KNApSAcK Metabolite C00031480
Metabolite
KNApSAcK Entry
| id | C00031480 |
|---|---|
| Name | 1,2,4-Trihydroxybenzene |
| CAS RN | 533-73-3 |
| Standard InChI | InChI=1S/C6H6O3/c7-4-1-2-5(8)6(9)3-4/h1-3,7-9H |
| Standard InChI (Main Layer) | InChI=1S/C6H6O3/c7-4-1-2-5(8)6(9)3-4/h1-3,7-9H |
Cluster
| Phytochemical cluster | No. 82 |
|---|---|
| KCF-S cluster | No. 1590 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer |
KEGG
| By LinkDB | C02814 |
|---|
CTD
| By CAS RN | C013038 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| rosids | 1 |
Family
| family name | count |
|---|---|
| Begoniaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Begonia nantoensis | 78253 | Begoniaceae | rosids | Viridiplantae |
Human Protein / Gene in interaction
CTD interaction (68)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C013038 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | hydroxyhydroquinone results in increased expression of ABCC1 mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 47 |
ACLY
ACL ATPCL CLATP |
ATP citrate lyase (EC:2.3.3.8) | hydroxyhydroquinone results in increased expression of ACLY mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 158 |
ADSL
AMPS ASASE ASL |
adenylosuccinate lyase (EC:4.3.2.2) | hydroxyhydroquinone results in decreased expression of ADSL mRNA |
decreases expression
|
mRNA |
17572062
|
| C013038 | 9870 |
AREL1
KIAA0317 |
apoptosis resistant E3 ubiquitin protein ligase 1 | hydroxyhydroquinone results in increased expression of AREL1 mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 10550 |
ARL6IP5
DERP11 GTRAP3-18 JWA PRAF3 addicsin hp22 jmx |
ADP-ribosylation-like factor 6 interacting protein 5 | hydroxyhydroquinone results in decreased expression of ARL6IP5 mRNA |
decreases expression
|
mRNA |
17572062
|
| C013038 | 571 |
BACH1
BACH-1 |
BTB and CNC homology 1, basic leucine zipper transcription factor 1 | hydroxyhydroquinone results in increased expression of BACH1 mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 6356 |
CCL11
SCYA11 |
chemokine (C-C motif) ligand 11 | hydroxyhydroquinone affects the expression of CCL11 protein |
affects expression
|
protein |
17572062
|
| C013038 | 6347 |
CCL2
GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF |
chemokine (C-C motif) ligand 2 | hydroxyhydroquinone affects the expression of CCL2 protein |
affects expression
|
protein |
17572062
|
| C013038 | 6348 |
CCL3
G0S19-1 LD78ALPHA MIP-1-alpha MIP1A SCYA3 |
chemokine (C-C motif) ligand 3 | hydroxyhydroquinone affects the expression of CCL3 protein |
affects expression
|
protein |
17572062
|
| C013038 | 6351 |
CCL4
ACT2 AT744.1 G-26 HC21 LAG-1 LAG1 MIP-1-beta MIP1B MIP1B1 SCYA2 SCYA4 |
chemokine (C-C motif) ligand 4 | hydroxyhydroquinone affects the expression of CCL4 protein |
affects expression
|
protein |
17572062
|
| C013038 | 6352 |
CCL5
D17S136E RANTES SCYA5 SIS-delta SISd TCP228 eoCP |
chemokine (C-C motif) ligand 5 | hydroxyhydroquinone affects the expression of CCL5 protein |
affects expression
|
protein |
17572062
|
| C013038 | 1436 |
CSF1R
C-FMS CD115 CSF-1R CSFR FIM2 FMS HDLS M-CSF-R |
colony stimulating factor 1 receptor (EC:2.7.10.1) | hydroxyhydroquinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide] |
affects cotreatment
/ increases abundance / increases reaction |
protein |
7884313
|
| C013038 | 2017 |
CTTN
EMS1 |
cortactin | hydroxyhydroquinone results in increased expression of CTTN mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 1545 |
CYP1B1
CP1B CYPIB1 GLC3A P4501B1 |
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) | hydroxyhydroquinone results in increased expression of CYP1B1 mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 1593 |
CYP27A1
CP27 CTX CYP27 |
cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15) | hydroxyhydroquinone results in increased expression of CYP27A1 mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 1571 |
CYP2E1
CPE1 CYP2E P450-J P450C2E |
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) | [CYP2E1 protein affects the metabolism of Benzene] which affects the chemical synthesis of hydroxyhydroquinone |
affects chemical synthesis
/ affects metabolic processing |
protein |
15051535
|
| C013038 | 3337 |
DNAJB1
HSPF1 Hdj1 Hsp40 RSPH16B Sis1 |
DnaJ (Hsp40) homolog, subfamily B, member 1 | hydroxyhydroquinone results in increased expression of DNAJB1 mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 8661 |
EIF3A
EIF3 EIF3S10 P167 TIF32 eIF3-p170 eIF3-theta p180 p185 |
eukaryotic translation initiation factor 3, subunit A | hydroxyhydroquinone results in decreased expression of EIF3A mRNA |
decreases expression
|
mRNA |
17572062
|
| C013038 | 51386 |
EIF3L
EIF3EIP EIF3S11 EIF3S6IP HSPC021 HSPC025 MSTP005 |
eukaryotic translation initiation factor 3, subunit L | hydroxyhydroquinone results in decreased expression of EIF3L mRNA |
decreases expression
|
mRNA |
17572062
|
| C013038 | 30001 |
ERO1L
ERO1-alpha ERO1A ERO1LA |
ERO1-like (S. cerevisiae) | hydroxyhydroquinone results in increased expression of ERO1L mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 55194 |
EVA1B
C1orf78 FAM176B RP11-268J15.2 |
eva-1 homolog B (C. elegans) | hydroxyhydroquinone results in increased expression of EVA1B mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 2232 |
FDXR
ADXR |
ferredoxin reductase (EC:1.18.1.6) | hydroxyhydroquinone results in increased expression of FDXR mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 126626 |
GABPB2
|
GA binding protein transcription factor, beta subunit 2 | hydroxyhydroquinone results in increased expression of GABPB2 mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 2623 |
GATA1
ERYF1 GATA-1 GF-1 GF1 NF-E1 NFE1 XLANP XLTDA XLTT |
GATA binding protein 1 (globin transcription factor 1) | hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of GATA1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21414390
|
| C013038 | 2624 |
GATA2
DCML MONOMAC NFE1B |
GATA binding protein 2 | hydroxyhydroquinone promotes the reaction [Hemin results in decreased expression of GATA2 mRNA] |
decreases expression
/ increases reaction |
mRNA |
21414390
|
| C013038 | 2624 |
GATA2
DCML MONOMAC NFE1B |
GATA binding protein 2 | hydroxyhydroquinone results in decreased expression of GATA2 mRNA |
decreases expression
|
mRNA |
21414390
|
| C013038 | 26088 |
GGA1
|
golgi-associated, gamma adaptin ear containing, ARF binding protein 1 | hydroxyhydroquinone results in increased expression of GGA1 mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 2781 |
GNAZ
|
guanine nucleotide binding protein (G protein), alpha z polypeptide | hydroxyhydroquinone results in increased expression of GNAZ mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 2812 |
GP1BB
BDPLT1 BS CD42C GPIBB |
glycoprotein Ib (platelet), beta polypeptide | hydroxyhydroquinone results in increased expression of GP1BB mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 2993 |
GYPA
CD235a GPA GPErik GPSAT HGpMiV HGpMiXI HGpSta(C) MN MNS PAS-2 |
glycophorin A (MNS blood group) | hydroxyhydroquinone results in decreased expression of GYPA protein |
decreases expression
|
protein |
21414390
|
| C013038 | 3043 |
HBB
CD113t-C beta-globin |
hemoglobin, beta | hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA] |
decreases reaction
/ increases expression |
mRNA |
21414390
|
| C013038 | 3280 |
HES1
HES-1 HHL HRY bHLHb39 |
hes family bHLH transcription factor 1 | hydroxyhydroquinone results in increased expression of HES1 mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 8339 |
HIST1H2BG
H2B.1A H2B/a H2BFA dJ221C16.8 |
histone cluster 1, H2bg | hydroxyhydroquinone results in increased expression of HIST1H2BG mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 8337 |
HIST2H2AA3
H2A H2A.2 H2A/O H2A/q H2AFO H2a-615 HIST2H2AA |
histone cluster 2, H2aa3 | hydroxyhydroquinone results in increased expression of HIST2H2AA3 mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 3113 |
HLA-DPA1
DP(W3) DP(W4) HLA-DP1A HLADP HLASB PLT1 |
major histocompatibility complex, class II, DP alpha 1 | hydroxyhydroquinone results in decreased expression of HLA-DPA1 mRNA |
decreases expression
|
mRNA |
17572062
|
| C013038 | 3115 |
HLA-DPB1
DPB1 HLA-DP HLA-DP1B HLA-DPB |
major histocompatibility complex, class II, DP beta 1 | hydroxyhydroquinone results in decreased expression of HLA-DPB1 mRNA |
decreases expression
|
mRNA |
17572062
|
| C013038 | 3145 |
HMBS
PBG-D PBGD PORC UPS |
hydroxymethylbilane synthase (EC:2.5.1.61) | hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of HMBS mRNA] |
decreases reaction
/ increases expression |
mRNA |
21414390
|
| C013038 | 3320 |
HSP90AA1
EL52 HSP86 HSP89A HSP90A HSP90N HSPC1 HSPCA HSPCAL1 HSPCAL4 HSPN Hsp89 Hsp90 LAP2 |
heat shock protein 90kDa alpha (cytosolic), class A member 1 | hydroxyhydroquinone results in increased expression of HSP90AA1 mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 3303 |
HSPA1A
HSP70-1 HSP70-1A HSP70I HSP72 HSPA1 |
heat shock 70kDa protein 1A | hydroxyhydroquinone results in increased expression of HSPA1A mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 3304 |
HSPA1B
HSP70-1B HSP70-2 |
heat shock 70kDa protein 1B | hydroxyhydroquinone results in increased expression of HSPA1B mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 3586 |
IL10
CSIF GVHDS IL-10 IL10A TGIF |
interleukin 10 | hydroxyhydroquinone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL10 protein] |
affects cotreatment
/ decreases reaction / increases expression |
protein |
17572062
|
| C013038 | 3569 |
IL6
BSF2 HGF HSF IFNB2 IL-6 |
interleukin 6 (interferon, beta 2) | hydroxyhydroquinone results in increased expression of IL6 protein |
increases expression
|
protein |
17572062
|
| C013038 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | hydroxyhydroquinone affects the expression of IL8 protein |
affects expression
|
protein |
17572062
|
| C013038 | 3674 |
ITGA2B
BDPLT16 BDPLT2 CD41 CD41B GP2B GPIIb GT GTA HPA3 |
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | hydroxyhydroquinone results in increased expression of ITGA2B mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 3690 |
ITGB3
BDPLT16 BDPLT2 CD61 GP3A GPIIIa GT |
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | hydroxyhydroquinone results in increased expression of ITGB3 mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 3720 |
JARID2
JMJ |
jumonji, AT rich interactive domain 2 | hydroxyhydroquinone results in increased expression of JARID2 mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 3750 |
KCND1
KV4.1 |
potassium voltage-gated channel, Shal-related subfamily, member 1 | hydroxyhydroquinone results in decreased expression of KCND1 mRNA |
decreases expression
|
mRNA |
17572062
|
| C013038 | 9817 |
KEAP1
INrf2 KLHL19 |
kelch-like ECH-associated protein 1 | hydroxyhydroquinone results in increased expression of KEAP1 mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 8440 |
NCK2
GRB4 NCKbeta |
NCK adaptor protein 2 | hydroxyhydroquinone results in increased expression of NCK2 mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 4778 |
NFE2
NF-E2 p45 |
nuclear factor, erythroid 2 | hydroxyhydroquinone inhibits the reaction [Hemin results in increased expression of NFE2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21414390
|
| C013038 | 22822 |
PHLDA1
DT1P1B11 PHRIP TDAG51 |
pleckstrin homology-like domain, family A, member 1 | hydroxyhydroquinone results in increased expression of PHLDA1 mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 123 |
PLIN2
ADFP ADRP |
perilipin 2 | hydroxyhydroquinone results in increased expression of PLIN2 mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 4659 |
PPP1R12A
M130 MBS MYPT1 |
protein phosphatase 1, regulatory subunit 12A | hydroxyhydroquinone results in increased expression of PPP1R12A mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 58497 |
PRUNE
DRES-17 DRES17 HTCD37 |
prune exopolyphosphatase (EC:3.6.1.1) | hydroxyhydroquinone results in increased expression of PRUNE mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 57403 |
RAB22A
|
RAB22A, member RAS oncogene family | hydroxyhydroquinone results in increased expression of RAB22A mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 6138 |
RPL15
EC45 L15 RPL10 RPLY10 RPYL10 |
ribosomal protein L15 | hydroxyhydroquinone results in decreased expression of RPL15 mRNA |
decreases expression
|
mRNA |
17572062
|
| C013038 | 6125 |
RPL5
DBA6 L5 |
ribosomal protein L5 | hydroxyhydroquinone results in decreased expression of RPL5 mRNA |
decreases expression
|
mRNA |
17572062
|
| C013038 | 5176 |
SERPINF1
EPC-1 OI12 OI6 PEDF |
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | hydroxyhydroquinone results in decreased expression of SERPINF1 mRNA |
decreases expression
|
mRNA |
17572062
|
| C013038 | 6452 |
SH3BP2
3BP-2 3BP2 CRBM CRPM |
SH3-domain binding protein 2 | hydroxyhydroquinone results in increased expression of SH3BP2 mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 6653 |
SORL1
C11orf32 LR11 LRP9 SORLA SorLA-1 gp250 |
sortilin-related receptor, L(DLR class) A repeats containing | hydroxyhydroquinone results in decreased expression of SORL1 mRNA |
decreases expression
|
mRNA |
17572062
|
| C013038 | 8683 |
SRSF9
SFRS9 SRp30c |
serine/arginine-rich splicing factor 9 | hydroxyhydroquinone results in decreased expression of SRSF9 mRNA |
decreases expression
|
mRNA |
17572062
|
| C013038 | 7037 |
TFRC
CD71 T9 TFR TFR1 TR TRFR p90 |
transferrin receptor | hydroxyhydroquinone promotes the reaction [Hemin results in decreased expression of TFRC mRNA] |
decreases expression
/ increases reaction |
mRNA |
21414390
|
| C013038 | 7037 |
TFRC
CD71 T9 TFR TFR1 TR TRFR p90 |
transferrin receptor | hydroxyhydroquinone results in decreased expression of TFRC protein |
decreases expression
|
protein |
21414390
|
| C013038 | 25907 |
TMEM158
BBP RIS1 p40BBP |
transmembrane protein 158 (gene/pseudogene) | hydroxyhydroquinone results in increased expression of TMEM158 mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | hydroxyhydroquinone results in increased expression of TNF mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 7153 |
TOP2A
TOP2 TP2A |
topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) | hydroxyhydroquinone results in decreased activity of TOP2A protein |
decreases activity
|
protein |
7586126
|
| C013038 | 9654 |
TTLL4
|
tubulin tyrosine ligase-like family, member 4 | hydroxyhydroquinone results in increased expression of TTLL4 mRNA |
increases expression
|
mRNA |
17572062
|
| C013038 | 7296 |
TXNRD1
GRIM-12 TR TR1 TRXR1 TXNR |
thioredoxin reductase 1 (EC:1.8.1.9) | hydroxyhydroquinone results in increased expression of TXNRD1 mRNA |
increases expression
|
mRNA |
17572062
|