Species

KNApSAcK Entry

Organism name Streptomyces verticillus
Genus Streptomyces
Family Streptomycetaceae
Kingdom Bacteria

NCBI taxonomy

Entry

Linked NCBI taxonomy name Streptomyces verticillus
Linked NCBI taxonomy ID 29309
Linked level species

Family

Family in NCBI taxonomy Streptomycetaceae
ID 2062

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Bacteria
ID 2

Plant class

Plant class
ID

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00027949 External link 512 Bleomycin A5
/ Pingyangmycin A5
/ Zhengguangmycin A5
CHEMBL2002141
CHEMBL2029115
C025703
88 / 1 No. 634

Human Protein / Gene in interactions

88 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
55347 ABHD10 abhydrolase domain containing 10 (EC:3.1.1.93) C00027949
79087 ALG12, CDG1G, ECM39, PP14673, hALG12 ALG12, alpha-1,6-mannosyltransferase (EC:2.4.1.260) C00027949
23600 AMACR, AMACRD, CBAS4, RACE, RM alpha-methylacyl-CoA racemase (EC:5.1.99.4) C00027949
378 ARF4, ARF2 ADP-ribosylation factor 4 C00027949
567 B2M beta-2-microglobulin C00027949
650 BMP2, BDA2, BMP2A bone morphogenetic protein 2 C00027949
768 CA9, CAIX, MN carbonic anhydrase IX (EC:4.2.1.1) C00027949
64921 CASD1, C7orf12, NBLA04196 CAS1 domain containing 1 C00027949
834 CASP1, ICE, IL1BC, P45 caspase 1, apoptosis-related cysteine peptidase (EC:3.4.22.36) C00027949
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00027949
53841 CDHR5, MU-PCDH, MUCDHL, MUPCDH cadherin-related family member 5 C00027949
1349 COX7B, APLCC cytochrome c oxidase subunit VIIb (EC:1.9.3.1) C00027949
8451 CUL4A cullin 4A C00027949
54541 DDIT4, Dig2, REDD-1, REDD1 DNA-damage-inducible transcript 4 C00027949
1718 DHCR24, DCE, Nbla03646, SELADIN1, seladin-1 24-dehydrocholesterol reductase (EC:1.3.1.72) C00027949
22943 DKK1, DKK-1, SK dickkopf WNT signaling pathway inhibitor 1 C00027949
1808 DPYSL2, CRMP-2, CRMP2, DHPRP2, DRP-2, DRP2, N2A3, ULIP-2, ULIP2 dihydropyrimidinase-like 2 C00027949
30844 EHD4, PAST4 EH-domain containing 4 C00027949
1981 EIF4G1, EIF-4G1, EIF4F, EIF4G, EIF4GI, P220, PARK18 eukaryotic translation initiation factor 4 gamma, 1 C00027949
51234 EMC4, PIG17, TMEM85 ER membrane protein complex subunit 4 C00027949
56851 EMC7, C11orf3, C15orf24, ORF1-FL1 ER membrane protein complex subunit 7 C00027949
2026 ENO2, NSE enolase 2 (gamma, neuronal) (EC:4.2.1.11) C00027949
2201 FBN2, CCA, DA9 fibrillin 2 C00027949
2280 FKBP1A, FKBP-12, FKBP-1A, FKBP1, FKBP12, PKC12, PKCI2, PPIASE FK506 binding protein 1A, 12kDa (EC:5.2.1.8) C00027949
11328 FKBP9, FKBP60, FKBP63, PPIase FK506 binding protein 9, 63 kDa (EC:5.2.1.8) C00027949
10817 FRS3, FRS2-beta, FRS2B, FRS2beta, SNT-2, SNT2 fibroblast growth factor receptor substrate 3 C00027949
55568 GALNT10, GALNACT10, PPGALNACT10, PPGANTASE10 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10) (EC:2.4.1.41) C00027949
2729 GCLC, GCL, GCS, GLCL, GLCLC glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) C00027949
2791 GNG11, GNGT11 guanine nucleotide binding protein (G protein), gamma 11 C00027949
373156 GSTK1, GST, GST_13-13, GST13, GST13-13, GSTK1-1, hGSTK1 glutathione S-transferase kappa 1 (EC:2.5.1.18) C00027949
85236 HIST1H2BK, H2B/S, H2BFAiii, H2BFT, H2BK histone cluster 1, H2bk C00027949
3107 HLA-C, D6S204, HLA-JY3, HLC-C, PSORS1 major histocompatibility complex, class I, C C00027949
3182 HNRNPAB, ABBP1, HNRPAB heterogeneous nuclear ribonucleoprotein A/B C00027949
3217 HOXB7, HHO.C1, HOX2, HOX2C, Hox-2.3 homeobox B7 C00027949
10808 HSPH1, HSP105, HSP105A, HSP105B, NY-CO-25 heat shock 105kDa/110kDa protein 1 C00027949
3419 IDH3A isocitrate dehydrogenase 3 (NAD+) alpha (EC:1.1.1.41) C00027949
3422 IDI1, IPP1, IPPI1 isopentenyl-diphosphate delta isomerase 1 (EC:5.3.3.2) C00027949
3678 ITGA5, CD49e, FNRA, VLA5A integrin, alpha 5 (fibronectin receptor, alpha polypeptide) C00027949
3693 ITGB5 integrin, beta 5 C00027949
3708 ITPR1, INSP3R1, IP3R, IP3R1, SCA15, SCA16, SCA29 inositol 1,4,5-trisphosphate receptor, type 1 C00027949
23522 KAT6B, GTPTS, MORF, MOZ2, MYST4, ZC2HC6B, qkf, querkopf K(lysine) acetyltransferase 6B (EC:2.3.1.48) C00027949
27076 LYPD3, C4.4A LY6/PLAUR domain containing 3 C00027949
4113 MAGEB2, CT3.2, DAM6, MAGE-XP-2 melanoma antigen family B, 2 C00027949
11253 MAN1B1, ERMAN1, MANA-ER, MRT15 mannosidase, alpha, class 1B, member 1 (EC:3.2.1.113) C00027949
4171 MCM2, BM28, CCNL1, CDCL1, D3S3194, MITOTIN, cdc19 minichromosome maintenance complex component 2 (EC:3.6.4.12) C00027949
400569 MED11 mediator complex subunit 11 C00027949
79006 METRN, C16orf23, c380A1.2 meteorin, glial cell differentiation regulator C00027949
4490 MT1B, MT1, MT1Q, MTP metallothionein 1B C00027949
4499 MT1M, MT-1M, MT-IM, MT1, MT1K metallothionein 1M C00027949
4502 MT2A, MT2 metallothionein 2A C00027949
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00027949
22916 NCBP2, CBC2, CBP20, NIP1 nuclear cap binding protein subunit 2, 20kDa C00027949
10397 NDRG1, CAP43, CMT4D, DRG-1, DRG1, GC4, HMSNL, NDR1, NMSL, PROXY1, RIT42, RTP, TARG1, TDD5 N-myc downstream regulated 1 C00027949
100301851 C00027949
10528 NOP56, NOL5A, SCA36 NOP56 ribonucleoprotein C00027949
4898 NRD1, hNRD1, hNRD2 nardilysin (N-arginine dibasic convertase) (EC:3.4.24.61) C00027949
5033 P4HA1, P4HA prolyl 4-hydroxylase, alpha polypeptide I (EC:1.14.11.2) C00027949
5073 PARN, DAN poly(A)-specific ribonuclease (EC:3.1.13.4) C00027949
5154 PDGFA, PDGF-A, PDGF1 platelet-derived growth factor alpha polypeptide C00027949
5226 PGD, 6PGD phosphogluconate dehydrogenase (EC:1.1.1.44) C00027949
10424 PGRMC2, DG6, PMBP progesterone receptor membrane component 2 C00027949
29941 PKN3, RP11-545E17.1 protein kinase N3 (EC:2.7.11.13) C00027949
5521 PPP2R2B, B55BETA, PP2AB55BETA, PP2ABBETA, PP2APR55B, PP2APR55BETA, PR2AB55BETA, PR2ABBETA, PR2APR55BETA, PR52B, PR55-BETA, PR55BETA, SCA12 protein phosphatase 2, regulatory subunit B, beta (EC:3.1.3.16) C00027949
10084 PQBP1, MRX55, MRXS3, MRXS8, NPW38, RENS1, SHS polyglutamine binding protein 1 C00027949
465383 C00027949
9536 PTGES, MGST-IV, MGST1-L1, MGST1L1, MPGES, PGES, PIG12, PP102, PP1294, TP53I12, mPGES-1 prostaglandin E synthase (EC:5.3.99.3) C00027949
11031 RAB31, Rab22B RAB31, member RAS oncogene family C00027949
5950 RBP4, RDCCAS retinol binding protein 4, plasma C00027949
6191 RPS4X, CCG2, DXS306, RPS4, S4, SCAR, SCR10 ribosomal protein S4, X-linked C00027949
26156 RSL1D1, CSIG, PBK1, UTP30 ribosomal L1 domain containing 1 C00027949
8607 RUVBL1, ECP54, INO80H, NMP238, PONTIN, Pontin52, RVB1, TIH1, TIP49, TIP49A RuvB-like AAA ATPase 1 (EC:3.6.4.12) C00027949
6337 SCNN1A, BESC2, ENaCa, ENaCalpha, SCNEA, SCNN1 sodium channel, non-voltage-gated 1 alpha subunit C00027949
6385 SDC4, SYND4 syndecan 4 C00027949
6421 SFPQ, POMP100, PSF splicing factor proline/glutamine-rich C00027949
6446 SGK1, SGK serum/glucocorticoid regulated kinase 1 (EC:2.7.11.1) C00027949
8778 SIGLEC5, CD170, CD33L2, OB-BP2, OBBP2, SIGLEC-5 sialic acid binding Ig-like lectin 5 C00027949
79811 SLTM, Met SAFB-like, transcription modulator C00027949
9021 SOCS3, ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3 suppressor of cytokine signaling 3 C00027949
140809 SRXN1, C20orf139, Npn3, SRX, SRX1 sulfiredoxin 1 (EC:1.8.98.2) C00027949
6950 TCP1, CCT-alpha, CCT1, CCTa, D6S230E, TCP-1-alpha t-complex 1 C00027949
51372 TMA7, CCDC72 translation machinery associated 7 homolog (S. cerevisiae) C00027949
29058 TMEM230, C20orf30, HSPC274, dJ1116H23.2.1 transmembrane protein 230 C00027949
7171 TPM4 tropomyosin 4 C00027949
8848 TSC22D1, Ptg-2, TGFB1I4, TSC22 TSC22 domain family, member 1 C00027949
7378 UPP1, UDRPASE, UP, UPASE, UPP uridine phosphorylase 1 (EC:2.4.2.3) C00027949
57695 USP37 ubiquitin specific peptidase 37 (EC:3.4.19.12) C00027949
8409 UXT, ART-27, STAP1 ubiquitously-expressed, prefoldin-like chaperone C00027949
84215 ZNF541 zinc finger protein 541 C00027949

Related Diseases

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D011658 Pulmonary Fibrosis C00027949