glial high affinity glutamate transporter), member 2 | cinnamic aldehyde results in increased expression of SLC1A2 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 115111 |
SLC26A7
SUT2 |
solute carrier family 26 (anion exchanger), member 7 | cinnamic aldehyde results in increased expression of SLC26A7 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 114134 |
SLC2A13
HMIT |
solute carrier family 2 (facilitated glucose transporter), member 13 | cinnamic aldehyde results in increased expression of SLC2A13 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 11046 |
SLC35D2
HFRC1 SQV7L UGTrel8 hfrc |
solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 | cinnamic aldehyde results in decreased expression of SLC35D2 mRNA |
decreases expression
|
mRNA |
17178418
|
| C012843 | 23657 |
SLC7A11
CCBR1 xCT |
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | cinnamic aldehyde results in increased expression of SLC7A11 mRNA |
increases expression
|
mRNA |
17178418
|
| C012843 | 6546 |
SLC8A1
NCX1 |
solute carrier family 8 (sodium/calcium exchanger), member 1 | cinnamic aldehyde results in increased expression of SLC8A1 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 4087 |
SMAD2
JV18 JV18-1 MADH2 MADR2 hMAD-2 hSMAD2 |
SMAD family member 2 | cinnamic aldehyde results in increased expression of SMAD2 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 28966 |
SNX24
PRO1284 |
sorting nexin 24 | cinnamic aldehyde results in increased expression of SNX24 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 9295 |
SRSF11
NET2 SFRS11 dJ677H15.2 p54 |
serine/arginine-rich splicing factor 11 | cinnamic aldehyde results in increased expression of SRSF11 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 140809 |
SRXN1
C20orf139 Npn3 SRX SRX1 |
sulfiredoxin 1 (EC:1.8.98.2) | cinnamic aldehyde results in increased expression of SRXN1 mRNA |
increases expression
|
mRNA |
19000754
|
| C012843 | 27067 |
STAU2
39K2 39K3 |
staufen double-stranded RNA binding protein 2 | cinnamic aldehyde results in increased expression of STAU2 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 8428 |
STK24
MST3 MST3B STE20 STK3 |
serine/threonine kinase 24 (EC:2.7.11.1) | cinnamic aldehyde results in decreased expression of STK24 mRNA |
decreases expression
|
mRNA |
19524605
|
| C012843 | 51684 |
SUFU
PRO1280 SUFUH SUFUXL |
suppressor of fused homolog (Drosophila) | cinnamic aldehyde results in increased expression of SUFU mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 6915 |
TBXA2R
BDPLT13 TXA2-R |
thromboxane A2 receptor | cinnamic aldehyde binds to and results in decreased activity of TBXA2R protein |
affects binding
/ decreases activity |
protein |
17079160
|
| C012843 | 7041 |
TGFB1I1
ARA55 HIC-5 HIC5 TSC-5 |
transforming growth factor beta 1 induced transcript 1 | cinnamic aldehyde results in decreased expression of TGFB1I1 mRNA |
decreases expression
|
mRNA |
17178418
|
| C012843 | 55258 |
THNSL2
SOFAT THS2 TSH2 |
threonine synthase-like 2 (S. cerevisiae) (EC:4.2.3.-) | cinnamic aldehyde results in increased expression of THNSL2 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 7099 |
TLR4
ARMD10 CD284 TLR-4 TOLL |
toll-like receptor 4 | cinnamic aldehyde results in increased expression of TLR4 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | Buthionine Sulfoximine inhibits the reaction [cinnamic aldehyde inhibits the reaction [TNF protein affects the localization of RELA protein]] |
affects localization
/ decreases reaction |
protein |
20351055
|
| C012843 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | Buthionine Sulfoximine inhibits the reaction [cinnamic aldehyde inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] |
decreases reaction
/ increases expression |
protein |
20351055
|
| C012843 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | cinnamic aldehyde inhibits the reaction [lipopolysaccharide, Escherichia coli 0111 B4 results in increased secretion of TNF protein] |
decreases reaction
/ increases secretion |
protein |
17868967
|
| C012843 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | cinnamic aldehyde inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of TNF protein] |
affects cotreatment
/ decreases reaction / increases secretion |
protein |
21807015
|
| C012843 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | cinnamic aldehyde inhibits the reaction [TNF protein affects the localization of RELA protein] |
affects localization
/ decreases reaction |
protein |
20351055
|
| C012843 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | cinnamic aldehyde inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
decreases reaction
/ increases expression |
protein |
20351055
|
| C012843 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | [cinnamic aldehyde results in increased activity of GLRX protein] inhibits the reaction [TNF protein affects the localization of RELA protein] |
affects localization
/ decreases reaction / increases activity |
protein |
20351055
|
| C012843 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | [cinnamic aldehyde results in increased activity of GLRX protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
decreases reaction
/ increases activity / increases expression |
protein |
20351055
|
| C012843 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | [cinnamic aldehyde results in increased activity of NFE2L2 protein] inhibits the reaction [TNF protein affects the localization of RELA protein] |
affects localization
/ decreases reaction / increases activity |
protein |
20351055
|
| C012843 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | [cinnamic aldehyde results in increased activity of NFE2L2 protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
decreases reaction
/ increases activity / increases expression |
protein |
20351055
|
| C012843 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | cinnamic aldehyde results in increased expression of TNF mRNA |
increases expression
|
mRNA |
20385217
|
| C012843 | 27242 |
TNFRSF21
BM-018 CD358 DR6 |
tumor necrosis factor receptor superfamily, member 21 | cinnamic aldehyde results in increased expression of TNFRSF21 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | cinnamic aldehyde results in decreased expression of TP53 mRNA |
decreases expression
|
mRNA |
17178418
|
| C012843 | 10626 |
TRIM16
EBBP |
tripartite motif containing 16 | cinnamic aldehyde results in increased expression of TRIM16 mRNA |
increases expression
|
mRNA |
17178418
19524605 |
| C012843 | 8989 |
TRPA1
ANKTM1 FEPS |
transient receptor potential cation channel, subfamily A, member 1 | 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein] |
decreases reaction
/ increases activity |
protein |
20720158
|
| C012843 | 8989 |
TRPA1
ANKTM1 FEPS |
transient receptor potential cation channel, subfamily A, member 1 | cinnamic aldehyde results in increased activity of TRPA1 protein |
increases activity
|
protein |
20720158
22863862 22935519 |
| C012843 | 8989 |
TRPA1
ANKTM1 FEPS |
transient receptor potential cation channel, subfamily A, member 1 | [cinnamic aldehyde results in increased activity of TRPA1 protein] which results in increased transport of Calcium |
increases activity
/ increases transport |
protein |
22863862
|
| C012843 | 8989 |
TRPA1
ANKTM1 FEPS |
transient receptor potential cation channel, subfamily A, member 1 | edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein]] |
decreases reaction
/ increases activity / increases reaction |
protein |
17571167
|
| C012843 | 8989 |
TRPA1
ANKTM1 FEPS |
transient receptor potential cation channel, subfamily A, member 1 | F2RL1 protein promotes the reaction [cinnamic aldehyde results in increased activity of TRPA1 protein] |
increases activity
/ increases reaction |
protein |
17571167
|
| C012843 | 8989 |
TRPA1
ANKTM1 FEPS |
transient receptor potential cation channel, subfamily A, member 1 | TRPA1 mRNA affects the reaction [cinnamic aldehyde results in increased secretion of Serotonin] |
affects reaction
/ increases secretion |
mRNA |
19507004
|
| C012843 | 8989 |
TRPA1
ANKTM1 FEPS |
transient receptor potential cation channel, subfamily A, member 1 | TRPA1 mRNA affects the reaction [cinnamic aldehyde results in increased uptake of Calcium] |
affects reaction
/ increases uptake |
mRNA |
19507004
|
| C012843 | 8989 |
TRPA1
ANKTM1 FEPS |
transient receptor potential cation channel, subfamily A, member 1 | TRPA1 mRNA affects the susceptibility to cinnamic aldehyde |
affects response to substance
|
mRNA |
19507004
|
| C012843 | 8989 |
TRPA1
ANKTM1 FEPS |
transient receptor potential cation channel, subfamily A, member 1 | TRPA1 protein results in increased susceptibility to cinnamic aldehyde |
increases response to substance
|
protein |
15046718
|
| C012843 | 7273 |
TTN
CMD1G CMH9 CMPD4 EOMFC HMERF LGMD2J MYLK5 TMD |
titin (EC:2.7.11.1) | cinnamic aldehyde results in decreased expression of TTN mRNA |
decreases expression
|
mRNA |
19000754
|
| C012843 | 7296 |
TXNRD1
GRIM-12 TR TR1 TRXR1 TXNR |
thioredoxin reductase 1 (EC:1.8.1.9) | cinnamic aldehyde results in increased expression of TXNRD1 mRNA |
increases expression
|
mRNA |
19000754
|
| C012843 | 7296 |
TXNRD1
GRIM-12 TR TR1 TRXR1 TXNR |
thioredoxin reductase 1 (EC:1.8.1.9) | cinnamic aldehyde results in increased expression of TXNRD1 protein |
increases expression
|
protein |
18304597
|
| C012843 | 7321 |
UBE2D1
E2(17)KB1 SFT UBC4/5 UBCH5 UBCH5A |
ubiquitin-conjugating enzyme E2D 1 (EC:6.3.2.19) | cinnamic aldehyde results in increased expression of UBE2D1 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 7360 |
UGP2
UDPG UDPGP UDPGP2 UGP1 UGPP1 UGPP2 pHC379 |
UDP-glucose pyrophosphorylase 2 (EC:2.7.7.9) | cinnamic aldehyde results in increased expression of UGP2 mRNA |
increases expression
|
mRNA |
17178418
|
| C012843 | 7374 |
UNG
DGU HIGM4 HIGM5 UDG UNG1 UNG15 UNG2 |
uracil-DNA glycosylase (EC:3.2.2.27) | cinnamic aldehyde results in decreased expression of UNG mRNA |
decreases expression
|
mRNA |
19000754
|
| C012843 | 331 |
XIAP
API3 BIRC4 IAP-3 ILP1 MIHA XLP2 hIAP-3 hIAP3 |
X-linked inhibitor of apoptosis | cinnamic aldehyde results in decreased expression of XIAP protein |
decreases expression
|
protein |
15566391
|
| C012843 | 331 |
XIAP
API3 BIRC4 IAP-3 ILP1 MIHA XLP2 hIAP-3 hIAP3 |
X-linked inhibitor of apoptosis | Vitamin E inhibits the reaction [cinnamic aldehyde results in decreased expression of XIAP protein] |
decreases expression
/ decreases reaction |
protein |
15566391
|
| C012843 | 340481 |
ZDHHC21
9130404H11Rik DHHC-21 DHHC21 DNZ1 HSPC097 |
zinc finger, DHHC-type containing 21 (EC:2.3.1.225) | cinnamic aldehyde results in increased expression of ZDHHC21 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 79973 |
ZNF442
|
zinc finger protein 442 | cinnamic aldehyde results in increased expression of ZNF442 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 440515 |
ZNF506
|
zinc finger protein 506 | cinnamic aldehyde results in increased expression of ZNF506 mRNA |
increases expression
|
mRNA |
19524605
|
| C012843 | 51193 |
ZNF639
6230400O18Rik ANC-2H01 ANC_2H01 ZASC1 |
zinc finger protein 639 | cinnamic aldehyde results in increased expression of ZNF639 mRNA |
increases expression
|
mRNA |
19524605
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (49)
| OMIM | preferred title | UniProt |
|---|---|---|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615040 | Episodic pain syndrome, familial, 1; feps1 |
O75762
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P04626 |
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #159900 | Myoclonic dystonia |
P14416
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #278300 | Xanthinuria, type i |
P47989
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (42)
| KEGG | disease name | UniProt |
|---|---|---|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00025 | Penile cancer |
P14780
(related)
P35354 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
Diseases related to CTD interactions
23 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D006528 | C012843 | Carcinoma, Hepatocellular |
therapeutic
|
16405947
|
|
| D002471 | C012843 | Cell Transformation, Neoplastic |
marker/mechanism
|
8243401
|
|
| D003110 | C012843 | Colonic Neoplasms |
therapeutic
|
16343908
17510524 |
|
| D003371 | C012843 | Cough |
marker/mechanism
|
19845671
22209625 |
|
| D003384 | C012843 | Coxsackievirus Infections |
therapeutic
|
20460981
|
|
| D017449 | C012843 | Dermatitis, Allergic Contact |
marker/mechanism
|
11042091
|
|
| D003921 | C012843 | Diabetes Mellitus, Experimental |
therapeutic
|
20363216
|
|
| D003924 | C012843 | Diabetes Mellitus, Type 2 |
therapeutic
|
19080170
|
|
| D004487 | C012843 | Edema |
marker/mechanism
|
21466812
|
|
| D004890 | C012843 | Erythema |
marker/mechanism
|
15931068
|
|
| D006470 | C012843 | Hemorrhage |
marker/mechanism
|
16626787
|
|
| D006930 | C012843 | Hyperalgesia |
marker/mechanism
|
15931068
17942619 18440147 20219630 |
|
| D006943 | C012843 | Hyperglycemia |
therapeutic
|
20363216
|
|
| D006984 | C012843 | Hypertrophy |
therapeutic
|
20060012
|
|
| D008545 | C012843 | Melanoma |
therapeutic
|
19000754
|
|
| D010146 | C012843 | Pain |
marker/mechanism
|
15931068
17728277 19220220 20042899 21353389 21981454 |
|
| D011655 | C012843 | Pulmonary Embolism |
therapeutic
|
16626787
|
|
| D012478 | C012843 | Salmonella Food Poisoning |
therapeutic
|
22327574
|
|
| D012481 | C012843 | Salmonella Infections, Animal |
therapeutic
|
22327574
|
|
| D012678 | C012843 | Sensation Disorders |
marker/mechanism
|
21550252
|
|
| D013927 | C012843 | Thrombosis |
therapeutic
|
17079160
|
|
| D014581 | C012843 | Urticaria |
marker/mechanism
|
6693599
|
|
| D014735 | C012843 | Vibrio Infections |
therapeutic
|
21249192
|