KNApSAcK Metabolite C00027893
Metabolite
KNApSAcK Entry
| id | C00027893 |
|---|---|
| Name | Arcyriaflavin A |
| CAS RN | 118458-54-1 |
| Standard InChI | InChI=1S/C20H11N3O2/c24-19-15-13-9-5-1-3-7-11(9)21-17(13)18-14(16(15)20(25)23-19)10-6-2-4-8-12(10)22-18/h1-8,21-22H,(H,23,24,25) |
| Standard InChI (Main Layer) | InChI=1S/C20H11N3O2/c24-19-15-13-9-5-1-3-7-11(9)21-17(13)18-14(16(15)20(25)23-19)10-6-2-4-8-12(10)22-18/h1-8,21-22H,(H,23,24,25) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 1236 |
Link
ChEMBL
| By standard InChI | CHEMBL268368 |
|---|---|
| By standard InChI Main Layer | CHEMBL268368 |
KEGG
| By LinkDB |
|---|
CTD
| By CAS RN |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Trichiidae | 2 |
| Enteridiidae | 1 |
List (3)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Arcyria denudata | 283669 | Trichiidae | Eukaryota | |
| Arcyria nutans | 137620 | Trichiidae | Eukaryota | |
| Lycogala epidendrum | 300236 | Enteridiidae | Eukaryota |
Human Protein / Gene in interaction
39 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P17252 | Protein kinase C alpha type | Alpha | CHEMBL268368 |
CHEMBL760356
(1)
CHEMBL767225
(1)
CHEMBL769346 (1) CHEMBL766548 (1) CHEMBL767445 (1) CHEMBL768338 (1) |
0 / 0 |
| Q05655 | Protein kinase C delta type | Delta | CHEMBL268368 |
CHEMBL760356
(1)
CHEMBL767225
(1)
CHEMBL766548 (1) CHEMBL767445 (1) CHEMBL768338 (1) CHEMBL2091239 (1) |
0 / 0 |
| Q02156 | Protein kinase C epsilon type | Eta | CHEMBL268368 |
CHEMBL760356
(1)
CHEMBL767225
(1)
CHEMBL766548 (1) CHEMBL767445 (1) CHEMBL768338 (1) CHEMBL2091240 (1) |
0 / 0 |
| P11802 | Cyclin-dependent kinase 4 | CMGC serine/threonine protein kinase family | CHEMBL268368 |
CHEMBL666305
(1)
CHEMBL666088
(1)
CHEMBL666089 (1) CHEMBL665277 (1) CHEMBL665279 (1) |
1 / 3 |
| P24385 | G1/S-specific cyclin-D1 | Other cytosolic protein | CHEMBL268368 |
CHEMBL666305
(1)
CHEMBL666088
(1)
CHEMBL666089 (1) CHEMBL665277 (1) CHEMBL665279 (1) |
1 / 10 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | CHEMBL268368 |
CHEMBL679549
(1)
|
1 / 11 |
| P11387 | DNA topoisomerase 1 | Isomerase | CHEMBL268368 |
CHEMBL857616
(1)
|
0 / 0 |
| P31751 | RAC-beta serine/threonine-protein kinase | Akt | CHEMBL268368 |
CHEMBL2091232
(1)
|
2 / 2 |
| Q9Y243 | RAC-gamma serine/threonine-protein kinase | Akt | CHEMBL268368 |
CHEMBL2091233
(1)
|
1 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | CHEMBL268368 |
CHEMBL685262
(1)
|
0 / 0 |
| P05129 | Protein kinase C gamma type | Alpha | CHEMBL268368 |
CHEMBL760356
(1)
CHEMBL767225
(1)
CHEMBL766548 (1) CHEMBL767445 (1) CHEMBL768338 (1) CHEMBL2091241 (1) |
1 / 1 |
| Q02880 | DNA topoisomerase 2-beta | Isomerase | CHEMBL268368 |
CHEMBL667221
(1)
|
0 / 0 |
| P31749 | RAC-alpha serine/threonine-protein kinase | Akt | CHEMBL268368 |
CHEMBL2091231
(1)
|
4 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | CHEMBL268368 |
CHEMBL1614421
(1)
CHEMBL1614502
(1)
|
4 / 3 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | CHEMBL268368 |
CHEMBL1794536
(1)
|
0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL268368 |
CHEMBL1738442
(1)
|
0 / 0 |
| O00255 | Menin | Unclassified protein | CHEMBL268368 |
CHEMBL1614257
(1)
CHEMBL1614531
(1)
|
2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | CHEMBL268368 |
CHEMBL1614257
(1)
CHEMBL1614531
(1)
|
1 / 3 |
| Q05513 | Protein kinase C zeta type | Iota | CHEMBL268368 |
CHEMBL760356
(1)
CHEMBL767225
(1)
CHEMBL766548 (1) CHEMBL767445 (1) CHEMBL768338 (1) |
0 / 0 |
| Q04759 | Protein kinase C theta type | Delta | CHEMBL268368 |
CHEMBL760356
(1)
CHEMBL767225
(1)
CHEMBL766548 (1) CHEMBL767445 (1) CHEMBL768338 (1) |
0 / 1 |
| O94806 | Serine/threonine-protein kinase D3 | Pkd | CHEMBL268368 |
CHEMBL760356
(1)
CHEMBL767225
(1)
CHEMBL766548 (1) CHEMBL767445 (1) CHEMBL768338 (1) |
0 / 0 |
| P05771 | Protein kinase C beta type | Alpha | CHEMBL268368 |
CHEMBL760356
(1)
CHEMBL767225
(1)
CHEMBL766548 (1) CHEMBL767445 (1) CHEMBL768338 (1) |
0 / 0 |
| P24723 | Protein kinase C eta type | Eta | CHEMBL268368 |
CHEMBL760356
(1)
CHEMBL767225
(1)
CHEMBL766548 (1) CHEMBL767445 (1) CHEMBL768338 (1) |
1 / 0 |
| P41743 | Protein kinase C iota type | Iota | CHEMBL268368 |
CHEMBL760356
(1)
CHEMBL767225
(1)
CHEMBL766548 (1) CHEMBL767445 (1) CHEMBL768338 (1) |
0 / 0 |
| Q15139 | Serine/threonine-protein kinase D1 | Pkd | CHEMBL268368 |
CHEMBL760356
(1)
CHEMBL767225
(1)
CHEMBL766548 (1) CHEMBL767445 (1) CHEMBL768338 (1) |
0 / 0 |
| Q9UQM7 | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Camk2 | CHEMBL268368 |
CHEMBL657561
(1)
CHEMBL653816
(1)
|
0 / 0 |
| Q13555 | Calcium/calmodulin-dependent protein kinase type II subunit gamma | Camk2 | CHEMBL268368 |
CHEMBL657561
(1)
CHEMBL653816
(1)
|
0 / 0 |
| Q13554 | Calcium/calmodulin-dependent protein kinase type II subunit beta | Camk2 | CHEMBL268368 |
CHEMBL657561
(1)
CHEMBL653816
(1)
|
0 / 0 |
| Q13557 | Calcium/calmodulin-dependent protein kinase type II subunit delta | Camk2 | CHEMBL268368 |
CHEMBL657561
(1)
CHEMBL653816
(1)
|
0 / 0 |
| P24864 | G1/S-specific cyclin-E1 | Other cytosolic protein | CHEMBL268368 |
CHEMBL663524
(1)
CHEMBL665281
(1)
CHEMBL665283 (1) CHEMBL664631 (1) |
0 / 2 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | CHEMBL268368 |
CHEMBL663524
(1)
CHEMBL665281
(1)
CHEMBL665283 (1) CHEMBL664631 (1) |
0 / 0 |
| O96020 | G1/S-specific cyclin-E2 | Other cytosolic protein | CHEMBL268368 |
CHEMBL663524
(1)
CHEMBL665281
(1)
CHEMBL665283 (1) CHEMBL664631 (1) |
0 / 2 |
| O95067 | G2/mitotic-specific cyclin-B2 | Other cytosolic protein | CHEMBL268368 |
CHEMBL658192
(1)
CHEMBL666084
(1)
|
0 / 0 |
| P14635 | G2/mitotic-specific cyclin-B1 | Other cytosolic protein | CHEMBL268368 |
CHEMBL658192
(1)
CHEMBL666084
(1)
|
0 / 0 |
| P06493 | Cyclin-dependent kinase 1 | Cdc2 | CHEMBL268368 |
CHEMBL658192
(1)
CHEMBL666084
(1)
|
0 / 0 |
| Q8WWL7 | G2/mitotic-specific cyclin-B3 | Other cytosolic protein | CHEMBL268368 |
CHEMBL658192
(1)
CHEMBL666084
(1)
|
0 / 0 |
| P22694 | cAMP-dependent protein kinase catalytic subunit beta | Pka | CHEMBL268368 |
CHEMBL769034
(1)
CHEMBL769037
(1)
CHEMBL771966 (1) CHEMBL772605 (1) CHEMBL767988 (1) |
0 / 0 |
| P17612 | cAMP-dependent protein kinase catalytic subunit alpha | Pka | CHEMBL268368 |
CHEMBL769034
(1)
CHEMBL769037
(1)
CHEMBL771966 (1) CHEMBL772605 (1) CHEMBL767988 (1) |
0 / 0 |
| P22612 | cAMP-dependent protein kinase catalytic subunit gamma | Pka | CHEMBL268368 |
CHEMBL769034
(1)
CHEMBL769037
(1)
CHEMBL771966 (1) CHEMBL772605 (1) CHEMBL767988 (1) |
0 / 0 |
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (19)
| OMIM | preferred title | UniProt |
|---|---|---|
| #114480 | Breast cancer |
P31749
|
| #114500 | Colorectal cancer; crc |
P31749
|
| #615109 | Cowden syndrome 6; cws6 |
P31749
|
| #125853 | Diabetes mellitus, noninsulin-dependent; niddm |
P31751
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #240900 | Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh |
P31751
|
| #211980 | Lung cancer |
P00533
|
| #603387 | Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome; mpph |
Q9Y243
|
| #609048 | Melanoma, cutaneous malignant, susceptibility to, 3; cmm3 |
P11802
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #254500 | Myeloma, multiple |
P24385
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #176920 | Proteus syndrome |
P31749
|
| #605361 | Spinocerebellar ataxia 14; sca14 |
P05129
|
| #601367 | Stroke, ischemic |
P24723
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
KEGG DISEASE (29)
| KEGG | disease name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00018 | Gastric cancer |
O96020
(related)
P00533 (related) P24864 (related) |
| H00055 | Laryngeal cancer |
O96020
(related)
P00533 (related) P00533 (marker) P24385 (related) P24385 (marker) P24864 (related) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P24385 (related) P24385 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P24385 (related) |
| H00022 | Bladder cancer |
P00533
(related)
|
| H00028 | Choriocarcinoma |
P00533
(related)
|
| H00030 | Cervical cancer |
P00533
(related)
P11802 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P11802 (related) |
| H00063 | Spinocerebellar ataxia (SCA) |
P05129
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00038 | Malignant melanoma |
P11802
(related)
|
| H00006 | Hairy-cell leukemia |
P24385
(related)
|
| H00010 | Multiple myeloma |
P24385
(related)
|
| H00031 | Breast cancer |
P24385
(related)
|
| H00559 | von Hippel-Lindau syndrome |
P24385
(related)
|
| H00047 | Gallbladder cancer |
P24385
(marker)
|
| H00539 | PTEN hamartoma tumor syndrome (PHTS) |
P31749
(related)
|
| H00027 | Ovarian cancer |
P31751
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P31751
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00408 | Type I diabetes mellitus |
Q04759
(related)
|