Metabolite

KNApSAcK Entry

id C00027949
Name Bleomycin A5 / Pingyangmycin A5 / Zhengguangmycin A5
CAS RN 11116-32-8
Standard InChI InChI=1S/C57H89N19O21S2/c1-22-35(73-48(76-46(22)61)27(14-33(60)80)68-15-26(59)47(62)86)52(90)75-37(43(28-16-65-21-69-28)95-56-45(41(84)39(82)31(17-77)94-56)96-55-42(85)44(97-57(63)92)40(83)32(18-78)93-55)53(91)70-24(3)38(81)23(2)49(87)74-36(25(4)79)51(89)67-13-8-34-71-30(20-98-34)54-72-29(19-99-54)50(88)66-12-7-11-64-10-6-5-9-58/h16,19-21,23-27,31-32,36-45,55-56,64,68,77-79,81-85H,5-15,17-18,58-59H2,1-4H3,(H2,60,80)(H2,62,86)(H2,63,92)(H,65,69)(H,66,88)(H,67,89)(H,70,91)(H,74,87)(H,75,90)(H2,61,73,76)
Standard InChI (Main Layer) InChI=1S/C57H89N19O21S2/c1-22-35(73-48(76-46(22)61)27(14-33(60)80)68-15-26(59)47(62)86)52(90)75-37(43(28-16-65-21-69-28)95-56-45(41(84)39(82)31(17-77)94-56)96-55-42(85)44(97-57(63)92)40(83)32(18-78)93-55)53(91)70-24(3)38(81)23(2)49(87)74-36(25(4)79)51(89)67-13-8-34-71-30(20-98-34)54-72-29(19-99-54)50(88)66-12-7-11-64-10-6-5-9-58/h16,19-21,23-27,31-32,36-45,55-56,64,68,77-79,81-85H,5-15,17-18,58-59H2,1-4H3,(H2,60,80)(H2,62,86)(H2,63,92)(H,65,69)(H,66,88)(H,67,89)(H,70,91)(H,74,87)(H,75,90)(H2,61,73,76)

Cluster

Phytochemical cluster
KCF-S cluster No. 634

Link

ChEMBL

By standard InChI CHEMBL2002141
By standard InChI Main Layer CHEMBL2002141 CHEMBL2029115

KEGG

By LinkDB

CTD

By CAS RN C025703

Species

Summary

Plant class

class name count

Family

family name count
Streptomycetaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Streptomyces verticillus 29309 Streptomycetaceae Bacteria

Human Protein / Gene in interaction

CTD interaction (94)

compound gene gene name gene description interaction interaction type form reference
pmid
C025703 55347 ABHD10
abhydrolase domain containing 10 (EC:3.1.1.93) bleomycetin results in decreased expression of ABHD10 mRNA decreases expression
mRNA 21040473
C025703 79087 ALG12
CDG1G
ECM39
PP14673
hALG12
ALG12, alpha-1,6-mannosyltransferase (EC:2.4.1.260) bleomycetin results in decreased expression of ALG12 mRNA decreases expression
mRNA 21040473
C025703 23600 AMACR
AMACRD
CBAS4
RACE
RM
alpha-methylacyl-CoA racemase (EC:5.1.99.4) bleomycetin results in decreased expression of AMACR mRNA decreases expression
mRNA 21040473
C025703 378 ARF4
ARF2
ADP-ribosylation factor 4 bleomycetin results in decreased expression of ARF4 mRNA decreases expression
mRNA 21040473
C025703 567 B2M
beta-2-microglobulin bleomycetin results in decreased expression of B2M mRNA decreases expression
mRNA 21040473
C025703 650 BMP2
BDA2
BMP2A
bone morphogenetic protein 2 bleomycetin results in increased expression of BMP2 mRNA increases expression
mRNA 21040473
C025703 768 CA9
CAIX
MN
carbonic anhydrase IX (EC:4.2.1.1) bleomycetin results in increased expression of CA9 mRNA increases expression
mRNA 21040473
C025703 768 CA9
CAIX
MN
carbonic anhydrase IX (EC:4.2.1.1) bleomycetin results in increased expression of CA9 protein increases expression
protein 21040473
C025703 768 CA9
CAIX
MN
carbonic anhydrase IX (EC:4.2.1.1) CA9 protein inhibits the reaction [bleomycetin results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 21040473
C025703 768 CA9
CAIX
MN
carbonic anhydrase IX (EC:4.2.1.1) CA9 protein results in decreased susceptibility to bleomycetin decreases response to substance
protein 21040473
C025703 64921 CASD1
C7orf12
NBLA04196
CAS1 domain containing 1 bleomycetin results in decreased expression of CASD1 mRNA decreases expression
mRNA 21040473
C025703 834 CASP1
ICE
IL1BC
P45
caspase 1, apoptosis-related cysteine peptidase (EC:3.4.22.36) bleomycetin results in decreased expression of CASP1 mRNA decreases expression
mRNA 21040473
C025703 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Acetazolamide promotes the reaction [bleomycetin results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 21040473
C025703 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) bleomycetin results in increased activity of CASP3 protein increases activity
protein 21040473
C025703 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) CA9 protein inhibits the reaction [bleomycetin results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 21040473
C025703 53841 CDHR5
MU-PCDH
MUCDHL
MUPCDH
cadherin-related family member 5 bleomycetin results in decreased expression of CDHR5 mRNA decreases expression
mRNA 21040473
C025703 1349 COX7B
APLCC
cytochrome c oxidase subunit VIIb (EC:1.9.3.1) bleomycetin results in decreased expression of COX7B mRNA decreases expression
mRNA 21040473
C025703 8451 CUL4A
cullin 4A bleomycetin results in increased expression of CUL4A mRNA increases expression
mRNA 21040473
C025703 54541 DDIT4
Dig2
REDD-1
REDD1
DNA-damage-inducible transcript 4 bleomycetin results in increased expression of DDIT4 mRNA increases expression
mRNA 21040473
C025703 1718 DHCR24
DCE
Nbla03646
SELADIN1
seladin-1
24-dehydrocholesterol reductase (EC:1.3.1.72) bleomycetin results in decreased expression of DHCR24 mRNA decreases expression
mRNA 21040473
C025703 22943 DKK1
DKK-1
SK
dickkopf WNT signaling pathway inhibitor 1 bleomycetin results in decreased expression of DKK1 mRNA decreases expression
mRNA 21040473
C025703 1808 DPYSL2
CRMP-2
CRMP2
DHPRP2
DRP-2
DRP2
N2A3
ULIP-2
ULIP2
dihydropyrimidinase-like 2 bleomycetin results in decreased expression of DPYSL2 mRNA decreases expression
mRNA 21040473
C025703 30844 EHD4
PAST4
EH-domain containing 4 bleomycetin results in increased expression of EHD4 mRNA increases expression
mRNA 21040473
C025703 1981 EIF4G1
EIF-4G1
EIF4F
EIF4G
EIF4GI
P220
PARK18
eukaryotic translation initiation factor 4 gamma, 1 bleomycetin results in increased expression of EIF4G1 mRNA increases expression
mRNA 21040473
C025703 51234 EMC4
PIG17
TMEM85
ER membrane protein complex subunit 4 bleomycetin results in decreased expression of EMC4 mRNA decreases expression
mRNA 21040473
C025703 56851 EMC7
C11orf3
C15orf24
ORF1-FL1
ER membrane protein complex subunit 7 bleomycetin results in decreased expression of EMC7 mRNA decreases expression
mRNA 21040473
C025703 2026 ENO2
NSE
enolase 2 (gamma, neuronal) (EC:4.2.1.11) bleomycetin results in increased expression of ENO2 mRNA increases expression
mRNA 21040473
C025703 2201 FBN2
CCA
DA9
fibrillin 2 bleomycetin results in decreased expression of FBN2 mRNA decreases expression
mRNA 21040473
C025703 2280 FKBP1A
FKBP-12
FKBP-1A
FKBP1
FKBP12
PKC12
PKCI2
PPIASE
FK506 binding protein 1A, 12kDa (EC:5.2.1.8) bleomycetin results in increased expression of FKBP1A mRNA increases expression
mRNA 21040473
C025703 11328 FKBP9
FKBP60
FKBP63
PPIase
FK506 binding protein 9, 63 kDa (EC:5.2.1.8) bleomycetin results in decreased expression of FKBP9 mRNA decreases expression
mRNA 21040473
C025703 10817 FRS3
FRS2-beta
FRS2B
FRS2beta
SNT-2
SNT2
fibroblast growth factor receptor substrate 3 bleomycetin results in increased expression of FRS3 mRNA increases expression
mRNA 21040473
C025703 55568 GALNT10
GALNACT10
PPGALNACT10
PPGANTASE10
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10) (EC:2.4.1.41) bleomycetin results in decreased expression of GALNT10 mRNA decreases expression
mRNA 21040473
C025703 2729 GCLC
GCL
GCS
GLCL
GLCLC
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) bleomycetin results in increased expression of GCLC mRNA increases expression
mRNA 21040473
C025703 2791 GNG11
GNGT11
guanine nucleotide binding protein (G protein), gamma 11 bleomycetin results in decreased expression of GNG11 mRNA decreases expression
mRNA 21040473
C025703 373156 GSTK1
GST
GST_13-13
GST13
GST13-13
GSTK1-1
hGSTK1
glutathione S-transferase kappa 1 (EC:2.5.1.18) bleomycetin results in decreased expression of GSTK1 mRNA decreases expression
mRNA 21040473
C025703 85236 HIST1H2BK
H2B/S
H2BFAiii
H2BFT
H2BK
histone cluster 1, H2bk bleomycetin results in decreased expression of HIST1H2BK mRNA decreases expression
mRNA 21040473
C025703 3107 HLA-C
D6S204
HLA-JY3
HLC-C
PSORS1
major histocompatibility complex, class I, C bleomycetin results in decreased expression of HLA-C mRNA decreases expression
mRNA 21040473
C025703 3182 HNRNPAB
ABBP1
HNRPAB
heterogeneous nuclear ribonucleoprotein A/B bleomycetin results in increased expression of HNRNPAB mRNA increases expression
mRNA 21040473
C025703 3217 HOXB7
HHO.C1
HOX2
HOX2C
Hox-2.3
homeobox B7 bleomycetin results in decreased expression of HOXB7 mRNA decreases expression
mRNA 21040473
C025703 10808 HSPH1
HSP105
HSP105A
HSP105B
NY-CO-25
heat shock 105kDa/110kDa protein 1 bleomycetin results in decreased expression of HSPH1 mRNA decreases expression
mRNA 21040473
C025703 3419 IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha (EC:1.1.1.41) bleomycetin results in decreased expression of IDH3A mRNA decreases expression
mRNA 21040473
C025703 3422 IDI1
IPP1
IPPI1
isopentenyl-diphosphate delta isomerase 1 (EC:5.3.3.2) bleomycetin results in decreased expression of IDI1 mRNA decreases expression
mRNA 21040473
C025703 3678 ITGA5
CD49e
FNRA
VLA5A
integrin, alpha 5 (fibronectin receptor, alpha polypeptide) bleomycetin results in increased expression of ITGA5 mRNA increases expression
mRNA 21040473
C025703 3693 ITGB5
integrin, beta 5 bleomycetin results in increased expression of ITGB5 mRNA increases expression
mRNA 21040473
C025703 3708 ITPR1
INSP3R1
IP3R
IP3R1
SCA15
SCA16
SCA29
inositol 1,4,5-trisphosphate receptor, type 1 bleomycetin results in increased expression of ITPR1 mRNA increases expression
mRNA 21040473
C025703 23522 KAT6B
GTPTS
MORF
MOZ2
MYST4
ZC2HC6B
qkf
querkopf
K(lysine) acetyltransferase 6B (EC:2.3.1.48) bleomycetin results in decreased expression of KAT6B mRNA decreases expression
mRNA 21040473
C025703 27076 LYPD3
C4.4A
LY6/PLAUR domain containing 3 bleomycetin results in increased expression of LYPD3 mRNA increases expression
mRNA 21040473
C025703 4113 MAGEB2
CT3.2
DAM6
MAGE-XP-2
melanoma antigen family B, 2 bleomycetin results in decreased expression of MAGEB2 mRNA decreases expression
mRNA 21040473
C025703 11253 MAN1B1
ERMAN1
MANA-ER
MRT15
mannosidase, alpha, class 1B, member 1 (EC:3.2.1.113) bleomycetin results in increased expression of MAN1B1 mRNA increases expression
mRNA 21040473
C025703 4171 MCM2
BM28
CCNL1
CDCL1
D3S3194
MITOTIN
cdc19
minichromosome maintenance complex component 2 (EC:3.6.4.12) bleomycetin results in increased expression of MCM2 mRNA increases expression
mRNA 21040473
C025703 400569 MED11
mediator complex subunit 11 bleomycetin results in decreased expression of MED11 mRNA decreases expression
mRNA 21040473
C025703 79006 METRN
C16orf23
c380A1.2
meteorin, glial cell differentiation regulator bleomycetin results in increased expression of METRN mRNA increases expression
mRNA 21040473
C025703 4490 MT1B
MT1
MT1Q
MTP
metallothionein 1B bleomycetin results in increased expression of MT1B mRNA increases expression
mRNA 21040473
C025703 4499 MT1M
MT-1M
MT-IM
MT1
MT1K
metallothionein 1M bleomycetin results in increased expression of MT1M mRNA increases expression
mRNA 21040473
C025703 4502 MT2A
MT2
metallothionein 2A bleomycetin results in increased expression of MT2A mRNA increases expression
mRNA 21040473
C025703 4502 MT2A
MT2
metallothionein 2A bleomycetin results in increased expression of MT2A protein increases expression
protein 21040473
C025703 4609 MYC
MRTL
MYCC
bHLHe39
c-Myc
v-myc avian myelocytomatosis viral oncogene homolog bleomycetin results in increased expression of MYC mRNA increases expression
mRNA 21040473
C025703 22916 NCBP2
CBC2
CBP20
NIP1
nuclear cap binding protein subunit 2, 20kDa bleomycetin results in increased expression of NCBP2 mRNA increases expression
mRNA 21040473
C025703 10397 NDRG1
CAP43
CMT4D
DRG-1
DRG1
GC4
HMSNL
NDR1
NMSL
PROXY1
RIT42
RTP
TARG1
TDD5
N-myc downstream regulated 1 bleomycetin results in increased expression of NDRG1 mRNA increases expression
mRNA 21040473
C025703 100301851 bleomycetin results in decreased expression of NOLA3 mRNA decreases expression
mRNA 21040473
C025703 10528 NOP56
NOL5A
SCA36
NOP56 ribonucleoprotein bleomycetin results in increased expression of NOP56 mRNA increases expression
mRNA 21040473
C025703 4898 NRD1
hNRD1
hNRD2
nardilysin (N-arginine dibasic convertase) (EC:3.4.24.61) bleomycetin results in decreased expression of NRD1 mRNA decreases expression
mRNA 21040473
C025703 5033 P4HA1
P4HA
prolyl 4-hydroxylase, alpha polypeptide I (EC:1.14.11.2) bleomycetin results in increased expression of P4HA1 mRNA increases expression
mRNA 21040473
C025703 5073 PARN
DAN
poly(A)-specific ribonuclease (EC:3.1.13.4) bleomycetin results in increased expression of PARN mRNA increases expression
mRNA 21040473
C025703 5154 PDGFA
PDGF-A
PDGF1
platelet-derived growth factor alpha polypeptide bleomycetin results in decreased expression of PDGFA mRNA decreases expression
mRNA 21040473
C025703 5226 PGD
6PGD
phosphogluconate dehydrogenase (EC:1.1.1.44) bleomycetin results in decreased expression of PGD mRNA decreases expression
mRNA 21040473
C025703 10424 PGRMC2
DG6
PMBP
progesterone receptor membrane component 2 bleomycetin results in increased expression of PGRMC2 mRNA increases expression
mRNA 21040473
C025703 29941 PKN3
RP11-545E17.1
protein kinase N3 (EC:2.7.11.13) bleomycetin results in decreased expression of PKN3 mRNA decreases expression
mRNA 21040473
C025703 5521 PPP2R2B
B55BETA
PP2AB55BETA
PP2ABBETA
PP2APR55B
PP2APR55BETA
PR2AB55BETA
PR2ABBETA
PR2APR55BETA
PR52B
PR55-BETA
PR55BETA
SCA12
protein phosphatase 2, regulatory subunit B, beta (EC:3.1.3.16) bleomycetin results in increased expression of PPP2R2B mRNA increases expression
mRNA 21040473
C025703 10084 PQBP1
MRX55
MRXS3
MRXS8
NPW38
RENS1
SHS
polyglutamine binding protein 1 bleomycetin results in decreased expression of PQBP1 mRNA decreases expression
mRNA 21040473
C025703 465383 bleomycetin results in decreased expression of PSPHL mRNA decreases expression
mRNA 21040473
C025703 9536 PTGES
MGST-IV
MGST1-L1
MGST1L1
MPGES
PGES
PIG12
PP102
PP1294
TP53I12
mPGES-1
prostaglandin E synthase (EC:5.3.99.3) bleomycetin results in decreased expression of PTGES mRNA decreases expression
mRNA 21040473
C025703 11031 RAB31
Rab22B
RAB31, member RAS oncogene family bleomycetin results in increased expression of RAB31 mRNA increases expression
mRNA 21040473
C025703 5950 RBP4
RDCCAS
retinol binding protein 4, plasma bleomycetin results in decreased expression of RBP4 mRNA decreases expression
mRNA 21040473
C025703 6191 RPS4X
CCG2
DXS306
RPS4
S4
SCAR
SCR10
ribosomal protein S4, X-linked bleomycetin results in decreased expression of RPS4X mRNA decreases expression
mRNA 21040473
C025703 26156 RSL1D1
CSIG
PBK1
UTP30
ribosomal L1 domain containing 1 bleomycetin results in increased expression of RSL1D1 mRNA increases expression
mRNA 21040473
C025703 8607 RUVBL1
ECP54
INO80H
NMP238
PONTIN
Pontin52
RVB1
TIH1
TIP49
TIP49A
RuvB-like AAA ATPase 1 (EC:3.6.4.12) bleomycetin results in increased expression of RUVBL1 mRNA increases expression
mRNA 21040473
C025703 6337 SCNN1A
BESC2
ENaCa
ENaCalpha
SCNEA
SCNN1
sodium channel, non-voltage-gated 1 alpha subunit bleomycetin results in decreased expression of SCNN1A mRNA decreases expression
mRNA 21040473
C025703 6385 SDC4
SYND4
syndecan 4 bleomycetin results in increased expression of SDC4 mRNA increases expression
mRNA 21040473
C025703 6421 SFPQ
POMP100
PSF
splicing factor proline/glutamine-rich bleomycetin results in increased expression of SFPQ mRNA increases expression
mRNA 21040473
C025703 6446 SGK1
SGK
serum/glucocorticoid regulated kinase 1 (EC:2.7.11.1) bleomycetin results in increased expression of SGK1 mRNA increases expression
mRNA 21040473
C025703 8778 SIGLEC5
CD170
CD33L2
OB-BP2
OBBP2
SIGLEC-5
sialic acid binding Ig-like lectin 5 bleomycetin results in decreased expression of SIGLEC5 mRNA decreases expression
mRNA 21040473
C025703 79811 SLTM
Met
SAFB-like, transcription modulator bleomycetin results in decreased expression of SLTM mRNA decreases expression
mRNA 21040473
C025703 9021 SOCS3
ATOD4
CIS3
Cish3
SOCS-3
SSI-3
SSI3
suppressor of cytokine signaling 3 bleomycetin results in increased expression of SOCS3 mRNA increases expression
mRNA 21040473
C025703 140809 SRXN1
C20orf139
Npn3
SRX
SRX1
sulfiredoxin 1 (EC:1.8.98.2) bleomycetin results in increased expression of SRXN1 mRNA increases expression
mRNA 21040473
C025703 6950 TCP1
CCT-alpha
CCT1
CCTa
D6S230E
TCP-1-alpha
t-complex 1 bleomycetin results in decreased expression of TCP1 mRNA decreases expression
mRNA 21040473
C025703 51372 TMA7
CCDC72
translation machinery associated 7 homolog (S. cerevisiae) bleomycetin results in decreased expression of TMA7 mRNA decreases expression
mRNA 21040473
C025703 29058 TMEM230
C20orf30
HSPC274
dJ1116H23.2.1
transmembrane protein 230 bleomycetin results in increased expression of TMEM230 mRNA increases expression
mRNA 21040473
C025703 7171 TPM4
tropomyosin 4 bleomycetin results in increased expression of TPM4 mRNA increases expression
mRNA 21040473
C025703 8848 TSC22D1
Ptg-2
TGFB1I4
TSC22
TSC22 domain family, member 1 bleomycetin results in increased expression of TSC22D1 mRNA increases expression
mRNA 21040473
C025703 7378 UPP1
UDRPASE
UP
UPASE
UPP
uridine phosphorylase 1 (EC:2.4.2.3) bleomycetin results in decreased expression of UPP1 mRNA decreases expression
mRNA 21040473
C025703 57695 USP37
ubiquitin specific peptidase 37 (EC:3.4.19.12) bleomycetin results in decreased expression of USP37 mRNA decreases expression
mRNA 21040473
C025703 8409 UXT
ART-27
STAP1
ubiquitously-expressed, prefoldin-like chaperone bleomycetin results in decreased expression of UXT mRNA decreases expression
mRNA 21040473
C025703 84215 ZNF541
zinc finger protein 541 bleomycetin results in decreased expression of ZNF541 mRNA decreases expression
mRNA 21040473

Related Disease

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D011658 C025703 Pulmonary Fibrosis marker/mechanism
20937628