PCIDB

KNApSAcK Metabolite C00017791

Metabolite

KNApSAcK Entry

id C00017791
Name K 252c / SD 1825 / Antibiotic K 252c
CAS RN 85753-43-1
Standard InChI InChI=1S/C20H13N3O/c24-20-17-12(9-21-20)15-10-5-1-3-7-13(10)22-18(15)19-16(17)11-6-2-4-8-14(11)23-19/h1-8,22-23H,9H2,(H,21,24)
Standard InChI (Main Layer) InChI=1S/C20H13N3O/c24-20-17-12(9-21-20)15-10-5-1-3-7-13(10)22-18(15)19-16(17)11-6-2-4-8-14(11)23-19/h1-8,22-23H,9H2,(H,21,24)

Cluster

Phytochemical cluster
KCF-S cluster No. 1236

Link

ChEMBL

By standard InChI CHEMBL16958
By standard InChI Main Layer CHEMBL16958

KEGG

By LinkDB

CTD

By CAS RN

Human Protein / Gene in interaction

54 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q15759 Mitogen-activated protein kinase 11 p38 CHEMBL16958 CHEMBL1247610 (1)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL16958 CHEMBL1247609 (1)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL16958 CHEMBL767226 (1) CHEMBL769346 (1)
CHEMBL767430 (1) CHEMBL767445 (1)
CHEMBL1247618 (1)
0 / 0
O14757 Serine/threonine-protein kinase Chk1 Chk1 CHEMBL16958 CHEMBL1247629 (1)
0 / 0
P80192 Mitogen-activated protein kinase kinase kinase 9 TKL dual-specificity kinase MLK CHEMBL16958 CHEMBL911978 (1)
0 / 0
P23443 Ribosomal protein S6 kinase beta-1 p70 CHEMBL16958 CHEMBL1247622 (1)
0 / 0
P11802 Cyclin-dependent kinase 4 CMGC serine/threonine protein kinase family CHEMBL16958 CHEMBL666088 (1) CHEMBL666089 (1)
1 / 3
P24385 G1/S-specific cyclin-D1 Other cytosolic protein CHEMBL16958 CHEMBL666088 (1) CHEMBL666089 (1)
1 / 10
P11387 DNA topoisomerase 1 Isomerase CHEMBL16958 CHEMBL857616 (1)
0 / 0
O75582 Ribosomal protein S6 kinase alpha-5 CAMK serine/threonine protein kinase MSKB subfamily CHEMBL16958 CHEMBL1247615 (1)
0 / 0
P17538 Chymotrypsinogen B S1A CHEMBL16958 CHEMBL661258 (1)
0 / 0
Q16584 Mitogen-activated protein kinase kinase kinase 11 TKL dual-specificity kinase MLK CHEMBL16958 CHEMBL911979 (1)
0 / 0
P08151 Zinc finger protein GLI1 Unclassified protein CHEMBL16958 CHEMBL972431 (1)
0 / 0
P10070 Zinc finger protein GLI2 Unclassified protein CHEMBL16958 CHEMBL972432 (1)
1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL16958 CHEMBL1794584 (1)
2 / 0
P49841 Glycogen synthase kinase-3 beta Gsk CHEMBL16958 CHEMBL1247623 (1)
0 / 0
O15264 Mitogen-activated protein kinase 13 p38 CHEMBL16958 CHEMBL1247612 (1)
0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein CHEMBL16958 CHEMBL1963893 (1)
0 / 0
P49137 MAP kinase-activated protein kinase 2 CAMK serine/threonine protein kinase MAPKAPK CHEMBL16958 CHEMBL1247614 (1)
0 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL16958 CHEMBL1247607 (1)
0 / 0
P45983 Mitogen-activated protein kinase 8 Jnk CHEMBL16958 CHEMBL1247608 (1)
0 / 0
Q8IW41 MAP kinase-activated protein kinase 5 CAMK serine/threonine protein kinase MAPKAPK CHEMBL16958 CHEMBL1247616 (1)
0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase CHEMBL16958 CHEMBL667221 (1)
0 / 0
P31749 RAC-alpha serine/threonine-protein kinase Akt CHEMBL16958 CHEMBL1247620 (1)
4 / 1
Q15118 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial Pdhk CHEMBL16958 CHEMBL1247619 (1)
0 / 0
O00141 Serine/threonine-protein kinase Sgk1 AGC serine/threonine protein kinase SGK subfamily CHEMBL16958 CHEMBL1247621 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL16958 CHEMBL1738184 (1)
0 / 0
P06239 Tyrosine-protein kinase Lck Src CHEMBL16958 CHEMBL1247628 (1)
0 / 1
P52333 Tyrosine-protein kinase JAK3 Jakb CHEMBL16958 CHEMBL1053840 (1)
1 / 1
P53778 Mitogen-activated protein kinase 12 p38 CHEMBL16958 CHEMBL1247611 (1)
0 / 0
Q05513 Protein kinase C zeta type Iota CHEMBL16958 CHEMBL767226 (1) CHEMBL767430 (1)
CHEMBL767445 (1)
0 / 0
Q04759 Protein kinase C theta type Delta CHEMBL16958 CHEMBL767226 (1) CHEMBL767430 (1)
CHEMBL767445 (1)
0 / 1
Q02156 Protein kinase C epsilon type Eta CHEMBL16958 CHEMBL767226 (1) CHEMBL767430 (1)
CHEMBL767445 (1)
0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd CHEMBL16958 CHEMBL767226 (1) CHEMBL767430 (1)
CHEMBL767445 (1)
0 / 0
Q05655 Protein kinase C delta type Delta CHEMBL16958 CHEMBL767226 (1) CHEMBL767430 (1)
CHEMBL767445 (1)
0 / 0
P05129 Protein kinase C gamma type Alpha CHEMBL16958 CHEMBL767226 (1) CHEMBL767430 (1)
CHEMBL767445 (1)
1 / 1
P05771 Protein kinase C beta type Alpha CHEMBL16958 CHEMBL767226 (1) CHEMBL767430 (1)
CHEMBL767445 (1)
0 / 0
P24723 Protein kinase C eta type Eta CHEMBL16958 CHEMBL767226 (1) CHEMBL767430 (1)
CHEMBL767445 (1)
1 / 0
P41743 Protein kinase C iota type Iota CHEMBL16958 CHEMBL767226 (1) CHEMBL767430 (1)
CHEMBL767445 (1)
0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd CHEMBL16958 CHEMBL767226 (1) CHEMBL767430 (1)
CHEMBL767445 (1)
0 / 0
Q9UQM7 Calcium/calmodulin-dependent protein kinase type II subunit alpha Camk2 CHEMBL16958 CHEMBL657561 (1)
0 / 0
Q13555 Calcium/calmodulin-dependent protein kinase type II subunit gamma Camk2 CHEMBL16958 CHEMBL657561 (1)
0 / 0
Q13554 Calcium/calmodulin-dependent protein kinase type II subunit beta Camk2 CHEMBL16958 CHEMBL657561 (1)
0 / 0
Q13557 Calcium/calmodulin-dependent protein kinase type II subunit delta Camk2 CHEMBL16958 CHEMBL657561 (1)
0 / 0
P24864 G1/S-specific cyclin-E1 Other cytosolic protein CHEMBL16958 CHEMBL665281 (1) CHEMBL665283 (1)
0 / 2
P24941 Cyclin-dependent kinase 2 Cdc2 CHEMBL16958 CHEMBL665281 (1) CHEMBL665283 (1)
0 / 0
O96020 G1/S-specific cyclin-E2 Other cytosolic protein CHEMBL16958 CHEMBL665281 (1) CHEMBL665283 (1)
0 / 2
O95067 G2/mitotic-specific cyclin-B2 Other cytosolic protein CHEMBL16958 CHEMBL666085 (1)
0 / 0
P14635 G2/mitotic-specific cyclin-B1 Other cytosolic protein CHEMBL16958 CHEMBL666085 (1)
0 / 0
P06493 Cyclin-dependent kinase 1 Cdc2 CHEMBL16958 CHEMBL666085 (1)
0 / 0
Q8WWL7 G2/mitotic-specific cyclin-B3 Other cytosolic protein CHEMBL16958 CHEMBL666085 (1)
0 / 0
P22694 cAMP-dependent protein kinase catalytic subunit beta Pka CHEMBL16958 CHEMBL769034 (1) CHEMBL772605 (1)
CHEMBL766683 (1)
0 / 0
P17612 cAMP-dependent protein kinase catalytic subunit alpha Pka CHEMBL16958 CHEMBL769034 (1) CHEMBL772605 (1)
CHEMBL766683 (1)
0 / 0
P22612 cAMP-dependent protein kinase catalytic subunit gamma Pka CHEMBL16958 CHEMBL769034 (1) CHEMBL772605 (1)
CHEMBL766683 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (11)

OMIM preferred title UniProt
#114480 Breast cancer P31749
#114500 Colorectal cancer; crc P31749
P84022
#615109 Cowden syndrome 6; cws6 P31749
#610829 Holoprosencephaly 9; hpe9 P10070
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#609048 Melanoma, cutaneous malignant, susceptibility to, 3; cmm3 P11802
#254500 Myeloma, multiple P24385
#176920 Proteus syndrome P31749
#600802 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative P52333
#605361 Spinocerebellar ataxia 14; sca14 P05129
#601367 Stroke, ischemic P24723

KEGG DISEASE (18)

KEGG disease name UniProt
H00018 Gastric cancer O96020 (related)
P24864 (related)
H00055 Laryngeal cancer O96020 (related)
P24385 (related)
P24385 (marker)
P24864 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00267 Holoprosencephaly (HPE) P10070 (related)
H00030 Cervical cancer P11802 (related)
H00038 Malignant melanoma P11802 (related)
H00042 Glioma P11802 (related)
H00006 Hairy-cell leukemia P24385 (related)
H00010 Multiple myeloma P24385 (related)
H00016 Oral cancer P24385 (related)
P24385 (marker)
H00017 Esophageal cancer P24385 (related)
H00031 Breast cancer P24385 (related)
H00559 von Hippel-Lindau syndrome P24385 (related)
H00047 Gallbladder cancer P24385 (marker)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P52333 (related)
H00408 Type I diabetes mellitus Q04759 (related)