PCIDB

KNApSAcK Metabolite C00029643

Metabolite

KNApSAcK Entry

id C00029643
Name Adrenalin
CAS RN 51-43-4
Standard InChI InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1
Standard InChI (Main Layer) InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3

Cluster

Phytochemical cluster
KCF-S cluster No. 3197

Link

ChEMBL

By standard InChI CHEMBL679
By standard InChI Main Layer CHEMBL679 CHEMBL42280 CHEMBL227634 CHEMBL1740

KEGG

By LinkDB C00788

CTD

By CAS RN D004837

Species

Summary

Plant class

class name count
asterids 1

Family

family name count
Plantaginaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Scoparia dulcis L. 107240 Plantaginaceae asterids Viridiplantae

Human Protein / Gene in interaction

126 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL679 CHEMBL1614110 (1) CHEMBL1741321 (1)
CHEMBL1909136 (2)
1 / 0
P42345 Serine/threonine-protein kinase mTOR Enzyme CHEMBL679 CHEMBL1613805 (1) CHEMBL1614293 (1)
0 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL1740 CHEMBL2114784 (1)
1 / 1
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL679 CHEMBL1740 CHEMBL669035 (1) CHEMBL669037 (1)
CHEMBL1738091 (2) CHEMBL1737859 (1)
CHEMBL1738565 (2) CHEMBL1909139 (2)
CHEMBL2114744 (2)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL679 CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL679 CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL679 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL679 CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL679 CHEMBL1909201 (2)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL679 CHEMBL1909176 (2)
0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase CHEMBL42280 CHEMBL987036 (1)
0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase CHEMBL679 CHEMBL42280 CHEMBL891288 (1) CHEMBL891294 (1)
CHEMBL987035 (1)
0 / 0
P43166 Carbonic anhydrase 7 Lyase CHEMBL679 CHEMBL42280 CHEMBL889439 (1) CHEMBL891289 (1)
CHEMBL891295 (1) CHEMBL987038 (1)
0 / 0
P29466 Caspase-1 C14 CHEMBL679 CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL679 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL679 CHEMBL1909199 (2)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL679 CHEMBL1909197 (2)
2 / 2
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL1740 CHEMBL1738600 (1)
0 / 0
O15245 Solute carrier family 22 member 1 Drug uniporter CHEMBL679 CHEMBL993349 (1)
0 / 0
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL679 CHEMBL1614281 (1) CHEMBL1614361 (1)
3 / 2
P00918 Carbonic anhydrase 2 Lyase CHEMBL679 CHEMBL42280 CHEMBL889437 (1) CHEMBL891286 (1)
CHEMBL891292 (1) CHEMBL932482 (1)
CHEMBL970751 (1) CHEMBL987029 (1)
CHEMBL987031 (1) CHEMBL953312 (1)
CHEMBL1017972 (1) CHEMBL1067709 (1)
CHEMBL1106967 (1) CHEMBL1909123 (2)
CHEMBL2318049 (1)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL679 CHEMBL1740 CHEMBL819727 (1) CHEMBL819728 (1)
CHEMBL1058735 (1) CHEMBL1613894 (1)
CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL679 CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL679 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL679 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL679 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL679 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL679 CHEMBL642057 (1) CHEMBL645613 (1)
CHEMBL649812 (1) CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL679 CHEMBL936719 (1) CHEMBL936720 (1)
CHEMBL936722 (1) CHEMBL1909093 (2)
0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL679 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL679 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL679 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL679 CHEMBL1741325 (1) CHEMBL1909135 (2)
0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL679 CHEMBL1909203 (2)
1 / 11
P11473 Vitamin D3 receptor NR1I1 CHEMBL679 CHEMBL1740 CHEMBL1794311 (5)
2 / 3
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL679 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL679 CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL679 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL679 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL679 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL679 CHEMBL1909214 (2)
0 / 0
P23280 Carbonic anhydrase 6 Lyase CHEMBL42280 CHEMBL987037 (1) CHEMBL1067710 (1)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL679 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL679 CHEMBL1909096 (2)
1 / 1
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL679 CHEMBL1613800 (1)
0 / 0
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL679 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL679 CHEMBL1909166 (2)
1 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase CHEMBL679 CHEMBL42280 CHEMBL889441 (1) CHEMBL891290 (1)
CHEMBL891296 (1) CHEMBL987042 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL679 CHEMBL1614458 (1)
0 / 0
O43570 Carbonic anhydrase 12 Lyase CHEMBL42280 CHEMBL932484 (1) CHEMBL987040 (1)
1 / 2
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL679 CHEMBL1909133 (2)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL679 CHEMBL1614456 (1) CHEMBL1613803 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL679 CHEMBL1740 CHEMBL1613922 (2) CHEMBL1794486 (2)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL679 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL679 CHEMBL642057 (1) CHEMBL645613 (1)
CHEMBL649812 (1) CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL679 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL679 CHEMBL1909101 (2)
0 / 0
P35348 Alpha-1A adrenergic receptor Adrenergic receptor CHEMBL679 CHEMBL646130 (1) CHEMBL873047 (1)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL679 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL679 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL679 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL679 CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL679 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL679 CHEMBL1909100 (2)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL679 CHEMBL1909167 (2)
1 / 0
P00915 Carbonic anhydrase 1 Lyase CHEMBL679 CHEMBL42280 CHEMBL889435 (1) CHEMBL891285 (1)
CHEMBL891291 (1) CHEMBL932481 (1)
CHEMBL970750 (1) CHEMBL987028 (1)
CHEMBL965608 (1) CHEMBL1067708 (1)
CHEMBL2318048 (1)
0 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL679 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL679 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL679 CHEMBL1909110 (2)
1 / 0
P03956 Interstitial collagenase M10A CHEMBL679 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL679 CHEMBL1909119 (2)
0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL679 CHEMBL1614410 (1) CHEMBL1614531 (2)
1 / 3
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL679 CHEMBL1794467 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL679 CHEMBL1794456 (1) CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL679 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL679 CHEMBL1909170 (2)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL679 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL679 CHEMBL1909109 (2)
2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL679 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL679 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL679 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL679 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL679 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL679 CHEMBL1909108 (2)
0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme CHEMBL679 CHEMBL1614252 (1)
2 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL679 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL679 CHEMBL1613808 (1) CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL679 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL679 CHEMBL1741322 (1) CHEMBL1909132 (2)
0 / 0
Q16790 Carbonic anhydrase 9 Lyase CHEMBL42280 CHEMBL932483 (1) CHEMBL987039 (1)
0 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL679 CHEMBL1614227 (1)
3 / 3
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL679 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL679 CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL679 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL679 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL679 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL679 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL679 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL679 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL679 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL679 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL679 CHEMBL1909168 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL679 CHEMBL1741323 (1) CHEMBL1909134 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL679 CHEMBL1614108 (1) CHEMBL1613886 (1)
CHEMBL1741324 (1) CHEMBL1909138 (2)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL679 CHEMBL1909137 (2)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL679 CHEMBL1614466 (1) CHEMBL1614211 (4)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL679 CHEMBL1614250 (2) CHEMBL1614421 (3)
CHEMBL1614502 (2)
4 / 3
Q99549 M-phase phosphoprotein 8 Unclassified protein CHEMBL679 CHEMBL1738402 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL679 CHEMBL2114890 (1)
0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL679 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL679 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL679 CHEMBL1909213 (2)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL679 CHEMBL642057 (1) CHEMBL645613 (1)
CHEMBL649812 (1) CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL679 CHEMBL1909116 (2)
1 / 1
P07451 Carbonic anhydrase 3 Lyase CHEMBL42280 CHEMBL970752 (1) CHEMBL987033 (1)
CHEMBL953319 (1)
0 / 0
P06239 Tyrosine-protein kinase Lck Src CHEMBL679 CHEMBL1909206 (2)
0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL679 CHEMBL1909128 (2)
0 / 0
P22748 Carbonic anhydrase 4 Lyase CHEMBL679 CHEMBL42280 CHEMBL891287 (1) CHEMBL891293 (1)
CHEMBL970753 (1) CHEMBL1008327 (1)
CHEMBL987034 (1)
1 / 1
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL679 CHEMBL1794536 (5)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL679 CHEMBL1613914 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL679 CHEMBL1613829 (1) CHEMBL1613928 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL679 CHEMBL1738442 (2)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL679 CHEMBL1614364 (3)
1 / 1
O00255 Menin Unclassified protein CHEMBL679 CHEMBL1614531 (2)
2 / 5
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL679 CHEMBL1613933 (3)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL679 CHEMBL1613933 (3)
1 / 6

CTD interaction (102)

compound gene gene name gene description interaction interaction type form reference
pmid
D004837 148 ADRA1A
ADRA1C
ADRA1L1
ALPHA1AAR
adrenoceptor alpha 1A carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium] decreases reaction
/ increases abundance
/ increases activity
protein 15306222
D004837 148 ADRA1A
ADRA1C
ADRA1L1
ALPHA1AAR
adrenoceptor alpha 1A Epinephrine binds to ADRA1A protein affects binding
protein 8183249
D004837 148 ADRA1A
ADRA1C
ADRA1L1
ALPHA1AAR
adrenoceptor alpha 1A Epinephrine binds to and results in increased activity of ADRA1A protein affects binding
/ increases activity
protein 20030735
D004837 148 ADRA1A
ADRA1C
ADRA1L1
ALPHA1AAR
adrenoceptor alpha 1A [Epinephrine binds to and results in increased activity of ADRA1A protein] which results in increased abundance of Calcium affects binding
/ increases abundance
/ increases activity
protein 20030735
D004837 148 ADRA1A
ADRA1C
ADRA1L1
ALPHA1AAR
adrenoceptor alpha 1A Epinephrine inhibits the reaction [ADRA1A protein binds to Prazosin] affects binding
/ decreases reaction
protein 20030735
D004837 148 ADRA1A
ADRA1C
ADRA1L1
ALPHA1AAR
adrenoceptor alpha 1A Epinephrine results in increased activity of ADRA1A protein increases activity
protein 15306222
D004837 148 ADRA1A
ADRA1C
ADRA1L1
ALPHA1AAR
adrenoceptor alpha 1A [Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium increases abundance
/ increases activity
protein 15306222
D004837 148 ADRA1A
ADRA1C
ADRA1L1
ALPHA1AAR
adrenoceptor alpha 1A Phentolamine inhibits the reaction [[Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium] decreases reaction
/ increases abundance
/ increases activity
protein 15306222
D004837 147 ADRA1B
ADRA1
ALPHA1BAR
adrenoceptor alpha 1B carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium] decreases reaction
/ increases abundance
/ increases activity
protein 15306222
D004837 147 ADRA1B
ADRA1
ALPHA1BAR
adrenoceptor alpha 1B Epinephrine binds to and results in increased activity of ADRA1B protein affects binding
/ increases activity
protein 20030735
D004837 147 ADRA1B
ADRA1
ALPHA1BAR
adrenoceptor alpha 1B [Epinephrine binds to and results in increased activity of ADRA1B protein] which results in increased abundance of Calcium affects binding
/ increases abundance
/ increases activity
protein 20030735
D004837 147 ADRA1B
ADRA1
ALPHA1BAR
adrenoceptor alpha 1B Epinephrine inhibits the reaction [ADRA1B protein binds to Prazosin] affects binding
/ decreases reaction
protein 20030735
D004837 147 ADRA1B
ADRA1
ALPHA1BAR
adrenoceptor alpha 1B Epinephrine results in increased activity of ADRA1B protein increases activity
protein 15306222
D004837 147 ADRA1B
ADRA1
ALPHA1BAR
adrenoceptor alpha 1B [Epinephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium increases abundance
/ increases activity
protein 15306222
D004837 147 ADRA1B
ADRA1
ALPHA1BAR
adrenoceptor alpha 1B Phentolamine inhibits the reaction [[Epinephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium] decreases reaction
/ increases abundance
/ increases activity
protein 15306222
D004837 146 ADRA1D
ADRA1
ADRA1A
ADRA1R
ALPHA1
DAR
dJ779E11.2
adrenoceptor alpha 1D carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium] decreases reaction
/ increases abundance
/ increases activity
protein 15306222
D004837 146 ADRA1D
ADRA1
ADRA1A
ADRA1R
ALPHA1
DAR
dJ779E11.2
adrenoceptor alpha 1D Epinephrine binds to ADRA1D protein affects binding
protein 8183249
D004837 146 ADRA1D
ADRA1
ADRA1A
ADRA1R
ALPHA1
DAR
dJ779E11.2
adrenoceptor alpha 1D Epinephrine binds to and results in increased activity of ADRA1D protein affects binding
/ increases activity
protein 20030735
D004837 146 ADRA1D
ADRA1
ADRA1A
ADRA1R
ALPHA1
DAR
dJ779E11.2
adrenoceptor alpha 1D [Epinephrine binds to and results in increased activity of ADRA1D protein] which results in increased abundance of Calcium affects binding
/ increases abundance
/ increases activity
protein 20030735
D004837 146 ADRA1D
ADRA1
ADRA1A
ADRA1R
ALPHA1
DAR
dJ779E11.2
adrenoceptor alpha 1D Epinephrine inhibits the reaction [ADRA1D protein binds to Prazosin] affects binding
/ decreases reaction
protein 20030735
D004837 146 ADRA1D
ADRA1
ADRA1A
ADRA1R
ALPHA1
DAR
dJ779E11.2
adrenoceptor alpha 1D Epinephrine results in increased activity of ADRA1D protein increases activity
protein 15306222
D004837 146 ADRA1D
ADRA1
ADRA1A
ADRA1R
ALPHA1
DAR
dJ779E11.2
adrenoceptor alpha 1D [Epinephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium increases abundance
/ increases activity
protein 15306222
D004837 146 ADRA1D
ADRA1
ADRA1A
ADRA1R
ALPHA1
DAR
dJ779E11.2
adrenoceptor alpha 1D Phentolamine inhibits the reaction [[Epinephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium] decreases reaction
/ increases abundance
/ increases activity
protein 15306222
D004837 150 ADRA2A
ADRA2
ADRA2R
ADRAR
ALPHA2AAR
ZNF32
adrenoceptor alpha 2A Epinephrine binds to and results in increased activity of ADRA2A protein affects binding
/ increases activity
protein 20030735
D004837 150 ADRA2A
ADRA2
ADRA2R
ADRAR
ALPHA2AAR
ZNF32
adrenoceptor alpha 2A [Epinephrine binds to and results in increased activity of ADRA2A protein] which results in increased abundance of Calcium affects binding
/ increases abundance
/ increases activity
protein 20030735
D004837 150 ADRA2A
ADRA2
ADRA2R
ADRAR
ALPHA2AAR
ZNF32
adrenoceptor alpha 2A Epinephrine inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan] affects binding
/ decreases reaction
protein 20030735
D004837 151 ADRA2B
ADRA2L1
ADRA2RL1
ADRARL1
ALPHA2BAR
alpha-2BAR
adrenoceptor alpha 2B Epinephrine binds to and results in increased activity of ADRA2B protein affects binding
/ increases activity
protein 20030735
D004837 151 ADRA2B
ADRA2L1
ADRA2RL1
ADRARL1
ALPHA2BAR
alpha-2BAR
adrenoceptor alpha 2B [Epinephrine binds to and results in increased activity of ADRA2B protein] which results in increased abundance of Calcium affects binding
/ increases abundance
/ increases activity
protein 20030735
D004837 151 ADRA2B
ADRA2L1
ADRA2RL1
ADRARL1
ALPHA2BAR
alpha-2BAR
adrenoceptor alpha 2B Epinephrine inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan] affects binding
/ decreases reaction
protein 20030735
D004837 152 ADRA2C
ADRA2L2
ADRA2RL2
ADRARL2
ALPHA2CAR
adrenoceptor alpha 2C Epinephrine binds to and results in increased activity of ADRA2C protein affects binding
/ increases activity
protein 20030735
D004837 152 ADRA2C
ADRA2L2
ADRA2RL2
ADRARL2
ALPHA2CAR
adrenoceptor alpha 2C [Epinephrine binds to and results in increased activity of ADRA2C protein] which results in increased abundance of Calcium affects binding
/ increases abundance
/ increases activity
protein 20030735
D004837 152 ADRA2C
ADRA2L2
ADRA2RL2
ADRARL2
ALPHA2CAR
adrenoceptor alpha 2C Epinephrine inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan] affects binding
/ decreases reaction
protein 20030735
D004837 153 ADRB1
ADRB1R
B1AR
BETA1AR
RHR
adrenoceptor beta 1 Epinephrine binds to and results in increased activity of ADRB1 protein affects binding
/ increases activity
protein 14730417
D004837 153 ADRB1
ADRB1R
B1AR
BETA1AR
RHR
adrenoceptor beta 1 [Epinephrine binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP affects binding
/ increases abundance
/ increases activity
protein 14730417
D004837 153 ADRB1
ADRB1R
B1AR
BETA1AR
RHR
adrenoceptor beta 1 Epinephrine inhibits the reaction [cyanopindolol binds to ADRB1 protein] affects binding
/ decreases reaction
protein 14730417
D004837 153 ADRB1
ADRB1R
B1AR
BETA1AR
RHR
adrenoceptor beta 1 Epinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein] affects binding
/ decreases reaction
protein 8096834
D004837 154 ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
adrenoceptor beta 2, surface Atenolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein] affects binding
/ decreases reaction
/ increases activity
protein 12920204
D004837 154 ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
adrenoceptor beta 2, surface Atenolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP] affects binding
/ decreases reaction
/ increases abundance
/ increases activity
protein 12920204
D004837 154 ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
adrenoceptor beta 2, surface carvedilol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein] affects binding
/ decreases reaction
/ increases activity
protein 16225854
D004837 154 ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
adrenoceptor beta 2, surface Epinephrine binds to and results in increased activity of ADRB2 protein affects binding
/ increases activity
protein 12920204
14730417
D004837 154 ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
adrenoceptor beta 2, surface [Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP affects binding
/ increases abundance
/ increases activity
protein 12920204
14730417
D004837 154 ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
adrenoceptor beta 2, surface Epinephrine inhibits the reaction [cyanopindolol binds to ADRB2 protein] affects binding
/ decreases reaction
protein 14730417
D004837 154 ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
adrenoceptor beta 2, surface Epinephrine promotes the reaction [ADRBK1 protein results in increased phosphorylation of ADRB2 protein] increases phosphorylation
/ increases reaction
protein 14722251
D004837 154 ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
adrenoceptor beta 2, surface Epinephrine promotes the reaction [GRK5 protein results in increased phosphorylation of ADRB2 protein] increases phosphorylation
/ increases reaction
protein 14722251
D004837 154 ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
adrenoceptor beta 2, surface Epinephrine results in increased activity of ADRB2 protein increases activity
protein 1389726
D004837 154 ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
adrenoceptor beta 2, surface Epinephrine results in increased phosphorylation of and results in increased localization of ADRB2 protein increases localization
/ increases phosphorylation
protein 14722251
D004837 154 ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
adrenoceptor beta 2, surface ICI 118551 inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein] affects binding
/ decreases reaction
/ increases activity
protein 12920204
D004837 154 ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
adrenoceptor beta 2, surface ICI 118551 inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP] affects binding
/ decreases reaction
/ increases abundance
/ increases activity
protein 12920204
D004837 154 ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
adrenoceptor beta 2, surface Propranolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein] affects binding
/ decreases reaction
/ increases activity
protein 12920204
D004837 154 ADRB2
ADRB2R
ADRBR
B2AR
BAR
BETA2AR
adrenoceptor beta 2, surface Propranolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP] affects binding
/ decreases reaction
/ increases abundance
/ increases activity
protein 12920204
D004837 155 ADRB3
BETA3AR
adrenoceptor beta 3 Epinephrine binds to and results in increased activity of ADRB3 protein affects binding
/ increases activity
protein 1682311
14730417
D004837 155 ADRB3
BETA3AR
adrenoceptor beta 3 [Epinephrine binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP affects binding
/ increases abundance
/ increases activity
protein 14730417
D004837 155 ADRB3
BETA3AR
adrenoceptor beta 3 Epinephrine inhibits the reaction [cyanopindolol binds to ADRB3 protein] affects binding
/ decreases reaction
protein 14730417
D004837 156 ADRBK1
BARK1
BETA-ARK1
GRK2
adrenergic, beta, receptor kinase 1 (EC:2.7.11.15) Epinephrine promotes the reaction [ADRBK1 protein results in increased phosphorylation of ADRB2 protein] increases phosphorylation
/ increases reaction
protein 14722251
D004837 760 CA2
CA-II
CAC
CAII
Car2
carbonic anhydrase II (EC:4.2.1.1) Epinephrine results in increased expression of CA2 mRNA increases expression
mRNA 12729923
D004837 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Atenolol inhibits the reaction [Epinephrine results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 10728402
D004837 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) carvedilol inhibits the reaction [Epinephrine results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 10728402
D004837 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Epinephrine results in increased activity of CASP3 protein increases activity
protein 10728402
D004837 6348 CCL3
G0S19-1
LD78ALPHA
MIP-1-alpha
MIP1A
SCYA3
chemokine (C-C motif) ligand 3 Epinephrine inhibits the reaction [lipopolysaccharide, Escherichia coli 0111 B4 results in increased expression of CCL3 mRNA] decreases reaction
/ increases expression
mRNA 12538206
D004837 6348 CCL3
G0S19-1
LD78ALPHA
MIP-1-alpha
MIP1A
SCYA3
chemokine (C-C motif) ligand 3 Epinephrine inhibits the reaction [lipopolysaccharide, Escherichia coli 0111 B4 results in increased expression of CCL3 protein] decreases reaction
/ increases expression
protein 12538206
D004837 6348 CCL3
G0S19-1
LD78ALPHA
MIP-1-alpha
MIP1A
SCYA3
chemokine (C-C motif) ligand 3 Propranolol inhibits the reaction [Epinephrine inhibits the reaction [lipopolysaccharide, Escherichia coli 0111 B4 results in increased expression of CCL3 protein]] decreases reaction
/ increases expression
protein 12538206
D004837 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased abundance of Epinephrine] affects binding
/ decreases activity
/ decreases reaction
/ increases abundance
protein 17498763
D004837 1312 COMT
catechol-O-methyltransferase (EC:2.1.1.6) COMT protein results in increased methylation of Epinephrine increases methylation
protein 11160877
D004837 1312 COMT
catechol-O-methyltransferase (EC:2.1.1.6) [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Epinephrine decreases activity
/ increases abundance
protein 11248589
D004837 1513 CTSK
CTS02
CTSO
CTSO1
CTSO2
PKND
PYCD
cathepsin K (EC:3.4.22.38) Epinephrine results in increased expression of CTSK mRNA increases expression
mRNA 12729923
D004837 355 FAS
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Fas cell surface death receptor Atenolol inhibits the reaction [Epinephrine results in increased expression of FAS protein] decreases reaction
/ increases expression
protein 10728402
D004837 355 FAS
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Fas cell surface death receptor carvedilol inhibits the reaction [Epinephrine results in increased expression of FAS protein] decreases reaction
/ increases expression
protein 10728402
D004837 355 FAS
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Fas cell surface death receptor Epinephrine results in increased expression of FAS protein increases expression
protein 10728402
D004837 356 FASLG
ALPS1B
APT1LG1
APTL
CD178
CD95-L
CD95L
FASL
TNFSF6
Fas ligand (TNF superfamily, member 6) Atenolol inhibits the reaction [Epinephrine results in increased expression of FASLG protein] decreases reaction
/ increases expression
protein 10728402
D004837 356 FASLG
ALPS1B
APT1LG1
APTL
CD178
CD95-L
CD95L
FASL
TNFSF6
Fas ligand (TNF superfamily, member 6) carvedilol inhibits the reaction [Epinephrine results in increased expression of FASLG protein] decreases reaction
/ increases expression
protein 10728402
D004837 356 FASLG
ALPS1B
APT1LG1
APTL
CD178
CD95-L
CD95L
FASL
TNFSF6
Fas ligand (TNF superfamily, member 6) Epinephrine results in increased expression of FASLG protein increases expression
protein 10728402
D004837 2869 GRK5
GPRK5
G protein-coupled receptor kinase 5 (EC:2.7.11.16) Epinephrine promotes the reaction [GRK5 protein results in increased phosphorylation of ADRB2 protein] increases phosphorylation
/ increases reaction
protein 14722251
D004837 3586 IL10
CSIF
GVHDS
IL-10
IL10A
TGIF
interleukin 10 Epinephrine promotes the reaction [Lipopolysaccharides results in increased expression of IL10 protein] increases expression
/ increases reaction
protein 10588509
D004837 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] decreases reaction
/ increases expression
protein 10588509
D004837 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] decreases reaction
/ increases expression
protein 10588509
D004837 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin Butoxamine inhibits the reaction [Epinephrine results in decreased expression of INS protein] decreases expression
/ decreases reaction
protein 6018752
D004837 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin Epinephrine results in decreased expression of INS protein decreases expression
protein 6018752
6314140
D004837 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin Pentolinium Tartrate inhibits the reaction [Epinephrine results in decreased secretion of INS protein] decreases reaction
/ decreases secretion
protein 1218171
D004837 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin Propranolol inhibits the reaction [Epinephrine results in decreased expression of INS protein] decreases expression
/ decreases reaction
protein 6018752
D004837 3673 ITGA2
BR
CD49B
GPIa
HPA-5
VLA-2
VLAA2
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Epinephrine] affects cotreatment
/ affects response to substance
gene 16214444
D004837 3685 ITGAV
CD51
MSK8
VNRA
VTNR
integrin, alpha V Epinephrine results in increased expression of ITGAV mRNA increases expression
mRNA 12729923
D004837 3991 LIPE
HSL
LHS
lipase, hormone-sensitive (EC:3.1.1.79) Epinephrine results in increased activity of LIPE protein increases activity
protein 7155675
D004837 3991 LIPE
HSL
LHS
lipase, hormone-sensitive (EC:3.1.1.79) Theophylline inhibits the reaction [Epinephrine results in increased activity of LIPE protein] decreases reaction
/ increases activity
protein 7155675
D004837 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Epinephrine inhibits the reaction [Estradiol results in decreased phosphorylation of MAPK1 protein] decreases phosphorylation
/ decreases reaction
protein 15292328
D004837 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Epinephrine inhibits the reaction [Estradiol results in decreased phosphorylation of MAPK3 protein] decreases phosphorylation
/ decreases reaction
protein 15292328
D004837 5027 P2RX7
P2X7
purinergic receptor P2X, ligand-gated ion channel, 7 Epinephrine results in decreased activity of P2RX7 protein decreases activity
protein 15459114
D004837 5972 REN
HNFJ2
renin (EC:3.4.23.15) Epinephrine results in increased activity of REN protein increases activity
protein 6314140
8592096
D004837 5972 REN
HNFJ2
renin (EC:3.4.23.15) ICI 118551 inhibits the reaction [Epinephrine results in increased activity of REN protein] decreases reaction
/ increases activity
protein 6314140
D004837 6647 SOD1
ALS
ALS1
IPOA
SOD
hSod1
homodimer
superoxide dismutase 1, soluble (EC:1.15.1.1) 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Epinephrine results in increased activity of SOD1 protein] decreases reaction
/ increases activity
protein 11163531
D004837 6647 SOD1
ALS
ALS1
IPOA
SOD
hSod1
homodimer
superoxide dismutase 1, soluble (EC:1.15.1.1) Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD1 protein] decreases reaction
/ increases activity
protein 11163531
D004837 6647 SOD1
ALS
ALS1
IPOA
SOD
hSod1
homodimer
superoxide dismutase 1, soluble (EC:1.15.1.1) Epinephrine results in increased activity of SOD1 protein increases activity
protein 11163531
D004837 6647 SOD1
ALS
ALS1
IPOA
SOD
hSod1
homodimer
superoxide dismutase 1, soluble (EC:1.15.1.1) Epinephrine results in increased expression of SOD1 mRNA increases expression
mRNA 11163531
D004837 6647 SOD1
ALS
ALS1
IPOA
SOD
hSod1
homodimer
superoxide dismutase 1, soluble (EC:1.15.1.1) Epinephrine results in increased expression of SOD1 protein increases expression
protein 11163531
D004837 6647 SOD1
ALS
ALS1
IPOA
SOD
hSod1
homodimer
superoxide dismutase 1, soluble (EC:1.15.1.1) Vitamin E inhibits the reaction [Epinephrine results in increased activity of SOD1 protein] decreases reaction
/ increases activity
protein 11163531
D004837 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Epinephrine results in increased activity of SOD2 protein] decreases reaction
/ increases activity
protein 11163531
D004837 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD2 protein] decreases reaction
/ increases activity
protein 11163531
D004837 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) Epinephrine results in increased activity of SOD2 protein increases activity
protein 11163531
D004837 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) Epinephrine results in increased expression of SOD2 mRNA increases expression
mRNA 11163531
D004837 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) Epinephrine results in increased expression of SOD2 protein increases expression
protein 11163531
D004837 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) Vitamin E inhibits the reaction [Epinephrine results in increased activity of SOD2 protein] decreases reaction
/ increases activity
protein 11163531
D004837 6818 SULT1A3
HAST
HAST3
M-PST
ST1A3/ST1A4
ST1A5
STM
TL-PST
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) SULT1A3 protein results in increased sulfation of Epinephrine increases sulfation
protein 11181495
D004837 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] decreases reaction
/ increases expression
protein 10588509

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (58)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#114500 Colorectal cancer; crc P18054
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#133239 Esophageal cancer P18054
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#607276 Resting heart rate, variation in P08588
#600852 Retinitis pigmentosa 17; rp17 P22748
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (55)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

171 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000138 D004837 Acidosis marker/mechanism
12113327
D000140 D004837 Acidosis, Lactic marker/mechanism
10925653
21037469
C538173 D004837 Acquired angioedema therapeutic
9839915
D058186 D004837 Acute Kidney Injury marker/mechanism
10726331
C538231 D004837 Adenocarcinoma of lung marker/mechanism
11079726
D000402 D004837 Airway Obstruction therapeutic
2233075
5075860
7723869
D000647 D004837 Amnesia therapeutic
3146778
D000707 D004837 Anaphylaxis therapeutic
8498731
9972775
11476468
12009227
12637407
15701770
16101941
16545221
17324313
17460744
19720784
20461973
20726206
D017542 D004837 Aneurysm, Ruptured marker/mechanism
17276843
D000787 D004837 Angina Pectoris marker/mechanism
4831651
6305298
16545221
D000799 D004837 Angioedema therapeutic
2115661
2224615
2233075
6476995
7596948
7723869
8380620
12637407
15811906
16684302
19767375
20726206
D000855 D004837 Anorexia marker/mechanism
14693591
D001008 D004837 Anxiety Disorders marker/mechanism
20580187
D001037 D004837 Aphasia marker/mechanism
12694015
D001044 D004837 Aphonia marker/mechanism
1343088
D001049 D004837 Apnea marker/mechanism
2331071
9067054
16953949
D001145 D004837 Arrhythmias, Cardiac marker/mechanism
therapeutic
4374
11153
22416
26160
32416
44072
148958
267751
442092
1111370
1137214
1166019
1190523
1279757
1389726
1444808
1528399
1654493
1657110
1700207
1820795
1952212
1973400
2276376
2331071
2435991
2488108
2559225
2600984
2616376
2656435
2804303
2865913
2883336
3116219
3210450
3404765
3404766
3412108
3421530
3507173
3575170
3720934
3723662
3782641
3820057
3985403
4021230
4039173
4103275
4155971
4380269
4405591
4456972
4766548
5458951
5534722
5902176
5956508
5961927
6009329
6124437
6175804
6181341
6199593
6268223
6623464
6827775
7091750
7270949
7359351
7486159
7486186
7509903
7511357
7527511
7594047
7762840
7802751
8383026
8449229
8490741
8606522
8732285
8846823
9162281
9503426
9689277
9730012
9846537
9846808
10367104
10391611
10856454
10874433
11182823
11214945
11346256
11558437
13662871
13662872
13886756
14988739
15015382
15215648
15237306
15381053
15571863
16160611
16301242
16995444
17806129
18084319
19108278
19306642
19447527
20360617
21037469
21419149
D001146 D004837 Arrhythmia, Sinus marker/mechanism
3359591
D018771 D004837 Arthralgia marker/mechanism
14693591
D001249 D004837 Asthma therapeutic
1572199
6435488
6787217
7211775
7235434
16713785
17087335
D001259 D004837 Ataxia therapeutic
18239784
D050197 D004837 Atherosclerosis marker/mechanism
413557
D001281 D004837 Atrial Fibrillation marker/mechanism
9698967
9772688
11938053
17073912
18144976
19098677
D054537 D004837 Atrioventricular Block marker/mechanism
therapeutic
1444808
10407528
D001416 D004837 Back Pain marker/mechanism
2528307
D001763 D004837 Blepharoptosis marker/mechanism
3395920
D016063 D004837 Blood Loss, Surgical therapeutic
1992259
3813644
D001919 D004837 Bradycardia marker/mechanism
therapeutic
24541
32359
155993
238228
755652
1451572
1953698
2576930
2894433
2910169
4401590
4945727
6105186
6350720
6527735
6621821
6813757
7131940
7391987
9366485
10407528
12873958
16803915
16953949
17494292
D002545 D004837 Brain Ischemia marker/mechanism
8099768
D020526 D004837 Brain Stem Infarctions marker/mechanism
10740180
D001986 D004837 Bronchial Spasm therapeutic
6476995
12637407
D001988 D004837 Bronchiolitis therapeutic
10390295
D010244 D004837 Bulbar Palsy, Progressive marker/mechanism
9172033
D002303 D004837 Cardiac Output, Low therapeutic
1678896
D009202 D004837 Cardiomyopathies marker/mechanism
therapeutic
515509
1990800
2361559
2364137
3196846
4757791
4762517
5491673
5989680
6636192
7226176
7936836
8392553
10691253
17460744
18987407
19120537
D002311 D004837 Cardiomyopathy, Dilated marker/mechanism
1389744
D016893 D004837 Carotid Stenosis marker/mechanism
16545221
D002543 D004837 Cerebral Hemorrhage marker/mechanism
2772511
10778580
15925872
D002544 D004837 Cerebral Infarction marker/mechanism
15625276
D002637 D004837 Chest Pain marker/mechanism
2757714
10217970
16713785
17324313
D019970 D004837 Cocaine-Related Disorders marker/mechanism
11750770
D003085 D004837 Colic marker/mechanism
15478394
D000013 D004837 Congenital Abnormalities marker/mechanism
1326132
D003324 D004837 Coronary Artery Disease marker/mechanism
therapeutic
4831651
20517968
D003328 D004837 Coronary Thrombosis marker/mechanism
6363581
D003329 D004837 Coronary Vasospasm marker/mechanism
2757714
7795130
19329720
20338114
20517969
D003371 D004837 Cough marker/mechanism
5075860
D003440 D004837 Croup therapeutic
10390295
D003556 D004837 Cystitis therapeutic
16527596
17392493
D003645 D004837 Death, Sudden marker/mechanism
571916
571917
2551060
6731915
8953972
D016757 D004837 Death, Sudden, Cardiac marker/mechanism
10819411
19261400
D004172 D004837 Diplopia marker/mechanism
15623733
D004211 D004837 Disseminated Intravascular Coagulation marker/mechanism
1894189
D004244 D004837 Dizziness marker/mechanism
therapeutic
11782332
15478394
D004342 D004837 Drug Hypersensitivity marker/mechanism
therapeutic
1138682
3462233
20461973
D062787 D004837 Drug Overdose therapeutic
12101159
D064420 D004837 Drug-Related Side Effects and Adverse Reactions marker/mechanism
21864640
D004387 D004837 Dupuytren Contracture therapeutic
9698967
D004401 D004837 Dysarthria marker/mechanism
19098677
D004417 D004837 Dyspnea marker/mechanism
therapeutic
81404
2629043
7596948
16545221
17276843
20726206
D004487 D004837 Edema marker/mechanism
therapeutic
11217590
16527596
17392493
19212002
D004827 D004837 Epilepsy therapeutic
821787
D004830 D004837 Epilepsy, Tonic-Clonic marker/mechanism
3132066
3752473
17276843
D005119 D004837 Extravasation of Diagnostic and Therapeutic Materials marker/mechanism
7238673
D015673 D004837 Fatigue Syndrome, Chronic marker/mechanism
10690878
D005512 D004837 Food Hypersensitivity therapeutic
18320924
D006471 D004837 Gastrointestinal Hemorrhage therapeutic
11938053
D005891 D004837 Gingivitis marker/mechanism
11217590
D005901 D004837 Glaucoma therapeutic
352088
D005902 D004837 Glaucoma, Open-Angle therapeutic
5646032
D006261 D004837 Headache marker/mechanism
2629043
5075860
7211775
11217590
17276843
20580187
D034381 D004837 Hearing Loss marker/mechanism
7880714
D006319 D004837 Hearing Loss, Sensorineural marker/mechanism
8579132
D006323 D004837 Heart Arrest marker/mechanism
therapeutic
1145841
2331071
6829949
7586280
8953972
10740180
11524350
15965562
16175059
17907030
18594552
18652106
19779368
19849674
20502771
D006327 D004837 Heart Block therapeutic
16506357
D006331 D004837 Heart Diseases marker/mechanism
597604
872969
983936
6682658
D006333 D004837 Heart Failure marker/mechanism
3813644
19464573
D006470 D004837 Hemorrhage marker/mechanism
therapeutic
16196187
17392493
19300450
D006732 D004837 Horner Syndrome marker/mechanism
10886715
D006930 D004837 Hyperalgesia marker/mechanism
therapeutic
11454025
12582831
14984413
15836982
16026475
16259764
16472913
18509033
20601862
D006934 D004837 Hypercalcemia marker/mechanism
7068199
D006940 D004837 Hyperemia marker/mechanism
1138682
2502780
5646032
D006943 D004837 Hyperglycemia marker/mechanism
1032269
2989959
8097719
10925653
22305719
D006945 D004837 Hyperhidrosis marker/mechanism
2757714
D006947 D004837 Hyperkalemia marker/mechanism
1032269
D006967 D004837 Hypersensitivity therapeutic
8953972
D006973 D004837 Hypertension marker/mechanism
43064
43065
755652
991929
1033105
1513750
1953698
2042788
2468958
2572185
2629043
2772511
2801151
2886572
2904523
2910169
2982537
3113166
3144597
3241254
3391446
4012388
5159427
6111172
6138461
6160347
6167799
6204165
6367368
6866430
7131940
7238673
7318322
7376807
7783978
7802751
7915249
8109997
8163143
8467547
8577804
8579132
8644093
8744119
8816361
9172033
9230324
9698967
9753960
10678130
10876433
10957659
11069044
11214945
11529687
11773822
12487093
14561528
14762759
15195355
15204054
15401091
15478394
17276843
17530270
18566202
19098677
19261400
19553172
19843802
19944906
20338114
20580187
20850911
D007008 D004837 Hypokalemia marker/mechanism
1032269
2468922
2600984
2863970
2885202
2893535
2905711
3010693
3320735
3402518
3545273
3632961
5013151
6134137
6143631
6314140
6861446
16164400
D007022 D004837 Hypotension marker/mechanism
therapeutic
24541
32359
755652
1148075
1343088
1797333
1801390
1897763
1934231
2402817
3662059
3786753
6117801
6481092
6542785
6691577
6740701
6756847
7802751
7917752
8329264
8542857
8816361
8881630
9105223
9645186
9666621
9689277
10407528
11133597
11234604
11476468
12113327
12637407
12703073
12859315
12873958
15055890
15689764
15995439
16188828
16223392
16713785
16803915
16959188
17198098
17460744
17711731
17893579
18320924
18399341
19049484
19470294
19485883
20580187
D007249 D004837 Inflammation therapeutic
16527596
17392493
D007299 D004837 Insect Bites and Stings therapeutic
20455042
D007431 D004837 Intraoperative Complications therapeutic
10407528
11234604
D007511 D004837 Ischemia marker/mechanism
2757714
2764457
10219148
12637407
D048949 D004837 Labor Pain therapeutic
9840847
11412732
15055890
D007819 D004837 Laryngeal Edema therapeutic
12637407
D007964 D004837 Leukocytosis marker/mechanism
3275734
D008133 D004837 Long QT Syndrome marker/mechanism
2905711
3010693
6861446
12766260
D008269 D004837 Macular Edema marker/mechanism
5646032
D008275 D004837 Magnesium Deficiency marker/mechanism
3402518
D009127 D004837 Muscle Rigidity marker/mechanism
8311329
D009135 D004837 Muscular Diseases marker/mechanism
6953098
D009203 D004837 Myocardial Infarction marker/mechanism
590420
624319
991929
1849082
2940853
4163310
8498731
9817002
10390295
11773822
16545221
17324313
19476257
D017202 D004837 Myocardial Ischemia marker/mechanism
1389726
3413271
3585303
6402132
10526815
15242440
15670093
16196187
D017682 D004837 Myocardial Stunning marker/mechanism
15188772
17087335
D009205 D004837 Myocarditis marker/mechanism
1138504
1926593
2174588
2541833
3000039
4130881
4199231
4398573
4788489
7256931
11140574
12924018
D009325 D004837 Nausea marker/mechanism
2629043
2757714
10490152
15055890
D009336 D004837 Necrosis marker/mechanism
2764457
6577117
6953098
18658020
21983523
D009422 D004837 Nervous System Diseases marker/mechanism
18633557
D009503 D004837 Neutropenia marker/mechanism
1329250
D009798 D004837 Ocular Hypertension therapeutic
32733
D018917 D004837 Optic Neuropathy, Ischemic marker/mechanism
2141858
D010146 D004837 Pain marker/mechanism
therapeutic
1218181
8034840
9718249
D010149 D004837 Pain, Postoperative marker/mechanism
therapeutic
1148075
8087910
8457049
8484525
9620513
10853568
17006078
D010167 D004837 Pallor marker/mechanism
20580187
D016584 D004837 Panic Disorder marker/mechanism
10094243
D010243 D004837 Paralysis marker/mechanism
2551060
3395920
3660330
9067054
12205962
12420277
14761666
16384677
17709257
D010292 D004837 Paresthesia marker/mechanism
11217590
D010673 D004837 Pheochromocytoma marker/mechanism
2217678
5919361
D011183 D004837 Postoperative Complications marker/mechanism
3395920
D020250 D004837 Postoperative Nausea and Vomiting marker/mechanism
8087910
9620513
D011297 D004837 Prenatal Exposure Delayed Effects marker/mechanism
3988167
D011317 D004837 Priapism therapeutic
2327828
18996674
D011537 D004837 Pruritus marker/mechanism
therapeutic
2629043
8087910
9620513
11476468
12694015
15055890
D011595 D004837 Psychomotor Agitation marker/mechanism
7211775
D029424 D004837 Pulmonary Disease, Chronic Obstructive therapeutic
234363
D011654 D004837 Pulmonary Edema marker/mechanism
4381193
6268223
7802751
8644093
9172033
9230324
9645186
14762759
16175059
16196187
19300450
D011655 D004837 Pulmonary Embolism marker/mechanism
1329250
2510358
7740511
8236159
9772649
14761666
15130911
15735806
16626787
17632098
18344422
19028587
D012019 D004837 Reflex Sympathetic Dystrophy therapeutic
8484525
D051437 D004837 Renal Insufficiency marker/mechanism
4012388
7232404
11910412
D015427 D004837 Reperfusion Injury marker/mechanism
19135123
19464573
D012120 D004837 Respiration Disorders therapeutic
11476468
D012131 D004837 Respiratory Insufficiency marker/mechanism
3422794
8425252
9620513
D012133 D004837 Respiratory Paralysis marker/mechanism
945016
1343088
D012135 D004837 Respiratory Sounds therapeutic
2629043
D015356 D004837 Retinal Artery Occlusion marker/mechanism
2141858
11130745
D012164 D004837 Retinal Diseases marker/mechanism
19682625
D012206 D004837 Rhabdomyolysis marker/mechanism
10726331
16164400
D012607 D004837 Scotoma marker/mechanism
2629043
19682625
D012640 D004837 Seizures marker/mechanism
therapeutic
2735539
6465582
7137613
8467547
10642045
16783089
17065893
D012769 D004837 Shock marker/mechanism
therapeutic
10570779
14122464
20580187
D012770 D004837 Shock, Cardiogenic therapeutic
21037469
D012892 D004837 Sleep Deprivation marker/mechanism
9620513
D013159 D004837 Splenic Infarction marker/mechanism
18991218
D013224 D004837 Status Asthmaticus therapeutic
19204641
D013276 D004837 Stomach Ulcer therapeutic
17372719
D013345 D004837 Subarachnoid Hemorrhage marker/mechanism
8953972
17276843
D013575 D004837 Syncope marker/mechanism
6388325
11469429
D019462 D004837 Syncope, Vasovagal marker/mechanism
16634720
D013610 D004837 Tachycardia marker/mechanism
755652
1797333
2417535
3689617
4012388
6018752
6314140
8561329
9645186
9846537
11863154
14256809
15478394
15670093
19098677
20580187
D013616 D004837 Tachycardia, Sinus marker/mechanism
51600
10526815
10707131
14762759
20406625
D013617 D004837 Tachycardia, Supraventricular marker/mechanism
862294
8291402
11767035
12010770
18594552
D017180 D004837 Tachycardia, Ventricular marker/mechanism
51600
2589679
2629043
3786753
4738201
5494279
6193348
6465582
6519768
8163143
8238988
8659767
8739209
9753960
10328182
10390295
10756546
10876433
11790077
12637407
13212649
14115535
16713785
19949624
20502771
20944434
D054549 D004837 Takotsubo Cardiomyopathy marker/mechanism
17087335
19204641
19300450
19358948
19584984
19720784
20455042
D013921 D004837 Thrombocytopenia marker/mechanism
1329250
2510358
D013923 D004837 Thromboembolism marker/mechanism
1475529
2704033
7495106
9296496
11175853
16009717
16564713
17047157
19808248
D013927 D004837 Thrombosis marker/mechanism
2751146
3660330
8794522
9263395
10193204
10404545
12205962
16384677
17482796
17709257
D014012 D004837 Tinnitus marker/mechanism
8579132
D016171 D004837 Torsades de Pointes marker/mechanism
1550292
10819411
D014202 D004837 Tremor marker/mechanism
12694015
D014456 D004837 Ulcer therapeutic
18991218
D014474 D004837 Unconsciousness marker/mechanism
17276843
D016055 D004837 Urinary Retention marker/mechanism
9031957
D014581 D004837 Urticaria therapeutic
81404
11476468
20726206
D014652 D004837 Vascular Diseases marker/mechanism
6463964
D018754 D004837 Ventricular Dysfunction marker/mechanism
12010770
D018487 D004837 Ventricular Dysfunction, Left marker/mechanism
15242440
D014693 D004837 Ventricular Fibrillation marker/mechanism
51600
95312
549440
1032389
1172400
1518666
1654493
2766111
4197360
4397376
4738201
6103072
6731915
7527510
10367104
10440086
11133597
18594552
18858160
D018879 D004837 Ventricular Premature Complexes marker/mechanism
4185489
7519951
D014786 D004837 Vision Disorders marker/mechanism
5646032
D015354 D004837 Vision, Low marker/mechanism
2629043
D014839 D004837 Vomiting marker/mechanism
2629043