PCIDB

KNApSAcK Metabolite C00002766

Metabolite

KNApSAcK Entry

id C00002766
Name Phenetyl caffeate
CAS RN 104594-70-9
Standard InChI InChI=1S/C17H16O4/c18-15-8-6-14(12-16(15)19)7-9-17(20)21-11-10-13-4-2-1-3-5-13/h1-9,12,18-19H,10-11H2/b9-7+
Standard InChI (Main Layer) InChI=1S/C17H16O4/c18-15-8-6-14(12-16(15)19)7-9-17(20)21-11-10-13-4-2-1-3-5-13/h1-9,12,18-19H,10-11H2

Cluster

Phytochemical cluster
KCF-S cluster No. 1829

Link

ChEMBL

By standard InChI CHEMBL319244
By standard InChI Main Layer CHEMBL319244 CHEMBL1397711

KEGG

By LinkDB C10484

CTD

By CAS RN C055494

Species

Summary

Plant class

class name count
rosids 1

Family

family name count
Salicaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Populus spp. 3689 Salicaceae rosids Viridiplantae

Human Protein / Gene in interaction

139 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL319244 CHEMBL1397711 CHEMBL1614110 (1) CHEMBL1741321 (1)
CHEMBL1909136 (2)
1 / 0
P42345 Serine/threonine-protein kinase mTOR Enzyme CHEMBL319244 CHEMBL1613805 (1) CHEMBL1614009 (1)
CHEMBL1614293 (1)
0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL1397711 CHEMBL1613992 (1) CHEMBL1613995 (1)
7 / 44
P17516 Aldo-keto reductase family 1 member C4 Enzyme CHEMBL319244 CHEMBL2038587 (1)
1 / 0
Q16637 Survival motor neuron protein Unclassified protein CHEMBL319244 CHEMBL1613842 (3)
4 / 2
Q99700 Ataxin-2 Unclassified protein CHEMBL319244 CHEMBL2114784 (2)
1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL319244 CHEMBL1794499 (1)
2 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme CHEMBL319244 CHEMBL1942328 (1) CHEMBL1942331 (1)
0 / 0
P14618 Pyruvate kinase PKM Enzyme CHEMBL1397711 CHEMBL1614177 (1) CHEMBL1614265 (1)
0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL319244 CHEMBL1737859 (1) CHEMBL1909139 (2)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL319244 CHEMBL1008495 (1) CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL319244 CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL319244 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL319244 CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL319244 CHEMBL1909201 (2)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL319244 CHEMBL1909176 (2)
0 / 0
P29466 Caspase-1 C14 CHEMBL319244 CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL319244 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL319244 CHEMBL1909199 (2)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL319244 CHEMBL1909197 (2)
2 / 2
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL319244 CHEMBL1794585 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL319244 CHEMBL1614310 (1) CHEMBL1614544 (1)
11 / 10
P37840 Alpha-synuclein Unclassified protein CHEMBL319244 CHEMBL2354282 (2)
4 / 2
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL1397711 CHEMBL1614281 (1) CHEMBL1614361 (1)
3 / 2
P00918 Carbonic anhydrase 2 Lyase CHEMBL319244 CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL319244 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL319244 CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL319244 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL319244 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL319244 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL319244 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL319244 CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL319244 CHEMBL1909093 (2)
0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL319244 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL319244 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL319244 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL319244 CHEMBL1397711 CHEMBL1614027 (1) CHEMBL1741325 (1)
CHEMBL1909135 (2)
0 / 1
P54132 Bloom syndrome protein Enzyme CHEMBL319244 CHEMBL1614522 (1) CHEMBL1614067 (1)
1 / 2
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL319244 CHEMBL1909203 (2)
1 / 11
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL319244 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL319244 CHEMBL1008496 (1) CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL319244 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL319244 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL319244 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL319244 CHEMBL1909214 (2)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL319244 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL319244 CHEMBL1909096 (2)
1 / 1
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL319244 CHEMBL1397711 CHEMBL1613800 (2)
0 / 0
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL319244 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL319244 CHEMBL1909166 (2)
1 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL319244 CHEMBL1614458 (2)
0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL319244 CHEMBL1909133 (2)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL1397711 CHEMBL1614456 (1) CHEMBL1613803 (1)
0 / 0
P42330 Aldo-keto reductase family 1 member C3 Enzyme CHEMBL319244 CHEMBL2038586 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL319244 CHEMBL1613941 (1) CHEMBL1738636 (1)
CHEMBL2114843 (1)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL319244 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL319244 CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL319244 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL319244 CHEMBL1909101 (2)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL319244 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL319244 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL319244 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL319244 CHEMBL1909104 (2)
0 / 0
P15121 Aldose reductase Enzyme CHEMBL319244 CHEMBL1942330 (1)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL319244 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL319244 CHEMBL1909100 (2)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL319244 CHEMBL1909167 (2)
1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL319244 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL319244 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL319244 CHEMBL1909110 (2)
1 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL319244 CHEMBL2114788 (1)
0 / 0
P03956 Interstitial collagenase M10A CHEMBL319244 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL319244 CHEMBL1909119 (2)
0 / 0
Q9Y253 DNA polymerase eta Enzyme CHEMBL319244 CHEMBL1794569 (1)
1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL319244 CHEMBL1738610 (1)
0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein CHEMBL319244 CHEMBL1794423 (1) CHEMBL1963893 (5)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL319244 CHEMBL1794467 (2)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL319244 CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL319244 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL319244 CHEMBL1909170 (2)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL319244 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL319244 CHEMBL1909109 (2)
2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL319244 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL319244 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL319244 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL319244 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL319244 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL319244 CHEMBL1909108 (2)
0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme CHEMBL319244 CHEMBL1397711 CHEMBL1614252 (2)
2 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL319244 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL319244 CHEMBL1397711 CHEMBL1613808 (1) CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL319244 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL319244 CHEMBL1397711 CHEMBL1741322 (1) CHEMBL1909132 (2)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL319244 CHEMBL1397711 CHEMBL1613910 (2) CHEMBL1614227 (1)
3 / 3
Q04828 Aldo-keto reductase family 1 member C1 Enzyme CHEMBL319244 CHEMBL2038584 (1)
0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL319244 CHEMBL1614038 (2)
2 / 2
Q01453 Peripheral myelin protein 22 Unclassified protein CHEMBL319244 CHEMBL1614171 (1)
5 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL319244 CHEMBL1738675 (1) CHEMBL1737868 (1)
0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL319244 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL319244 CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL319244 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL319244 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL319244 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL319244 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL319244 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL319244 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL319244 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL319244 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL319244 CHEMBL1909168 (2)
0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL1397711 CHEMBL1614274 (1) CHEMBL1613823 (1)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL319244 CHEMBL1397711 CHEMBL1614240 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL319244 CHEMBL1397711 CHEMBL1613777 (1) CHEMBL1741323 (1)
CHEMBL1909134 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL319244 CHEMBL1397711 CHEMBL1614108 (2) CHEMBL1613886 (2)
CHEMBL1741324 (1) CHEMBL1909138 (2)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL319244 CHEMBL1909137 (2)
0 / 0
P52895 Aldo-keto reductase family 1 member C2 Enzyme CHEMBL319244 CHEMBL2038585 (1)
1 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL319244 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL319244 CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL319244 CHEMBL1614250 (1) CHEMBL1614421 (3)
CHEMBL1614502 (3)
4 / 3
Q99549 M-phase phosphoprotein 8 Unclassified protein CHEMBL319244 CHEMBL1738402 (2)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL319244 CHEMBL2114908 (1)
0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL319244 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL319244 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL319244 CHEMBL1909213 (2)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL319244 CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL319244 CHEMBL1909116 (2)
1 / 1
P06239 Tyrosine-protein kinase Lck Src CHEMBL319244 CHEMBL1909206 (2)
0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL319244 CHEMBL1909128 (2)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL319244 CHEMBL1613914 (2)
0 / 0
P40225 Thrombopoietin Unclassified protein CHEMBL1397711 CHEMBL1614086 (1) CHEMBL1614034 (1)
1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL319244 CHEMBL1738442 (3)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL319244 CHEMBL1614364 (1)
1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL319244 CHEMBL2354311 (1)
1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme CHEMBL319244 CHEMBL1963966 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL319244 CHEMBL1614257 (3)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL319244 CHEMBL1614257 (3)
1 / 3
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL319244 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL319244 CHEMBL1613933 (1)
1 / 6
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL319244 CHEMBL2114738 (1)
0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL319244 CHEMBL2354287 (1)
1 / 1

CTD interaction (68)

compound gene gene name gene description interaction interaction type form reference
pmid
C055494 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 caffeic acid phenethyl ester metabolite results in decreased activity of ABCC1 protein decreases activity
protein 15885658
C055494 196 AHR
bHLHe76
aryl hydrocarbon receptor caffeic acid phenethyl ester promotes the reaction [Nitrogen Mustard Compounds results in decreased expression of AHR protein] decreases expression
/ increases reaction
protein 17204746
C055494 9564 BCAR1
CAS
CAS1
CASS1
CRKAS
P130Cas
breast cancer anti-estrogen resistance 1 caffeic acid phenethyl ester results in decreased phosphorylation of BCAR1 protein decreases phosphorylation
protein 10741720
C055494 329 BIRC2
API1
HIAP2
Hiap-2
MIHB
RNF48
c-IAP1
cIAP1
baculoviral IAP repeat containing 2 caffeic acid phenethyl ester results in decreased expression of BIRC2 protein decreases expression
protein 15291876
C055494 330 BIRC3
AIP1
API2
CIAP2
HAIP1
HIAP1
MALT2
MIHC
RNF49
c-IAP2
baculoviral IAP repeat containing 3 caffeic acid phenethyl ester results in decreased expression of BIRC3 protein decreases expression
protein 15291876
C055494 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 caffeic acid phenethyl ester inhibits the reaction [arsenite results in decreased expression of CCL2 mRNA] decreases expression
/ decreases reaction
mRNA 16085347
C055494 891 CCNB1
CCNB
cyclin B1 caffeic acid phenethyl ester results in decreased expression of CCNB1 protein decreases expression
protein 16085347
C055494 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 caffeic acid phenethyl ester inhibits the reaction [sodium arsenite results in increased expression of CCND1 protein] decreases reaction
/ increases expression
protein 20420878
C055494 898 CCNE1
CCNE
cyclin E1 [Tretinoin co-treated with caffeic acid phenethyl ester] inhibits the reaction [CDK2 protein binds to CCNE1 protein] affects binding
/ affects cotreatment
/ decreases reaction
protein 16766008
C055494 929 CD14
CD14 molecule caffeic acid phenethyl ester promotes the reaction [Tretinoin results in increased expression of CD14 protein] increases expression
/ increases reaction
protein 16766008
C055494 929 CD14
CD14 molecule caffeic acid phenethyl ester results in increased expression of CD14 protein increases expression
protein 16766008
C055494 983 CDK1
CDC2
CDC28A
P34CDC2
cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) caffeic acid phenethyl ester results in decreased expression of CDK1 protein decreases expression
protein 16085347
C055494 1017 CDK2
p33(CDK2)
cyclin-dependent kinase 2 (EC:2.7.11.22) [Tretinoin co-treated with caffeic acid phenethyl ester] inhibits the reaction [CDK2 protein binds to CCNE1 protein] affects binding
/ affects cotreatment
/ decreases reaction
protein 16766008
C055494 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) caffeic acid phenethyl ester results in increased expression of CDKN1A protein increases expression
protein 16766008
C055494 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Tretinoin promotes the reaction [caffeic acid phenethyl ester results in increased expression of CDKN1A protein] increases expression
/ increases reaction
protein 16766008
C055494 1053 CEBPE
C/EBP-epsilon
CRP1
CCAAT/enhancer binding protein (C/EBP), epsilon caffeic acid phenethyl ester results in increased expression of CEBPE protein increases expression
protein 16766008
C055494 1053 CEBPE
C/EBP-epsilon
CRP1
CCAAT/enhancer binding protein (C/EBP), epsilon Tretinoin promotes the reaction [caffeic acid phenethyl ester results in increased expression of CEBPE protein] increases expression
/ increases reaction
protein 16766008
C055494 1906 EDN1
ET1
HDLCQ7
PPET1
endothelin 1 caffeic acid phenethyl ester inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA] decreases reaction
/ increases expression
mRNA 21926265
C055494 1906 EDN1
ET1
HDLCQ7
PPET1
endothelin 1 caffeic acid phenethyl ester inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein] decreases reaction
/ increases expression
protein 21926265
C055494 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) caffeic acid phenethyl ester analog results in increased expression of HMOX1 mRNA increases expression
mRNA 20226179
C055494 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) caffeic acid phenethyl ester analog results in increased expression of HMOX1 protein increases expression
protein 20226179
C055494 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) caffeic acid phenethyl ester results in increased expression of HMOX1 mRNA increases expression
mRNA 20226179
C055494 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) caffeic acid phenethyl ester results in increased expression of HMOX1 protein increases expression
protein 20226179
20950636
C055494 3458 IFNG
IFG
IFI
interferon, gamma caffeic acid phenethyl ester inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]] decreases reaction
/ increases expression
/ increases reaction
protein 18953428
C055494 3606 IL18
IGIF
IL-18
IL-1g
IL1F4
interleukin 18 (interferon-gamma-inducing factor) caffeic acid phenethyl ester inhibits the reaction [arsenite results in decreased expression of IL18 mRNA] decreases expression
/ decreases reaction
mRNA 16085347
C055494 3552 IL1A
IL-1A
IL1
IL1-ALPHA
IL1F1
interleukin 1, alpha caffeic acid phenethyl ester inhibits the reaction [arsenite results in decreased expression of IL1A mRNA] decreases expression
/ decreases reaction
mRNA 16085347
C055494 3558 IL2
IL-2
TCGF
lymphokine
interleukin 2 caffeic acid phenethyl ester inhibits the reaction [arsenite results in decreased expression of IL2 mRNA] decreases expression
/ decreases reaction
mRNA 16085347
C055494 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 caffeic acid phenethyl ester inhibits the reaction [arsenite results in decreased expression of IL8 mRNA] decreases expression
/ decreases reaction
mRNA 16085347
C055494 3684 ITGAM
CD11B
CR3A
MAC-1
MAC1A
MO1A
SLEB6
integrin, alpha M (complement component 3 receptor 3 subunit) caffeic acid phenethyl ester promotes the reaction [Tretinoin results in increased expression of ITGAM protein] increases expression
/ increases reaction
protein 16766008
C055494 3684 ITGAM
CD11B
CR3A
MAC-1
MAC1A
MO1A
SLEB6
integrin, alpha M (complement component 3 receptor 3 subunit) caffeic acid phenethyl ester results in increased expression of ITGAM protein increases expression
protein 16766008
C055494 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene caffeic acid phenethyl ester inhibits the reaction [arsenite results in increased expression of JUN mRNA] decreases reaction
/ increases expression
mRNA 16085347
C055494 4780 NFE2L2
NRF2
nuclear factor, erythroid 2-like 2 caffeic acid phenethyl ester promotes the reaction [Nitrogen Mustard Compounds results in increased expression of NFE2L2 protein] increases expression
/ increases reaction
protein 17204746
C055494 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 caffeic acid phenethyl ester results in decreased activity of [NFKB1 protein binds to RELA protein] affects binding
/ decreases activity
protein 16052512
C055494 4791 NFKB2
H2TF1
LYT-10
LYT10
NF-kB2
p105
p52
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) caffeic acid phenethyl ester inhibits the reaction [sodium arsenite results in increased expression of NFKB2 protein] decreases reaction
/ increases expression
protein 20420878
C055494 5320 PLA2G2A
MOM1
PLA2
PLA2B
PLA2L
PLA2S
PLAS1
sPLA2
phospholipase A2, group IIA (platelets, synovial fluid) (EC:3.1.1.4) caffeic acid phenethyl ester inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]] decreases reaction
/ increases expression
/ increases reaction
protein 18953428
C055494 5747 PTK2
FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
protein tyrosine kinase 2 (EC:2.7.10.2) caffeic acid phenethyl ester results in decreased phosphorylation of PTK2 protein decreases phosphorylation
protein 10741720
C055494 5914 RARA
NR1B1
RAR
retinoic acid receptor, alpha caffeic acid phenethyl ester promotes the reaction [Tretinoin results in increased activity of RARA protein] increases activity
/ increases reaction
protein 16766008
C055494 5914 RARA
NR1B1
RAR
retinoic acid receptor, alpha caffeic acid phenethyl ester results in increased activity of RARA protein increases activity
protein 16766008
C055494 5914 RARA
NR1B1
RAR
retinoic acid receptor, alpha caffeic acid phenethyl ester results in increased expression of RARA mRNA increases expression
mRNA 16766008
C055494 5914 RARA
NR1B1
RAR
retinoic acid receptor, alpha caffeic acid phenethyl ester results in increased expression of RARA protein increases expression
protein 16766008
C055494 5914 RARA
NR1B1
RAR
retinoic acid receptor, alpha [Tretinoin co-treated with caffeic acid phenethyl ester] results in increased expression of RARA mRNA affects cotreatment
/ increases expression
mRNA 16766008
C055494 5914 RARA
NR1B1
RAR
retinoic acid receptor, alpha [Tretinoin co-treated with caffeic acid phenethyl ester] results in increased expression of RARA protein affects cotreatment
/ increases expression
protein 16766008
C055494 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A caffeic acid phenethyl ester inhibits the reaction [Paclitaxel results in increased activity of RELA protein] decreases reaction
/ increases activity
protein 15291876
C055494 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A caffeic acid phenethyl ester inhibits the reaction [TNF protein results in increased activity of RELA protein] decreases reaction
/ increases activity
protein 15291876
C055494 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A caffeic acid phenethyl ester results in decreased activity of [NFKB1 protein binds to RELA protein] affects binding
/ decreases activity
protein 16052512
C055494 6196 RPS6KA2
HU-2
MAPKAPK1C
RSK
RSK3
S6K-alpha
S6K-alpha2
p90-RSK3
pp90RSK3
ribosomal protein S6 kinase, 90kDa, polypeptide 2 (EC:2.7.11.1) caffeic acid phenethyl ester inhibits the reaction [Mustard Compounds results in increased phosphorylation of RPS6KA2 protein] decreases reaction
/ increases phosphorylation
protein 17204746
C055494 6196 RPS6KA2
HU-2
MAPKAPK1C
RSK
RSK3
S6K-alpha
S6K-alpha2
p90-RSK3
pp90RSK3
ribosomal protein S6 kinase, 90kDa, polypeptide 2 (EC:2.7.11.1) caffeic acid phenethyl ester inhibits the reaction [Nitrogen Mustard Compounds results in increased phosphorylation of RPS6KA2 protein] decreases reaction
/ increases phosphorylation
protein 17204746
C055494 7042 TGFB2
LDS4
TGF-beta2
transforming growth factor, beta 2 caffeic acid phenethyl ester inhibits the reaction [arsenite results in decreased expression of TGFB2 mRNA] decreases expression
/ decreases reaction
mRNA 16085347
C055494 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor caffeic acid phenethyl ester inhibits the reaction [arsenite results in decreased expression of TNF mRNA] decreases expression
/ decreases reaction
mRNA 16085347
C055494 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor caffeic acid phenethyl ester inhibits the reaction [TNF protein results in increased activity of RELA protein] decreases reaction
/ increases activity
protein 15291876
C055494 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor caffeic acid phenethyl ester inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 16271621
C055494 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 caffeic acid phenethyl ester inhibits the reaction [Mustard Compounds results in increased phosphorylation of TP53 protein] decreases reaction
/ increases phosphorylation
protein 17204746
C055494 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 caffeic acid phenethyl ester inhibits the reaction [Nitrogen Mustard Compounds results in increased phosphorylation of TP53 protein] decreases reaction
/ increases phosphorylation
protein 17204746
C055494 7299 TYR
ATN
CMM8
OCA1
OCA1A
OCAIA
SHEP3
tyrosinase (EC:1.14.18.1) ethylenediamine inhibits the reaction [TYR protein results in increased oxidation of caffeic acid phenethyl ester] decreases reaction
/ increases oxidation
protein 20685355
C055494 7299 TYR
ATN
CMM8
OCA1
OCA1A
OCAIA
SHEP3
tyrosinase (EC:1.14.18.1) ethylenediamine inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of Ascorbic Acid] decreases reaction
/ increases oxidation
protein 20685355
C055494 7299 TYR
ATN
CMM8
OCA1
OCA1A
OCAIA
SHEP3
tyrosinase (EC:1.14.18.1) ethylenediamine inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of NAD] decreases reaction
/ increases oxidation
protein 20685355
C055494 7299 TYR
ATN
CMM8
OCA1
OCA1A
OCAIA
SHEP3
tyrosinase (EC:1.14.18.1) Glutathione inhibits the reaction [TYR protein results in increased oxidation of caffeic acid phenethyl ester] decreases reaction
/ increases oxidation
protein 20685355
C055494 7299 TYR
ATN
CMM8
OCA1
OCA1A
OCAIA
SHEP3
tyrosinase (EC:1.14.18.1) Glutathione inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of Ascorbic Acid] decreases reaction
/ increases oxidation
protein 20685355
C055494 7299 TYR
ATN
CMM8
OCA1
OCA1A
OCAIA
SHEP3
tyrosinase (EC:1.14.18.1) Glutathione inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of NAD] decreases reaction
/ increases oxidation
protein 20685355
C055494 7299 TYR
ATN
CMM8
OCA1
OCA1A
OCAIA
SHEP3
tyrosinase (EC:1.14.18.1) TYR protein affects the susceptibility to caffeic acid phenethyl ester affects response to substance
protein 20685355
C055494 7299 TYR
ATN
CMM8
OCA1
OCA1A
OCAIA
SHEP3
tyrosinase (EC:1.14.18.1) [TYR protein affects the susceptibility to caffeic acid phenethyl ester] which affects the abundance of Glutathione affects abundance
/ affects response to substance
protein 20685355
C055494 7299 TYR
ATN
CMM8
OCA1
OCA1A
OCAIA
SHEP3
tyrosinase (EC:1.14.18.1) [TYR protein affects the susceptibility to caffeic acid phenethyl ester] which affects the abundance of Reactive Oxygen Species affects abundance
/ affects response to substance
protein 20685355
C055494 7299 TYR
ATN
CMM8
OCA1
OCA1A
OCAIA
SHEP3
tyrosinase (EC:1.14.18.1) TYR protein results in increased metabolism of and results in increased susceptibility to caffeic acid phenethyl ester increases metabolic processing
/ increases response to substance
protein 21458432
C055494 7299 TYR
ATN
CMM8
OCA1
OCA1A
OCAIA
SHEP3
tyrosinase (EC:1.14.18.1) TYR protein results in increased oxidation of caffeic acid phenethyl ester increases oxidation
protein 20685355
C055494 7299 TYR
ATN
CMM8
OCA1
OCA1A
OCAIA
SHEP3
tyrosinase (EC:1.14.18.1) [TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of Ascorbic Acid increases oxidation
protein 20685355
C055494 7299 TYR
ATN
CMM8
OCA1
OCA1A
OCAIA
SHEP3
tyrosinase (EC:1.14.18.1) [TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of NAD increases oxidation
protein 20685355
C055494 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 caffeic acid phenethyl ester inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 16271621
C055494 331 XIAP
API3
BIRC4
IAP-3
ILP1
MIHA
XLP2
hIAP-3
hIAP3
X-linked inhibitor of apoptosis caffeic acid phenethyl ester results in decreased expression of XIAP protein decreases expression
protein 15291876

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (92)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#614279 46,xy sex reversal 8; srxy8 P17516
P52895
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103780 Alcohol dependence P08172
P14416
P31645
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#210900 Bloom syndrome; blm P54132
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P18054
#162800 Cyclic neutropenia P08246
#127750 Dementia, lewy body; dlb P37840
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
P18054
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 O75874
P04626
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260500 Papilloma of choroid plexus; cpp P04637
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (90)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

20 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D002286 C055494 Carcinoma, Ehrlich Tumor therapeutic
20433813
D005910 C055494 Glioma therapeutic
20836997
D006331 C055494 Heart Diseases therapeutic
14745846
D020925 C055494 Hypoxia-Ischemia, Brain therapeutic
15469948
D007414 C055494 Intestinal Neoplasms therapeutic
10783313
D007674 C055494 Kidney Diseases therapeutic
15369732
17448119
D015473 C055494 Leukemia, Promyelocytic, Acute therapeutic
16766008
D008107 C055494 Liver Diseases therapeutic
18397917
D008113 C055494 Liver Neoplasms therapeutic
22291063
D008545 C055494 Melanoma therapeutic
20685355
D028361 C055494 Mitochondrial Diseases therapeutic
14745846
D009203 C055494 Myocardial Infarction therapeutic
20693123
D009336 C055494 Necrosis therapeutic
18397917
D009361 C055494 Neoplasm Invasiveness therapeutic
20836997
D009362 C055494 Neoplasm Metastasis therapeutic
20836997
D009410 C055494 Nerve Degeneration therapeutic
15469948
D011041 C055494 Poisoning marker/mechanism
22155090
D011230 C055494 Precancerous Conditions therapeutic
18397917
D015427 C055494 Reperfusion Injury therapeutic
12910483
D013118 C055494 Spinal Cord Diseases therapeutic
16325979