PCIDB

KNApSAcK Metabolite C00027940

Metabolite

KNApSAcK Entry

id C00027940
Name Arcyriarubin A / bisindolylmaleimide IV
CAS RN 119139-23-0
Standard InChI InChI=1S/C22H29NO4/c1-4-13-14-7-5-6-8-23-16(17-9-11(2)21(24)26-17)10-15(19(14)23)18-12(3)22(25)27-20(13)18/h10-14,17-18,20H,4-9H2,1-3H3/t11-,12-,13+,14+,17-,18-,20+/m0/s1
Standard InChI (Main Layer) InChI=1S/C22H29NO4/c1-4-13-14-7-5-6-8-23-16(17-9-11(2)21(24)26-17)10-15(19(14)23)18-12(3)22(25)27-20(13)18/h10-14,17-18,20H,4-9H2,1-3H3

Cluster

Phytochemical cluster
KCF-S cluster No. 4086

Link

ChEMBL

By standard InChI
By standard InChI Main Layer

KEGG

By LinkDB

CTD

By CAS RN C088060

Human Protein / Gene in interaction

CTD interaction (18)

compound gene gene name gene description interaction interaction type form reference
pmid
C088060 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) bisindolylmaleimide inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C088060 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) bisindolylmaleimide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CDKN1A protein] decreases reaction
/ increases expression
protein 15976015
C088060 1588 CYP19A1
ARO
ARO1
CPV1
CYAR
CYP19
CYPXIX
P-450AROM
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) bisindolylmaleimide results in decreased activity of CYP19A1 protein decreases activity
protein 15955695
C088060 1956 EGFR
ERBB
ERBB1
HER1
PIG61
mENA
epidermal growth factor receptor (EC:2.7.10.1) bisindolylmaleimide inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C088060 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) bisindolylmaleimide inhibits the reaction [Capsaicin results in increased expression of IL6 protein] decreases reaction
/ increases expression
protein 21474332
C088060 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) bisindolylmaleimide inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C088060 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) bisindolylmaleimide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 12761878
C088060 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) bisindolylmaleimide inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C088060 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) bisindolylmaleimide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 12761878
C088060 4922 NTS
NMN-125
NN
NT
NT/N
NTS1
neurotensin bisindolylmaleimide inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C088060 4922 NTS
NMN-125
NN
NT
NT/N
NTS1
neurotensin bisindolylmaleimide inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C088060 4922 NTS
NMN-125
NN
NT
NT/N
NTS1
neurotensin bisindolylmaleimide inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C088060 4922 NTS
NMN-125
NN
NT
NT/N
NTS1
neurotensin bisindolylmaleimide inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 15177934
C088060 5578 PRKCA
AAG6
PKC-alpha
PKCA
PRKACA
protein kinase C, alpha (EC:2.7.11.13) bisindolylmaleimide inhibits the reaction [Capsaicin results in increased expression of PRKCA protein] decreases reaction
/ increases expression
protein 21474332
C088060 10928 RALBP1
RIP1
RLIP1
RLIP76
ralA binding protein 1 bisindolylmaleimide results in decreased phosphorylation of RALBP1 protein decreases phosphorylation
protein 16087181
C088060 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) bisindolylmaleimide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 mRNA] decreases reaction
/ increases expression
mRNA 21705328
C088060 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) bisindolylmaleimide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 protein] decreases reaction
/ increases expression
protein 21705328
C088060 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor bisindolylmaleimide inhibits the reaction [Capsaicin results in increased secretion of TNF protein] decreases reaction
/ increases secretion
protein 21474332