PCIDB

KNApSAcK Metabolite C00003576

Metabolite

KNApSAcK Entry

id C00003576
Name Diosgenin
CAS RN 512-04-9
Standard InChI InChI=1S/C27H42O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28H,6-15H2,1-4H3/t16-,17+,19+,20-,21+,22+,23+,24+,25+,26+,27-/m1/s1
Standard InChI (Main Layer) InChI=1S/C27H42O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28H,6-15H2,1-4H3

Cluster

Phytochemical cluster No. 11
KCF-S cluster No. 171

Link

ChEMBL

By standard InChI CHEMBL412437
By standard InChI Main Layer CHEMBL412437 CHEMBL1551855 CHEMBL1553328

KEGG

By LinkDB C08898

CTD

By CAS RN D004144

Species

Summary

Plant class

class name count
Liliopsida 39
asterids 4
rosids 2

Family

family name count
Dioscoreaceae 27
Melanthiaceae 4
Asparagaceae 4
Solanaceae 3
Fabaceae 2
Costaceae 2
Apiaceae 1
Smilacaceae 1
Arecaceae 1

List (45)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Borassus flabellifer 145675 Arecaceae Liliopsida Viridiplantae
Costus speciosus 49577 Costaceae Liliopsida Viridiplantae
Costus spp. 4631 Costaceae Liliopsida Viridiplantae
Daucus carota L. 4039 Apiaceae asterids Viridiplantae
Dioscorea capillaris 4672 Dioscoreaceae Liliopsida Viridiplantae
Dioscorea colletii 4672 Dioscoreaceae Liliopsida Viridiplantae
Dioscorea composita 374975 Dioscoreaceae Liliopsida Viridiplantae
Dioscorea cyphocarpa 4672 Dioscoreaceae Liliopsida Viridiplantae
Dioscorea dugesii 4672 Dioscoreaceae Liliopsida Viridiplantae
Dioscorea galeottiana 323667 Dioscoreaceae Liliopsida Viridiplantae
Dioscorea grandiflora 4672 Dioscoreaceae Liliopsida Viridiplantae
Dioscorea hirsuta Blume 4672 Dioscoreaceae Liliopsida Viridiplantae
Dioscorea hirsuticaulis 4672 Dioscoreaceae Liliopsida Viridiplantae
Dioscorea jaliscana 4672 Dioscoreaceae Liliopsida Viridiplantae
Dioscorea lobata 4672 Dioscoreaceae Liliopsida Viridiplantae
Dioscorea macrostachya 143782 Dioscoreaceae Liliopsida Viridiplantae
Dioscorea mexicana 143782 Dioscoreaceae Liliopsida Viridiplantae
Dioscorea militaris 4672 Dioscoreaceae Liliopsida Viridiplantae
Dioscorea minima 167591 Dioscoreaceae Liliopsida Viridiplantae
Dioscorea mutinervis 4672 Dioscoreaceae Liliopsida Viridiplantae
Dioscorea palmifera 4672 Dioscoreaceae Liliopsida Viridiplantae
Dioscorea parviflora 930788 Dioscoreaceae Liliopsida Viridiplantae
Dioscorea platycalpata 4672 Dioscoreaceae Liliopsida Viridiplantae
Dioscorea pringlei 4672 Dioscoreaceae Liliopsida Viridiplantae
Dioscorea remotiflora 4672 Dioscoreaceae Liliopsida Viridiplantae
Dioscorea spp. 4672 Dioscoreaceae Liliopsida Viridiplantae
Dioscorea subtomentosa 4672 Dioscoreaceae Liliopsida Viridiplantae
Dioscorea testudinaria 4672 Dioscoreaceae Liliopsida Viridiplantae
Dioscorea tokoro Makino. 4672 Dioscoreaceae Liliopsida Viridiplantae
Dioscorea ulinei 4672 Dioscoreaceae Liliopsida Viridiplantae
Dioscorea urceolata 4672 Dioscoreaceae Liliopsida Viridiplantae
Dracaena draco 100532 Asparagaceae Liliopsida Viridiplantae
Nolina erumpens 15970 Asparagaceae Liliopsida Viridiplantae
Nolina greeni 15970 Asparagaceae Liliopsida Viridiplantae
Paris spp. 49669 Melanthiaceae Liliopsida Viridiplantae
Smilacina stellata 191661 Asparagaceae Liliopsida Viridiplantae
Smilax china 49657 Smilacaceae Liliopsida Viridiplantae
Solanum aurantiacobaccatum 4107 Solanaceae asterids Viridiplantae
Solanum globiferum 4107 Solanaceae asterids Viridiplantae
Solanum laciniatum Ait. 4107 Solanaceae asterids Viridiplantae
Trigonella coerulea 78532 Fabaceae rosids Viridiplantae
Trigonella spp. 78532 Fabaceae rosids Viridiplantae
Trillium sessile subsp.californicum. 49674 Melanthiaceae Liliopsida Viridiplantae
Trillium spp. 49674 Melanthiaceae Liliopsida Viridiplantae
Trillium stylorum 49674 Melanthiaceae Liliopsida Viridiplantae

Human Protein / Gene in interaction

6 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P22310 UDP-glucuronosyltransferase 1-4 Enzyme CHEMBL412437 CHEMBL816283 (1) CHEMBL1908081 (1)
CHEMBL1908082 (1)
3 / 0
P40763 Signal transducer and activator of transcription 3 Transcription Factor CHEMBL412437 CHEMBL1775507 (1) CHEMBL1775508 (1)
1 / 2
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme CHEMBL412437 CHEMBL1908085 (1)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1551855 CHEMBL1614108 (1) CHEMBL1613886 (1)
0 / 1
P22309 UDP-glucuronosyltransferase 1-1 Enzyme CHEMBL412437 CHEMBL1908080 (1)
5 / 1
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1553328 CHEMBL1614250 (1)
4 / 3

CTD interaction (38)

compound gene gene name gene description interaction interaction type form reference
pmid
D004144 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) Diosgenin inhibits the reaction [TNF protein results in increased activity of AKT1 protein] decreases reaction
/ increases activity
protein 16331273
D004144 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2 protein] decreases reaction
/ increases expression
protein 16331273
D004144 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Diosgenin results in decreased expression of BCL2 protein decreases expression
protein 16331273
D004144 597 BCL2A1
ACC-1
ACC-2
BCL2L5
BFL1
GRS
HBPA1
BCL2-related protein A1 Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein] decreases reaction
/ increases expression
protein 16331273
D004144 597 BCL2A1
ACC-1
ACC-2
BCL2L5
BFL1
GRS
HBPA1
BCL2-related protein A1 Diosgenin results in decreased expression of BCL2A1 protein decreases expression
protein 16331273
D004144 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein] decreases reaction
/ increases expression
protein 16331273
D004144 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 Diosgenin results in decreased expression of BCL2L1 protein decreases expression
protein 16331273
D004144 329 BIRC2
API1
HIAP2
Hiap-2
MIHB
RNF48
c-IAP1
cIAP1
baculoviral IAP repeat containing 2 Diosgenin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein] decreases reaction
/ increases expression
protein 16331273
D004144 329 BIRC2
API1
HIAP2
Hiap-2
MIHB
RNF48
c-IAP1
cIAP1
baculoviral IAP repeat containing 2 Diosgenin results in decreased expression of BIRC2 protein decreases expression
protein 16331273
D004144 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 Diosgenin inhibits the reaction [TNF protein results in increased expression of CCND1 protein] decreases reaction
/ increases expression
protein 16331273
D004144 8837 CFLAR
CASH
CASP8AP1
CLARP
Casper
FLAME
FLAME-1
FLAME1
FLIP
I-FLICE
MRIT
c-FLIP
c-FLIPL
c-FLIPR
c-FLIPS
CASP8 and FADD-like apoptosis regulator Diosgenin inhibits the reaction [TNF protein results in increased expression of CFLAR protein] decreases reaction
/ increases expression
protein 16331273
D004144 8837 CFLAR
CASH
CASP8AP1
CLARP
Casper
FLAME
FLAME-1
FLAME1
FLIP
I-FLICE
MRIT
c-FLIP
c-FLIPL
c-FLIPR
c-FLIPS
CASP8 and FADD-like apoptosis regulator Diosgenin results in decreased expression of CFLAR protein decreases expression
protein 16331273
D004144 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) Diosgenin inhibits the reaction [TNF protein results in increased expression of MMP9 protein] decreases reaction
/ increases expression
protein 16331273
D004144 4609 MYC
MRTL
MYCC
bHLHe39
c-Myc
v-myc avian myelocytomatosis viral oncogene homolog Diosgenin inhibits the reaction [TNF protein results in increased expression of MYC protein] decreases reaction
/ increases expression
protein 16331273
D004144 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Diosgenin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] decreases reaction
/ increases activity
protein 16331273
D004144 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Diosgenin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein] decreases reaction
/ increases degradation
protein 16331273
D004144 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Diosgenin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] decreases reaction
/ increases phosphorylation
protein 16331273
D004144 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Diosgenin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] decreases reaction
/ increases expression
protein 16331273
D004144 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Diosgenin inhibits the reaction [TNF protein results in increased activity of RELA protein] decreases reaction
/ increases activity
protein 16331273
D004144 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Diosgenin inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein] affects localization
/ decreases reaction
/ increases phosphorylation
protein 16331273
D004144 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Diosgenin inhibits the reaction [TNF protein results in increased activity of AKT1 protein] decreases reaction
/ increases activity
protein 16331273
D004144 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Diosgenin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] decreases reaction
/ increases activity
protein 16331273
D004144 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Diosgenin inhibits the reaction [TNF protein results in increased activity of RELA protein] decreases reaction
/ increases activity
protein 16331273
D004144 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Diosgenin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein] decreases reaction
/ increases degradation
protein 16331273
D004144 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein] decreases reaction
/ increases expression
protein 16331273
D004144 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein] decreases reaction
/ increases expression
protein 16331273
D004144 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Diosgenin inhibits the reaction [TNF protein results in increased expression of BCL2 protein] decreases reaction
/ increases expression
protein 16331273
D004144 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Diosgenin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein] decreases reaction
/ increases expression
protein 16331273
D004144 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Diosgenin inhibits the reaction [TNF protein results in increased expression of CCND1 protein] decreases reaction
/ increases expression
protein 16331273
D004144 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Diosgenin inhibits the reaction [TNF protein results in increased expression of CFLAR protein] decreases reaction
/ increases expression
protein 16331273
D004144 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Diosgenin inhibits the reaction [TNF protein results in increased expression of MMP9 protein] decreases reaction
/ increases expression
protein 16331273
D004144 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Diosgenin inhibits the reaction [TNF protein results in increased expression of MYC protein] decreases reaction
/ increases expression
protein 16331273
D004144 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Diosgenin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] decreases reaction
/ increases expression
protein 16331273
D004144 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Diosgenin inhibits the reaction [TNF protein results in increased expression of VEGFA protein] decreases reaction
/ increases expression
protein 16331273
D004144 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Diosgenin inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein] affects localization
/ decreases reaction
/ increases phosphorylation
protein 16331273
D004144 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Diosgenin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] decreases reaction
/ increases phosphorylation
protein 16331273
D004144 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Diosgenin results in decreased activity of TNF protein decreases activity
protein 16331273
D004144 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Diosgenin inhibits the reaction [TNF protein results in increased expression of VEGFA protein] decreases reaction
/ increases expression
protein 16331273

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (10)

OMIM preferred title UniProt
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#600274 Frontotemporal dementia; ftd P10636
#143500 Gilbert syndrome P22309
P22310
#147060 Hyper-ige recurrent infection syndrome, autosomal dominant P40763
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (7)

KEGG disease name UniProt
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00016 Oral cancer P40763 (related)
H00107 Other well-defined immunodeficiency syndromes P40763 (related)

Diseases related to CTD interactions

2 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D002779 D004144 Cholestasis marker/mechanism
therapeutic
9657105
16105132
D006949 D004144 Hyperlipidemias therapeutic
20149787