Species

KNApSAcK Entry

Organism name Lycogala epidendrum
Genus Lycogala
Family Reticulariaceae
Kingdom Amoebozoa

NCBI taxonomy

Entry

Linked NCBI taxonomy name Lycogala epidendrum
Linked NCBI taxonomy ID 300236
Linked level species

Family

Family in NCBI taxonomy Enteridiidae
ID 211105

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Eukaryota
ID 2759

Plant class

Plant class
ID

Metabolite list (10)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00022822 External link 512 3,4-Didehydrolycopene
/ 3,4-Didehydro-psi,psi-carotene
No. 97 No. 59
C00028503 External link 512 Lycogarubin C
CHEMBL371472
18 / 3 / 10 No. 1057
C00028501 External link 512 Lycogarubin A
/ Lycogalic acid dimethyl ester C
CHEMBL2040600
No. 1057
C00028502 External link 512 Lycogarubin B
/ Lycogalic acid dimethyl ester B
CHEMBL439675
18 / 3 / 10 No. 1057
C00017791 External link 512 K 252c
/ SD 1825
/ Antibiotic K 252c
CHEMBL16958
54 / 11 / 18 No. 1236
C00027893 External link 512 Arcyriaflavin A
CHEMBL268368
39 / 19 / 29 No. 1236
C00027940 External link 512 Arcyriarubin A
/ bisindolylmaleimide IV
C088060
12 / 0 No. 4086
C00037450 External link 512 Lycogalinoside A
No. 4531
C00037451 External link 512 Lycogalinoside B
No. 4531
C00028500 External link 512 Lycogalic acid A
/ Chromopyrrolic acid
CHEMBL491841
No. 7636

Human Protein / Gene in interactions

65 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P22612 cAMP-dependent protein kinase catalytic subunit gamma Pka C00017791 C00027893 C00028502 C00028503 0 / 0
P17612 cAMP-dependent protein kinase catalytic subunit alpha Pka C00017791 C00027893 C00028502 C00028503 0 / 0
P17252 Protein kinase C alpha type Alpha C00017791 C00027893 C00028502 C00028503 0 / 0
Q05655 Protein kinase C delta type Delta C00017791 C00027893 C00028502 C00028503 0 / 0
P22694 cAMP-dependent protein kinase catalytic subunit beta Pka C00017791 C00027893 C00028502 C00028503 0 / 0
Q02156 Protein kinase C epsilon type Eta C00017791 C00027893 C00028502 C00028503 0 / 0
Q04759 Protein kinase C theta type Delta C00017791 C00027893 C00028502 C00028503 0 / 1
O94806 Serine/threonine-protein kinase D3 Pkd C00017791 C00027893 C00028502 C00028503 0 / 0
P05771 Protein kinase C beta type Alpha C00017791 C00027893 C00028502 C00028503 0 / 0
P24723 Protein kinase C eta type Eta C00017791 C00027893 C00028502 C00028503 1 / 0
P41743 Protein kinase C iota type Iota C00017791 C00027893 C00028502 C00028503 0 / 0
P05129 Protein kinase C gamma type Alpha C00017791 C00027893 C00028502 C00028503 1 / 1
Q15139 Serine/threonine-protein kinase D1 Pkd C00017791 C00027893 C00028502 C00028503 0 / 0
Q05513 Protein kinase C zeta type Iota C00017791 C00027893 C00028502 C00028503 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00027893 C00028502 C00028503 1 / 8
P12931 Proto-oncogene tyrosine-protein kinase Src Src C00028502 C00028503 0 / 0
O00418 Eukaryotic elongation factor 2 kinase Atypical serine/threonine protein kinase alpha subfamily C00028502 C00028503 0 / 0
O95067 G2/mitotic-specific cyclin-B2 Other cytosolic protein C00017791 C00027893 0 / 0
Q13557 Calcium/calmodulin-dependent protein kinase type II subunit delta Camk2 C00017791 C00027893 0 / 0
Q13554 Calcium/calmodulin-dependent protein kinase type II subunit beta Camk2 C00017791 C00027893 0 / 0
Q13555 Calcium/calmodulin-dependent protein kinase type II subunit gamma Camk2 C00017791 C00027893 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00017791 C00027893 0 / 0
Q9UQM7 Calcium/calmodulin-dependent protein kinase type II subunit alpha Camk2 C00017791 C00027893 0 / 0
P14635 G2/mitotic-specific cyclin-B1 Other cytosolic protein C00017791 C00027893 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00017791 C00027893 0 / 0
P11387 DNA topoisomerase 1 Isomerase C00017791 C00027893 0 / 0
O96020 G1/S-specific cyclin-E2 Other cytosolic protein C00017791 C00027893 0 / 2
P24385 G1/S-specific cyclin-D1 Other cytosolic protein C00017791 C00027893 1 / 8
P11802 Cyclin-dependent kinase 4 CMGC serine/threonine protein kinase family C00017791 C00027893 1 / 3
P06493 Cyclin-dependent kinase 1 Cdc2 C00017791 C00027893 0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase C00017791 C00027893 0 / 0
P31749 RAC-alpha serine/threonine-protein kinase Akt C00017791 C00027893 4 / 1
Q8WWL7 G2/mitotic-specific cyclin-B3 Other cytosolic protein C00017791 C00027893 0 / 0
P24864 G1/S-specific cyclin-E1 Other cytosolic protein C00017791 C00027893 0 / 2
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00028502 C00028503 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00017791 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00017791 0 / 1
P52333 Tyrosine-protein kinase JAK3 Jakb C00017791 1 / 1
P53778 Mitogen-activated protein kinase 12 p38 C00017791 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00027893 4 / 3
Q9UBT6 DNA polymerase kappa Enzyme C00027893 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00027893 0 / 0
O00255 Menin Unclassified protein C00027893 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00027893 1 / 2
O00141 Serine/threonine-protein kinase Sgk1 AGC serine/threonine protein kinase SGK subfamily C00017791 0 / 0
Q15118 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial Pdhk C00017791 0 / 0
Q8IW41 MAP kinase-activated protein kinase 5 CAMK serine/threonine protein kinase MAPKAPK C00017791 0 / 0
P45983 Mitogen-activated protein kinase 8 Jnk C00017791 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00017791 0 / 0
P49137 MAP kinase-activated protein kinase 2 CAMK serine/threonine protein kinase MAPKAPK C00017791 0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00017791 0 / 0
O15264 Mitogen-activated protein kinase 13 p38 C00017791 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00017791 2 / 0
P10070 Zinc finger protein GLI2 Unclassified protein C00017791 1 / 1
P08151 Zinc finger protein GLI1 Unclassified protein C00017791 0 / 0
Q16584 Mitogen-activated protein kinase kinase kinase 11 TKL dual-specificity kinase MLK C00017791 0 / 0
P17538 Chymotrypsinogen B S1A C00017791 0 / 0
O75582 Ribosomal protein S6 kinase alpha-5 CAMK serine/threonine protein kinase MSKB subfamily C00017791 0 / 0
Q9Y243 RAC-gamma serine/threonine-protein kinase Akt C00027893 1 / 0
P31751 RAC-beta serine/threonine-protein kinase Akt C00027893 2 / 2
P23443 Ribosomal protein S6 kinase beta-1 p70 C00017791 0 / 0
P80192 Mitogen-activated protein kinase kinase kinase 9 TKL dual-specificity kinase MLK C00017791 0 / 0
O14757 Serine/threonine-protein kinase Chk1 Chk1 C00017791 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00017791 0 / 0
Q15759 Mitogen-activated protein kinase 11 p38 C00017791 0 / 0

12 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00027940
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00027940
1588 CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) C00027940
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00027940
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00027940
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00027940
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00027940
4922 NTS, NMN-125, NN, NT, NT/N, NTS1 neurotensin C00027940
5578 PRKCA, AAG6, PKC-alpha, PKCA, PRKACA protein kinase C, alpha (EC:2.7.11.13) C00027940
10928 RALBP1, RIP1, RLIP1, RLIP76 ralA binding protein 1 C00027940
6648 SOD2, IPOB, MNSOD, MVCD6 superoxide dismutase 2, mitochondrial (EC:1.15.1.1) C00027940
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00027940

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (22)

OMIM preferred title UniProt
#114480 Breast cancer P31749
#114500 Colorectal cancer; crc P31749
P84022
#615109 Cowden syndrome 6; cws6 P31749
#125853 Diabetes mellitus, noninsulin-dependent; niddm P31751
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610829 Holoprosencephaly 9; hpe9 P10070
#145000 Hyperparathyroidism 1; hrpt1 O00255
#240900 Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh P31751
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P00533
#603387 Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome; mpph Q9Y243
#609048 Melanoma, cutaneous malignant, susceptibility to, 3; cmm3 P11802
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#254500 Myeloma, multiple P24385
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#176920 Proteus syndrome P31749
#600802 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative P52333
#605361 Spinocerebellar ataxia 14; sca14 P05129
#601367 Stroke, ischemic P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (32)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00018 Gastric cancer O96020 (related)
P00533 (related)
P24864 (related)
H00055 Laryngeal cancer O96020 (related)
P00533 (related)
P00533 (marker)
P24385 (related)
P24385 (marker)
P24864 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P24385 (related)
P24385 (marker)
H00017 Esophageal cancer P00533 (related)
P24385 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
H00030 Cervical cancer P00533 (related)
P11802 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P11802 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00267 Holoprosencephaly (HPE) P10070 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00038 Malignant melanoma P11802 (related)
H00006 Hairy-cell leukemia P24385 (related)
H00010 Multiple myeloma P24385 (related)
H00031 Breast cancer P24385 (related)
H00559 von Hippel-Lindau syndrome P24385 (related)
H00047 Gallbladder cancer P24385 (marker)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H00027 Ovarian cancer P31751 (related)
H00420 Familial partial lipodystrophy (FPL) P31751 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P52333 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00408 Type I diabetes mellitus Q04759 (related)