Species

KNApSAcK Entry

Organism name Arcyria denudata
Genus Arcyria
Family Arcyriaceae
Kingdom Amoebozoa

NCBI taxonomy

Entry

Linked NCBI taxonomy name Arcyria denudata
Linked NCBI taxonomy ID 283669
Linked level species

Family

Family in NCBI taxonomy Trichiidae
ID 208472

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Eukaryota
ID 2759

Plant class

Plant class
ID

Metabolite list (13)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00027893 External link 512 Arcyriaflavin A
CHEMBL268368
39 / 19 / 29 No. 1236
C00023963 External link 512 Arcyriaflavin B
No. 1236
C00023964 External link 512 Arcyriaflavin C
CHEMBL95476
2 / 1 / 1 No. 1236
C00024681 External link 512 Arcyriaflavin B
No. 1236
C00027896 External link 512 Arcyroxocin A
No. 2289
C00027897 External link 512 Arcyroxocin B
CHEMBL498290
No. 2289
C00027895 External link 512 Arcyroxepin A
C068343
No. 2289
C00023962 External link 512 Arcyroxepin A
C068343
No. 2289
C00027892 External link 512 Arcyriacyanin A
No. 2289
C00023966 External link 512 Arcyriarubin C
No. 3481
C00023965 External link 512 Arcyriarubin B
CHEMBL495845
No. 3481
C00027940 External link 512 Arcyriarubin A
/ bisindolylmaleimide IV
C088060
12 / 0 No. 4086
C00028190 External link 512 Dihydroarcyriacyanin A
CHEMBL524642
No. 5545

Human Protein / Gene in interactions

41 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P17252 Protein kinase C alpha type Alpha C00027893 0 / 0
Q05655 Protein kinase C delta type Delta C00027893 0 / 0
Q02156 Protein kinase C epsilon type Eta C00027893 0 / 0
P11802 Cyclin-dependent kinase 4 CMGC serine/threonine protein kinase family C00027893 1 / 3
P24385 G1/S-specific cyclin-D1 Other cytosolic protein C00027893 1 / 8
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00027893 1 / 8
P11387 DNA topoisomerase 1 Isomerase C00027893 0 / 0
P31751 RAC-beta serine/threonine-protein kinase Akt C00027893 2 / 2
Q9Y243 RAC-gamma serine/threonine-protein kinase Akt C00027893 1 / 0
P08151 Zinc finger protein GLI1 Unclassified protein C00023964 0 / 0
P10070 Zinc finger protein GLI2 Unclassified protein C00023964 1 / 1
P49841 Glycogen synthase kinase-3 beta Gsk C00027893 0 / 0
P05129 Protein kinase C gamma type Alpha C00027893 1 / 1
Q02880 DNA topoisomerase 2-beta Isomerase C00027893 0 / 0
P31749 RAC-alpha serine/threonine-protein kinase Akt C00027893 4 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00027893 4 / 3
Q9UBT6 DNA polymerase kappa Enzyme C00027893 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00027893 0 / 0
O00255 Menin Unclassified protein C00027893 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00027893 1 / 2
Q05513 Protein kinase C zeta type Iota C00027893 0 / 0
Q04759 Protein kinase C theta type Delta C00027893 0 / 1
O94806 Serine/threonine-protein kinase D3 Pkd C00027893 0 / 0
P05771 Protein kinase C beta type Alpha C00027893 0 / 0
P24723 Protein kinase C eta type Eta C00027893 1 / 0
P41743 Protein kinase C iota type Iota C00027893 0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd C00027893 0 / 0
Q9UQM7 Calcium/calmodulin-dependent protein kinase type II subunit alpha Camk2 C00027893 0 / 0
Q13555 Calcium/calmodulin-dependent protein kinase type II subunit gamma Camk2 C00027893 0 / 0
Q13554 Calcium/calmodulin-dependent protein kinase type II subunit beta Camk2 C00027893 0 / 0
Q13557 Calcium/calmodulin-dependent protein kinase type II subunit delta Camk2 C00027893 0 / 0
P24864 G1/S-specific cyclin-E1 Other cytosolic protein C00027893 0 / 2
P24941 Cyclin-dependent kinase 2 Cdc2 C00027893 0 / 0
O96020 G1/S-specific cyclin-E2 Other cytosolic protein C00027893 0 / 2
O95067 G2/mitotic-specific cyclin-B2 Other cytosolic protein C00027893 0 / 0
P14635 G2/mitotic-specific cyclin-B1 Other cytosolic protein C00027893 0 / 0
P06493 Cyclin-dependent kinase 1 Cdc2 C00027893 0 / 0
Q8WWL7 G2/mitotic-specific cyclin-B3 Other cytosolic protein C00027893 0 / 0
P22694 cAMP-dependent protein kinase catalytic subunit beta Pka C00027893 0 / 0
P17612 cAMP-dependent protein kinase catalytic subunit alpha Pka C00027893 0 / 0
P22612 cAMP-dependent protein kinase catalytic subunit gamma Pka C00027893 0 / 0

12 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00027940
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00027940
1588 CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) C00027940
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00027940
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00027940
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00027940
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00027940
4922 NTS, NMN-125, NN, NT, NT/N, NTS1 neurotensin C00027940
5578 PRKCA, AAG6, PKC-alpha, PKCA, PRKACA protein kinase C, alpha (EC:2.7.11.13) C00027940
10928 RALBP1, RIP1, RLIP1, RLIP76 ralA binding protein 1 C00027940
6648 SOD2, IPOB, MNSOD, MVCD6 superoxide dismutase 2, mitochondrial (EC:1.15.1.1) C00027940
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00027940

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (20)

OMIM preferred title UniProt
#114480 Breast cancer P31749
#114500 Colorectal cancer; crc P31749
#615109 Cowden syndrome 6; cws6 P31749
#125853 Diabetes mellitus, noninsulin-dependent; niddm P31751
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610829 Holoprosencephaly 9; hpe9 P10070
#145000 Hyperparathyroidism 1; hrpt1 O00255
#240900 Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh P31751
#211980 Lung cancer P00533
#603387 Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome; mpph Q9Y243
#609048 Melanoma, cutaneous malignant, susceptibility to, 3; cmm3 P11802
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#254500 Myeloma, multiple P24385
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#176920 Proteus syndrome P31749
#605361 Spinocerebellar ataxia 14; sca14 P05129
#601367 Stroke, ischemic P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (30)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00018 Gastric cancer O96020 (related)
P00533 (related)
P24864 (related)
H00055 Laryngeal cancer O96020 (related)
P00533 (related)
P00533 (marker)
P24385 (related)
P24385 (marker)
P24864 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P24385 (related)
P24385 (marker)
H00017 Esophageal cancer P00533 (related)
P24385 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
H00030 Cervical cancer P00533 (related)
P11802 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P11802 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
H00267 Holoprosencephaly (HPE) P10070 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00038 Malignant melanoma P11802 (related)
H00006 Hairy-cell leukemia P24385 (related)
H00010 Multiple myeloma P24385 (related)
H00031 Breast cancer P24385 (related)
H00559 von Hippel-Lindau syndrome P24385 (related)
H00047 Gallbladder cancer P24385 (marker)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H00027 Ovarian cancer P31751 (related)
H00420 Familial partial lipodystrophy (FPL) P31751 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00408 Type I diabetes mellitus Q04759 (related)