Smilax china
Species
KNApSAcK Entry
| Organism name | Smilax china |
|---|---|
| Genus | Smilax |
| Family | Smilacaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Smilax china |
|---|---|
| Linked NCBI taxonomy ID | 49657 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Smilacaceae |
|---|---|
| ID | 4703 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Liliopsida |
|---|---|
| ID | 4447 |
Metabolite list (15)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00003575
|
Dioscin
|
CHEMBL507001
CHEMBL2036081 CHEMBL2036082 |
C019357
|
0 / 2 | No. 17 | No. 11 |
|
|
|
C00030764
|
Smilax saponin B
/ Methylprotodioscin / Methyl protodioscin / (-)-Methylprotodioscin |
CHEMBL453625
CHEMBL1993106 CHEMBL2004298 |
No. 21 | No. 11 |
|
|||
|
C00003585
|
Protodioscin
/ 3beta,22alpha,26-Trihydroxyfurost-5-ene-3-O-beta-chacotrioside-26-O-beta-D-glucopyranoside |
CHEMBL1163175
CHEMBL1981285 CHEMBL1995734 |
No. 21 | No. 11 |
|
|||
|
C00031101
|
Pseudoprotodioscin
/ (-)-Pseudoprotodioscin |
No. 21 | No. 11 |
|
||||
|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00003576
|
Diosgenin
|
CHEMBL412437
CHEMBL1551855 CHEMBL1553328 |
D004144
|
6 / 10 / 7 | 15 / 2 | No. 171 | No. 11 |
|
|
C00043008
|
Smilaside F
/ (+)-Smilaside F |
CHEMBL500983
|
No. 334 |
|
||||
|
C00043007
|
Smilaside E
/ (+)-Smilaside E |
CHEMBL507530
|
No. 334 |
|
||||
|
C00043006
|
Smilaside D
/ (+)-Smilaside D |
CHEMBL490680
|
No. 334 |
|
||||
|
C00043005
|
Smilaside C
/ (+)-Smilaside C |
CHEMBL502580
|
No. 334 |
|
||||
|
C00043004
|
Smilaside B
/ (+)-Smilaside B |
CHEMBL475478
|
No. 418 |
|
||||
|
C00033906
|
Helonioside A
|
CHEMBL2151691
|
No. 418 |
|
||||
|
C00043003
|
Smilaside A
|
CHEMBL446732
|
No. 418 |
|
||||
|
C00019308
|
Doursterol
/ Daucosterin / 3-O-beta-D-Glucopyranosyl sitosterol / beta-Sitosterol 3-O-beta-D-glucopyranoside |
CHEMBL197711
CHEMBL506678 CHEMBL2304043 |
C011015
|
5 / 4 / 2 | 0 / 3 | No. 520 |
|
|
|
C00030221
|
Ethyl caffeate
/ Ethyl 3,4-dihydroxy cinnamate |
CHEMBL17347
|
C032773
|
No. 876 |
|
Human Protein / Gene in interactions
22 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P00734 | Prothrombin | S1A | C00003672 C00019308 | 4 / 2 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003576 C00003672 | 0 / 1 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00003672 C00019308 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 C00019308 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00003672 C00019308 | 0 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 C00019308 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003672 | 1 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00003672 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003672 | 0 / 1 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 | 2 / 0 |
| P40763 | Signal transducer and activator of transcription 3 | Transcription Factor | C00003576 | 1 / 2 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00003672 | 3 / 2 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 | 4 / 2 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003672 | 0 / 0 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00003576 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00003672 | 1 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003672 | 1 / 1 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00003576 | 3 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00003576 | 5 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00003576 | 4 / 3 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 | 1 / 1 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00003672 | 1 / 1 |
15 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00003576
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00003576
|
| 597 | BCL2A1, ACC-1, ACC-2, BCL2L5, BFL1, GRS, HBPA1 | BCL2-related protein A1 |
C00003576
|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00003576
|
| 329 | BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 | baculoviral IAP repeat containing 2 |
C00003576
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00003576
|
| 8837 | CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS | CASP8 and FADD-like apoptosis regulator |
C00003576
|
| 4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) |
C00003576
|
| 4609 | MYC, MRTL, MYCC, bHLHe39, c-Myc | v-myc avian myelocytomatosis viral oncogene homolog |
C00003576
|
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
C00003576
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00003576
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00003576
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00003576
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00003576
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00003576
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (29)
| OMIM | preferred title | UniProt |
|---|---|---|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #147060 | Hyper-ige recurrent infection syndrome, autosomal dominant |
P40763
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601367 | Stroke, ischemic |
P00734
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
KEGG DISEASE (18)
| KEGG | name | UniProt |
|---|---|---|
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00016 | Oral cancer |
P40763
(related)
|
| H00107 | Other well-defined immunodeficiency syndromes |
P40763
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
7 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D002493 | Central Nervous System Diseases |
C00019308
|
| D003072 | Cognition Disorders |
C00019308
|
| D013118 | Spinal Cord Diseases |
C00019308
|
| D056486 | Drug-Induced Liver Injury |
C00003575
|
| D009336 | Necrosis |
C00003575
|
| D002779 | Cholestasis |
C00003576
|
| D006949 | Hyperlipidemias |
C00003576
|