Digitalis purpurea
Species
KNApSAcK Entry
| Organism name | Digitalis purpurea |
|---|---|
| Genus | Digitalis |
| Family | Plantaginaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Digitalis purpurea |
|---|---|
| Linked NCBI taxonomy ID | 4164 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Plantaginaceae |
|---|---|
| ID | 156152 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (16)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00004867
|
Digicitrin
|
CHEMBL470677
|
No. 8 | No. 15 |
|
|||
|
C00003578
|
Gitonin
|
CHEMBL510031
CHEMBL1971976 |
C029021
|
No. 21 | No. 11 |
|
||
|
C00003594
|
Tigonin
|
No. 21 | No. 11 |
|
||||
|
C00003574
|
Digitonin
|
CHEMBL404811
CHEMBL509531 CHEMBL2005540 |
D004072
|
105 / 60 / 67 | No. 21 | No. 11 |
|
|
|
C00002769
|
Purpureaside C
|
CHEMBL393090
CHEMBL510539 |
6 / 3 / 4 | No. 33 |
|
|||
|
C00002767
|
Plantamajoside
|
C421173
|
No. 33 |
|
||||
|
C00035379
|
Purpureaside B
|
No. 33 |
|
|||||
|
C00003577
|
Gitogenin
|
CHEMBL1770687
|
C012999
|
No. 171 | No. 11 |
|
||
|
C00003573
|
Digitogenin
|
No. 171 | No. 11 |
|
||||
|
C00003622
|
Gitoxin
|
CHEMBL109317
CHEMBL137281 CHEMBL2069121 |
C005003
|
15 / 29 / 19 | No. 272 | No. 56 |
|
|
|
C00003616
|
Digitalin
/ Digitalinum verum / Schmiedeberg's digitalin |
CHEMBL505674
|
C034791
|
0 / 1 | No. 272 | No. 56 |
|
|
|
C00003617
|
Digitoxin
|
CHEMBL267817
CHEMBL254219 CHEMBL1324812 CHEMBL1899295 |
D004074
|
124 / 85 / 86 | 22 / 43 | No. 272 | No. 56 |
|
|
C00000615
|
Caffeic acid
|
CHEMBL145
CHEMBL1320034 |
68 / 64 / 63 | No. 904 | No. 6 |
|
||
|
C00001116
|
Digitalose
/ beta-D-Digitalopyranose / 6-Deoxy-3-O-methylgalactose |
C000964
|
No. 1283 |
|
||||
|
C00001191
|
L-Lactic acid
/ (S)-(+)-Lactic acid |
CHEMBL330546
CHEMBL358850 CHEMBL1200559 |
96 / 44 / 56 | No. 5531 |
|
|||
|
C00035271
|
Cornoside
|
C473622
|
No. 7173 |
|
Human Protein / Gene in interactions
189 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000615 C00001191 C00002769 C00003574 C00003617 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000615 C00001191 C00002769 C00003574 C00003617 | 0 / 1 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00000615 C00001191 C00003574 C00003617 | 1 / 8 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000615 C00001191 C00003574 C00003617 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00000615 C00001191 C00003574 C00003617 | 1 / 1 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000615 C00002769 C00003574 C00003622 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00000615 C00001191 C00003574 C00003617 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000615 C00001191 C00003574 C00003617 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000615 C00001191 C00003574 C00003617 | 0 / 1 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00000615 C00001191 C00003574 C00003617 | 1 / 2 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00000615 C00001191 C00003574 C00003617 | 2 / 2 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000615 C00001191 C00003574 C00003617 | 1 / 1 |
| P03956 | Interstitial collagenase | M10A | C00000615 C00001191 C00003574 C00003617 | 0 / 1 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000615 C00001191 C00003574 C00003617 | 0 / 3 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00000615 C00001191 C00003574 C00003617 | 2 / 2 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00003574 C00003617 C00003622 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00001191 C00003574 C00003617 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000615 C00003617 C00003622 | 4 / 3 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00001191 C00003574 C00003617 | 0 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00001191 C00003574 C00003617 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00001191 C00003574 C00003617 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00001191 C00003574 C00003617 | 0 / 0 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00001191 C00003574 C00003617 | 1 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00001191 C00003574 C00003617 | 1 / 1 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00001191 C00003574 C00003617 | 5 / 9 |
| P02545 | Prelamin-A/C | Unclassified protein | C00000615 C00003617 C00003622 | 11 / 10 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00001191 C00003574 C00003617 | 2 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00000615 C00003574 C00003617 | 3 / 1 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00001191 C00003574 C00003617 | 0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00001191 C00003574 C00003617 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00001191 C00003574 C00003617 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00001191 C00003574 C00003617 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00001191 C00003574 C00003617 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00001191 C00003574 C00003617 | 3 / 0 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00001191 C00003574 C00003617 | 2 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00001191 C00003574 C00003617 | 1 / 1 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00001191 C00003574 C00003617 | 1 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00001191 C00003574 C00003617 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00001191 C00003574 C00003617 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00001191 C00003574 C00003617 | 1 / 0 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00001191 C00003574 C00003617 | 1 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00001191 C00003574 C00003617 | 0 / 1 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00003574 C00003617 C00003622 | 4 / 1 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00001191 C00003574 C00003617 | 0 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00001191 C00003574 C00003617 | 0 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00001191 C00003574 C00003617 | 2 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00001191 C00003574 C00003617 | 0 / 1 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00001191 C00003574 C00003617 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P08246 | Neutrophil elastase | S1A | C00001191 C00003574 C00003617 | 2 / 1 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00001191 C00003574 C00003617 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00001191 C00003574 C00003617 | 0 / 1 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00001191 C00003574 C00003617 | 1 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00001191 C00003574 C00003617 | 2 / 1 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00001191 C00003574 C00003617 | 1 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00001191 C00003574 C00003617 | 1 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00001191 C00003574 C00003617 | 7 / 37 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00001191 C00003574 C00003617 | 0 / 0 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00001191 C00003574 C00003617 | 0 / 0 |
| P10145 | Interleukin-8 | Secreted protein | C00002769 C00003574 | 0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00003574 C00003617 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00003617 C00003622 | 1 / 0 |
| O75496 | Geminin | Unclassified protein | C00003617 C00003622 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00003617 C00003622 | 2 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000615 C00002769 | 3 / 3 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00003617 C00003622 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00000615 C00003574 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00003574 C00003617 | 2 / 3 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00003574 C00003617 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000615 C00003574 | 3 / 2 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00003574 C00003617 | 5 / 3 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00003617 C00003622 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00003574 C00003617 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00003574 C00003617 | 3 / 4 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00000615 C00003574 | 0 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00000615 | 4 / 2 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00003622 | 0 / 0 |
| P06280 | Alpha-galactosidase A | Enzyme | C00000615 | 1 / 1 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00003622 | 0 / 0 |
| P35236 | Tyrosine-protein phosphatase non-receptor type 7 | Tyr | C00000615 | 0 / 0 |
| P40763 | Signal transducer and activator of transcription 3 | Transcription Factor | C00003617 | 1 / 2 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00000615 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00000615 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00003617 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00000615 | 0 / 1 |
| P08253 | 72 kDa type IV collagenase | M10A | C00000615 | 1 / 3 |
| Q8TDS4 | Hydroxycarboxylic acid receptor 2 | Hydroxycarboxylic acid receptor | C00000615 | 0 / 0 |
| Q04828 | Aldo-keto reductase family 1 member C1 | Enzyme | C00000615 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000615 | 2 / 2 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00003617 | 1 / 1 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00000615 | 5 / 2 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00003574 | 0 / 0 |
| P42330 | Aldo-keto reductase family 1 member C3 | Enzyme | C00000615 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00000615 | 1 / 2 |
| P68871 | Hemoglobin subunit beta | Secreted protein | C00003622 | 4 / 4 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00000615 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00000615 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00003617 | 0 / 0 |
| Q9GZT9 | Egl nine homolog 1 | Enzyme | C00000615 | 1 / 1 |
| P08183 | Multidrug resistance protein 1 | drug | C00003617 | 1 / 0 |
| P51452 | Dual specificity protein phosphatase 3 | Ser_Thr_Tyr | C00000615 | 0 / 0 |
| P02768 | Serum albumin | Secreted protein | C00003617 | 0 / 0 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00000615 | 1 / 1 |
| Q06124 | Tyrosine-protein phosphatase non-receptor type 11 | Tyr | C00000615 | 4 / 2 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00000615 | 0 / 0 |
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00003617 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00002769 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00000615 | 0 / 0 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00000615 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00000615 | 1 / 1 |
| P52895 | Aldo-keto reductase family 1 member C2 | Enzyme | C00000615 | 1 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00000615 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000615 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00000615 | 0 / 0 |
| Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00000615 | 3 / 0 |
| P27338 | Amine oxidase [flavin-containing] B | Oxidoreductase | C00003617 | 0 / 0 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00000615 | 0 / 0 |
| O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00000615 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003622 | 2 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00003622 | 1 / 1 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | C00001191 | 0 / 0 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00000615 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00000615 | 0 / 0 |
| P17516 | Aldo-keto reductase family 1 member C4 | Enzyme | C00000615 | 1 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00000615 | 1 / 1 |
| Q12794 | Hyaluronidase-1 | Enzyme | C00000615 | 1 / 2 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00000615 | 0 / 0 |
| P24298 | Alanine aminotransferase 1 | Enzyme | C00000615 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000615 | 0 / 0 |
| P42224 | Signal transducer and activator of transcription 1-alpha/beta | Unclassified protein | C00003617 | 3 / 3 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000615 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00000615 | 1 / 1 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00000615 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00000615 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000615 | 1 / 2 |
| O15427 | Monocarboxylate transporter 4 | Unclassified protein | C00001191 | 0 / 0 |
| Q6ZQN7 | Solute carrier organic anion transporter family member 4C1 | Unclassified protein | C00003617 | 0 / 0 |
| Q92959 | Solute carrier organic anion transporter family member 2A1 | Unclassified protein | C00001191 | 1 / 0 |
| O60669 | Monocarboxylate transporter 2 | Unclassified protein | C00001191 | 0 / 0 |
| Q05BR4 | SLC16A10 protein | Unclassified protein | C00001191 | 0 / 0 |
| P07900 | Heat shock protein HSP 90-alpha | Other cytosolic protein | C00000615 | 0 / 0 |
| P08238 | Heat shock protein HSP 90-beta | Other cytosolic protein | C00000615 | 0 / 0 |
| P05023 | Sodium/potassium-transporting ATPase subunit alpha-1 | Hydrolase | C00003617 | 0 / 0 |
| P14415 | Sodium/potassium-transporting ATPase subunit beta-2 | potassium_sodium | C00003617 | 0 / 0 |
| P13637 | Sodium/potassium-transporting ATPase subunit alpha-3 | Hydrolase | C00003617 | 2 / 1 |
| Q13733 | Sodium/potassium-transporting ATPase subunit alpha-4 | Hydrolase | C00003617 | 0 / 0 |
| P54710 | Sodium/potassium-transporting ATPase subunit gamma | potassium_sodium | C00003617 | 1 / 1 |
| P54709 | Sodium/potassium-transporting ATPase subunit beta-3 | potassium_sodium | C00003617 | 0 / 0 |
| P50993 | Sodium/potassium-transporting ATPase subunit alpha-2 | Hydrolase | C00003617 | 2 / 2 |
| P05026 | Sodium/potassium-transporting ATPase subunit beta-1 | potassium_sodium | C00003617 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00000615 | 0 / 0 |
| Q9C0B1 | Alpha-ketoglutarate-dependent dioxygenase FTO | Unclassified protein | C00001191 | 1 / 2 |
22 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00003617
|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 |
C00003617
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00003617
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00003617
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00003617
|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00003617
|
| 891 | CCNB1, CCNB | cyclin B1 |
C00003617
|
| 983 | CDK1, CDC2, CDC28A, P34CDC2 | cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) |
C00003617
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00003617
|
| 1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
C00003617
|
| 1111 | CHEK1, CHK1 | checkpoint kinase 1 (EC:2.7.11.1) |
C00003617
|
| 11200 | CHEK2, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1 | checkpoint kinase 2 (EC:2.7.11.1) |
C00003617
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00003617
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00003617
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00003617
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00003617
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00003617
|
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
C00003617
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00003617
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00003617
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00003617
|
| 7412 | VCAM1, CD106, INCAM-100 | vascular cell adhesion molecule 1 |
C00003617
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (131)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #614279 | 46,xy sex reversal 8; srxy8 |
P17516
P52895 |
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #104290 | Alternating hemiplegia of childhood 1; ahc1 |
P50993
|
| #614820 | Alternating hemiplegia of childhood 2; ahc2 |
P13637
|
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #600807 | Asthma, susceptibility to |
Q13093
|
| #209950 | Atypical mycobacteriosis, familial |
P42224
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #613985 | Beta-thalassemia |
P68871
|
| #603902 | Beta-thalassemia, dominant inclusion body type |
P68871
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| %606641 | Body mass index; bmi |
P37231
|
| #300615 | Brunner syndrome |
P21397
|
| #614162 | Candidiasis, familial, 7; candf7 |
P42224
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #128235 | Dystonia 12; dyt12 |
P13637
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #609820 | Erythrocytosis, familial, 3; ecyt3 |
Q9GZT9
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P04626 P37231 |
| #232300 | Glycogen storage disease ii |
P10253
|
| #612938 | Growth retardation, developmental delay, coarse facies, and early death; gdfd |
Q9C0B1
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #140700 | Heinz body anemias |
P68871
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #147060 | Hyper-ige recurrent infection syndrome, autosomal dominant |
P40763
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #614441 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 2; phoar2 |
Q92959
|
| #154020 | Hypomagnesemia 2, renal; homg2 |
P54710
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #147050 | Ige responsiveness, atopic; iger |
Q13093
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #607785 | Juvenile myelomonocytic leukemia; jmml |
Q06124
|
| #151100 | Leopard syndrome 1 |
Q06124
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 P04637 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #156250 | Metachondromatosis; metcds |
Q06124
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #602481 | Migraine, familial hemiplegic, 2; fhm2 |
P50993
|
| #601492 | Mucopolysaccharidosis, type ix; mps9 |
Q12794
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #613796 | Mycobacterial and viral infections, susceptibility to, autosomal recessive |
P42224
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #159900 | Myoclonic dystonia |
P14416
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #163950 | Noonan syndrome 1; ns1 |
Q06124
|
| #601665 | Obesity |
P32245
P37231 |
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #172700 | Pick disease of brain |
P10636
|
| #614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #603903 | Sickle cell anemia |
P68871
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #278300 | Xanthinuria, type i |
P47989
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (115)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
P04637 (marker) Q16790 (marker) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) P40763 (related) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) P04637 (related) P68871 (marker) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) P04637 (related) P08253 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) P04637 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
P04637 (related) P04637 (marker) |
| H00027 | Ovarian cancer |
P04626
(related)
P04637 (related) |
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) P04637 (related) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P04637 (related) P35354 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) P68871 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P08253 (related) P14780 (related) P35354 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
P14679 (marker) |
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00831 | Primary dystonia |
P13637
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
Q9C0B1 (related) |
| H00107 | Other well-defined immunodeficiency syndromes |
P40763
(related)
|
| H00089 | IFN-gamma/IL-12 axis |
P42224
(related)
|
| H00363 | Candidiasis |
P42224
(related)
|
| H01109 | Chronic mucocutaneous candidiasis (CMC) |
P42224
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
Q99714 (related) |
| H00775 | Familial or sporadic hemiplegic migraine |
P50993
(related)
|
| H00998 | Alternating hemiplegia of childhood |
P50993
(related)
|
| H01210 | Hypomagnesemia |
P54710
(related)
|
| H00228 | Thalassemia |
P68871
(related)
|
| H00229 | Sickle cell anemia (SCA) |
P68871
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00523 | Noonan syndrome and related disorders |
Q06124
(related)
|
| H01018 | Metachondromatosis |
Q06124
(related)
|
| H00133 | Mucopolysaccharidosis type IX (MPS9) |
Q12794
(related)
|
| H00421 | Mucopolysaccharidosis (MPS) |
Q12794
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00926 | Growth retardation, developmental delay, coarse facies, and early death |
Q9C0B1
(related)
|
| H00236 | Congenital polycythemia |
Q9GZT9
(related)
|
Diseases related to CTD interactions
43 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D001281 | Atrial Fibrillation |
C00003616
C00003617 |
| D006973 | Hypertension |
C00003617
|
| D001282 | Atrial Flutter |
C00003617
|
| D018880 | Atrial Premature Complexes |
C00003617
|
| D054537 | Atrioventricular Block |
C00003617
|
| C535438 | Bidirectional tachycardia |
C00003617
|
| D001919 | Bradycardia |
C00003617
|
| D002037 | Bundle-Branch Block |
C00003617
|
| D002289 | Carcinoma, Non-Small-Cell Lung |
C00003617
|
| D006332 | Cardiomegaly |
C00003617
|
| D009202 | Cardiomyopathies |
C00003617
|
| D002318 | Cardiovascular Diseases |
C00003617
|
| D003221 | Confusion |
C00003617
|
| D003251 | Constriction, Pathologic |
C00003617
|
| D003693 | Delirium |
C00003617
|
| D003866 | Depressive Disorder |
C00003617
|
| D064420 | Drug-Related Side Effects and Adverse Reactions |
C00003617
|
| D006323 | Heart Arrest |
C00003617
|
| D006331 | Heart Diseases |
C00003617
|
| D006333 | Heart Failure |
C00003617
|
| D006530 | Hepatorenal Syndrome |
C00003617
|
| D001145 | Arrhythmias, Cardiac |
C00003617
|
| D007022 | Hypotension |
C00003617
|
| D020925 | Hypoxia-Ischemia, Brain |
C00003617
|
| D053609 | Lethargy |
C00003617
|
| C537347 | Mesenteric vascular disease |
C00003617
|
| D009069 | Movement Disorders |
C00003617
|
| D020258 | Neurotoxicity Syndromes |
C00003617
|
| D010554 | Personality Disorders |
C00003617
|
| D011660 | Pulmonary Heart Disease |
C00003617
|
| D012021 | Reflex, Abnormal |
C00003617
|
| D012640 | Seizures |
C00003617
|
| D012804 | Sick Sinus Syndrome |
C00003617
|
| D012848 | Sinoatrial Block |
C00003617
|
| D013617 | Tachycardia, Supraventricular |
C00003617
|
| D017180 | Tachycardia, Ventricular |
C00003617
|
| D013921 | Thrombocytopenia |
C00003617
|
| D014202 | Tremor |
C00003617
|
| D014549 | Urinary Incontinence |
C00003617
|
| D020301 | Vasospasm, Intracranial |
C00003617
|
| D018487 | Ventricular Dysfunction, Left |
C00003617
|
| D014693 | Ventricular Fibrillation |
C00003617
|
| D018879 | Ventricular Premature Complexes |
C00003617
|