KNApSAcK Metabolite C00029828
Metabolite
KNApSAcK Entry
| id | C00029828 |
|---|---|
| Name | Bilirubin / (Z,Z)-Bilirubin |
| CAS RN | 635-65-4 |
| Standard InChI | InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14- |
| Standard InChI (Main Layer) | InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 6732 |
Link
ChEMBL
| By standard InChI | CHEMBL501680 |
|---|---|
| By standard InChI Main Layer | CHEMBL501680 |
KEGG
| By LinkDB | C00486 |
|---|
CTD
| By CAS RN | D001663 |
|---|
Human Protein / Gene in interaction
22 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | CHEMBL501680 |
CHEMBL1908082
(1)
|
3 / 0 |
| O75795 | UDP-glucuronosyltransferase 2B17 | Enzyme | CHEMBL501680 |
CHEMBL1908091
(2)
|
1 / 0 |
| Q9Y6L6 | Solute carrier organic anion transporter family member 1B1 | Electrochemical transporter | CHEMBL501680 |
CHEMBL1743145
(1)
CHEMBL2076793
(1)
CHEMBL2077460 (1) CHEMBL2078132 (1) |
1 / 0 |
| P29466 | Caspase-1 | C14 | CHEMBL501680 |
CHEMBL1614158
(1)
|
0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | CHEMBL501680 |
CHEMBL1614544
(1)
|
11 / 10 |
| P16662 | UDP-glucuronosyltransferase 2B7 | Enzyme | CHEMBL501680 |
CHEMBL1908093
(3)
|
0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | CHEMBL501680 |
CHEMBL1794311
(1)
|
2 / 3 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL501680 |
CHEMBL1614458
(1)
|
0 / 0 |
| P46721 | Solute carrier organic anion transporter family member 1A2 | Unclassified protein | CHEMBL501680 |
CHEMBL2076559
(1)
|
0 / 0 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | CHEMBL501680 |
CHEMBL1908086
(4)
|
0 / 0 |
| Q9NPD5 | Solute carrier organic anion transporter family member 1B3 | Electrochemical transporter | CHEMBL501680 |
CHEMBL2075540
(1)
CHEMBL2076009
(1)
|
1 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | CHEMBL501680 |
CHEMBL1794467
(1)
|
0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | CHEMBL501680 |
CHEMBL1613910
(1)
|
3 / 3 |
| P55210 | Caspase-7 | C14 | CHEMBL501680 |
CHEMBL1613779
(1)
|
0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | CHEMBL501680 |
CHEMBL1743324
(1)
CHEMBL1908080
(2)
|
5 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | CHEMBL501680 |
CHEMBL1614250
(1)
CHEMBL1614421
(1)
CHEMBL1614502 (1) |
4 / 3 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | CHEMBL501680 |
CHEMBL1908083
(4)
|
0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | CHEMBL501680 |
CHEMBL1794536
(1)
|
0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | CHEMBL501680 |
CHEMBL1613914
(1)
|
0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | CHEMBL501680 |
CHEMBL1614364
(1)
|
1 / 1 |
| O00255 | Menin | Unclassified protein | CHEMBL501680 |
CHEMBL1614257
(1)
CHEMBL1614531
(1)
|
2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | CHEMBL501680 |
CHEMBL1614257
(1)
CHEMBL1614531
(1)
|
1 / 3 |
CTD interaction (198)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D001663 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | ABCC1 protein affects the transport of Bilirubin |
affects transport
|
protein |
15245331
|
| D001663 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Bilirubin] |
affects transport
/ increases reaction |
protein |
15245331
|
| D001663 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | Bilirubin inhibits the reaction [ABCC1 protein affects the transport of Leukotriene C4] |
affects transport
/ decreases reaction |
protein |
15245331
|
| D001663 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | Glutathione promotes the reaction [ABCC1 protein affects the transport of Bilirubin] |
affects transport
/ increases reaction |
protein |
15245331
|
| D001663 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | verlukast inhibits the reaction [ABCC1 protein affects the transport of Bilirubin] |
affects transport
/ decreases reaction |
protein |
15245331
|
| D001663 | 207 |
AKT1
AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA |
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | Bilirubin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein] |
decreases phosphorylation
/ decreases reaction |
protein |
18215737
|
| D001663 | 210 |
ALAD
ALADH PBGS |
aminolevulinate dehydratase (EC:4.2.1.24) | Bilirubin results in decreased expression of ALAD mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 301 |
ANXA1
ANX1 LPC1 |
annexin A1 | Bilirubin results in decreased expression of ANXA1 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 374 |
AREG
AR CRDGF SDGF |
amphiregulin | Bilirubin results in increased expression of AREG mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 9411 |
ARHGAP29
PARG1 RP11-255E17.1 |
Rho GTPase activating protein 29 | Bilirubin results in decreased expression of ARHGAP29 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 79754 |
ASB13
|
ankyrin repeat and SOCS box containing 13 | Bilirubin results in decreased expression of ASB13 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 467 |
ATF3
|
activating transcription factor 3 | Bilirubin results in increased expression of ATF3 mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 476 |
ATP1A1
|
ATPase, Na+/K+ transporting, alpha 1 polypeptide (EC:3.6.3.9) | Bilirubin results in decreased expression of ATP1A1 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 8313 |
AXIN2
AXIL ODCRCS |
axin 2 | Bilirubin results in decreased expression of AXIN2 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 2647 |
BLOC1S1
BLOS1 GCN5L1 MICoA RT14 |
biogenesis of lysosomal organelles complex-1, subunit 1 | Bilirubin results in decreased expression of BLOC1S1 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 10438 |
C1D
LRP1 SUN-CoR SUNCOR hC1D |
C1D nuclear receptor corepressor | Bilirubin results in decreased expression of C1D mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 847 |
CAT
|
catalase (EC:1.11.1.6) | Bilirubin results in decreased expression of CAT mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 151887 |
CCDC80
DRO1 SSG1 URB okuribin |
coiled-coil domain containing 80 | Bilirubin results in decreased expression of CCDC80 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 595 |
CCND1
BCL1 D11S287E PRAD1 U21B31 |
cyclin D1 | Bilirubin results in decreased expression of CCND1 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 25819 |
CCRN4L
CCR4L NOC |
CCR4 carbon catabolite repression 4-like (S. cerevisiae) | Bilirubin results in increased expression of CCRN4L mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 9936 |
CD302
BIMLEC CLEC13A DCL-1 DCL1 |
CD302 molecule | Bilirubin results in decreased expression of CD302 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 79094 |
CHAC1
|
ChaC, cation transport regulator homolog 1 (E. coli) | Bilirubin results in increased expression of CHAC1 mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 1119 |
CHKA
CHK CK CKI EK |
choline kinase alpha (EC:2.7.1.32 2.7.1.82) | Bilirubin results in increased expression of CHKA mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 23155 |
CLCC1
MCLC |
chloride channel CLIC-like 1 | Bilirubin results in decreased expression of CLCC1 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 6249 |
CLIP1
CLIP CLIP-170 CLIP170 CYLN1 RSN |
CAP-GLY domain containing linker protein 1 | Bilirubin results in decreased expression of CLIP1 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 1281 |
COL3A1
EDS4A |
collagen, type III, alpha 1 | Bilirubin results in decreased expression of COL3A1 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 1355 |
COX15
CEMCOX2 |
cytochrome c oxidase assembly homolog 15 (yeast) | Bilirubin results in decreased expression of COX15 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 1362 |
CPD
GP180 |
carboxypeptidase D (EC:3.4.17.22) | Bilirubin results in decreased expression of CPD mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 1437 |
CSF2
GMCSF |
colony stimulating factor 2 (granulocyte-macrophage) | Bilirubin results in increased expression of CSF2 mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 1512 |
CTSH
ACC-4 ACC-5 CPSB minichain |
cathepsin H (EC:3.4.22.16) | Bilirubin results in decreased expression of CTSH mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 3627 |
CXCL10
C7 IFI10 INP10 IP-10 SCYB10 crg-2 gIP-10 mob-1 |
chemokine (C-X-C motif) ligand 10 | Bilirubin results in increased expression of CXCL10 mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 6373 |
CXCL11
H174 I-TAC IP-9 IP9 SCYB11 SCYB9B b-R1 |
chemokine (C-X-C motif) ligand 11 | Bilirubin results in increased expression of CXCL11 mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 2920 |
CXCL2
CINC-2a GRO2 GROb MGSA-b MIP-2a MIP2 MIP2A SCYB2 |
chemokine (C-X-C motif) ligand 2 | Bilirubin results in increased expression of CXCL2 mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | Bilirubin results in increased expression of CYP1A1 mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | Bilirubin results in increased expression of CYP1A1 protein |
increases expression
|
protein |
20196124
|
| D001663 | 1548 |
CYP2A6
CPA6 CYP2A CYP2A3 CYPIIA6 P450C2A P450PB |
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) | Bilirubin inhibits the reaction [Cycloheximide results in decreased expression of CYP2A6 protein] |
decreases expression
/ decreases reaction |
protein |
22465937
|
| D001663 | 1548 |
CYP2A6
CPA6 CYP2A CYP2A3 CYPIIA6 P450C2A P450PB |
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) | Bilirubin results in decreased activity of CYP2A6 protein |
decreases activity
|
protein |
22465937
|
| D001663 | 1548 |
CYP2A6
CPA6 CYP2A CYP2A3 CYPIIA6 P450C2A P450PB |
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) | Bilirubin results in increased expression of and results in increased activity of CYP2A6 protein |
increases activity
/ increases expression |
protein |
22465937
|
| D001663 | 1548 |
CYP2A6
CPA6 CYP2A CYP2A3 CYPIIA6 P450C2A P450PB |
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) | Bilirubin results in increased stability of CYP2A6 protein |
increases stability
|
protein |
22465937
|
| D001663 | 1548 |
CYP2A6
CPA6 CYP2A CYP2A3 CYPIIA6 P450C2A P450PB |
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) | CYP2A6 protein results in increased oxidation of Bilirubin |
increases oxidation
|
protein |
22465937
|
| D001663 | 1548 |
CYP2A6
CPA6 CYP2A CYP2A3 CYPIIA6 P450C2A P450PB |
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) | [CYP2A6 protein results in increased oxidation of Bilirubin] which results in increased chemical synthesis of Biliverdine |
increases chemical synthesis
/ increases oxidation |
protein |
22465937
|
| D001663 | 1555 |
CYP2B6
CPB6 CYP2B CYP2B7 CYP2B7P CYPIIB6 EFVM IIB1 P450 |
cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1) | Bilirubin results in increased expression of CYP2B6 mRNA |
increases expression
|
mRNA |
15382119
|
| D001663 | 1555 |
CYP2B6
CPB6 CYP2B CYP2B7 CYP2B7P CYPIIB6 EFVM IIB1 P450 |
cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1) | IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP2B6 mRNA] |
decreases reaction
/ increases expression |
mRNA |
15382119
|
| D001663 | 1559 |
CYP2C9
CPC9 CYP2C CYP2C10 CYPIIC9 P450IIC9 |
cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) | Bilirubin results in increased expression of CYP2C9 mRNA |
increases expression
|
mRNA |
15382119
|
| D001663 | 1559 |
CYP2C9
CPC9 CYP2C CYP2C10 CYPIIC9 P450IIC9 |
cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) | IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP2C9 mRNA] |
decreases reaction
/ increases expression |
mRNA |
15382119
|
| D001663 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | Bilirubin results in increased expression of CYP3A4 mRNA |
increases expression
|
mRNA |
15382119
|
| D001663 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP3A4 mRNA] |
decreases reaction
/ increases expression |
mRNA |
15382119
|
| D001663 | 1649 |
DDIT3
CEBPZ CHOP CHOP-10 CHOP10 GADD153 |
DNA-damage-inducible transcript 3 | Bilirubin results in increased expression of DDIT3 mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 420357 | Bilirubin results in decreased expression of DEPDC6 mRNA |
decreases expression
|
mRNA |
20196124
|
||
| D001663 | 93099 |
DMKN
UNQ729 ZD52F10 |
dermokine | Bilirubin results in decreased expression of DMKN mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 3337 |
DNAJB1
HSPF1 Hdj1 Hsp40 RSPH16B Sis1 |
DnaJ (Hsp40) homolog, subfamily B, member 1 | Bilirubin affects the expression of DNAJB1 mRNA |
affects expression
|
mRNA |
20196124
|
| D001663 | 23549 |
DNPEP
ASPEP DAP |
aspartyl aminopeptidase (EC:3.4.11.21) | Bilirubin results in decreased expression of DNPEP mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 23333 |
DPY19L1
|
dpy-19-like 1 (C. elegans) | Bilirubin results in decreased expression of DPY19L1 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 1847 |
DUSP5
DUSP HVH3 |
dual specificity phosphatase 5 (EC:3.1.3.16 3.1.3.48) | Bilirubin results in increased expression of DUSP5 mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 54583 |
EGLN1
C1orf12 ECYT3 HIF-PH2 HIFPH2 HPH-2 HPH2 PHD2 SM20 ZMYND6 |
egl-9 family hypoxia-inducible factor 1 (EC:1.14.11.29) | Bilirubin results in decreased expression of EGLN1 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 9538 |
EI24
EPG4 PIG8 TP53I8 |
etoposide induced 2.4 | Bilirubin results in decreased expression of EI24 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 23741 |
EID1
C15orf3 CRI1 EID-1 IRO45620 PTD014 RBP21 |
EP300 interacting inhibitor of differentiation 1 | Bilirubin results in decreased expression of EID1 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 9451 |
EIF2AK3
PEK PERK WRS |
eukaryotic translation initiation factor 2-alpha kinase 3 (EC:2.7.11.1) | Bilirubin results in increased phosphorylation of and results in increased activity of EIF2AK3 protein |
increases activity
/ increases phosphorylation |
protein |
20196124
|
| D001663 | 1965 |
EIF2S1
EIF-2 EIF-2A EIF-2alpha EIF2 EIF2A |
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa | Bilirubin results in increased phosphorylation of and results in increased activity of EIF2S1 protein |
increases activity
/ increases phosphorylation |
protein |
20196124
|
| D001663 | 23052 |
ENDOD1
|
endonuclease domain containing 1 | Bilirubin results in decreased expression of ENDOD1 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 345757 |
FAM174A
TMEM157 UNQ1912 |
family with sequence similarity 174, member A | Bilirubin results in decreased expression of FAM174A mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 8061 |
FOSL1
FRA FRA1 fra-1 |
FOS-like antigen 1 | Bilirubin results in increased expression of FOSL1 mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 4616 |
GADD45B
GADD45BETA MYD118 |
growth arrest and DNA-damage-inducible, beta | Bilirubin results in increased expression of GADD45B mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 60674 |
GAS5
NCRNA00030 SNHG2 |
growth arrest-specific 5 (non-protein coding) | Bilirubin results in decreased expression of GAS5 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 2934 |
GSN
ADF AGEL |
gelsolin | Bilirubin results in decreased expression of GSN mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 2938 |
GSTA1
GST2 GSTA1-1 GTH1 |
glutathione S-transferase alpha 1 (EC:2.5.1.18) | Bilirubin results in increased expression of GSTA1 mRNA |
increases expression
|
mRNA |
15382119
|
| D001663 | 2938 |
GSTA1
GST2 GSTA1-1 GTH1 |
glutathione S-transferase alpha 1 (EC:2.5.1.18) | IL1B protein inhibits the reaction [Bilirubin results in increased expression of GSTA1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
15382119
|
| D001663 | 2939 |
GSTA2
GST2 GSTA2-2 GTA2 GTH2 |
glutathione S-transferase alpha 2 (EC:2.5.1.18) | Bilirubin results in increased expression of GSTA2 mRNA |
increases expression
|
mRNA |
15382119
|
| D001663 | 2939 |
GSTA2
GST2 GSTA2-2 GTA2 GTH2 |
glutathione S-transferase alpha 2 (EC:2.5.1.18) | IL1B protein inhibits the reaction [Bilirubin results in increased expression of GSTA2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
15382119
|
| D001663 | 2940 |
GSTA3
GSTA3-3 GTA3 |
glutathione S-transferase alpha 3 (EC:2.5.1.18) | Bilirubin results in decreased expression of GSTA3 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 2941 |
GSTA4
GSTA4-4 GTA4 |
glutathione S-transferase alpha 4 (EC:2.5.1.18) | Bilirubin results in decreased expression of GSTA4 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 373156 |
GSTK1
GST GST_13-13 GST13 GST13-13 GSTK1-1 hGSTK1 |
glutathione S-transferase kappa 1 (EC:2.5.1.18) | Bilirubin results in decreased expression of GSTK1 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 2944 |
GSTM1
GST1 GSTM1-1 GSTM1a-1a GSTM1b-1b GTH4 GTM1 H-B MU MU-1 |
glutathione S-transferase mu 1 (EC:2.5.1.18) | Bilirubin results in decreased expression of GSTM1 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 2950 |
GSTP1
DFN7 FAEES3 GST3 GSTP PI |
glutathione S-transferase pi 1 (EC:2.5.1.18) | Bilirubin results in decreased expression of GSTP1 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 9843 |
HEPH
CPL |
hephaestin | Bilirubin results in decreased expression of HEPH mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 9709 |
HERPUD1
HERP Mif1 SUP |
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | Bilirubin results in increased expression of HERPUD1 mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 3008 |
HIST1H1E
H1.4 H1E H1F4 H1s-4 dJ221C16.5 |
histone cluster 1, H1e | Bilirubin results in increased expression of HIST1H1E mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 8347 |
HIST1H2BC
H2B.1 H2B/l H2BFL dJ221C16.3 |
histone cluster 1, H2bc | Bilirubin results in increased expression of HIST1H2BC mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 319188 | Bilirubin results in increased expression of HIST1H2BP mRNA |
increases expression
|
mRNA |
20196124
|
||
| D001663 | 8294 |
HIST1H4I
H4/m H4FM H4M |
histone cluster 1, H4i | Bilirubin results in increased expression of HIST1H4I mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 97114 | Bilirubin results in increased expression of HIST2H3C2 mRNA |
increases expression
|
mRNA |
20196124
|
||
| D001663 | 92815 |
HIST3H2A
|
histone cluster 3, H2a | Bilirubin results in increased expression of HIST3H2A mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | Bilirubin affects the activity of HMOX1 protein |
affects activity
|
protein |
12690112
|
| D001663 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | Bilirubin inhibits the reaction [[tin protoporphyrin IX results in decreased activity of HMOX1 protein] which results in increased chemical synthesis of Reactive Oxygen Species] |
decreases activity
/ decreases reaction / increases chemical synthesis |
protein |
12690112
|
| D001663 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | Bilirubin results in increased expression of HMOX1 mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | [Ethanol results in increased expression of HMOX1 protein] which results in increased abundance of Bilirubin |
increases abundance
/ increases expression |
protein |
15602829
|
| D001663 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | HMOX1 protein results in increased abundance of Bilirubin |
increases abundance
|
protein |
15226216
|
| D001663 | 373300 | Bilirubin results in increased expression of HSP110 mRNA |
increases expression
|
mRNA |
20196124
|
||
| D001663 | 3309 |
HSPA5
BIP GRP78 MIF2 |
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Bilirubin results in increased expression of HSPA5 mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 3418 |
IDH2
D2HGA2 ICD-M IDH IDHM IDP IDPM mNADP-IDH |
isocitrate dehydrogenase 2 (NADP+), mitochondrial (EC:1.1.1.42) | Bilirubin results in decreased expression of IDH2 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 3475 |
IFRD1
PC4 TIS7 |
interferon-related developmental regulator 1 | Bilirubin results in increased expression of IFRD1 mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 3486 |
IGFBP3
BP-53 IBP3 |
insulin-like growth factor binding protein 3 | Bilirubin results in decreased expression of IGFBP3 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 3606 |
IL18
IGIF IL-18 IL-1g IL1F4 |
interleukin 18 (interferon-gamma-inducing factor) | Bilirubin inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein] |
decreases phosphorylation
/ decreases reaction |
protein |
18215737
|
| D001663 | 3606 |
IL18
IGIF IL-18 IL-1g IL1F4 |
interleukin 18 (interferon-gamma-inducing factor) | Bilirubin inhibits the reaction [IL18 protein results in increased expression of PTEN protein] |
decreases reaction
/ increases expression |
protein |
18215737
|
| D001663 | 3606 |
IL18
IGIF IL-18 IL-1g IL1F4 |
interleukin 18 (interferon-gamma-inducing factor) | Bilirubin results in decreased susceptibility to IL18 protein |
decreases response to substance
|
protein |
18215737
|
| D001663 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP2B6 mRNA] |
decreases reaction
/ increases expression |
protein |
15382119
|
| D001663 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP2C9 mRNA] |
decreases reaction
/ increases expression |
protein |
15382119
|
| D001663 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP3A4 mRNA] |
decreases reaction
/ increases expression |
protein |
15382119
|
| D001663 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | IL1B protein inhibits the reaction [Bilirubin results in increased expression of GSTA1 mRNA] |
decreases reaction
/ increases expression |
protein |
15382119
|
| D001663 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | IL1B protein inhibits the reaction [Bilirubin results in increased expression of GSTA2 mRNA] |
decreases reaction
/ increases expression |
protein |
15382119
|
| D001663 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | IL1B protein inhibits the reaction [Bilirubin results in increased expression of SLCO1B1 mRNA] |
decreases reaction
/ increases expression |
protein |
15382119
|
| D001663 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | IL1B protein inhibits the reaction [Bilirubin results in increased expression of UGT1A1 mRNA] |
decreases reaction
/ increases expression |
protein |
15382119
|
| D001663 | 3569 |
IL6
BSF2 HGF HSF IFNB2 IL-6 |
interleukin 6 (interferon, beta 2) | Bilirubin results in increased expression of IL6 mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 3912 |
LAMB1
CLM LIS5 |
laminin, beta 1 | Bilirubin results in decreased expression of LAMB1 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 3920 |
LAMP2
CD107b LAMP-2 LAMPB LGP110 |
lysosomal-associated membrane protein 2 | Bilirubin results in decreased expression of LAMP2 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 54741 |
LEPROT
LEPR OB-RGRP OBRGRP VPS55 |
leptin receptor overlapping transcript | Bilirubin results in decreased expression of LEPROT mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 3976 |
LIF
CDF DIA HILDA MLPLI |
leukemia inhibitory factor | Bilirubin results in increased expression of LIF mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 4035 |
LRP1
A2MR APOER APR CD91 IGFBP3R LRP LRP1A TGFBR5 |
low density lipoprotein receptor-related protein 1 | Bilirubin results in decreased expression of LRP1 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 110454 | Bilirubin results in decreased expression of LY6A mRNA |
decreases expression
|
mRNA |
20196124
|
||
| D001663 | 4094 |
MAF
CCA4 c-MAF |
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog | Bilirubin results in decreased expression of MAF mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | Bilirubin results in decreased phosphorylation of MAPK1 protein |
decreases phosphorylation
|
protein |
12690112
|
| D001663 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | Bilirubin results in decreased phosphorylation of MAPK3 protein |
decreases phosphorylation
|
protein |
12690112
|
| D001663 | 10982 |
MAPRE2
EB1 EB2 RP1 |
microtubule-associated protein, RP/EB family, member 2 | Bilirubin results in decreased expression of MAPRE2 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 4200 |
ME2
ODS1 |
malic enzyme 2, NAD(+)-dependent, mitochondrial (EC:1.1.1.38) | Bilirubin results in decreased expression of ME2 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 1955 |
MEGF9
EGFL5 |
multiple EGF-like-domains 9 | Bilirubin results in decreased expression of MEGF9 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 4258 |
MGST2
GST2 MGST-II |
microsomal glutathione S-transferase 2 (EC:2.5.1.18) | Bilirubin results in decreased expression of MGST2 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 4322 |
MMP13
CLG3 MANDP1 |
matrix metallopeptidase 13 (collagenase 3) (EC:3.4.24.-) | Bilirubin results in increased expression of MMP13 mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 10205 |
MPZL2
EVA EVA1 |
myelin protein zero-like 2 | Bilirubin results in decreased expression of MPZL2 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 29074 |
MRPL18
L18mt MRP-L18 |
mitochondrial ribosomal protein L18 | Bilirubin results in decreased expression of MRPL18 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 4811 |
NID1
NID |
nidogen 1 | Bilirubin results in decreased expression of NID1 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 23530 |
NNT
GCCD4 |
nicotinamide nucleotide transhydrogenase (EC:1.6.1.2) | Bilirubin results in decreased expression of NNT mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 8856 |
NR1I2
BXR ONR1 PAR PAR1 PAR2 PARq PRR PXR SAR SXR |
nuclear receptor subfamily 1, group I, member 2 | Bilirubin results in increased expression of NR1I2 mRNA |
increases expression
|
mRNA |
18706437
|
| D001663 | 9970 |
NR1I3
CAR CAR1 MB67 |
nuclear receptor subfamily 1, group I, member 3 | Bilirubin results in increased expression of NR1I3 mRNA |
increases expression
|
mRNA |
18706437
|
| D001663 | 29948 |
OSGIN1
BDGI OKL38 |
oxidative stress induced growth inhibitor 1 | Bilirubin results in increased expression of OSGIN1 mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 5163 |
PDK1
|
pyruvate dehydrogenase kinase, isozyme 1 (EC:2.7.11.2) | Bilirubin results in decreased expression of PDK1 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 27315 |
PGAP2
CWH43-N FRAG1 HPMRS3 MRT17 MRT21 |
post-GPI attachment to proteins 2 | Bilirubin results in decreased expression of PGAP2 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 5245 |
PHB
PHB1 |
prohibitin | Bilirubin results in decreased expression of PHB mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 8554 |
PIAS1
DDXBP1 GBP GU/RH-II ZMIZ3 |
protein inhibitor of activated STAT, 1 | Bilirubin results in decreased expression of PIAS1 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 5295 |
PIK3R1
AGM7 GRB1 p85 p85-ALPHA |
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | Bilirubin results in decreased expression of PIK3R1 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 18722 | Bilirubin results in increased expression of PIRA1 mRNA |
increases expression
|
mRNA |
20196124
|
||
| D001663 | 51365 |
PLA1A
PS-PLA1 PSPLA1 |
phospholipase A1 member A (EC:3.1.1.-) | Bilirubin results in decreased expression of PLA1A mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 5376 |
PMP22
CMT1A CMT1E DSS GAS-3 HMSNIA HNPP Sp110 |
peripheral myelin protein 22 | Bilirubin results in decreased expression of PMP22 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 5445 |
PON2
|
paraoxonase 2 (EC:3.1.1.2 3.1.1.81) | Bilirubin results in decreased expression of PON2 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 10549 |
PRDX4
AOE37-2 PRX-4 |
peroxiredoxin 4 (EC:1.11.1.15) | Bilirubin results in decreased expression of PRDX4 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 5728 |
PTEN
10q23del BZS CWS1 DEC GLM2 MHAM MMAC1 PTEN1 TEP1 |
phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) | Bilirubin inhibits the reaction [IL18 protein results in increased expression of PTEN protein] |
decreases reaction
/ increases expression |
protein |
18215737
|
| D001663 | 401494 |
PTPLAD2
HACD4 |
protein tyrosine phosphatase-like A domain containing 2 (EC:4.2.1.134) | Bilirubin results in decreased expression of PTPLAD2 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 83937 |
RASSF4
AD037 |
Ras association (RalGDS/AF-6) domain family member 4 | Bilirubin results in increased expression of RASSF4 mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 9584 |
RBM39
CAPER CAPERalpha FSAP59 HCC1 RNPC2 |
RNA binding motif protein 39 | Bilirubin results in decreased expression of RBM39 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 10181 |
RBM5
G15 LUCA15 RMB5 |
RNA binding motif protein 5 | Bilirubin results in decreased expression of RBM5 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 22836 |
RHOBTB3
|
Rho-related BTB domain containing 3 | Bilirubin results in decreased expression of RHOBTB3 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 6038 |
RNASE4
RNS4 |
ribonuclease, RNase A family, 4 (EC:3.1.27.-) | Bilirubin results in decreased expression of RNASE4 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 6281 |
S100A10
42C ANX2L ANX2LG CAL1L CLP11 Ca[1] GP11 P11 p10 |
S100 calcium binding protein A10 | Bilirubin results in decreased expression of S100A10 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 6275 |
S100A4
18A2 42A CAPL FSP1 MTS1 P9KA PEL98 |
S100 calcium binding protein A4 | Bilirubin results in decreased expression of S100A4 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 6342 |
SCP2
NLTP NSL-TP SCP-2 SCP-CHI SCP-X SCPX |
sterol carrier protein 2 (EC:2.3.1.176) | Bilirubin results in decreased expression of SCP2 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 8991 |
SELENBP1
LPSB SBP56 SP56 hSBP |
selenium binding protein 1 | Bilirubin results in decreased expression of SELENBP1 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 66222 | Bilirubin results in decreased expression of SERPINB1A mRNA |
decreases expression
|
mRNA |
20196124
|
||
| D001663 | 5054 |
SERPINE1
PAI PAI-1 PAI1 PLANH1 |
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | Bilirubin results in increased expression of SERPINE1 mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 27244 |
SESN1
PA26 SEST1 |
sestrin 1 | Bilirubin results in decreased expression of SESN1 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 81537 |
SGPP1
SPPase1 |
sphingosine-1-phosphate phosphatase 1 | Bilirubin results in decreased expression of SGPP1 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 387700 |
SLC16A12
CJMG MCT12 |
solute carrier family 16, member 12 | Bilirubin results in decreased expression of SLC16A12 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 9963 |
SLC23A1
SLC23A2 SVCT1 YSPL3 |
solute carrier family 23 (ascorbic acid transporter), member 1 | Bilirubin results in increased expression of SLC23A1 mRNA |
increases expression
|
mRNA |
18706437
|
| D001663 | 9962 |
SLC23A2
NBTL1 SLC23A1 SVCT2 YSPL2 |
solute carrier family 23 (ascorbic acid transporter), member 2 | Bilirubin results in increased expression of SLC23A2 mRNA |
increases expression
|
mRNA |
18706437
|
| D001663 | 6520 |
SLC3A2
4F2 4F2HC 4T2HC CD98 CD98HC MDU1 NACAE |
solute carrier family 3 (amino acid transporter heavy chain), member 2 | Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein] |
affects cotreatment
/ increases activity |
protein |
22216172
|
| D001663 | 6520 |
SLC3A2
4F2 4F2HC 4T2HC CD98 CD98HC MDU1 NACAE |
solute carrier family 3 (amino acid transporter heavy chain), member 2 | [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine |
affects cotreatment
/ increases activity / increases uptake |
protein |
22216172
|
| D001663 | 6520 |
SLC3A2
4F2 4F2HC 4T2HC CD98 CD98HC MDU1 NACAE |
solute carrier family 3 (amino acid transporter heavy chain), member 2 | [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione |
affects cotreatment
/ increases abundance / increases activity / increases uptake |
protein |
22216172
|
| D001663 | 6520 |
SLC3A2
4F2 4F2HC 4T2HC CD98 CD98HC MDU1 NACAE |
solute carrier family 3 (amino acid transporter heavy chain), member 2 | [[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide |
affects cotreatment
/ decreases response to substance / increases abundance / increases activity / increases uptake |
protein |
22216172
|
| D001663 | 6520 |
SLC3A2
4F2 4F2HC 4T2HC CD98 CD98HC MDU1 NACAE |
solute carrier family 3 (amino acid transporter heavy chain), member 2 | Bilirubin results in increased expression of SLC3A2 mRNA |
increases expression
|
mRNA |
22216172
|
| D001663 | 23657 |
SLC7A11
CCBR1 xCT |
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein] |
affects cotreatment
/ increases activity |
protein |
22216172
|
| D001663 | 23657 |
SLC7A11
CCBR1 xCT |
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine |
affects cotreatment
/ increases activity / increases uptake |
protein |
22216172
|
| D001663 | 23657 |
SLC7A11
CCBR1 xCT |
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione |
affects cotreatment
/ increases abundance / increases activity / increases uptake |
protein |
22216172
|
| D001663 | 23657 |
SLC7A11
CCBR1 xCT |
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | [[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide |
affects cotreatment
/ decreases response to substance / increases abundance / increases activity / increases uptake |
protein |
22216172
|
| D001663 | 23657 |
SLC7A11
CCBR1 xCT |
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | Bilirubin results in increased expression of SLC7A11 mRNA |
increases expression
|
mRNA |
22216172
|
| D001663 | 10599 |
SLCO1B1
HBLRR LST-1 LST1 OATP-C OATP1B1 OATP2 OATPC SLC21A6 |
solute carrier organic anion transporter family, member 1B1 | Bilirubin inhibits the reaction [SLCO1B1 protein results in increased import of estradiol-17 beta-glucuronide] |
decreases reaction
/ increases import |
protein |
19560444
|
| D001663 | 10599 |
SLCO1B1
HBLRR LST-1 LST1 OATP-C OATP1B1 OATP2 OATPC SLC21A6 |
solute carrier organic anion transporter family, member 1B1 | Bilirubin results in increased expression of SLCO1B1 mRNA |
increases expression
|
mRNA |
15382119
|
| D001663 | 10599 |
SLCO1B1
HBLRR LST-1 LST1 OATP-C OATP1B1 OATP2 OATPC SLC21A6 |
solute carrier organic anion transporter family, member 1B1 | IL1B protein inhibits the reaction [Bilirubin results in increased expression of SLCO1B1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
15382119
|
| D001663 | 57231 |
SNX14
RGS-PX2 |
sorting nexin 14 | Bilirubin results in decreased expression of SNX14 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 50964 |
SOST
CDD VBCH |
sclerostin | Bilirubin results in decreased expression of SOST mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 389058 |
SP5
|
Sp5 transcription factor | Bilirubin results in decreased expression of SP5 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 73526 | Bilirubin results in increased expression of SPEER4B mRNA |
increases expression
|
mRNA |
20196124
|
||
| D001663 | 6892 |
TAPBP
NGS17 TAPA TPN TPSN |
TAP binding protein (tapasin) | Bilirubin results in decreased expression of TAPBP mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 6925 |
TCF4
E2-2 ITF-2 ITF2 PTHS SEF-2 SEF2 SEF2-1 SEF2-1A SEF2-1B TCF-4 bHLHb19 |
transcription factor 4 | Bilirubin results in decreased expression of TCF4 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 25976 |
TIPARP
ARTD14 PARP7 pART14 |
TCDD-inducible poly(ADP-ribose) polymerase (EC:2.4.2.30) | Bilirubin results in increased expression of TIPARP mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 9375 |
TM9SF2
P76 |
transmembrane 9 superfamily member 2 | Bilirubin results in decreased expression of TM9SF2 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 55504 |
TNFRSF19
TAJ TAJ-alpha TRADE TROY |
tumor necrosis factor receptor superfamily, member 19 | Bilirubin results in decreased expression of TNFRSF19 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 1200 |
TPP1
CLN2 LPIC TPP-1 |
tripeptidyl peptidase I (EC:3.4.14.9) | Bilirubin results in decreased expression of TPP1 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 28951 |
TRIB2
C5FW GS3955 TRB2 |
tribbles pseudokinase 2 | Bilirubin results in decreased expression of TRIB2 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 7329 |
UBE2I
C358B7.1 P18 UBC9 |
ubiquitin-conjugating enzyme E2I (EC:6.3.2.19) | Bilirubin results in decreased expression of UBE2I mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 54658 |
UGT1A1
BILIQTL1 GNT1 HUG-BR1 UDPGT UDPGT_1-1 UGT1 UGT1A |
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) | Bilirubin results in decreased activity of UGT1A1 protein |
decreases activity
|
protein |
15334623
|
| D001663 | 54658 |
UGT1A1
BILIQTL1 GNT1 HUG-BR1 UDPGT UDPGT_1-1 UGT1 UGT1A |
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) | Bilirubin results in increased expression of UGT1A1 mRNA |
increases expression
|
mRNA |
15382119
|
| D001663 | 54658 |
UGT1A1
BILIQTL1 GNT1 HUG-BR1 UDPGT UDPGT_1-1 UGT1 UGT1A |
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) | chrysin promotes the reaction [UGT1A1 protein affects the glucuronidation of Bilirubin] |
affects glucuronidation
/ increases reaction |
protein |
10950852
|
| D001663 | 54658 |
UGT1A1
BILIQTL1 GNT1 HUG-BR1 UDPGT UDPGT_1-1 UGT1 UGT1A |
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) | IL1B protein inhibits the reaction [Bilirubin results in increased expression of UGT1A1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
15382119
|
| D001663 | 54658 |
UGT1A1
BILIQTL1 GNT1 HUG-BR1 UDPGT UDPGT_1-1 UGT1 UGT1A |
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) | UGT1A1 gene mutant form results in decreased glucuronidation of Bilirubin |
decreases glucuronidation
|
gene |
17898154
|
| D001663 | 54658 |
UGT1A1
BILIQTL1 GNT1 HUG-BR1 UDPGT UDPGT_1-1 UGT1 UGT1A |
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) | UGT1A1 protein results in increased glucuronidation of and results in decreased activity of Bilirubin |
decreases activity
/ increases glucuronidation |
protein |
15557560
|
| D001663 | 54658 |
UGT1A1
BILIQTL1 GNT1 HUG-BR1 UDPGT UDPGT_1-1 UGT1 UGT1A |
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) | UGT1A1 protein results in increased glucuronidation of Bilirubin |
increases glucuronidation
|
protein |
15988124
17898154 |
| D001663 | 54659 |
UGT1A3
UDPGT UDPGT_1-3 UGT-1C UGT1-03 UGT1.3 UGT1C |
UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) | Bilirubin results in decreased activity of UGT1A3 protein |
decreases activity
|
protein |
15334623
|
| D001663 | 7366 |
UGT2B15
HLUG4 UDPGT_2B8 UDPGT2B15 UDPGTH3 UGT2B8 |
UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) | Bilirubin results in decreased activity of UGT2B15 protein |
decreases activity
|
protein |
15334623
|
| D001663 | 708396 | Bilirubin results in decreased expression of UQCR mRNA |
decreases expression
|
mRNA |
20196124
|
||
| D001663 | 7381 |
UQCRB
MC3DN3 QCR7 QP-C QPC UQBC UQBP UQCR6 UQPC |
ubiquinol-cytochrome c reductase binding protein (EC:1.10.2.2) | Bilirubin results in decreased expression of UQCRB mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 7384 |
UQCRC1
D3S3191 QCR1 UQCR1 |
ubiquinol-cytochrome c reductase core protein I (EC:1.10.2.2) | Bilirubin results in decreased expression of UQCRC1 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 7388 |
UQCRH
QCR6 UQCR8 |
ubiquinol-cytochrome c reductase hinge protein (EC:1.10.2.2) | Bilirubin results in decreased expression of UQCRH mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 80146 |
UXS1
SDR6E1 UGD |
UDP-glucuronate decarboxylase 1 (EC:4.1.1.35) | Bilirubin results in decreased expression of UXS1 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 7436 |
VLDLR
CARMQ1 CHRMQ1 VLDLRCH |
very low density lipoprotein receptor | Bilirubin results in decreased expression of VLDLR mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 26137 |
ZBTB20
DPZF HOF ODA-8S ZNF288 |
zinc finger and BTB domain containing 20 | Bilirubin results in decreased expression of ZBTB20 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 339487 |
ZBTB8OS
ARCH ARCH2 |
zinc finger and BTB domain containing 8 opposite strand | Bilirubin results in decreased expression of ZBTB8OS mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 84186 |
ZCCHC7
AIR1 RP11-397D12.1 |
zinc finger, CCHC domain containing 7 | Bilirubin results in decreased expression of ZCCHC7 mRNA |
decreases expression
|
mRNA |
20196124
|
| D001663 | 90637 |
ZFAND2A
AIRAP |
zinc finger, AN1-type domain 2A | Bilirubin results in increased expression of ZFAND2A mRNA |
increases expression
|
mRNA |
20196124
|
| D001663 | 22680 | Bilirubin results in decreased expression of ZFP207 mRNA |
decreases expression
|
mRNA |
20196124
|
||
| D001663 | 24132 | Bilirubin results in decreased expression of ZFP53 mRNA |
decreases expression
|
mRNA |
20196124
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (31)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #612560 | Bone mineral density quantitative trait locus 12; bmnd12 |
O75795
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237450 | Hyperbilirubinemia, rotor type; hblrr |
Q9NPD5
Q9Y6L6 |
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (28)
| KEGG | disease name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
20 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D000743 | D001663 | Anemia, Hemolytic |
marker/mechanism
|
10644400
|
|
| D001145 | D001663 | Arrhythmias, Cardiac |
marker/mechanism
|
10343081
|
|
| D054537 | D001663 | Atrioventricular Block |
marker/mechanism
|
10343081
|
|
| D002779 | D001663 | Cholestasis |
marker/mechanism
|
12700418
|
|
| D002780 | D001663 | Cholestasis, Intrahepatic |
marker/mechanism
|
10343081
|
|
| D003244 | D001663 | Consciousness Disorders |
marker/mechanism
|
10343081
|
|
| D056486 | D001663 | Drug-Induced Liver Injury |
marker/mechanism
|
10343081
20466777 |
|
| D006504 | D001663 | Hepatic Veno-Occlusive Disease |
marker/mechanism
|
9334484
|
|
| D006505 | D001663 | Hepatitis |
marker/mechanism
|
10343081
|
|
| D006932 | D001663 | Hyperbilirubinemia |
marker/mechanism
|
10343081
|
|
| D006975 | D001663 | Hypertension, Portal |
marker/mechanism
|
10833103
18431703 |
|
| D007249 | D001663 | Inflammation |
therapeutic
|
18206168
|
|
| D007567 | D001663 | Jaundice, Neonatal |
marker/mechanism
|
20196124
|
|
| D007681 | D001663 | Kidney Papillary Necrosis |
marker/mechanism
|
4640596
|
|
| D008103 | D001663 | Liver Cirrhosis |
marker/mechanism
|
17977396
|
|
| D008107 | D001663 | Liver Diseases |
marker/mechanism
|
18431703
|
|
| D017093 | D001663 | Liver Failure |
marker/mechanism
|
18618250
|
|
| D009336 | D001663 | Necrosis |
marker/mechanism
|
20466777
|
|
| D012640 | D001663 | Seizures |
marker/mechanism
|
10343081
|
|
| D013226 | D001663 | Status Epilepticus |
marker/mechanism
|
10343081
|