PCIDB

KNApSAcK Metabolite C00003617

Metabolite

KNApSAcK Entry

id C00003617
Name Digitoxin
CAS RN 71-63-6
Standard InChI InChI=1S/C41H64O13/c1-20-36(46)29(42)16-34(49-20)53-38-22(3)51-35(18-31(38)44)54-37-21(2)50-33(17-30(37)43)52-25-8-11-39(4)24(15-25)6-7-28-27(39)9-12-40(5)26(10-13-41(28,40)47)23-14-32(45)48-19-23/h14,20-22,24-31,33-38,42-44,46-47H,6-13,15-19H2,1-5H3/t20?,21?,22?,24-,25+,26-,27+,28-,29+,30-,31+,33+,34-,35-,36?,37-,38?,39+,40-,41+/m1/s1
Standard InChI (Main Layer) InChI=1S/C41H64O13/c1-20-36(46)29(42)16-34(49-20)53-38-22(3)51-35(18-31(38)44)54-37-21(2)50-33(17-30(37)43)52-25-8-11-39(4)24(15-25)6-7-28-27(39)9-12-40(5)26(10-13-41(28,40)47)23-14-32(45)48-19-23/h14,20-22,24-31,33-38,42-44,46-47H,6-13,15-19H2,1-5H3

Cluster

Phytochemical cluster No. 56
KCF-S cluster No. 272

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL267817 CHEMBL254219 CHEMBL1324812 CHEMBL1899295

KEGG

By LinkDB C06955

CTD

By CAS RN D004074

Species

Summary

Plant class

class name count
asterids 1

Family

family name count
Plantaginaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Digitalis purpurea 4164 Plantaginaceae asterids Viridiplantae

Human Protein / Gene in interaction

124 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL254219 CHEMBL1909136 (2)
1 / 0
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL254219 CHEMBL1324812 CHEMBL1613992 (2)
7 / 44
Q16637 Survival motor neuron protein Unclassified protein CHEMBL1324812 CHEMBL1613842 (1)
4 / 2
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL254219 CHEMBL1909139 (2)
0 / 0
P27338 Amine oxidase [flavin-containing] B Oxidoreductase CHEMBL254219 CHEMBL965575 (1)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL254219 CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL254219 CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL254219 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL254219 CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL254219 CHEMBL1909201 (2)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL254219 CHEMBL1909176 (2)
0 / 0
P29466 Caspase-1 C14 CHEMBL254219 CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL254219 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL254219 CHEMBL1909199 (2)
0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 CHEMBL254219 CHEMBL1794524 (1) CHEMBL1794552 (1)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL254219 CHEMBL1909197 (2)
2 / 2
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL1324812 CHEMBL1614331 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL267817 CHEMBL254219 CHEMBL1614544 (2)
11 / 10
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL254219 CHEMBL1794399 (1)
3 / 1
P19793 Retinoic acid receptor RXR-alpha NR2B1 CHEMBL254219 CHEMBL1794371 (1) CHEMBL1794471 (1)
0 / 0
P00918 Carbonic anhydrase 2 Lyase CHEMBL254219 CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL254219 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL254219 CHEMBL965569 (1) CHEMBL965573 (1)
CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL254219 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL254219 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL254219 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL254219 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL254219 CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL254219 CHEMBL1909093 (2)
0 / 0
P02768 Serum albumin Secreted protein CHEMBL254219 CHEMBL646313 (1) CHEMBL702884 (1)
CHEMBL702885 (1)
0 / 0
P08183 Multidrug resistance protein 1 drug CHEMBL254219 CHEMBL2077338 (1)
1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL254219 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL254219 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL254219 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL254219 CHEMBL1909135 (2)
0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL254219 CHEMBL1909203 (2)
1 / 11
P11388 DNA topoisomerase 2-alpha Isomerase CHEMBL254219 CHEMBL1025063 (1) CHEMBL1025064 (1)
CHEMBL1025065 (1)
0 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL254219 CHEMBL1794376 (1)
2 / 3
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL254219 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL254219 CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL254219 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL254219 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL254219 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL254219 CHEMBL1909214 (2)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL254219 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL254219 CHEMBL1909096 (2)
1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL254219 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL254219 CHEMBL1909166 (2)
1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL254219 CHEMBL1909133 (2)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL254219 CHEMBL1899295 CHEMBL1794584 (2)
2 / 0
O75496 Geminin Unclassified protein CHEMBL267817 CHEMBL254219 CHEMBL2114843 (2) CHEMBL2114780 (2)
0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein CHEMBL254219 CHEMBL1613838 (1)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL254219 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL254219 CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL254219 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL254219 CHEMBL1909101 (2)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL254219 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL254219 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL254219 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL254219 CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL254219 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL254219 CHEMBL1909100 (2)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL254219 CHEMBL1909167 (2)
1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL254219 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL254219 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL254219 CHEMBL1909110 (2)
1 / 0
P40763 Signal transducer and activator of transcription 3 Transcription Factor CHEMBL254219 CHEMBL1614133 (1)
1 / 2
P03956 Interstitial collagenase M10A CHEMBL254219 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL254219 CHEMBL1909119 (2)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL254219 CHEMBL1794382 (1) CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL254219 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL254219 CHEMBL1909170 (2)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL254219 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL254219 CHEMBL1909109 (2)
2 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL254219 CHEMBL1794293 (1)
5 / 3
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL254219 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL254219 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL254219 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL254219 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL254219 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL254219 CHEMBL1909108 (2)
0 / 0
Q96RI1 Bile acid receptor NR1H4 CHEMBL254219 CHEMBL1794437 (1)
0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL254219 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL254219 CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL254219 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL254219 CHEMBL1909132 (2)
0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein CHEMBL254219 CHEMBL1614342 (1)
1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL254219 CHEMBL1738588 (1)
0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL254219 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL254219 CHEMBL1794364 (1) CHEMBL1794542 (1)
CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL254219 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL254219 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL254219 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL254219 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL254219 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL254219 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL254219 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL254219 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL254219 CHEMBL1909168 (2)
0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase CHEMBL254219 CHEMBL1025066 (1) CHEMBL1025067 (1)
CHEMBL1025069 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL254219 CHEMBL1909134 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL254219 CHEMBL1909138 (2)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL254219 CHEMBL1909137 (2)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL254219 CHEMBL1614421 (2)
4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL254219 CHEMBL1738184 (1) CHEMBL2114890 (1)
0 / 0
P10275 Androgen receptor NR3C4 CHEMBL254219 CHEMBL1794321 (1)
3 / 4
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL254219 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL254219 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL254219 CHEMBL1909213 (2)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL254219 CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL254219 CHEMBL1909116 (2)
1 / 1
P06239 Tyrosine-protein kinase Lck Src CHEMBL254219 CHEMBL1909206 (2)
0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL254219 CHEMBL1909128 (2)
0 / 0
P42224 Signal transducer and activator of transcription 1-alpha/beta Unclassified protein CHEMBL254219 CHEMBL1614313 (1)
3 / 3
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL254219 CHEMBL2354311 (1)
1 / 0
Q6ZQN7 Solute carrier organic anion transporter family member 4C1 Unclassified protein CHEMBL254219 CHEMBL2075764 (1)
0 / 0
P05023 Sodium/potassium-transporting ATPase subunit alpha-1 Hydrolase CHEMBL254219 CHEMBL669631 (1)
0 / 0
P14415 Sodium/potassium-transporting ATPase subunit beta-2 potassium_sodium CHEMBL254219 CHEMBL669631 (1)
0 / 0
P13637 Sodium/potassium-transporting ATPase subunit alpha-3 Hydrolase CHEMBL254219 CHEMBL669631 (1)
2 / 1
Q13733 Sodium/potassium-transporting ATPase subunit alpha-4 Hydrolase CHEMBL254219 CHEMBL669631 (1)
0 / 0
P54710 Sodium/potassium-transporting ATPase subunit gamma potassium_sodium CHEMBL254219 CHEMBL669631 (1)
1 / 1
P54709 Sodium/potassium-transporting ATPase subunit beta-3 potassium_sodium CHEMBL254219 CHEMBL669631 (1)
0 / 0
P50993 Sodium/potassium-transporting ATPase subunit alpha-2 Hydrolase CHEMBL254219 CHEMBL669631 (1)
2 / 2
P05026 Sodium/potassium-transporting ATPase subunit beta-1 potassium_sodium CHEMBL254219 CHEMBL669631 (1)
0 / 0

CTD interaction (48)

compound gene gene name gene description interaction interaction type form reference
pmid
D004074 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Digitoxin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium] decreases reaction
/ increases transport
protein 23104431
D004074 332 BIRC5
API4
EPR-1
baculoviral IAP repeat containing 5 Digitoxin analog results in decreased expression of BIRC5 protein decreases expression
protein 22037315
D004074 332 BIRC5
API4
EPR-1
baculoviral IAP repeat containing 5 Digitoxin results in decreased expression of BIRC5 protein decreases expression
protein 22037315
D004074 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Digitoxin analog results in decreased expression of CASP3 protein decreases expression
protein 22037315
D004074 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Digitoxin results in decreased expression of CASP3 protein decreases expression
protein 22037315
D004074 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) Digitoxin analog results in increased cleavage of CASP8 protein increases cleavage
protein 22037315
D004074 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) Digitoxin results in increased cleavage of CASP8 protein increases cleavage
protein 22037315
D004074 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Digitoxin analog results in increased cleavage of CASP9 protein increases cleavage
protein 22037315
D004074 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Digitoxin results in increased cleavage of CASP9 protein increases cleavage
protein 22037315
D004074 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]] decreases reaction
/ increases expression
protein 19446813
D004074 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein] decreases reaction
/ increases expression
protein 19446813
D004074 891 CCNB1
CCNB
cyclin B1 Digitoxin analog results in decreased expression of CCNB1 protein decreases expression
protein 22037315
D004074 891 CCNB1
CCNB
cyclin B1 Digitoxin analog results in decreased expression of [CCNB1 protein binds to CDK1 protein] affects binding
/ decreases expression
protein 22037315
D004074 891 CCNB1
CCNB
cyclin B1 Digitoxin results in decreased expression of CCNB1 protein decreases expression
protein 22037315
D004074 891 CCNB1
CCNB
cyclin B1 Digitoxin results in decreased expression of [CCNB1 protein binds to CDK1 protein] affects binding
/ decreases expression
protein 22037315
D004074 983 CDK1
CDC2
CDC28A
P34CDC2
cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) Digitoxin analog results in decreased expression of [CCNB1 protein binds to CDK1 protein] affects binding
/ decreases expression
protein 22037315
D004074 983 CDK1
CDC2
CDC28A
P34CDC2
cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) Digitoxin analog results in decreased expression of CDK1 protein decreases expression
protein 22037315
D004074 983 CDK1
CDC2
CDC28A
P34CDC2
cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) Digitoxin results in decreased expression of [CCNB1 protein binds to CDK1 protein] affects binding
/ decreases expression
protein 22037315
D004074 983 CDK1
CDC2
CDC28A
P34CDC2
cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) Digitoxin results in decreased expression of CDK1 protein decreases expression
protein 22037315
D004074 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Digitoxin analog results in decreased expression of CDKN1A protein decreases expression
protein 22037315
D004074 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Digitoxin results in decreased expression of CDKN1A protein decreases expression
protein 22037315
D004074 1027 CDKN1B
CDKN4
KIP1
MEN1B
MEN4
P27KIP1
cyclin-dependent kinase inhibitor 1B (p27, Kip1) Digitoxin analog results in decreased expression of CDKN1B protein decreases expression
protein 22037315
D004074 1027 CDKN1B
CDKN4
KIP1
MEN1B
MEN4
P27KIP1
cyclin-dependent kinase inhibitor 1B (p27, Kip1) Digitoxin results in decreased expression of CDKN1B protein decreases expression
protein 22037315
D004074 1111 CHEK1
CHK1
checkpoint kinase 1 (EC:2.7.11.1) Digitoxin analog results in decreased expression of CHEK1 protein decreases expression
protein 22037315
D004074 1111 CHEK1
CHK1
checkpoint kinase 1 (EC:2.7.11.1) Digitoxin results in decreased expression of CHEK1 protein decreases expression
protein 22037315
D004074 11200 CHEK2
CDS1
CHK2
HuCds1
LFS2
PP1425
RAD53
hCds1
checkpoint kinase 2 (EC:2.7.11.1) Digitoxin analog results in decreased expression of CHEK2 protein decreases expression
protein 22037315
D004074 11200 CHEK2
CDS1
CHK2
HuCds1
LFS2
PP1425
RAD53
hCds1
checkpoint kinase 2 (EC:2.7.11.1) Digitoxin results in decreased expression of CHEK2 protein decreases expression
protein 22037315
D004074 54205 CYCS
CYC
HCS
THC4
cytochrome c, somatic Digitoxin analog results in increased expression of CYCS protein increases expression
protein 22037315
D004074 54205 CYCS
CYC
HCS
THC4
cytochrome c, somatic Digitoxin results in increased expression of CYCS protein increases expression
protein 22037315
D004074 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]] decreases reaction
/ increases activity
protein 19446813
D004074 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]] decreases reaction
/ increases expression
protein 19446813
D004074 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
protein 19446813
D004074 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
protein 19446813
D004074 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein] decreases reaction
/ increases activity
protein 19446813
D004074 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein] decreases reaction
/ increases expression
protein 19446813
D004074 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Digitoxin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 19446813
D004074 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Digitoxin results in decreased secretion of IL8 protein decreases secretion
protein 15136726
D004074 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
protein 19446813
D004074 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Digitoxin inhibits the reaction [IL1B protein results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
protein 19446813
D004074 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]] decreases reaction
/ increases activity
protein 19446813
D004074 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein] decreases reaction
/ increases activity
protein 19446813
D004074 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Digitoxin results in decreased phosphorylation of NFKBIA protein decreases phosphorylation
protein 15136726
D004074 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin results in increased activity of NOS3 protein] decreases reaction
/ increases activity
protein 19446813
D004074 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) Calcium deficiency inhibits the reaction [Digitoxin results in increased activity of NOS3 protein] decreases reaction
/ increases activity
protein 19446813
D004074 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) Digitoxin results in increased activity of NOS3 protein increases activity
protein 19446813
D004074 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Digitoxin analog results in decreased expression of TP53 protein decreases expression
protein 22037315
D004074 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Digitoxin results in decreased expression of TP53 protein decreases expression
protein 22037315
D004074 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 Digitoxin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 19446813

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (85)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103780 Alcohol dependence P08172
P14416
P31645
#104290 Alternating hemiplegia of childhood 1; ahc1 P50993
#614820 Alternating hemiplegia of childhood 2; ahc2 P13637
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#209950 Atypical mycobacteriosis, familial P42224
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
%606641 Body mass index; bmi P37231
#300615 Brunner syndrome P21397
#614162 Candidiasis, familial, 7; candf7 P42224
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#128235 Dystonia 12; dyt12 P13637
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 O75874
P04626
P37231
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#147060 Hyper-ige recurrent infection syndrome, autosomal dominant P40763
#154020 Hypomagnesemia 2, renal; homg2 P54710
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#602481 Migraine, familial hemiplegic, 2; fhm2 P50993
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#613796 Mycobacterial and viral infections, susceptibility to, autosomal recessive P42224
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P32245
P37231
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (86)

KEGG disease name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
P40763 (related)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00831 Primary dystonia P13637 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00107 Other well-defined immunodeficiency syndromes P40763 (related)
H00089 IFN-gamma/IL-12 axis P42224 (related)
H00363 Candidiasis P42224 (related)
H01109 Chronic mucocutaneous candidiasis (CMC) P42224 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00775 Familial or sporadic hemiplegic migraine P50993 (related)
H00998 Alternating hemiplegia of childhood P50993 (related)
H01210 Hypomagnesemia P54710 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)

Diseases related to CTD interactions

43 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D001145 D004074 Arrhythmias, Cardiac marker/mechanism
6022657
D001281 D004074 Atrial Fibrillation therapeutic
4255107
17460324
D001282 D004074 Atrial Flutter marker/mechanism
5654317
D018880 D004074 Atrial Premature Complexes therapeutic
2447325
D054537 D004074 Atrioventricular Block marker/mechanism
4255107
5654317
5727264
C535438 D004074 Bidirectional tachycardia marker/mechanism
4781244
12145041
15674736
D001919 D004074 Bradycardia marker/mechanism
1179459
8212711
D002037 D004074 Bundle-Branch Block marker/mechanism
15674736
D002289 D004074 Carcinoma, Non-Small-Cell Lung therapeutic
22037315
D006332 D004074 Cardiomegaly therapeutic
2436403
D009202 D004074 Cardiomyopathies marker/mechanism
4909201
5384065
D002318 D004074 Cardiovascular Diseases therapeutic
19446813
D003221 D004074 Confusion marker/mechanism
7361148
D003251 D004074 Constriction, Pathologic marker/mechanism
7059269
D003693 D004074 Delirium marker/mechanism
7361148
D003866 D004074 Depressive Disorder marker/mechanism
5643946
D064420 D004074 Drug-Related Side Effects and Adverse Reactions marker/mechanism
4255107
4418514
4781244
5130149
5447167
7146044
7162976
8212711
15674736
18272488
D006323 D004074 Heart Arrest marker/mechanism
7119638
D006331 D004074 Heart Diseases therapeutic
11532201
D006333 D004074 Heart Failure therapeutic
18272488
D006530 D004074 Hepatorenal Syndrome therapeutic
11051385
D006973 D004074 Hypertension therapeutic
11016824
D007022 D004074 Hypotension marker/mechanism
11016824
D020925 D004074 Hypoxia-Ischemia, Brain marker/mechanism
14574425
D053609 D004074 Lethargy marker/mechanism
7361148
C537347 D004074 Mesenteric vascular disease marker/mechanism
7059269
D009069 D004074 Movement Disorders marker/mechanism
7146044
7361148
D020258 D004074 Neurotoxicity Syndromes marker/mechanism
14574425
D010554 D004074 Personality Disorders marker/mechanism
7361148
D011660 D004074 Pulmonary Heart Disease therapeutic
4018179
D012021 D004074 Reflex, Abnormal marker/mechanism
7146044
D012640 D004074 Seizures marker/mechanism
5569832
5643946
7146044
D012804 D004074 Sick Sinus Syndrome marker/mechanism
17460324
D012848 D004074 Sinoatrial Block marker/mechanism
8212711
D013617 D004074 Tachycardia, Supraventricular marker/mechanism
therapeutic
2447325
4255107
5727264
D017180 D004074 Tachycardia, Ventricular marker/mechanism
914999
4255107
D013921 D004074 Thrombocytopenia marker/mechanism
8212711
D014202 D004074 Tremor marker/mechanism
7146044
D014549 D004074 Urinary Incontinence marker/mechanism
7361148
D020301 D004074 Vasospasm, Intracranial marker/mechanism
14574425
D018487 D004074 Ventricular Dysfunction, Left therapeutic
4018179
D014693 D004074 Ventricular Fibrillation marker/mechanism
11808
7162976
D018879 D004074 Ventricular Premature Complexes marker/mechanism
4255107