PCIDB

KNApSAcK Metabolite C00003633

Metabolite

KNApSAcK Entry

id C00003633
Name Ouabain
CAS RN 630-60-4
Standard InChI InChI=1S/C29H44O12/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31/h7,13,15-19,21-25,30-32,34-38H,3-6,8-12H2,1-2H3/t13?,15-,16+,17+,18+,19+,21+,22-,23-,24?,25-,26+,27-,28+,29-/m0/s1
Standard InChI (Main Layer) InChI=1S/C29H44O12/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31/h7,13,15-19,21-25,30-32,34-38H,3-6,8-12H2,1-2H3

Cluster

Phytochemical cluster No. 56
KCF-S cluster No. 109

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL222863 CHEMBL1320401 CHEMBL1493751 CHEMBL1512393 CHEMBL1524156 CHEMBL1591556 CHEMBL1617838 CHEMBL1720907 CHEMBL2069120

KEGG

By LinkDB C01443

CTD

By CAS RN D010042

Species

Summary

Plant class

class name count
asterids 2

Family

family name count
Apocynaceae 2

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Acokanthera ouabaio 52819 Apocynaceae asterids Viridiplantae
Strophanthus gratus 141614 Apocynaceae asterids Viridiplantae

Human Protein / Gene in interaction

120 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL222863 CHEMBL1493751 CHEMBL1512393 CHEMBL2069120 CHEMBL1614110 (1) CHEMBL1741321 (3)
CHEMBL1909136 (2)
1 / 0
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL222863 CHEMBL1493751 CHEMBL1512393 CHEMBL1591556 CHEMBL2069120 CHEMBL1613992 (5) CHEMBL1613995 (3)
7 / 44
Q16637 Survival motor neuron protein Unclassified protein CHEMBL222863 CHEMBL1320401 CHEMBL1591556 CHEMBL2069120 CHEMBL1613842 (6)
4 / 2
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter CHEMBL222863 CHEMBL2169429 (1)
1 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein CHEMBL222863 CHEMBL2169431 (1)
0 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL222863 CHEMBL1720907 CHEMBL2114784 (2)
1 / 1
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL222863 CHEMBL1909139 (2)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL222863 CHEMBL1014033 (1) CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL222863 CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL222863 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL222863 CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL222863 CHEMBL1909201 (2)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL222863 CHEMBL1909176 (2)
0 / 0
P29466 Caspase-1 C14 CHEMBL222863 CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL222863 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL222863 CHEMBL1909199 (2)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL222863 CHEMBL1909197 (2)
2 / 2
P02545 Prelamin-A/C Unclassified protein CHEMBL222863 CHEMBL1320401 CHEMBL2069120 CHEMBL1614310 (1) CHEMBL1614544 (4)
CHEMBL1614073 (1)
11 / 10
A2TJX0 Krueppel-like factor 5 Unclassified protein CHEMBL222863 CHEMBL1613906 (1)
0 / 0
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL1512393 CHEMBL2069120 CHEMBL1614281 (2) CHEMBL1614361 (2)
3 / 2
P00918 Carbonic anhydrase 2 Lyase CHEMBL222863 CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL222863 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL222863 CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL222863 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL222863 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL222863 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL222863 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL222863 CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL222863 CHEMBL1909093 (2)
0 / 0
P02768 Serum albumin Secreted protein CHEMBL222863 CHEMBL702884 (1)
0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL222863 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL222863 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL222863 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL222863 CHEMBL1493751 CHEMBL1512393 CHEMBL2069120 CHEMBL1741325 (3) CHEMBL1909135 (2)
0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL222863 CHEMBL1909203 (2)
1 / 11
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL222863 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL222863 CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL222863 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL222863 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL222863 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL222863 CHEMBL1909214 (2)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL222863 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL222863 CHEMBL1909096 (2)
1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL222863 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL222863 CHEMBL1909166 (2)
1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL222863 CHEMBL1909133 (2)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL1512393 CHEMBL2069120 CHEMBL1614456 (2) CHEMBL1613803 (2)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL2069120 CHEMBL1738606 (1)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL1320401 CHEMBL1720907 CHEMBL1794584 (2)
2 / 0
O75496 Geminin Unclassified protein CHEMBL222863 CHEMBL1720907 CHEMBL1613941 (1) CHEMBL2114843 (2)
CHEMBL2114780 (2)
0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein CHEMBL222863 CHEMBL1613838 (2)
0 / 0
Q8TCC7 Solute carrier family 22 member 8 Antiporter CHEMBL222863 CHEMBL2076662 (1)
0 / 0
P46721 Solute carrier organic anion transporter family member 1A2 Unclassified protein CHEMBL222863 CHEMBL1743150 (1) CHEMBL2077101 (1)
CHEMBL2076344 (1)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL222863 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL222863 CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL222863 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL222863 CHEMBL1909101 (2)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL222863 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL222863 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL222863 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL222863 CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL222863 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL222863 CHEMBL1909100 (2)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL222863 CHEMBL1909167 (2)
1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL222863 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL222863 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL222863 CHEMBL1909110 (2)
1 / 0
P40763 Signal transducer and activator of transcription 3 Transcription Factor CHEMBL222863 CHEMBL1614133 (1)
1 / 2
P03956 Interstitial collagenase M10A CHEMBL222863 CHEMBL1909196 (2)
0 / 1
P54707 Potassium-transporting ATPase alpha chain 2 Potassium-transporting P-type ATPase alpha subunit CHEMBL222863 CHEMBL751518 (1)
0 / 0
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL222863 CHEMBL1909119 (2)
0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL1720907 CHEMBL2114810 (1)
7 / 3
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter CHEMBL222863 CHEMBL2076238 (1) CHEMBL2169430 (1)
1 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL222863 CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL222863 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL222863 CHEMBL1909170 (2)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL222863 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL222863 CHEMBL1909109 (2)
2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL222863 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL222863 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL222863 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL222863 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL222863 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL222863 CHEMBL1909108 (2)
0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL222863 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL222863 CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL222863 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL222863 CHEMBL1493751 CHEMBL1512393 CHEMBL2069120 CHEMBL1741322 (3) CHEMBL1909132 (2)
0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein CHEMBL222863 CHEMBL1614342 (2)
1 / 1
Q01453 Peripheral myelin protein 22 Unclassified protein CHEMBL222863 CHEMBL1614171 (1)
5 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL222863 CHEMBL1738588 (1) CHEMBL1738675 (1)
CHEMBL1737868 (1)
0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL222863 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL222863 CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL222863 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL222863 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL222863 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL222863 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL222863 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL222863 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL222863 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL222863 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL222863 CHEMBL1909168 (2)
0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL1512393 CHEMBL1614274 (1) CHEMBL1613823 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL222863 CHEMBL1493751 CHEMBL1512393 CHEMBL1524156 CHEMBL2069120 CHEMBL1613777 (1) CHEMBL1741323 (3)
CHEMBL1909134 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL222863 CHEMBL1493751 CHEMBL1512393 CHEMBL2069120 CHEMBL1741324 (3) CHEMBL1909138 (2)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL222863 CHEMBL1909137 (2)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL222863 CHEMBL1720907 CHEMBL1737980 (1) CHEMBL1738184 (1)
0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL222863 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL222863 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL222863 CHEMBL1909213 (2)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL222863 CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL222863 CHEMBL1909116 (2)
1 / 1
P06239 Tyrosine-protein kinase Lck Src CHEMBL222863 CHEMBL1909206 (2)
0 / 1
P31939 Bifunctional purine biosynthesis protein PURH Enzyme CHEMBL222863 CHEMBL914875 (1)
1 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL222863 CHEMBL1909128 (2)
0 / 0
P42224 Signal transducer and activator of transcription 1-alpha/beta Unclassified protein CHEMBL222863 CHEMBL1614313 (1)
3 / 3
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL222863 CHEMBL1738442 (2)
0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL1720907 CHEMBL2354311 (1)
1 / 0
Q6ZQN7 Solute carrier organic anion transporter family member 4C1 Unclassified protein CHEMBL222863 CHEMBL2076885 (1)
0 / 0
Q9NYB5 Solute carrier organic anion transporter family member 1C1 Unclassified protein CHEMBL222863 CHEMBL2076222 (1)
0 / 0

CTD interaction (122)

compound gene gene name gene description interaction interaction type form reference
pmid
D010042 2 A2M
A2MD
CPAMD5
FWP007
S863-7
alpha-2-macroglobulin Ouabain affects the expression of A2M protein affects expression
protein 17268060
D010042 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain results in increased expression of ABCB1 protein] decreases reaction
/ increases expression
protein 19647009
D010042 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain results in increased expression of ABCB1 mRNA] decreases reaction
/ increases expression
mRNA 19647009
D010042 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain results in increased expression of ABCB1 protein] decreases reaction
/ increases expression
protein 19647009
D010042 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) KN 93 inhibits the reaction [Ouabain results in increased expression of ABCB1 protein] decreases reaction
/ increases expression
protein 19647009
D010042 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Ouabain results in increased expression of ABCB1 mRNA increases expression
mRNA 19647009
D010042 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Ouabain results in increased expression of ABCB1 protein increases expression
protein 19647009
D010042 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) [Ouabain results in increased expression of ABCB1] which results in decreased susceptibility to Doxorubicin decreases response to substance
/ increases expression
19647009
D010042 10449 ACAA2
DSAEC
acetyl-CoA acyltransferase 2 (EC:2.3.1.16) Ouabain affects the expression of ACAA2 protein affects expression
protein 17268060
D010042 59 ACTA2
AAT6
ACTSA
MYMY5
actin, alpha 2, smooth muscle, aorta Ouabain affects the expression of ACTA2 protein affects expression
protein 17268060
D010042 126 ADH1C
ADH3
alcohol dehydrogenase 1C (class I), gamma polypeptide (EC:1.1.1.1) Ouabain affects the expression of ADH1C protein affects expression
protein 17268060
D010042 301 ANXA1
ANX1
LPC1
annexin A1 Ouabain affects the expression of ANXA1 protein affects expression
protein 17268060
D010042 302 ANXA2
ANX2
ANX2L4
CAL1H
LIP2
LPC2
LPC2D
P36
PAP-IV
annexin A2 Ouabain affects the expression of ANXA2 protein affects expression
protein 17268060
D010042 369 ARAF
A-RAF
ARAF1
PKS2
RAFA1
v-raf murine sarcoma 3611 viral oncogene homolog (EC:2.7.11.1) Ouabain results in decreased expression of ARAF mRNA decreases expression
mRNA 16412265
D010042 25820 ARIH1
ARI
HARI
HHARI
UBCH7BP
ariadne RBR E3 ubiquitin protein ligase 1 Ouabain results in decreased expression of ARIH1 mRNA decreases expression
mRNA 16412265
D010042 10092 ARPC5
ARC16
dJ127C7.3
p16-Arc
actin related protein 2/3 complex, subunit 5, 16kDa Ouabain affects the expression of ARPC5 protein affects expression
protein 17268060
D010042 408 ARRB1
ARB1
ARR1
arrestin, beta 1 Ouabain results in increased expression of ARRB1 mRNA increases expression
mRNA 16412265
D010042 427 ASAH1
AC
ACDase
ASAH
PHP
PHP32
SMAPME
N-acylsphingosine amidohydrolase (acid ceramidase) 1 (EC:3.5.1.23) Ouabain affects the expression of ASAH1 protein affects expression
protein 17268060
D010042 479 ATP12A
ATP1AL1
ATPase, H+/K+ transporting, nongastric, alpha polypeptide (EC:3.6.3.10) Ouabain inhibits the reaction [[ATP12A protein co-treated with ATP4B protein] results in increased uptake of Rubidium] affects cotreatment
/ decreases reaction
/ increases uptake
protein 8853415
D010042 476 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide (EC:3.6.3.9) Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 mRNA] decreases reaction
/ increases expression
mRNA 19995221
D010042 476 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide (EC:3.6.3.9) Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 protein] decreases reaction
/ increases expression
protein 19995221
D010042 476 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide (EC:3.6.3.9) Ouabain binds to ATP1A1 protein affects binding
protein 12479229
D010042 476 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide (EC:3.6.3.9) Ouabain results in increased expression of ATP1A1 mRNA increases expression
mRNA 19995221
D010042 476 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide (EC:3.6.3.9) Ouabain results in increased expression of ATP1A1 protein increases expression
protein 19995221
D010042 477 ATP1A2
FHM2
MHP2
ATPase, Na+/K+ transporting, alpha 2 polypeptide (EC:3.6.3.9) Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A2 mRNA] decreases reaction
/ increases expression
mRNA 19995221
D010042 477 ATP1A2
FHM2
MHP2
ATPase, Na+/K+ transporting, alpha 2 polypeptide (EC:3.6.3.9) Ouabain binds to ATP1A2 protein affects binding
protein 12479229
D010042 477 ATP1A2
FHM2
MHP2
ATPase, Na+/K+ transporting, alpha 2 polypeptide (EC:3.6.3.9) Ouabain results in increased expression of ATP1A2 mRNA increases expression
mRNA 19995221
D010042 478 ATP1A3
AHC2
DYT12
RDP
ATPase, Na+/K+ transporting, alpha 3 polypeptide (EC:3.6.3.9) Ouabain binds to ATP1A3 protein affects binding
protein 12479229
D010042 478 ATP1A3
AHC2
DYT12
RDP
ATPase, Na+/K+ transporting, alpha 3 polypeptide (EC:3.6.3.9) Ouabain results in increased expression of ATP1A3 mRNA increases expression
mRNA 19995221
D010042 478 ATP1A3
AHC2
DYT12
RDP
ATPase, Na+/K+ transporting, alpha 3 polypeptide (EC:3.6.3.9) Ouabain results in increased expression of ATP1A3 protein increases expression
protein 19995221
D010042 496 ATP4B
ATP6B
ATPase, H+/K+ exchanging, beta polypeptide Ouabain inhibits the reaction [[ATP12A protein co-treated with ATP4B protein] results in increased uptake of Rubidium] affects cotreatment
/ decreases reaction
/ increases uptake
protein 8853415
D010042 498 ATP5A1
ATP5A
ATP5AL2
ATPM
MC5DN4
MOM2
OMR
ORM
hATP1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle Ouabain affects the expression of ATP5A1 protein affects expression
protein 17268060
D010042 22893 BAHD1
bromo adjacent homology domain containing 1 Ouabain results in decreased expression of BAHD1 mRNA decreases expression
mRNA 16412265
D010042 581 BAX
BCL2L4
BCL2-associated X protein Ouabain affects the localization of BAX protein affects localization
protein 18247327
D010042 581 BAX
BCL2L4
BCL2-associated X protein Ouabain inhibits the reaction [HSPD1 protein binds to BAX protein] affects binding
/ decreases reaction
protein 18247327
D010042 581 BAX
BCL2L4
BCL2-associated X protein Ouabain results in increased expression of BAX protein increases expression
protein 17096883
D010042 51806 CALML5
CLSP
calmodulin-like 5 Ouabain affects the expression of CALML5 protein affects expression
protein 17268060
D010042 821 CANX
CNX
IP90
P90
calnexin Ouabain results in increased expression of CANX protein increases expression
protein 18247327
D010042 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Ouabain results in increased activity of CASP3 protein increases activity
protein 11435898
18247327
D010042 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Ouabain results in increased expression of CASP3 protein increases expression
protein 17096883
D010042 64770 CCDC14
coiled-coil domain containing 14 Ouabain results in decreased expression of CCDC14 mRNA decreases expression
mRNA 16412265
D010042 8900 CCNA1
cyclin A1 Ouabain results in decreased expression of CCNA1 mRNA decreases expression
mRNA 20460749
D010042 890 CCNA2
CCN1
CCNA
cyclin A2 Ouabain results in decreased expression of CCNA2 mRNA decreases expression
mRNA 21215801
D010042 1017 CDK2
p33(CDK2)
cyclin-dependent kinase 2 (EC:2.7.11.22) Ouabain results in decreased expression of CDK2 mRNA decreases expression
mRNA 20460749
21215801
D010042 1017 CDK2
p33(CDK2)
cyclin-dependent kinase 2 (EC:2.7.11.22) Ouabain results in decreased expression of CDK2 protein decreases expression
protein 21215801
D010042 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Ouabain results in decreased expression of CDKN1A mRNA decreases expression
mRNA 21215801
D010042 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Ouabain results in decreased expression of CDKN1A protein decreases expression
protein 21215801
D010042 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Ouabain results in increased expression of CDKN1A mRNA increases expression
mRNA 20460749
D010042 9076 CLDN1
CLD1
ILVASC
SEMP1
claudin 1 Ouabain results in decreased expression of CLDN1 protein decreases expression
protein 18247327
D010042 10330 CNPY2
HP10390
MSAP
TMEM4
ZSIG9
canopy FGF signaling regulator 2 Ouabain affects the expression of CNPY2 protein affects expression
protein 17268060
D010042 1537 CYC1
MC3DN6
UQCR4
cytochrome c-1 Ouabain results in decreased expression of and affects the localization of CYC1 protein affects localization
/ decreases expression
protein 18247327
D010042 1650 DDOST
AGER1
CDG1R
OKSWcl45
OST
OST48
WBP1
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) (EC:2.4.99.18) Ouabain results in decreased expression of DDOST mRNA decreases expression
mRNA 16412265
D010042 1812 DRD1
DADR
DRD1A
dopamine receptor D1 Ouabain results in decreased expression of and results in increased phosphorylation of DRD1 protein decreases expression
/ increases phosphorylation
protein 20132239
D010042 1812 DRD1
DADR
DRD1A
dopamine receptor D1 Ouabain results in decreased expression of DRD1 mRNA decreases expression
mRNA 20132239
D010042 1828 DSG1
CDHF4
DG1
DSG
EPKHIA
PPKS1
SPPK1
desmoglein 1 Ouabain affects the expression of DSG1 protein affects expression
protein 17268060
D010042 1854 DUT
dUTPase
deoxyuridine triphosphatase (EC:3.6.1.23) Ouabain affects the expression of DUT protein affects expression
protein 17268060
D010042 1889 ECE1
ECE
endothelin converting enzyme 1 (EC:3.4.24.71) Ouabain results in increased expression of ECE1 protein increases expression
protein 18247327
D010042 1892 ECHS1
SCEH
enoyl CoA hydratase, short chain, 1, mitochondrial (EC:4.2.1.17) Ouabain affects the expression of ECHS1 protein affects expression
protein 17268060
D010042 27335 EIF3K
EIF3-p28
EIF3S12
HSPC029
M9
MSTP001
PLAC-24
PLAC24
PRO1474
PTD001
eukaryotic translation initiation factor 3, subunit K Ouabain affects the expression of EIF3K protein affects expression
protein 17268060
D010042 10667 FARS2
COXPD14
FARS1
HSPC320
PheRS
dJ520B18.2
phenylalanyl-tRNA synthetase 2, mitochondrial (EC:6.1.1.20) Ouabain results in increased expression of FARS2 mRNA increases expression
mRNA 16412265
D010042 2271 FH
HLRCC
LRCC
MCL
MCUL1
fumarate hydratase (EC:4.2.1.2) Ouabain affects the expression of FH protein affects expression
protein 17268060
D010042 51661 FKBP7
FKBP23
PPIase
FK506 binding protein 7 (EC:5.2.1.8) Ouabain results in increased expression of FKBP7 mRNA increases expression
mRNA 16412265
D010042 2638 GC
DBP
DBP/GC
GRD3
VDBG
VDBP
group-specific component (vitamin D binding protein) (EC:6.4.-.-) Ouabain affects the expression of GC protein affects expression
protein 17268060
D010042 2743 GLRB
HKPX2
glycine receptor, beta Ouabain results in increased expression of GLRB mRNA increases expression
mRNA 16412265
D010042 8225 GTPBP6
PGPL
GTP binding protein 6 (putative) Ouabain results in increased expression of GTPBP6 mRNA increases expression
mRNA 16412265
D010042 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain affects the localization of HIF1A protein] affects localization
/ decreases reaction
protein 19647009
D010042 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein] decreases reaction
/ increases phosphorylation
protein 19647009
D010042 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain affects the localization of HIF1A protein] affects localization
/ decreases reaction
protein 19647009
D010042 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) KN 93 inhibits the reaction [Ouabain affects the localization of HIF1A protein] affects localization
/ decreases reaction
protein 19647009
D010042 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) KN 93 inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein] decreases reaction
/ increases phosphorylation
protein 19647009
D010042 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Ouabain affects the localization of HIF1A protein affects localization
protein 19647009
D010042 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Ouabain results in increased activity of HIF1A protein increases activity
protein 19647009
D010042 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Ouabain results in increased phosphorylation of and results in increased expression of HIF1A protein increases expression
/ increases phosphorylation
protein 19647009
D010042 3181 HNRNPA2B1
HNRNPA2
HNRNPB1
HNRPA2
HNRPA2B1
HNRPB1
IBMPFD2
RNPA2
SNRPB1
heterogeneous nuclear ribonucleoprotein A2/B1 Ouabain affects the expression of HNRNPA2B1 protein affects expression
protein 17268060
D010042 9987 HNRNPDL
HNRNP
HNRPDL
JKTBP
JKTBP2
laAUF1
heterogeneous nuclear ribonucleoprotein D-like Ouabain results in decreased expression of HNRNPDL mRNA decreases expression
mRNA 16412265
D010042 3241 HPCAL1
BDR1
HLP2
VILIP-3
hippocalcin-like 1 Ouabain affects the expression of HPCAL1 protein affects expression
protein 17268060
D010042 3273 HRG
HPRG
HRGP
THPH11
histidine-rich glycoprotein Ouabain affects the expression of HRG protein affects expression
protein 17268060
D010042 3329 HSPD1
CPN60
GROEL
HLD4
HSP-60
HSP60
HSP65
HuCHA60
SPG13
heat shock 60kDa protein 1 (chaperonin) Ouabain affects the expression of HSPD1 protein affects expression
protein 17268060
D010042 3329 HSPD1
CPN60
GROEL
HLD4
HSP-60
HSP60
HSP65
HuCHA60
SPG13
heat shock 60kDa protein 1 (chaperonin) Ouabain inhibits the reaction [HSPD1 protein binds to BAX protein] affects binding
/ decreases reaction
protein 18247327
D010042 3329 HSPD1
CPN60
GROEL
HLD4
HSP-60
HSP60
HSP65
HuCHA60
SPG13
heat shock 60kDa protein 1 (chaperonin) Ouabain results in decreased expression of and affects the localization of HSPD1 protein affects localization
/ decreases expression
protein 18247327
D010042 3559 IL2RA
CD25
IDDM10
IL2R
TCGFR
interleukin 2 receptor, alpha Ouabain results in decreased expression of IL2RA mRNA decreases expression
mRNA 7593202
D010042 3560 IL2RB
CD122
IL15RB
P70-75
interleukin 2 receptor, beta Ouabain results in decreased expression of IL2RB decreases expression
7593202
D010042 3751 KCND2
KV4.2
RK5
potassium voltage-gated channel, Shal-related subfamily, member 2 Ouabain results in increased expression of KCND2 mRNA increases expression
mRNA 16412265
D010042 3757 KCNH2
ERG1
HERG
HERG1
Kv11.1
LQT2
SQT1
potassium voltage-gated channel, subfamily H (eag-related), member 2 Ouabain inhibits the reaction [KCNH2 protein results in increased transport of Thallium] decreases reaction
/ increases transport
protein 21158687
D010042 3757 KCNH2
ERG1
HERG
HERG1
Kv11.1
LQT2
SQT1
potassium voltage-gated channel, subfamily H (eag-related), member 2 Ouabain results in decreased activity of KCNH2 protein decreases activity
protein 21158687
D010042 3757 KCNH2
ERG1
HERG
HERG1
Kv11.1
LQT2
SQT1
potassium voltage-gated channel, subfamily H (eag-related), member 2 Ouabain results in decreased expression of KCNH2 protein modified form decreases expression
protein 19139152
D010042 3956 LGALS1
GAL1
GBP
lectin, galactoside-binding, soluble, 1 Ouabain affects the expression of LGALS1 protein affects expression
protein 17268060
D010042 3956 LGALS1
GAL1
GBP
lectin, galactoside-binding, soluble, 1 Ouabain results in increased expression of LGALS1 protein increases expression
protein 18247327
D010042 4047 LSS
OSC
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) (EC:5.4.99.7) LSS protein results in increased abundance of Ouabain increases abundance
protein 21106941
D010042 5598 MAPK7
BMK1
ERK4
ERK5
PRKM7
mitogen-activated protein kinase 7 (EC:2.7.11.24) Ouabain inhibits the reaction [palytoxin results in increased phosphorylation of and results in increased activity of MAPK7 protein] decreases reaction
/ increases activity
/ increases phosphorylation
protein 19716839
D010042 4191 MDH2
M-MDH
MDH
MGC:3559
MOR1
malate dehydrogenase 2, NAD (mitochondrial) (EC:1.1.1.37) Ouabain affects the expression of MDH2 protein affects expression
protein 17268060
D010042 4609 MYC
MRTL
MYCC
bHLHe39
c-Myc
v-myc avian myelocytomatosis viral oncogene homolog Ouabain results in decreased expression of MYC mRNA decreases expression
mRNA 21215801
D010042 4609 MYC
MRTL
MYCC
bHLHe39
c-Myc
v-myc avian myelocytomatosis viral oncogene homolog Ouabain results in decreased expression of MYC protein decreases expression
protein 21215801
D010042 4609 MYC
MRTL
MYCC
bHLHe39
c-Myc
v-myc avian myelocytomatosis viral oncogene homolog Ouabain results in increased expression of MYC protein increases expression
protein 9653513
D010042 10627 MYL12A
MLCB
MRCL3
MRLC3
MYL2B
myosin, light chain 12A, regulatory, non-sarcomeric Ouabain results in increased expression of MYL12A protein increases expression
protein 17268060
D010042 10577 NPC2
EDDM1
HE1
Niemann-Pick disease, type C2 Ouabain results in decreased expression of NPC2 mRNA decreases expression
mRNA 16412265
D010042 5111 PCNA
proliferating cell nuclear antigen Ouabain results in decreased expression of PCNA mRNA decreases expression
mRNA 20460749
21215801
D010042 5111 PCNA
proliferating cell nuclear antigen Ouabain results in decreased expression of PCNA protein decreases expression
protein 21215801
D010042 10016 PDCD6
ALG-2
PEF1B
programmed cell death 6 Ouabain results in increased expression of PDCD6 protein increases expression
protein 18247327
D010042 5204 PFDN5
MM-1
MM1
PFD5
prefoldin subunit 5 Ouabain affects the expression of PFDN5 protein affects expression
protein 17268060
D010042 5216 PFN1
ALS18
profilin 1 Ouabain affects the expression of PFN1 protein affects expression
protein 17268060
D010042 5216 PFN1
ALS18
profilin 1 Ouabain results in decreased expression of PFN1 protein decreases expression
protein 18247327
D010042 9374 PPT2
C6orf8
G14
PPT-2
palmitoyl-protein thioesterase 2 (EC:3.1.2.22) Ouabain results in decreased expression of PPT2 mRNA decreases expression
mRNA 16412265
D010042 5694 PSMB6
DELTA
LMPY
Y
proteasome (prosome, macropain) subunit, beta type, 6 (EC:3.4.25.1) Ouabain affects the expression of PSMB6 protein affects expression
protein 17268060
D010042 5771 PTPN2
PTN2
PTPT
TC-PTP
TCELLPTP
TCPTP
protein tyrosine phosphatase, non-receptor type 2 (EC:3.1.3.48) Ouabain results in decreased expression of PTPN2 mRNA decreases expression
mRNA 16412265
D010042 9230 RAB11B
H-YPT3
RAB11B, member RAS oncogene family Ouabain results in increased expression of RAB11B protein increases expression
protein 18247327
D010042 6093 ROCK1
P160ROCK
ROCK-I
Rho-associated, coiled-coil containing protein kinase 1 (EC:2.7.11.1) benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK1 protein] decreases reaction
/ increases cleavage
protein 20661774
D010042 6093 ROCK1
P160ROCK
ROCK-I
Rho-associated, coiled-coil containing protein kinase 1 (EC:2.7.11.1) Ouabain results in increased cleavage of ROCK1 protein increases cleavage
protein 20661774
D010042 9475 ROCK2
ROCK-II
Rho-associated, coiled-coil containing protein kinase 2 (EC:2.7.11.1) benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK2 protein] decreases reaction
/ increases cleavage
protein 20661774
D010042 9475 ROCK2
ROCK-II
Rho-associated, coiled-coil containing protein kinase 2 (EC:2.7.11.1) Ouabain results in increased cleavage of ROCK2 protein increases cleavage
protein 20661774
D010042 6119 RPA3
REPA3
replication protein A3, 14kDa Ouabain affects the expression of RPA3 protein affects expression
protein 17268060
D010042 23322 RPGRIP1L
CORS3
FTM
JBTS7
MKS5
NPHP8
RPGRIP1-like Ouabain results in decreased expression of RPGRIP1L mRNA decreases expression
mRNA 16412265
D010042 6284 S100A13
S100 calcium binding protein A13 Ouabain affects the expression of S100A13 protein affects expression
protein 17268060
D010042 6446 SGK1
SGK
serum/glucocorticoid regulated kinase 1 (EC:2.7.11.1) Ouabain inhibits the reaction [SGK1 protein results in increased transport of Potassium] decreases reaction
/ increases transport
protein 12590200
D010042 10110 SGK2
H-SGK2
dJ138B7.2
serum/glucocorticoid regulated kinase 2 (EC:2.7.11.1) Ouabain inhibits the reaction [SGK2 protein results in increased transport of Potassium] decreases reaction
/ increases transport
protein 12590200
D010042 23678 SGK3
CISK
SGK2
SGKL
serum/glucocorticoid regulated kinase family, member 3 (EC:2.7.11.1) Ouabain inhibits the reaction [SGK3 protein results in increased transport of Potassium] decreases reaction
/ increases transport
protein 12590200
D010042 6528 SLC5A5
NIS
TDH1
solute carrier family 5 (sodium/iodide cotransporter), member 5 Ouabain inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide] decreases reaction
/ increases uptake
protein 12541134
D010042 8884 SLC5A6
SMVT
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 Ouabain inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] decreases reaction
/ increases transport
protein 15561972
D010042 7167 TPI1
TIM
TPI
TPID
triosephosphate isomerase 1 (EC:5.3.1.1) Ouabain affects the expression of TPI1 protein affects expression
protein 17268060
D010042 7178 TPT1
HRF
TCTP
p02
p23
tumor protein, translationally-controlled 1 Ouabain affects the expression of TPT1 protein affects expression
protein 17268060
D010042 7295 TXN
TRDX
TRX
TRX1
thioredoxin Ouabain affects the expression of TXN protein affects expression
protein 17268060
D010042 463 ZFHX3
ATBF1
ATBT
ZNF927
zinc finger homeobox 3 Ouabain results in decreased expression of ZFHX3 mRNA decreases expression
mRNA 16412265

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (82)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#608688 Aicar transformylase/imp cyclohydrolase deficiency P31939
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#209950 Atypical mycobacteriosis, familial P42224
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#614162 Candidiasis, familial, 7; candf7 P42224
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P84022
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 O75874
P04626
#139393 Guillain-barre syndrome, familial; gbs Q01453
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#147060 Hyper-ige recurrent infection syndrome, autosomal dominant P40763
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#613796 Mycobacterial and viral infections, susceptibility to, autosomal recessive P42224
#159900 Myoclonic dystonia P14416
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260500 Papilloma of choroid plexus; cpp P04637
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (78)

KEGG disease name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
P40763 (related)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H00966 AICA-ribosiduria P31939 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00107 Other well-defined immunodeficiency syndromes P40763 (related)
H00089 IFN-gamma/IL-12 axis P42224 (related)
H00363 Candidiasis P42224 (related)
H01109 Chronic mucocutaneous candidiasis (CMC) P42224 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

33 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000014 D010042 Abnormalities, Drug-Induced marker/mechanism
21269433
D000647 D010042 Amnesia marker/mechanism
561405
2883982
14643695
D001145 D010042 Arrhythmias, Cardiac marker/mechanism
3420
11153
40389
44072
44326
60151
125678
818008
1213789
1219628
1442066
1700207
1973400
2299628
2413295
2468949
2470357
2726785
3404766
3420160
3595441
3718425
4039173
4380269
4404413
4728330
4826935
4850183
6111982
6124437
6195467
6852683
7205883
7416554
8606522
9500127
9846808
12428430
12590405
12939524
13748516
19721134
21693436
D001281 D010042 Atrial Fibrillation marker/mechanism
9772688
D001714 D010042 Bipolar Disorder marker/mechanism
15581912
19447152
19911114
19954800
20372980
20627318
20636639
D001919 D010042 Bradycardia marker/mechanism
2767134
D001927 D010042 Brain Diseases marker/mechanism
840393
1173001
D001929 D010042 Brain Edema marker/mechanism
11517236
D020520 D010042 Brain Infarction marker/mechanism
18657834
D001930 D010042 Brain Injuries marker/mechanism
7541299
D002303 D010042 Cardiac Output, Low marker/mechanism
783197
2767134
D006332 D010042 Cardiomegaly marker/mechanism
19687166
D003251 D010042 Constriction, Pathologic marker/mechanism
19617413
D064420 D010042 Drug-Related Side Effects and Adverse Reactions marker/mechanism
4418514
D006323 D010042 Heart Arrest marker/mechanism
2443123
4039173
8356102
D006327 D010042 Heart Block marker/mechanism
3420160
7216388
D006331 D010042 Heart Diseases marker/mechanism
2867195
D006948 D010042 Hyperkinesis marker/mechanism
19954800
20056132
20636639
D006973 D010042 Hypertension marker/mechanism
4155971
4684093
7792794
7911450
7930555
9772400
9887018
10406832
10973588
11016823
11016824
11179079
11230321
11448869
11768735
11834625
12384489
15097235
15276875
15302685
15458945
15477225
16178440
16412265
16473962
16565308
16716361
16982439
17062336
17980562
18346177
18945826
18976649
19043981
19145772
19617413
19626329
20855264
D020925 D010042 Hypoxia-Ischemia, Brain marker/mechanism
1528398
D009336 D010042 Necrosis marker/mechanism
3526175
7378406
7953637
11435898
20435043
D009410 D010042 Nerve Degeneration marker/mechanism
11517236
17592671
D010243 D010042 Paralysis marker/mechanism
21139329
D012164 D010042 Retinal Diseases marker/mechanism
17592671
D012640 D010042 Seizures marker/mechanism
608666
743650
2905779
5643946
7541299
D020182 D010042 Sleep Apnea, Central marker/mechanism
8458769
D013610 D010042 Tachycardia marker/mechanism
2434745
3092755
5149891
D013616 D010042 Tachycardia, Sinus marker/mechanism
7357695
D017180 D010042 Tachycardia, Ventricular marker/mechanism
5922
17729
235395
238019
1151768
1167743
1261591
2300532
2389698
2439717
2443123
2476777
2624512
2767010
2767130
2880726
3359591
3945176
3950909
4103275
4155971
4412561
5045595
5071786
5561410
6066973
6072571
6144380
6150094
6175804
6404541
6501720
6634932
6834268
7511755
7967644
8178656
8221803
8313422
8739209
8907798
13172862
13821777
19108278
D014570 D010042 Urologic Diseases marker/mechanism
1364106
D014693 D010042 Ventricular Fibrillation marker/mechanism
1632298
3841597
4147426
6501720
8356102
10218734
D018879 D010042 Ventricular Premature Complexes marker/mechanism
677962
2443123
3404766
3945176
6404541
7967644
10218734
D015837 D010042 Vestibular Diseases therapeutic
21269433