PCIDB

KCF-S cluster No. 3197 (3 metabolites)

Plant Species

Cumulative plant class count

class name count
rosids 6
asterids 3
Liliopsida 1
eudicotyledons 1

Cumulative family count

class name count
Fabaceae 5
Solanaceae 2
Passifloraceae 1
Musaceae 1
Portulacaceae 1
Plantaginaceae 1

KEGG BRITE br08003 External link 512

Categories (0)

br08003 Category # of metabolite

metabolites link (0)

br08003 Category KEGG ID KNApSAcK ID

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		figure
C00001424 External link 512 Norepinephrine
/ L-Noradrenaline
/ (-)-Norepinephrine
CHEMBL432
CHEMBL18824
CHEMBL1437
CHEMBL2311152
D009638
50 / 33 / 35 36 / 90
C00029643 External link 512 Adrenalin
CHEMBL679
CHEMBL42280
CHEMBL227634
CHEMBL1740
D004837
126 / 58 / 55 34 / 171
C00037562 External link 512 Normetanephrine
CHEMBL774
CHEMBL1559460
D009647
8 / 2 / 3 1 / 2

Human Protein / Gene in interactions

146 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001424 C00029643 C00037562 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001424 C00029643 C00037562 0 / 1
P35372 Mu-type opioid receptor Opioid receptor C00001424 C00029643 0 / 0
O00255 Menin Unclassified protein C00001424 C00029643 2 / 5
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001424 C00029643 1 / 1
P21728 D(1A) dopamine receptor Dopamine receptor C00001424 C00029643 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00029643 C00037562 1 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001424 C00029643 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001424 C00029643 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001424 C00029643 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00001424 C00029643 0 / 0
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00001424 C00029643 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00001424 C00029643 1 / 1
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001424 C00029643 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001424 C00029643 4 / 3
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001424 C00029643 0 / 0
Q01196 Runt-related transcription factor 1 Unclassified protein C00001424 C00029643 1 / 4
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00029643 C00037562 1 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00001424 C00029643 0 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001424 C00029643 0 / 0
O15245 Solute carrier family 22 member 1 Drug uniporter C00029643 C00037562 0 / 0
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00001424 C00029643 1 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00029643 C00037562 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00001424 C00029643 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001424 C00029643 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001424 C00029643 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00001424 C00029643 0 / 1
P35348 Alpha-1A adrenergic receptor Adrenergic receptor C00001424 C00029643 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00001424 C00029643 0 / 0
P39748 Flap endonuclease 1 Enzyme C00001424 C00029643 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00001424 C00029643 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00001424 C00029643 2 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00001424 C00029643 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00001424 C00029643 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00001424 C00029643 2 / 3
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00029643 C00037562 0 / 1
P22303 Acetylcholinesterase Hydrolase C00029643 1 / 0
P06241 Tyrosine-protein kinase Fyn Src C00029643 0 / 0
P14920 D-amino-acid oxidase Enzyme C00001424 0 / 0
P54132 Bloom syndrome protein Enzyme C00001424 1 / 2
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001424 1 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00029643 1 / 8
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00029643 0 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00029643 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00029643 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00029643 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00029643 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00029643 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00029643 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00029643 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00029643 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00029643 1 / 1
Q01959 Sodium-dependent dopamine transporter Dopamine C00029643 1 / 0
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00029643 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00029643 1 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00029643 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00029643 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00029643 1 / 2
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00029643 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00029643 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00029643 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00001424 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00029643 0 / 0
P25021 Histamine H2 receptor Histamine receptor C00029643 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00029643 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00029643 0 / 0
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00029643 1 / 1
P35462 D(3) dopamine receptor Dopamine receptor C00029643 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00029643 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00029643 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00029643 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00029643 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00029643 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00029643 1 / 0
P00915 Carbonic anhydrase 1 Lyase C00029643 0 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00029643 0 / 0
P08311 Cathepsin G S1A C00029643 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00029643 1 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00001424 0 / 0
P03956 Interstitial collagenase M10A C00029643 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00029643 0 / 0
Q9GZT4 Serine racemase Enzyme C00001424 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00029643 1 / 2
P83916 Chromobox protein homolog 1 Unclassified protein C00001424 0 / 0
P50224 Sulfotransferase 1A3/1A4 Enzyme C00001424 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00001424 3 / 1
P04150 Glucocorticoid receptor NR3C1 C00029643 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00029643 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00029643 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00029643 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00029643 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00029643 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00029643 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00029643 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00029643 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00029643 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00029643 0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00029643 2 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00029643 1 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00029643 3 / 2
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00029643 2 / 1
P02545 Prelamin-A/C Unclassified protein C00001424 11 / 10
Q16790 Carbonic anhydrase 9 Lyase C00029643 0 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00029643 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001424 2 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001424 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00029643 0 / 0
P03372 Estrogen receptor NR3A1 C00029643 1 / 1
Q99489 D-aspartate oxidase Enzyme C00001424 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00029643 0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00029643 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00029643 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00029643 2 / 2
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00029643 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00029643 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00029643 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00029643 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00037562 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00029643 0 / 0
P17252 Protein kinase C alpha type Alpha C00029643 0 / 0
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00029643 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00001424 0 / 0
P29466 Caspase-1 C14 C00029643 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00029643 0 / 0
Q99549 M-phase phosphoprotein 8 Unclassified protein C00029643 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00029643 0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00029643 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00029643 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00029643 0 / 0
P35368 Alpha-1B adrenergic receptor Adrenergic receptor C00001424 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00029643 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00029643 1 / 1
P07451 Carbonic anhydrase 3 Lyase C00029643 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00029643 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00029643 0 / 0
P22748 Carbonic anhydrase 4 Lyase C00029643 1 / 1
P33765 Adenosine receptor A3 Adenosine receptor C00029643 0 / 0
P08246 Neutrophil elastase S1A C00029643 2 / 1
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00029643 2 / 2
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00029643 0 / 3
Q99700 Ataxin-2 Unclassified protein C00029643 1 / 1
O15244 Solute carrier family 22 member 2 Drug uniporter C00001424 0 / 0
Q9Y2I1 Nischarin Other cytosolic protein C00001424 0 / 0
P42345 Serine/threonine-protein kinase mTOR Enzyme C00029643 0 / 0
O75751 Solute carrier family 22 member 3 Unclassified protein C00001424 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001424 0 / 0

55 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
6818 SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) C00001424 C00029643 C00037562
154 ADRB2, ADRB2R, ADRBR, B2AR, BAR, BETA2AR adrenoceptor beta 2, surface C00001424 C00029643
146 ADRA1D, ADRA1, ADRA1A, ADRA1R, ALPHA1, DAR, dJ779E11.2 adrenoceptor alpha 1D C00001424 C00029643
150 ADRA2A, ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32 adrenoceptor alpha 2A C00001424 C00029643
151 ADRA2B, ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, alpha-2BAR adrenoceptor alpha 2B C00001424 C00029643
152 ADRA2C, ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR adrenoceptor alpha 2C C00001424 C00029643
153 ADRB1, ADRB1R, B1AR, BETA1AR, RHR adrenoceptor beta 1 C00001424 C00029643
147 ADRA1B, ADRA1, ALPHA1BAR adrenoceptor alpha 1B C00001424 C00029643
155 ADRB3, BETA3AR adrenoceptor beta 3 C00001424 C00029643
148 ADRA1A, ADRA1C, ADRA1L1, ALPHA1AAR adrenoceptor alpha 1A C00001424 C00029643
1312 COMT catechol-O-methyltransferase (EC:2.1.1.6) C00001424 C00029643
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00001424 C00029643
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00001424 C00029643
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00001424 C00029643
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00001424 C00029643
1513 CTSK, CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD cathepsin K (EC:3.4.22.38) C00029643
355 FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 Fas cell surface death receptor C00029643
356 FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 Fas ligand (TNF superfamily, member 6) C00029643
2869 GRK5, GPRK5 G protein-coupled receptor kinase 5 (EC:2.7.11.16) C00029643
3586 IL10, CSIF, GVHDS, IL-10, IL10A, TGIF interleukin 10 C00029643
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00029643
1139 CHRNA7, CHRNA7-2, NACHRA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) C00029643
3630 INS, IDDM2, ILPR, IRDN, MODY10 insulin C00029643
3673 ITGA2, BR, CD49B, GPIa, HPA-5, VLA-2, VLAA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) C00029643
3685 ITGAV, CD51, MSK8, VNRA, VTNR integrin, alpha V C00029643
3991 LIPE, HSL, LHS lipase, hormone-sensitive (EC:3.1.1.79) C00029643
6348 CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 chemokine (C-C motif) ligand 3 C00029643
760 CA2, CA-II, CAC, CAII, Car2 carbonic anhydrase II (EC:4.2.1.1) C00029643
5027 P2RX7, P2X7 purinergic receptor P2X, ligand-gated ion channel, 7 C00029643
5972 REN, HNFJ2 renin (EC:3.4.23.15) C00029643
6647 SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer superoxide dismutase 1, soluble (EC:1.15.1.1) C00029643
6648 SOD2, IPOB, MNSOD, MVCD6 superoxide dismutase 2, mitochondrial (EC:1.15.1.1) C00029643
156 ADRBK1, BARK1, BETA-ARK1, GRK2 adrenergic, beta, receptor kinase 1 (EC:2.7.11.15) C00029643
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00029643
840 CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) C00001424
6352 CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP chemokine (C-C motif) ligand 5 C00001424
1813 DRD2, D2DR, D2R dopamine receptor D2 C00001424
2335 FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF fibronectin 1 C00001424
2778 GNAS, AHO, C20orf45, GNAS1, GPSA, GSA, GSP, NESP, PHP1A, PHP1B, PHP1C, POH GNAS complex locus C00001424
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00001424
4128 MAOA, MAO-A monoamine oxidase A (EC:1.4.3.4) C00001424
4790 NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 C00001424
4879 NPPB, BNP natriuretic peptide B C00001424
4852 NPY, PYY4 neuropeptide Y C00001424
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00001424
6279 S100A8, 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8 S100 calcium binding protein A8 C00001424
6280 S100A9, 60B8AG, CAGB, CFAG, CGLB, L1AG, LIAG, MAC387, MIF, MRP14, NIF, P14 S100 calcium binding protein A9 C00001424
6285 S100B, NEF, S100, S100-B, S100beta S100 calcium binding protein B C00001424
6570 SLC18A1, CGAT, VAT1, VMAT1 solute carrier family 18 (vesicular monoamine transporter), member 1 C00001424
6571 SLC18A2, SVAT, SVMT, VAT2, VMAT2 solute carrier family 18 (vesicular monoamine transporter), member 2 C00001424
6530 SLC6A2, NAT1, NET, NET1, SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 2 C00001424
6531 SLC6A3, DAT, DAT1, PKDYS solute carrier family 6 (neurotransmitter transporter), member 3 C00001424
6532 SLC6A4, 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT solute carrier family 6 (neurotransmitter transporter), member 4 C00001424
134864 TAAR1, RP11-295F4.9, TA1, TAR1, TRAR1 trace amine associated receptor 1 C00001424
7391 USF1, FCHL, FCHL1, HYPLIP1, MLTF, MLTFI, UEF, bHLHb11 upstream transcription factor 1 C00001424

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (76)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#210900 Bloom syndrome; blm P54132
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P18054
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P18054
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#600852 Retinitis pigmentosa 17; rp17 P22748
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (70)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

213 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006973 Hypertension C00029643
C00001424
C00037562
D010146 Pain C00029643
C00001424
D018487 Ventricular Dysfunction, Left C00029643
C00001424
D018754 Ventricular Dysfunction C00029643
C00001424
D017180 Tachycardia, Ventricular C00029643
C00001424
D013616 Tachycardia, Sinus C00029643
C00001424
D000647 Amnesia C00029643
C00001424
D013610 Tachycardia C00029643
C00001424
D017542 Aneurysm, Ruptured C00029643
C00001424
D013345 Subarachnoid Hemorrhage C00029643
C00001424
D012770 Shock, Cardiogenic C00029643
C00001424
D012769 Shock C00029643
C00001424
D001008 Anxiety Disorders C00029643
C00001424
D012640 Seizures C00029643
C00001424
D012206 Rhabdomyolysis C00029643
C00001424
D012164 Retinal Diseases C00029643
C00001424
D001145 Arrhythmias, Cardiac C00029643
C00001424
D012131 Respiratory Insufficiency C00029643
C00001424
D012120 Respiration Disorders C00029643
C00001424
D051437 Renal Insufficiency C00029643
C00001424
D029424 Pulmonary Disease, Chronic Obstructive C00029643
C00001424
D011297 Prenatal Exposure Delayed Effects C00029643
C00001424
D011183 Postoperative Complications C00029643
C00001424
D010243 Paralysis C00029643
C00001424
D014693 Ventricular Fibrillation C00029643
C00001424
D009798 Ocular Hypertension C00029643
C00001424
D009336 Necrosis C00029643
C00001424
D001919 Bradycardia C00029643
C00001424
D002545 Brain Ischemia C00029643
C00001424
D017202 Myocardial Ischemia C00029643
C00001424
D009203 Myocardial Infarction C00029643
C00001424
D007511 Ischemia C00029643
C00001424
D007022 Hypotension C00029643
C00001424
D002303 Cardiac Output, Low C00029643
C00001424
D009202 Cardiomyopathies C00029643
C00001424
D007008 Hypokalemia C00029643
C00001424
D058186 Acute Kidney Injury C00029643
C00001424
D002543 Cerebral Hemorrhage C00029643
C00001424
D006940 Hyperemia C00029643
C00001424
D006934 Hypercalcemia C00029643
C00037562
D019970 Cocaine-Related Disorders C00029643
C00001424
D006930 Hyperalgesia C00029643
C00001424
D006470 Hemorrhage C00029643
C00001424
D006333 Heart Failure C00029643
C00001424
D006331 Heart Diseases C00029643
C00001424
D006323 Heart Arrest C00029643
C00001424
D006261 Headache C00029643
C00001424
D005901 Glaucoma C00029643
C00001424
D004827 Epilepsy C00029643
C00001424
D005921 Glomerulonephritis C00001424
D016757 Death, Sudden, Cardiac C00029643
D004172 Diplopia C00029643
D004211 Disseminated Intravascular Coagulation C00029643
D004244 Dizziness C00029643
D004342 Drug Hypersensitivity C00029643
D062787 Drug Overdose C00029643
D064420 Drug-Related Side Effects and Adverse Reactions C00029643
D004387 Dupuytren Contracture C00029643
D004401 Dysarthria C00029643
D004417 Dyspnea C00029643
D004487 Edema C00029643
D003556 Cystitis C00029643
D004830 Epilepsy, Tonic-Clonic C00029643
D005119 Extravasation of Diagnostic and Therapeutic Materials C00029643
D015673 Fatigue Syndrome, Chronic C00029643
D005512 Food Hypersensitivity C00029643
D006471 Gastrointestinal Hemorrhage C00029643
D005891 Gingivitis C00029643
D003440 Croup C00029643
D005902 Glaucoma, Open-Angle C00029643
D003371 Cough C00029643
D034381 Hearing Loss C00029643
D006319 Hearing Loss, Sensorineural C00029643
D003329 Coronary Vasospasm C00029643
D006327 Heart Block C00029643
D003328 Coronary Thrombosis C00029643
D003324 Coronary Artery Disease C00029643
D000013 Congenital Abnormalities C00029643
D006732 Horner Syndrome C00029643
D003085 Colic C00029643
D002637 Chest Pain C00029643
D002544 Cerebral Infarction C00029643
D006943 Hyperglycemia C00029643
D006945 Hyperhidrosis C00029643
D006947 Hyperkalemia C00029643
D006967 Hypersensitivity C00029643
D016893 Carotid Stenosis C00029643
D002311 Cardiomyopathy, Dilated C00029643
D010244 Bulbar Palsy, Progressive C00029643
D007249 Inflammation C00029643
D007299 Insect Bites and Stings C00029643
D007431 Intraoperative Complications C00029643
D001988 Bronchiolitis C00029643
D048949 Labor Pain C00029643
D007819 Laryngeal Edema C00029643
D007964 Leukocytosis C00029643
D008133 Long QT Syndrome C00029643
D008269 Macular Edema C00029643
D008275 Magnesium Deficiency C00029643
D009127 Muscle Rigidity C00029643
D009135 Muscular Diseases C00029643
D001986 Bronchial Spasm C00029643
D020526 Brain Stem Infarctions C00029643
D017682 Myocardial Stunning C00029643
D009205 Myocarditis C00029643
D009325 Nausea C00029643
D016063 Blood Loss, Surgical C00029643
D009422 Nervous System Diseases C00029643
D009503 Neutropenia C00029643
D001763 Blepharoptosis C00029643
D018917 Optic Neuropathy, Ischemic C00029643
D001416 Back Pain C00029643
D010149 Pain, Postoperative C00029643
D010167 Pallor C00029643
D016584 Panic Disorder C00029643
D054537 Atrioventricular Block C00029643
D010292 Paresthesia C00029643
D010673 Pheochromocytoma C00029643
D001281 Atrial Fibrillation C00029643
D020250 Postoperative Nausea and Vomiting C00029643
D050197 Atherosclerosis C00029643
D011317 Priapism C00029643
D011537 Pruritus C00029643
D011595 Psychomotor Agitation C00029643
D001259 Ataxia C00029643
D011654 Pulmonary Edema C00029643
D011655 Pulmonary Embolism C00029643
D012019 Reflex Sympathetic Dystrophy C00029643
D001249 Asthma C00029643
D015427 Reperfusion Injury C00029643
D018771 Arthralgia C00029643
D001146 Arrhythmia, Sinus C00029643
D012133 Respiratory Paralysis C00029643
D012135 Respiratory Sounds C00029643
D015356 Retinal Artery Occlusion C00029643
D001049 Apnea C00029643
D001044 Aphonia C00029643
D012607 Scotoma C00029643
D001037 Aphasia C00029643
D000855 Anorexia C00029643
D000799 Angioedema C00029643
D012892 Sleep Deprivation C00029643
D013159 Splenic Infarction C00029643
D013224 Status Asthmaticus C00029643
D013276 Stomach Ulcer C00029643
D000787 Angina Pectoris C00029643
D013575 Syncope C00029643
D019462 Syncope, Vasovagal C00029643
D000707 Anaphylaxis C00029643
D000402 Airway Obstruction C00029643
D013617 Tachycardia, Supraventricular C00029643
C538231 Adenocarcinoma of lung C00029643
D054549 Takotsubo Cardiomyopathy C00029643
D013921 Thrombocytopenia C00029643
D013923 Thromboembolism C00029643
D013927 Thrombosis C00029643
D014012 Tinnitus C00029643
D016171 Torsades de Pointes C00029643
D014202 Tremor C00029643
D014456 Ulcer C00029643
D014474 Unconsciousness C00029643
D016055 Urinary Retention C00029643
D014581 Urticaria C00029643
D014652 Vascular Diseases C00029643
D000138 Acidosis C00029643
C538173 Acquired angioedema C00029643
D000140 Acidosis, Lactic C00029643
D018879 Ventricular Premature Complexes C00029643
D014786 Vision Disorders C00029643
D015354 Vision, Low C00029643
D014839 Vomiting C00029643
D019969 Amphetamine-Related Disorders C00001424
D000860 Anoxia C00001424
D001002 Anuria C00001424
D001237 Asphyxia C00001424
D001321 Autistic Disorder C00001424
D001766 Blindness C00001424
D002037 Bundle-Branch Block C00001424
D002100 Cachexia C00001424
D006332 Cardiomegaly C00001424
D002375 Catalepsy C00001424
D003922 Diabetes Mellitus, Type 1 C00001424
D004409 Dyskinesia, Drug-Induced C00001424
D004421 Dystonia C00001424
D003645 Death, Sudden C00029643
D005923 Glomerulosclerosis, Focal Segmental C00001424
D006935 Hypercapnia C00001424
D006974 Hypertension, Malignant C00001424
D006976 Hypertension, Pulmonary C00001424
D006984 Hypertrophy C00001424
D017379 Hypertrophy, Left Ventricular C00001424
D007024 Hypotension, Orthostatic C00001424
D007035 Hypothermia C00001424
D007674 Kidney Diseases C00001424
D008113 Liver Neoplasms C00001424
D008114 Liver Neoplasms, Experimental C00001424
D015428 Myocardial Reperfusion Injury C00001424
D009410 Nerve Degeneration C00001424
D009846 Oliguria C00001424
D009901 Optic Nerve Diseases C00001424
D010554 Personality Disorders C00001424
D011249 Pregnancy Complications, Cardiovascular C00001424
D011507 Proteinuria C00001424
D011605 Psychoses, Substance-Induced C00001424
D018805 Sepsis C00001424
D012771 Shock, Hemorrhagic C00001424
D012772 Shock, Septic C00001424
D013035 Spasm C00001424
D013226 Status Epilepticus C00001424
D013274 Stomach Neoplasms C00001424
D013375 Substance Withdrawal Syndrome C00001424
D014511 Uremia C00001424
D056987 Vasoplegia C00001424