KNApSAcK Metabolite C00032469
Metabolite
KNApSAcK Entry
| id | C00032469 |
|---|---|
| Name | Uzarigenin |
| CAS RN | 466-09-1 |
| Standard InChI | InChI=1S/C23H34O4/c1-21-8-5-16(24)12-15(21)3-4-19-18(21)6-9-22(2)17(7-10-23(19,22)26)14-11-20(25)27-13-14/h11,15-19,24,26H,3-10,12-13H2,1-2H3/t15-,16-,17+,18-,19+,21-,22+,23-/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C23H34O4/c1-21-8-5-16(24)12-15(21)3-4-19-18(21)6-9-22(2)17(7-10-23(19,22)26)14-11-20(25)27-13-14/h11,15-19,24,26H,3-10,12-13H2,1-2H3 |
Cluster
| Phytochemical cluster | No. 56 |
|---|---|
| KCF-S cluster | No. 822 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer | CHEMBL21214 CHEMBL1453 CHEMBL1591205 |
KEGG
| By LinkDB |
|---|
CTD
| By CAS RN |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| asterids | 2 |
Family
| family name | count |
|---|---|
| Apocynaceae | 2 |
List (2)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Asclepias curassavica L. | 52823 | Apocynaceae | asterids | Viridiplantae |
| Calotropis gigantea | 4066 | Apocynaceae | asterids | Viridiplantae |
Human Protein / Gene in interaction
33 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL1591205 |
CHEMBL1741321
(1)
|
1 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | CHEMBL1453 |
CHEMBL1908082
(1)
|
3 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | CHEMBL1591205 |
CHEMBL1613992
(1)
|
7 / 44 |
| Q16637 | Survival motor neuron protein | Unclassified protein | CHEMBL1591205 |
CHEMBL1613842
(1)
|
4 / 2 |
| Q99700 | Ataxin-2 | Unclassified protein | CHEMBL21214 CHEMBL1591205 |
CHEMBL2114784
(2)
|
1 / 1 |
| P02545 | Prelamin-A/C | Unclassified protein | CHEMBL1591205 |
CHEMBL1614544
(1)
|
11 / 10 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | CHEMBL1453 CHEMBL1591205 |
CHEMBL1614361
(1)
CHEMBL1964011
(1)
|
3 / 2 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL1591205 |
CHEMBL1741325
(1)
|
0 / 1 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | CHEMBL1591205 |
CHEMBL1614456
(1)
CHEMBL1613803
(1)
|
0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | CHEMBL21214 CHEMBL1453 |
CHEMBL1794584
(2)
|
2 / 0 |
| O75496 | Geminin | Unclassified protein | CHEMBL21214 CHEMBL1453 |
CHEMBL2114843
(2)
CHEMBL2114780
(2)
|
0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | CHEMBL1453 |
CHEMBL1613838
(1)
|
0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | CHEMBL21214 CHEMBL1453 |
CHEMBL2114788
(2)
|
0 / 0 |
| P54707 | Potassium-transporting ATPase alpha chain 2 | Potassium-transporting P-type ATPase alpha subunit | CHEMBL1453 |
CHEMBL751505
(1)
|
0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | CHEMBL1453 |
CHEMBL1794401
(1)
|
0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL1591205 |
CHEMBL1741322
(1)
|
0 / 0 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | CHEMBL1453 |
CHEMBL1614342
(1)
|
1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | CHEMBL1453 |
CHEMBL1738588
(1)
CHEMBL1738317
(1)
|
0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL1591205 |
CHEMBL1741323
(1)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL1591205 |
CHEMBL1614108
(1)
CHEMBL1613886
(1)
CHEMBL1741324 (1) |
0 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL21214 CHEMBL1453 |
CHEMBL1738184
(2)
|
0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL1453 |
CHEMBL1738442
(1)
|
0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | CHEMBL21214 CHEMBL1453 |
CHEMBL2354311
(2)
|
1 / 0 |
| Q6ZQN7 | Solute carrier organic anion transporter family member 4C1 | Unclassified protein | CHEMBL1453 |
CHEMBL2075764
(1)
|
0 / 0 |
| P05023 | Sodium/potassium-transporting ATPase subunit alpha-1 | Hydrolase | CHEMBL1453 |
CHEMBL660914
(1)
CHEMBL669631
(1)
CHEMBL750865 (1) CHEMBL750867 (1) CHEMBL751502 (2) CHEMBL751509 (1) |
0 / 0 |
| P14415 | Sodium/potassium-transporting ATPase subunit beta-2 | potassium_sodium | CHEMBL1453 |
CHEMBL660914
(1)
CHEMBL669631
(1)
CHEMBL750865 (1) CHEMBL750867 (1) CHEMBL751502 (2) CHEMBL751509 (1) |
0 / 0 |
| P13637 | Sodium/potassium-transporting ATPase subunit alpha-3 | Hydrolase | CHEMBL1453 |
CHEMBL660914
(1)
CHEMBL669631
(1)
CHEMBL750865 (1) CHEMBL750867 (1) CHEMBL751502 (2) CHEMBL751509 (1) |
2 / 1 |
| Q13733 | Sodium/potassium-transporting ATPase subunit alpha-4 | Hydrolase | CHEMBL1453 |
CHEMBL660914
(1)
CHEMBL669631
(1)
CHEMBL750865 (1) CHEMBL750867 (1) CHEMBL751502 (2) CHEMBL751509 (1) |
0 / 0 |
| P54710 | Sodium/potassium-transporting ATPase subunit gamma | potassium_sodium | CHEMBL1453 |
CHEMBL660914
(1)
CHEMBL669631
(1)
CHEMBL750865 (1) CHEMBL750867 (1) CHEMBL751502 (2) CHEMBL751509 (1) |
1 / 1 |
| P54709 | Sodium/potassium-transporting ATPase subunit beta-3 | potassium_sodium | CHEMBL1453 |
CHEMBL660914
(1)
CHEMBL669631
(1)
CHEMBL750865 (1) CHEMBL750867 (1) CHEMBL751502 (2) CHEMBL751509 (1) |
0 / 0 |
| P50993 | Sodium/potassium-transporting ATPase subunit alpha-2 | Hydrolase | CHEMBL1453 |
CHEMBL660914
(1)
CHEMBL669631
(1)
CHEMBL750865 (1) CHEMBL750867 (1) CHEMBL751502 (2) CHEMBL751509 (1) |
2 / 2 |
| P05026 | Sodium/potassium-transporting ATPase subunit beta-1 | potassium_sodium | CHEMBL1453 |
CHEMBL660914
(1)
CHEMBL669631
(1)
CHEMBL750865 (1) CHEMBL750867 (1) CHEMBL751502 (2) CHEMBL751509 (1) |
0 / 0 |
| Q06710 | Paired box protein Pax-8 | Unclassified protein | CHEMBL21214 CHEMBL1453 |
CHEMBL2354301
(2)
|
1 / 2 |
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (41)
| OMIM | preferred title | UniProt |
|---|---|---|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #104290 | Alternating hemiplegia of childhood 1; ahc1 |
P50993
|
| #614820 | Alternating hemiplegia of childhood 2; ahc2 |
P13637
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #218800 | Crigler-najjar syndrome, type i |
P22310
|
| #606785 | Crigler-najjar syndrome, type ii |
P22310
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #128235 | Dystonia 12; dyt12 |
P13637
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
|
| #143500 | Gilbert syndrome |
P22310
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #154020 | Hypomagnesemia 2, renal; homg2 |
P54710
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #218700 | Hypothyroidism, congenital, nongoitrous, 2; chng2 |
Q06710
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P04637
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #602481 | Migraine, familial hemiplegic, 2; fhm2 |
P50993
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
KEGG DISEASE (58)
| KEGG | disease name | UniProt |
|---|---|---|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
Q06710 (related) |
| H00033 | Adrenal carcinoma |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00831 | Primary dystonia |
P13637
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
Q06710 (related) |
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00775 | Familial or sporadic hemiplegic migraine |
P50993
(related)
|
| H00998 | Alternating hemiplegia of childhood |
P50993
(related)
|
| H01210 | Hypomagnesemia |
P54710
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
Q16637 (related) |
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|