Dracaena draco
Species
KNApSAcK Entry
| Organism name | Dracaena draco |
|---|---|
| Genus | Dracaena |
| Family | Dracaenaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Dracaena draco |
|---|---|
| Linked NCBI taxonomy ID | 100532 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Asparagaceae |
|---|---|
| ID | 40552 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Liliopsida |
|---|---|
| ID | 4447 |
Natural Activity
List (6)
| Species | Activity |
|---|---|
| Dracaena draco (L.) L. | Antileukemic |
| Dracaena draco (L.) L. | Antitussive |
| Dracaena draco (L.) L. | Apoptotic |
| Dracaena draco (L.) L. | Cicatrizant |
| Dracaena draco (L.) L. | Cytotoxic |
| Dracaena draco (L.) L. | Hemostat |
Metabolite list (24)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00000977
|
Liquiritigenin
|
CHEMBL252642
CHEMBL271939 |
C083152
|
5 / 4 / 4 | 1 / 1 | No. 25 | No. 14 |
|
|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00004541
|
5-Deoxyrhamnocitrin
|
No. 76 | No. 15 |
|
||||
|
C00007923
|
Loureirin C
|
CHEMBL253778
|
No. 90 | No. 13 |
|
|||
|
C00006927
|
Isoliquiritigenin 2'-methy ether
/ 4,4'-Dihydroxy-2'-methoxychalcone |
CHEMBL253777
|
7 / 20 / 19 | No. 92 | No. 13 |
|
||
|
C00006925
|
Isoliquiritigenin
|
CHEMBL129795
CHEMBL1395334 |
C040920
|
59 / 83 / 90 | 12 / 3 | No. 92 | No. 13 |
|
|
C00046586
|
5,7-Dihydroxy-3-(4-hydroxybenzyl)-chromone
|
CHEMBL1080799
|
No. 106 | No. 14 |
|
|||
|
C00003576
|
Diosgenin
|
CHEMBL412437
CHEMBL1551855 CHEMBL1553328 |
D004144
|
6 / 10 / 7 | 15 / 2 | No. 171 | No. 11 |
|
|
C00008780
|
5,4'-Dihydroxy-7'-methoxy-8-methylflavan
|
CHEMBL253562
|
No. 179 | No. 15 |
|
|||
|
C00000953
|
7,4'-Dihydroxy-8-methylflavan
|
CHEMBL251978
CHEMBL1077942 |
No. 179 | No. 15 |
|
|||
|
C00008759
|
7,4'-Dihydroxy-3'-methoxyflavan
|
No. 179 | No. 15 |
|
||||
|
C00008779
|
7,4'-Dihydroxy-3'-methoxy-8-methylflavan
|
No. 179 | No. 15 |
|
||||
|
C00038096
|
(2S)-4',5-Dihydroxy-7-methoxy-8-methylflavan
|
CHEMBL253562
|
No. 179 | No. 15 |
|
|||
|
C00008783
|
7-Hydroxy-5-methoxy-6-methylflavan
|
No. 179 | No. 15 |
|
||||
|
C00000950
|
Cassiaflavan
/ 7,4'-Dihydroxyflavan |
CHEMBL508033
CHEMBL463804 CHEMBL463168 |
4 / 3 / 3 | No. 179 | No. 15 |
|
||
|
C00014596
|
2,4,4'-Trihydroxydihydrochalcone
|
CHEMBL253564
|
No. 548 | No. 13 |
|
|||
|
C00035486
|
3,4,5-Trimethoxycinnamyl alcohol
/ 3',4',5'-Trimethoxycinnamyl alcohol |
No. 723 | No. 6 |
|
||||
|
C00045115
|
trans-beta-Apo-8'-carotenal
|
C004984
|
82 / 0 | No. 747 |
|
|||
|
C00008791
|
8-trans-[2-(6-Benzoyloxy-4-hydroxy-2-methoxy-3-methylphenyl)ethenyl]-5-methoxyflavan-7-ol
|
No. 1113 |
|
|||||
|
C00044730
|
Draconin C
/ (-)-Draconin C |
CHEMBL504939
|
No. 1919 |
|
||||
|
C00044729
|
Draconin B
/ (-)-Draconin B |
CHEMBL447737
|
No. 1919 |
|
||||
|
C00044728
|
Draconin A
/ (-)-Draconin A |
CHEMBL525243
|
No. 1919 |
|
||||
|
C00000955
|
Dracorubin
|
CHEMBL485799
|
No. 4424 | No. 19 |
|
|||
|
C00008799
|
Nordracorubin
|
CHEMBL520374
CHEMBL1996924 |
No. 4424 | No. 19 |
|
Human Protein / Gene in interactions
77 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00000977 C00003672 C00006925 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003576 C00003672 C00006925 | 0 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003672 C00006925 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003672 C00006925 | 1 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00003576 C00006925 | 4 / 3 |
| P05412 | Transcription factor AP-1 | Transcription Factor | C00000977 C00006925 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003672 C00006925 | 1 / 1 |
| P11362 | Fibroblast growth factor receptor 1 | Fgfr | C00006925 C00006927 | 4 / 5 |
| P03372 | Estrogen receptor | NR3A1 | C00000950 C00003672 | 1 / 1 |
| P10721 | Mast/stem cell growth factor receptor Kit | Pdgfr | C00006925 C00006927 | 4 / 3 |
| P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00006925 C00006927 | 2 / 3 |
| P21802 | Fibroblast growth factor receptor 2 | TK tyrosine-protein kinase TLK subfamily | C00006925 C00006927 | 9 / 3 |
| P35968 | Vascular endothelial growth factor receptor 2 | Vegfr | C00006925 C00006927 | 1 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00000977 C00006925 | 2 / 2 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00006925 C00006927 | 0 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00000950 C00000977 | 2 / 2 |
| Q04206 | Transcription factor p65 | Transcription Factor | C00000977 C00006925 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00006925 C00006927 | 1 / 8 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003672 C00006925 | 0 / 1 |
| P00734 | Prothrombin | S1A | C00003672 | 4 / 2 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00003672 | 3 / 2 |
| P54132 | Bloom syndrome protein | Enzyme | C00006925 | 1 / 2 |
| P37840 | Alpha-synuclein | Unclassified protein | C00006925 | 4 / 2 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00006925 | 2 / 3 |
| P14555 | Phospholipase A2, membrane associated | Enzyme | C00000950 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00006925 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00006925 | 2 / 0 |
| O75496 | Geminin | Unclassified protein | C00006925 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00000950 | 0 / 1 |
| P15121 | Aldose reductase | Enzyme | C00006925 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 | 0 / 0 |
| P40763 | Signal transducer and activator of transcription 3 | Transcription Factor | C00003576 | 1 / 2 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00006925 | 0 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00006925 | 1 / 2 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00006925 | 0 / 0 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00006925 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00006925 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00003672 | 1 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00006925 | 11 / 10 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 | 4 / 2 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00006925 | 5 / 3 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00006925 | 0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00006925 | 6 / 4 |
| P06746 | DNA polymerase beta | Enzyme | C00003672 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00006925 | 0 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00006925 | 2 / 2 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00006925 | 3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00006925 | 2 / 2 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00006925 | 5 / 2 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00006925 | 0 / 0 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00003576 | 0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00006925 | 0 / 0 |
| P14618 | Pyruvate kinase PKM | Enzyme | C00006925 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00006925 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00006925 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 | 2 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00006925 | 1 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00006925 | 0 / 0 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00006925 | 1 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00006925 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00003576 | 5 / 1 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00006925 | 7 / 37 |
| Q99549 | M-phase phosphoprotein 8 | Unclassified protein | C00006925 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00006925 | 0 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00003576 | 3 / 0 |
| P42345 | Serine/threonine-protein kinase mTOR | Enzyme | C00006925 | 0 / 0 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 | 1 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00006925 | 0 / 0 |
| P40225 | Thrombopoietin | Unclassified protein | C00006925 | 1 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00006925 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00003672 | 1 / 1 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00006925 | 1 / 0 |
| O00255 | Menin | Unclassified protein | C00006925 | 2 / 5 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00006925 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00006925 | 0 / 3 |
| P51531 | Probable global transcription activator SNF2L2 | Unclassified protein | C00006925 | 1 / 0 |
106 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00003576
C00006925
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00003576
C00006925
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00003576
C00006925
|
| 329 | BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 | baculoviral IAP repeat containing 2 |
C00003576
C00006925
|
| 8743 | TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL | tumor necrosis factor (ligand) superfamily, member 10 |
C00045115
|
| 8659 | ALDH4A1, ALDH4, P5CD, P5CDh | aldehyde dehydrogenase 4 family, member A1 (EC:1.2.1.88) |
C00045115
|
| 287 | ANK2, ANK-2, LQT4, brank-2 | ankyrin 2, neuronal |
C00045115
|
| 288 | ANK3, ANKYRIN-G, MRT37 | ankyrin 3, node of Ranvier (ankyrin G) |
C00045115
|
| 427 | ASAH1, AC, ACDase, ASAH, PHP, PHP32, SMAPME | N-acylsphingosine amidohydrolase (acid ceramidase) 1 (EC:3.5.1.23) |
C00045115
|
| 51665 | ASB1, ASB-1 | ankyrin repeat and SOCS box containing 1 |
C00045115
|
| 140462 | ASB9 | ankyrin repeat and SOCS box containing 9 |
C00045115
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00045115
|
| 9994 | CASP8AP2, CED-4, FLASH, RIP25 | caspase 8 associated protein 2 |
C00045115
|
| 999 | CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO | cadherin 1, type 1, E-cadherin (epithelial) |
C00045115
|
| 9071 | CLDN10, CPETRL3, OSP-L | claudin 10 |
C00045115
|
| 51208 | CLDN18, SFTA5, SFTPJ | claudin 18 |
C00045115
|
| 1277 | COL1A1, OI4 | collagen, type I, alpha 1 |
C00045115
|
| 1282 | COL4A1, HANAC, ICH, POREN1, arresten | collagen, type IV, alpha 1 |
C00045115
|
| 1284 | COL4A2, ICH, POREN2 | collagen, type IV, alpha 2 |
C00045115
|
| 1382 | CRABP2, CRABP-II, RBP6 | cellular retinoic acid binding protein 2 |
C00045115
|
| 1508 | CTSB, APPS, CPSB | cathepsin B (EC:3.4.22.1) |
C00045115
|
| 6387 | CXCL12, IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, SDF1A, SDF1B | chemokine (C-X-C motif) ligand 12 |
C00045115
|
| 6372 | CXCL6, CKA-3, GCP-2, GCP2, SCYB6 | chemokine (C-X-C motif) ligand 6 |
C00045115
|
| 4283 | CXCL9, CMK, Humig, MIG, SCYB9, crg-10 | chemokine (C-X-C motif) ligand 9 |
C00045115
|
| 7852 | CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM | chemokine (C-X-C motif) receptor 4 |
C00045115
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00045115
|
| 1746 | DLX2, TES-1, TES1 | distal-less homeobox 2 |
C00045115
|
| 1748 | DLX4, BP1, DLX7, DLX8, DLX9 | distal-less homeobox 4 |
C00045115
|
| 2068 | ERCC2, COFS2, EM9, TTD, XPD | excision repair cross-complementing rodent repair deficiency, complementation group 2 (EC:3.6.4.12) |
C00045115
|
| 2113 | ETS1, ETS-1, EWSR2 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 |
C00045115
|
| 355 | FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 | Fas cell surface death receptor |
C00045115
|
| 2194 | FASN, FAS, OA-519, SDR27X1 | fatty acid synthase (EC:2.3.1.85 2.3.1.38 2.3.1.39 2.3.1.41 3.1.2.14 4.2.1.59 1.1.1.100 1.3.1.39) |
C00045115
|
| 2627 | GATA6 | GATA binding protein 6 |
C00045115
|
| 2633 | GBP1 | guanylate binding protein 1, interferon-inducible |
C00045115
|
| 81025 | GJA9, CX58, CX59, GJA10 | gap junction protein, alpha 9, 59kDa |
C00045115
|
| 373156 | GSTK1, GST, GST_13-13, GST13, GST13-13, GSTK1-1, hGSTK1 | glutathione S-transferase kappa 1 (EC:2.5.1.18) |
C00045115
|
| 2946 | GSTM2, GST4, GSTM, GSTM2-2, GTHMUS | glutathione S-transferase mu 2 (muscle) (EC:2.5.1.18) |
C00045115
|
| 2948 | GSTM4, GSTM4-4, GTM4 | glutathione S-transferase mu 4 (EC:2.5.1.18) |
C00045115
|
| 2949 | GSTM5, GSTM5-5, GTM5 | glutathione S-transferase mu 5 (EC:2.5.1.18) |
C00045115
|
| 2954 | GSTZ1, GSTZ1-1, MAAI, MAI | glutathione S-transferase zeta 1 (EC:2.5.1.18 5.2.1.2) |
C00045115
|
| 3204 | HOXA7, ANTP, HOX1, HOX1.1, HOX1A | homeobox A7 |
C00045115
|
| 3216 | HOXB6, HOX2, HOX2B, HU-2, Hox-2.2 | homeobox B6 |
C00045115
|
| 3226 | HOXC10, HOX3I | homeobox C10 |
C00045115
|
| 3448 | IFNA14, IFN-alphaH, LEIF2H | interferon, alpha 14 |
C00045115
|
| 3449 | IFNA16, IFN-alphaO | interferon, alpha 16 |
C00045115
|
| 3451 | IFNA17, IFN-alphaI, IFNA, INFA, LEIF2C1 | interferon, alpha 17 |
C00045115
|
| 3442 | IFNA5, IFN-alpha-5, IFN-alphaG, INA5, INFA5, leIF_G | interferon, alpha 5 |
C00045115
|
| 3394 | IRF8, H-ICSBP, ICSBP, ICSBP1, IRF-8 | interferon regulatory factor 8 |
C00045115
|
| 50805 | IRX4, IRXA3 | iroquois homeobox 4 |
C00045115
|
| 3691 | ITGB4, CD104 | integrin, beta 4 |
C00045115
|
| 3713 | IVL | involucrin |
C00045115
|
| 3872 | KRT17, K17, PC, PC2, PCHC1 | keratin 17 |
C00045115
|
| 3849 | KRT2, CK-2e, K2e, KRT2A, KRT2E, KRTE | keratin 2 |
C00045115
|
| 3855 | KRT7, CK7, K2C7, K7, SCL | keratin 7 |
C00045115
|
| 8022 | LHX3, CPHD3, LIM3, M2-LHX3 | LIM homeobox 3 |
C00045115
|
| 4170 | MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT | myeloid cell leukemia sequence 1 (BCL2-related) |
C00045115
|
| 4212 | MEIS2, HsT18361, MRG1 | Meis homeobox 2 |
C00045115
|
| 4222 | MEOX1, KFS2, MOX1 | mesenchyme homeobox 1 |
C00045115
|
| 3110 | MNX1, HB9, HLXB9, HOXHB9, SCRA1 | motor neuron and pancreas homeobox 1 |
C00045115
|
| 4439 | MSH5, G7, MUTSH5, NG23 | mutS homolog 5 |
C00045115
|
| 4586 | MUC5AC, MUC5, TBM, leB | mucin 5AC, oligomeric mucus/gel-forming |
C00045115
|
| 4842 | NOS1, IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS | nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) |
C00045115
|
| 4973 | OLR1, CLEC8A, LOX1, LOXIN, SCARE1, SLOX1 | oxidized low density lipoprotein (lectin-like) receptor 1 |
C00045115
|
| 5098 | PCDHGC3, PC43, PCDH-GAMMA-C3, PCDH2 | protocadherin gamma subfamily C, 3 |
C00045115
|
| 5359 | PLSCR1, MMTRA1B | phospholipid scramblase 1 |
C00045115
|
| 57048 | PLSCR3 | phospholipid scramblase 3 |
C00045115
|
| 57088 | PLSCR4, TRA1 | phospholipid scramblase 4 |
C00045115
|
| 10635 | RAD51AP1, PIR51 | RAD51 associated protein 1 |
C00045115
|
| 5892 | RAD51D, BROVCA4, R51H3, RAD51L3, TRAD | RAD51 paralog D |
C00045115
|
| 5914 | RARA, NR1B1, RAR | retinoic acid receptor, alpha |
C00045115
|
| 5915 | RARB, HAP, NR1B2, RRB2 | retinoic acid receptor, beta |
C00045115
|
| 5918 | RARRES1, LXNL, TIG1 | retinoic acid receptor responder (tazarotene induced) 1 |
C00045115
|
| 5920 | RARRES3, HRASLS4, HRSL4, PLA1/2-3, RIG1, TIG3 | retinoic acid receptor responder (tazarotene induced) 3 |
C00045115
|
| 4990 | SIX6, MCOPCT2, OPTX2, Six9 | SIX homeobox 6 |
C00045115
|
| 6647 | SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer | superoxide dismutase 1, soluble (EC:1.15.1.1) |
C00045115
|
| 9517 | SPTLC2, HSN1C, LCB2, LCB2A, NSAN1C, SPT2, hLCB2a | serine palmitoyltransferase, long chain base subunit 2 (EC:2.3.1.50) |
C00045115
|
| 6720 | SREBF1, SREBP-1c, SREBP1, bHLHd1 | sterol regulatory element binding transcription factor 1 |
C00045115
|
| 7047 | TGM4, TGP, hTGP | transglutaminase 4 (EC:2.3.2.13) |
C00045115
|
| 3604 | TNFRSF9, 4-1BB, CD137, CDw137, ILA | tumor necrosis factor receptor superfamily, member 9 |
C00045115
|
| 221 | ALDH3B1, ALDH4, ALDH7 | aldehyde dehydrogenase 3 family, member B1 (EC:1.2.1.5) |
C00045115
|
| 10190 | TXNDC9, APACD, PHLP3 | thioredoxin domain containing 9 |
C00045115
|
| 7517 | XRCC3, CMM6 | X-ray repair complementing defective repair in Chinese hamster cells 3 |
C00045115
|
| 34 | ACADM, ACAD1, MCAD, MCADH | acyl-CoA dehydrogenase, C-4 to C-12 straight chain (EC:1.3.8.7) |
C00045115
|
| 219 | ALDH1B1, ALDH5, ALDHX | aldehyde dehydrogenase 1 family, member B1 (EC:1.2.1.3) |
C00045115
|
| 330 | BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 | baculoviral IAP repeat containing 3 |
C00006925
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00006925
|
| 128 | ADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR | alcohol dehydrogenase 5 (class III), chi polypeptide (EC:1.1.1.1 1.1.1.284) |
C00045115
|
| 124 | ADH1A, ADH1 | alcohol dehydrogenase 1A (class I), alpha polypeptide (EC:1.1.1.1) |
C00045115
|
| 6513 | SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED | solute carrier family 2 (facilitated glucose transporter), member 1 |
C00006925
|
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) |
C00006925
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00006925
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00006925
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00006925
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00006925
|
| 1831 | TSC22D3, DIP, DSIPI, GILZ, TSC-22R, hDIP | TSC22 domain family, member 3 |
C00000977
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00003576
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00003576
|
| 597 | BCL2A1, ACC-1, ACC-2, BCL2L5, BFL1, GRS, HBPA1 | BCL2-related protein A1 |
C00003576
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00003576
|
| 8837 | CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS | CASP8 and FADD-like apoptosis regulator |
C00003576
|
| 4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) |
C00003576
|
| 4609 | MYC, MRTL, MYCC, bHLHe39, c-Myc | v-myc avian myelocytomatosis viral oncogene homolog |
C00003576
|
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
C00003576
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00003576
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00003576
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00003576
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (108)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #207410 | Antley-bixler syndrome without genital anomalies or disordered steroidogenesis; abs2 |
P21802
|
| #101200 | Apert syndrome |
P21802
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #123790 | Beare-stevenson cutis gyrata syndrome; bstvs |
P21802
|
| #614592 | Bent bone dysplasia syndrome; bbds |
P21802
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #210900 | Bloom syndrome; blm |
P54132
|
| %606641 | Body mass index; bmi |
P37231
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #123500 | Crouzon syndrome |
P21802
|
| #127750 | Dementia, lewy body; dlb |
P37840
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #606764 | Gastrointestinal stromal tumor; gist |
P10721
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P37231 |
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #602089 | Hemangioma, capillary infantile |
P35968
|
| #114550 | Hepatocellular carcinoma |
P08581
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #147060 | Hyper-ige recurrent infection syndrome, autosomal dominant |
P40763
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #147950 | Hypogonadotropic hypogonadism 2 with or without anosmia; hh2 |
P11362
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #123150 | Jackson-weiss syndrome; jws |
P21802
|
| #149730 | Lacrimoauriculodentodigital syndrome; ladd |
P21802
|
| #601626 | Leukemia, acute myeloid; aml |
P10721
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04637 |
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #601358 | Nicolaides-baraitser syndrome; ncbrs |
P51531
|
| #601665 | Obesity |
P37231
|
| #166250 | Osteoglophonic dysplasia; ogd |
P11362
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168601 | Parkinson disease 1, autosomal dominant; park1 |
P37840
|
| #605543 | Parkinson disease 4, autosomal dominant; park4 |
P37840
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
P37840 |
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #101600 | Pfeiffer syndrome |
P11362
P21802 |
| #172700 | Pick disease of brain |
P10636
|
| #172800 | Piebald trait; pbt |
P10721
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #605074 | Renal cell carcinoma, papillary, 1; rccp1 |
P08581
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #609579 | Scaphocephaly, maxillary retrusion, and mental retardation |
P21802
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601367 | Stroke, ischemic |
P00734
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #273300 | Testicular germ cell tumor; tgct |
P10721
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #190440 | Trigonocephaly 1; trigno1 |
P11362
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (100)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) P40763 (related) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04637 (related) P08581 (related) P21802 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04637 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P04637 (related) |
| H00030 | Cervical cancer |
P00533
(related)
|
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) Q92731 (marker) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
P37840 (related) |
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P14780 (related) P35354 (related) |
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
P14679 (marker) |
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
P08581 (related) P35354 (related) |
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
P08581 (related) |
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P10721
(related)
P10721 (marker) |
| H00170 | Piebaldism |
P10721
(related)
|
| H00023 | Testicular cancer |
P10721
(marker)
|
| H00255 | Hypogonadotropic hypogonadism |
P11362
(related)
|
| H00443 | Osteoglophonic dysplasia (OD) |
P11362
(related)
|
| H00458 | Craniosynostosis |
P11362
(related)
P21802 (related) |
| H00516 | Isolated orofacial clefts |
P11362
(related)
|
| H01207 | Trigonocephaly |
P11362
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P11511
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00642 | Lacrimo-auriculo-dento-digital syndrome (LADD) |
P21802
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00057 | Parkinson's disease (PD) |
P37840
(related)
|
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00107 | Other well-defined immunodeficiency syndromes |
P40763
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|