| class name | count |
|---|
| class name | count |
|---|---|
| Trichiidae | 10 |
| Streptomycetaceae | 3 |
| Enteridiidae | 2 |
| Polycitoridae | 2 |
| Reticulariaceae | 2 |
| Dictydiaethaliaceae | 1 |
| br08003 Category | # of metabolite |
|---|
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00017103
|
BE 13793C
|
CHEMBL279481
|
C070538
|
5 / 1 / 8 |
|
|
|
C00017791
|
K 252c
/ SD 1825 / Antibiotic K 252c |
CHEMBL16958
|
54 / 11 / 18 |
|
||
|
C00023963
|
Arcyriaflavin B
|
|
||||
|
C00023964
|
Arcyriaflavin C
|
CHEMBL95476
|
2 / 1 / 1 |
|
||
|
C00024681
|
Arcyriaflavin B
|
|
||||
|
C00027893
|
Arcyriaflavin A
|
CHEMBL268368
|
39 / 19 / 29 |
|
||
|
C00027894
|
Arcyriaflavin D
|
|
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P17252 | Protein kinase C alpha type | Alpha | C00017103 C00017791 C00027893 | 0 / 0 |
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00017103 C00017791 C00027893 | 0 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00017103 C00017791 C00027893 | 0 / 0 |
| P08151 | Zinc finger protein GLI1 | Unclassified protein | C00017791 C00023964 | 0 / 0 |
| P22694 | cAMP-dependent protein kinase catalytic subunit beta | Pka | C00017791 C00027893 | 0 / 0 |
| Q02156 | Protein kinase C epsilon type | Eta | C00017791 C00027893 | 0 / 0 |
| Q8WWL7 | G2/mitotic-specific cyclin-B3 | Other cytosolic protein | C00017791 C00027893 | 0 / 0 |
| P06493 | Cyclin-dependent kinase 1 | Cdc2 | C00017791 C00027893 | 0 / 0 |
| P11802 | Cyclin-dependent kinase 4 | CMGC serine/threonine protein kinase family | C00017791 C00027893 | 1 / 3 |
| P24385 | G1/S-specific cyclin-D1 | Other cytosolic protein | C00017791 C00027893 | 1 / 8 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00017103 C00027893 | 1 / 8 |
| P17612 | cAMP-dependent protein kinase catalytic subunit alpha | Pka | C00017791 C00027893 | 0 / 0 |
| P14635 | G2/mitotic-specific cyclin-B1 | Other cytosolic protein | C00017791 C00027893 | 0 / 0 |
| O95067 | G2/mitotic-specific cyclin-B2 | Other cytosolic protein | C00017791 C00027893 | 0 / 0 |
| O96020 | G1/S-specific cyclin-E2 | Other cytosolic protein | C00017791 C00027893 | 0 / 2 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00017791 C00027893 | 0 / 0 |
| P24864 | G1/S-specific cyclin-E1 | Other cytosolic protein | C00017791 C00027893 | 0 / 2 |
| Q05655 | Protein kinase C delta type | Delta | C00017791 C00027893 | 0 / 0 |
| P10070 | Zinc finger protein GLI2 | Unclassified protein | C00017791 C00023964 | 1 / 1 |
| Q13557 | Calcium/calmodulin-dependent protein kinase type II subunit delta | Camk2 | C00017791 C00027893 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00017791 C00027893 | 0 / 0 |
| Q13554 | Calcium/calmodulin-dependent protein kinase type II subunit beta | Camk2 | C00017791 C00027893 | 0 / 0 |
| Q13555 | Calcium/calmodulin-dependent protein kinase type II subunit gamma | Camk2 | C00017791 C00027893 | 0 / 0 |
| P05129 | Protein kinase C gamma type | Alpha | C00017791 C00027893 | 1 / 1 |
| Q9UQM7 | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Camk2 | C00017791 C00027893 | 0 / 0 |
| Q15139 | Serine/threonine-protein kinase D1 | Pkd | C00017791 C00027893 | 0 / 0 |
| P41743 | Protein kinase C iota type | Iota | C00017791 C00027893 | 0 / 0 |
| P24723 | Protein kinase C eta type | Eta | C00017791 C00027893 | 1 / 0 |
| P22612 | cAMP-dependent protein kinase catalytic subunit gamma | Pka | C00017791 C00027893 | 0 / 0 |
| P31749 | RAC-alpha serine/threonine-protein kinase | Akt | C00017791 C00027893 | 4 / 1 |
| P05771 | Protein kinase C beta type | Alpha | C00017791 C00027893 | 0 / 0 |
| O94806 | Serine/threonine-protein kinase D3 | Pkd | C00017791 C00027893 | 0 / 0 |
| Q04759 | Protein kinase C theta type | Delta | C00017791 C00027893 | 0 / 1 |
| Q05513 | Protein kinase C zeta type | Iota | C00017791 C00027893 | 0 / 0 |
| O00141 | Serine/threonine-protein kinase Sgk1 | AGC serine/threonine protein kinase SGK subfamily | C00017791 | 0 / 0 |
| P52333 | Tyrosine-protein kinase JAK3 | Jakb | C00017791 | 1 / 1 |
| P53778 | Mitogen-activated protein kinase 12 | p38 | C00017791 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00027893 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00027893 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00027893 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00027893 | 1 / 2 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00017791 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00027893 | 4 / 3 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00017791 | 0 / 1 |
| Q15118 | [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial | Pdhk | C00017791 | 0 / 0 |
| Q8IW41 | MAP kinase-activated protein kinase 5 | CAMK serine/threonine protein kinase MAPKAPK | C00017791 | 0 / 0 |
| P45983 | Mitogen-activated protein kinase 8 | Jnk | C00017791 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00017791 | 0 / 0 |
| P49137 | MAP kinase-activated protein kinase 2 | CAMK serine/threonine protein kinase MAPKAPK | C00017791 | 0 / 0 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00017791 | 0 / 0 |
| O15264 | Mitogen-activated protein kinase 13 | p38 | C00017791 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00017791 | 2 / 0 |
| Q16584 | Mitogen-activated protein kinase kinase kinase 11 | TKL dual-specificity kinase MLK | C00017791 | 0 / 0 |
| P17538 | Chymotrypsinogen B | S1A | C00017791 | 0 / 0 |
| O75582 | Ribosomal protein S6 kinase alpha-5 | CAMK serine/threonine protein kinase MSKB subfamily | C00017791 | 0 / 0 |
| Q9Y243 | RAC-gamma serine/threonine-protein kinase | Akt | C00027893 | 1 / 0 |
| P31751 | RAC-beta serine/threonine-protein kinase | Akt | C00027893 | 2 / 2 |
| P23443 | Ribosomal protein S6 kinase beta-1 | p70 | C00017791 | 0 / 0 |
| P80192 | Mitogen-activated protein kinase kinase kinase 9 | TKL dual-specificity kinase MLK | C00017791 | 0 / 0 |
| O14757 | Serine/threonine-protein kinase Chk1 | Chk1 | C00017791 | 0 / 0 |
| Q15759 | Mitogen-activated protein kinase 11 | p38 | C00017791 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00017791 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00017103 | 0 / 0 |
| OMIM | preferred title | UniProt |
|---|---|---|
| #114480 | Breast cancer |
P31749
|
| #114500 | Colorectal cancer; crc |
P31749
P84022 |
| #615109 | Cowden syndrome 6; cws6 |
P31749
|
| #125853 | Diabetes mellitus, noninsulin-dependent; niddm |
P31751
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610829 | Holoprosencephaly 9; hpe9 |
P10070
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #240900 | Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh |
P31751
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P00533
|
| #603387 | Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome; mpph |
Q9Y243
|
| #609048 | Melanoma, cutaneous malignant, susceptibility to, 3; cmm3 |
P11802
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #254500 | Myeloma, multiple |
P24385
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #176920 | Proteus syndrome |
P31749
|
| #600802 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative |
P52333
|
| #605361 | Spinocerebellar ataxia 14; sca14 |
P05129
|
| #601367 | Stroke, ischemic |
P24723
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00018 | Gastric cancer |
O96020
(related)
P00533 (related) P24864 (related) |
| H00055 | Laryngeal cancer |
O96020
(related)
P00533 (related) P00533 (marker) P24385 (related) P24385 (marker) P24864 (related) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P24385 (related) P24385 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P24385 (related) |
| H00022 | Bladder cancer |
P00533
(related)
|
| H00028 | Choriocarcinoma |
P00533
(related)
|
| H00030 | Cervical cancer |
P00533
(related)
P11802 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P11802 (related) |
| H00063 | Spinocerebellar ataxia (SCA) |
P05129
(related)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00267 | Holoprosencephaly (HPE) |
P10070
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00038 | Malignant melanoma |
P11802
(related)
|
| H00006 | Hairy-cell leukemia |
P24385
(related)
|
| H00010 | Multiple myeloma |
P24385
(related)
|
| H00031 | Breast cancer |
P24385
(related)
|
| H00559 | von Hippel-Lindau syndrome |
P24385
(related)
|
| H00047 | Gallbladder cancer |
P24385
(marker)
|
| H00539 | PTEN hamartoma tumor syndrome (PHTS) |
P31749
(related)
|
| H00027 | Ovarian cancer |
P31751
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P31751
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P52333
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00408 | Type I diabetes mellitus |
Q04759
(related)
|