| Organism name | Lycogala epidendrum | 
|---|---|
| Genus | Lycogala | 
| Family | Reticulariaceae | 
| Kingdom | Amoebozoa | 
| Linked NCBI taxonomy name | Lycogala epidendrum | 
|---|---|
| Linked NCBI taxonomy ID | 300236 | 
| Linked level | species | 
| Family in NCBI taxonomy | Enteridiidae | 
|---|---|
| ID | 211105 | 
| Kingdom (Superkingdom) in NCBI taxonomy | Eukaryota | 
|---|---|
| ID | 2759 | 
| Plant class | |
|---|---|
| ID | 
| KNApSAcK ID | name | ChEMBL link | CTD link | # of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE | # of genes in CTD interaction / related diseases | KCF-S cluster | phytochemical cluster | figure | 
|---|---|---|---|---|---|---|---|---|
| C00022822   | 3,4-Didehydrolycopene / 3,4-Didehydro-psi,psi-carotene | No. 97 | No. 59 |   | ||||
| C00028503   | Lycogarubin C | CHEMBL371472 | 18 / 3 / 10 | No. 1057 |   | |||
| C00028501   | Lycogarubin A / Lycogalic acid dimethyl ester C | CHEMBL2040600 | No. 1057 |   | ||||
| C00028502   | Lycogarubin B / Lycogalic acid dimethyl ester B | CHEMBL439675 | 18 / 3 / 10 | No. 1057 |   | |||
| C00017791   | K 252c / SD 1825 / Antibiotic K 252c | CHEMBL16958 | 54 / 11 / 18 | No. 1236 |   | |||
| C00027893   | Arcyriaflavin A | CHEMBL268368 | 39 / 19 / 29 | No. 1236 |   | |||
| C00027940   | Arcyriarubin A / bisindolylmaleimide IV | C088060 | 12 / 0 | No. 4086 |   | |||
| C00037450   | Lycogalinoside A | No. 4531 |   | |||||
| C00037451   | Lycogalinoside B | No. 4531 |   | |||||
| C00028500   | Lycogalic acid A / Chromopyrrolic acid | CHEMBL491841 | No. 7636 |   | 
| accession | description | class description | KNApSAcK metabolite in interactions | # of diseases (OMIM / KEGG) | 
|---|---|---|---|---|
| P22612 | cAMP-dependent protein kinase catalytic subunit gamma | Pka | C00017791 C00027893 C00028502 C00028503 | 0 / 0 | 
| P17612 | cAMP-dependent protein kinase catalytic subunit alpha | Pka | C00017791 C00027893 C00028502 C00028503 | 0 / 0 | 
| P17252 | Protein kinase C alpha type | Alpha | C00017791 C00027893 C00028502 C00028503 | 0 / 0 | 
| Q05655 | Protein kinase C delta type | Delta | C00017791 C00027893 C00028502 C00028503 | 0 / 0 | 
| P22694 | cAMP-dependent protein kinase catalytic subunit beta | Pka | C00017791 C00027893 C00028502 C00028503 | 0 / 0 | 
| Q02156 | Protein kinase C epsilon type | Eta | C00017791 C00027893 C00028502 C00028503 | 0 / 0 | 
| Q04759 | Protein kinase C theta type | Delta | C00017791 C00027893 C00028502 C00028503 | 0 / 1 | 
| O94806 | Serine/threonine-protein kinase D3 | Pkd | C00017791 C00027893 C00028502 C00028503 | 0 / 0 | 
| P05771 | Protein kinase C beta type | Alpha | C00017791 C00027893 C00028502 C00028503 | 0 / 0 | 
| P24723 | Protein kinase C eta type | Eta | C00017791 C00027893 C00028502 C00028503 | 1 / 0 | 
| P41743 | Protein kinase C iota type | Iota | C00017791 C00027893 C00028502 C00028503 | 0 / 0 | 
| P05129 | Protein kinase C gamma type | Alpha | C00017791 C00027893 C00028502 C00028503 | 1 / 1 | 
| Q15139 | Serine/threonine-protein kinase D1 | Pkd | C00017791 C00027893 C00028502 C00028503 | 0 / 0 | 
| Q05513 | Protein kinase C zeta type | Iota | C00017791 C00027893 C00028502 C00028503 | 0 / 0 | 
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00027893 C00028502 C00028503 | 1 / 8 | 
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00028502 C00028503 | 0 / 0 | 
| O00418 | Eukaryotic elongation factor 2 kinase | Atypical serine/threonine protein kinase alpha subfamily | C00028502 C00028503 | 0 / 0 | 
| O95067 | G2/mitotic-specific cyclin-B2 | Other cytosolic protein | C00017791 C00027893 | 0 / 0 | 
| Q13557 | Calcium/calmodulin-dependent protein kinase type II subunit delta | Camk2 | C00017791 C00027893 | 0 / 0 | 
| Q13554 | Calcium/calmodulin-dependent protein kinase type II subunit beta | Camk2 | C00017791 C00027893 | 0 / 0 | 
| Q13555 | Calcium/calmodulin-dependent protein kinase type II subunit gamma | Camk2 | C00017791 C00027893 | 0 / 0 | 
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00017791 C00027893 | 0 / 0 | 
| Q9UQM7 | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Camk2 | C00017791 C00027893 | 0 / 0 | 
| P14635 | G2/mitotic-specific cyclin-B1 | Other cytosolic protein | C00017791 C00027893 | 0 / 0 | 
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00017791 C00027893 | 0 / 0 | 
| P11387 | DNA topoisomerase 1 | Isomerase | C00017791 C00027893 | 0 / 0 | 
| O96020 | G1/S-specific cyclin-E2 | Other cytosolic protein | C00017791 C00027893 | 0 / 2 | 
| P24385 | G1/S-specific cyclin-D1 | Other cytosolic protein | C00017791 C00027893 | 1 / 8 | 
| P11802 | Cyclin-dependent kinase 4 | CMGC serine/threonine protein kinase family | C00017791 C00027893 | 1 / 3 | 
| P06493 | Cyclin-dependent kinase 1 | Cdc2 | C00017791 C00027893 | 0 / 0 | 
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00017791 C00027893 | 0 / 0 | 
| P31749 | RAC-alpha serine/threonine-protein kinase | Akt | C00017791 C00027893 | 4 / 1 | 
| Q8WWL7 | G2/mitotic-specific cyclin-B3 | Other cytosolic protein | C00017791 C00027893 | 0 / 0 | 
| P24864 | G1/S-specific cyclin-E1 | Other cytosolic protein | C00017791 C00027893 | 0 / 2 | 
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00028502 C00028503 | 0 / 0 | 
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00017791 | 0 / 0 | 
| P06239 | Tyrosine-protein kinase Lck | Src | C00017791 | 0 / 1 | 
| P52333 | Tyrosine-protein kinase JAK3 | Jakb | C00017791 | 1 / 1 | 
| P53778 | Mitogen-activated protein kinase 12 | p38 | C00017791 | 0 / 0 | 
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00027893 | 4 / 3 | 
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00027893 | 0 / 0 | 
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00027893 | 0 / 0 | 
| O00255 | Menin | Unclassified protein | C00027893 | 2 / 5 | 
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00027893 | 1 / 2 | 
| O00141 | Serine/threonine-protein kinase Sgk1 | AGC serine/threonine protein kinase SGK subfamily | C00017791 | 0 / 0 | 
| Q15118 | [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial | Pdhk | C00017791 | 0 / 0 | 
| Q8IW41 | MAP kinase-activated protein kinase 5 | CAMK serine/threonine protein kinase MAPKAPK | C00017791 | 0 / 0 | 
| P45983 | Mitogen-activated protein kinase 8 | Jnk | C00017791 | 0 / 0 | 
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00017791 | 0 / 0 | 
| P49137 | MAP kinase-activated protein kinase 2 | CAMK serine/threonine protein kinase MAPKAPK | C00017791 | 0 / 0 | 
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00017791 | 0 / 0 | 
| O15264 | Mitogen-activated protein kinase 13 | p38 | C00017791 | 0 / 0 | 
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00017791 | 2 / 0 | 
| P10070 | Zinc finger protein GLI2 | Unclassified protein | C00017791 | 1 / 1 | 
| P08151 | Zinc finger protein GLI1 | Unclassified protein | C00017791 | 0 / 0 | 
| Q16584 | Mitogen-activated protein kinase kinase kinase 11 | TKL dual-specificity kinase MLK | C00017791 | 0 / 0 | 
| P17538 | Chymotrypsinogen B | S1A | C00017791 | 0 / 0 | 
| O75582 | Ribosomal protein S6 kinase alpha-5 | CAMK serine/threonine protein kinase MSKB subfamily | C00017791 | 0 / 0 | 
| Q9Y243 | RAC-gamma serine/threonine-protein kinase | Akt | C00027893 | 1 / 0 | 
| P31751 | RAC-beta serine/threonine-protein kinase | Akt | C00027893 | 2 / 2 | 
| P23443 | Ribosomal protein S6 kinase beta-1 | p70 | C00017791 | 0 / 0 | 
| P80192 | Mitogen-activated protein kinase kinase kinase 9 | TKL dual-specificity kinase MLK | C00017791 | 0 / 0 | 
| O14757 | Serine/threonine-protein kinase Chk1 | Chk1 | C00017791 | 0 / 0 | 
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00017791 | 0 / 0 | 
| Q15759 | Mitogen-activated protein kinase 11 | p38 | C00017791 | 0 / 0 | 
| gene | gene name | gene description | KNApSAcK metabolite in interactions | 
|---|---|---|---|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | C00027940 | 
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | C00027940 | 
| 1588 | CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM | cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) | C00027940 | 
| 1956 | EGFR, ERBB, ERBB1, HER1, PIG61, mENA | epidermal growth factor receptor (EC:2.7.10.1) | C00027940 | 
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) | C00027940 | 
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) | C00027940 | 
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) | C00027940 | 
| 4922 | NTS, NMN-125, NN, NT, NT/N, NTS1 | neurotensin | C00027940 | 
| 5578 | PRKCA, AAG6, PKC-alpha, PKCA, PRKACA | protein kinase C, alpha (EC:2.7.11.13) | C00027940 | 
| 10928 | RALBP1, RIP1, RLIP1, RLIP76 | ralA binding protein 1 | C00027940 | 
| 6648 | SOD2, IPOB, MNSOD, MVCD6 | superoxide dismutase 2, mitochondrial (EC:1.15.1.1) | C00027940 | 
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor | C00027940 | 
| OMIM | preferred title | UniProt | 
|---|---|---|
| #114480 | Breast cancer | P31749 | 
| #114500 | Colorectal cancer; crc | P31749 P84022 | 
| #615109 | Cowden syndrome 6; cws6 | P31749 | 
| #125853 | Diabetes mellitus, noninsulin-dependent; niddm | P31751 | 
| #600274 | Frontotemporal dementia; ftd | P10636 | 
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay | Q03164 | 
| #610829 | Holoprosencephaly 9; hpe9 | P10070 | 
| #145000 | Hyperparathyroidism 1; hrpt1 | O00255 | 
| #240900 | Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh | P31751 | 
| #613795 | Loeys-dietz syndrome, type 3; lds3 | P84022 | 
| #211980 | Lung cancer | P00533 | 
| #603387 | Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome; mpph | Q9Y243 | 
| #609048 | Melanoma, cutaneous malignant, susceptibility to, 3; cmm3 | P11802 | 
| #131100 | Multiple endocrine neoplasia, type i; men1 | O00255 | 
| #254500 | Myeloma, multiple | P24385 | 
| #260540 | Parkinson-dementia syndrome | P10636 | 
| #172700 | Pick disease of brain | P10636 | 
| #176920 | Proteus syndrome | P31749 | 
| #600802 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative | P52333 | 
| #605361 | Spinocerebellar ataxia 14; sca14 | P05129 | 
| #601367 | Stroke, ischemic | P24723 | 
| #601104 | Supranuclear palsy, progressive, 1; psnp1 | P10636 | 
| KEGG | name | UniProt | 
|---|---|---|
| H00033 | Adrenal carcinoma | O00255
                            (related) | 
| H00034 | Carcinoid | O00255
                            (related) | 
| H00045 | Malignant islet cell carcinoma | O00255
                            (related) | 
| H00246 | Primary hyperparathyroidism | O00255
                            (related) | 
| H01102 | Pituitary adenomas | O00255
                            (related) | 
| H00018 | Gastric cancer | O96020
                            (related) P00533 (related) P24864 (related) | 
| H00055 | Laryngeal cancer | O96020
                            (related) P00533 (related) P00533 (marker) P24385 (related) P24385 (marker) P24864 (related) | 
| H00016 | Oral cancer | P00533
                            (related) P00533 (marker) P24385 (related) P24385 (marker) | 
| H00017 | Esophageal cancer | P00533
                            (related) P24385 (related) | 
| H00022 | Bladder cancer | P00533
                            (related) | 
| H00028 | Choriocarcinoma | P00533
                            (related) | 
| H00030 | Cervical cancer | P00533
                            (related) P11802 (related) | 
| H00042 | Glioma | P00533
                            (related) P00533 (marker) P11802 (related) | 
| H00063 | Spinocerebellar ataxia (SCA) | P05129
                            (related) | 
| H00093 | Combined immunodeficiencies (CIDs) | P06239
                            (related) | 
| H00267 | Holoprosencephaly (HPE) | P10070
                            (related) | 
| H00058 | Amyotrophic lateral sclerosis (ALS) | P10636
                            (related) | 
| H00077 | Progressive supranuclear palsy (PSP) | P10636
                            (related) | 
| H00078 | Frontotemporal lobar degeneration (FTLD) | P10636
                            (related) | 
| H00038 | Malignant melanoma | P11802
                            (related) | 
| H00006 | Hairy-cell leukemia | P24385
                            (related) | 
| H00010 | Multiple myeloma | P24385
                            (related) | 
| H00031 | Breast cancer | P24385
                            (related) | 
| H00559 | von Hippel-Lindau syndrome | P24385
                            (related) | 
| H00047 | Gallbladder cancer | P24385
                            (marker) | 
| H00539 | PTEN hamartoma tumor syndrome (PHTS) | P31749
                            (related) | 
| H00027 | Ovarian cancer | P31751
                            (related) | 
| H00420 | Familial partial lipodystrophy (FPL) | P31751
                            (related) | 
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) | P52333
                            (related) | 
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) | Q03164
                            (related) Q03164 (marker) | 
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) | Q03164
                            (related) | 
| H00408 | Type I diabetes mellitus | Q04759
                            (related) |