PCIDB

Strophanthus gratus

Species

KNApSAcK Entry

Organism name Strophanthus gratus
Genus Strophanthus
Family Apocynaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Strophanthus gratus
Linked NCBI taxonomy ID 141614
Linked level species

Family

Family in NCBI taxonomy Apocynaceae
ID 4056

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Natural Activity

List (10)

Species Activity
Strophanthus gratus (Wall. & Hook.) Baill. Anxiolytic
Strophanthus gratus (Wall. & Hook.) Baill. Cardiotonic
Strophanthus gratus (Wall. & Hook.) Baill. Curare
Strophanthus gratus (Wall. & Hook.) Baill. Digitalic
Strophanthus gratus (Wall. & Hook.) Baill. Diuretic
Strophanthus gratus (Wall. & Hook.) Baill. Negative Chronotropic
Strophanthus gratus (Wall. & Hook.) Baill. Negative Dromotropic
Strophanthus gratus (Wall. & Hook.) Baill. Pediculicide
Strophanthus gratus (Wall. & Hook.) Baill. Positive Bathmotropic
Strophanthus gratus (Wall. & Hook.) Baill. Positive Inotropic

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00007190 External link 512 (+)-Pinoresinol
CHEMBL267963
CHEMBL487611
CHEMBL460862
C103298
7 / 5 / 6 No. 38 No. 21
C00003633 External link 512 Ouabain
CHEMBL222863
CHEMBL1320401
CHEMBL1493751
CHEMBL1512393
CHEMBL1524156
CHEMBL1591556
CHEMBL1617838
CHEMBL1720907
CHEMBL2069120
D010042
120 / 82 / 78 83 / 33 No. 109 No. 56
C00000682 External link 512 (-)-Olivil
/ Vladinol C
CHEMBL517144
1 / 1 / 1 No. 700 No. 21
C00007191 External link 512 (+)-8(1)-Hydroxypinoresinol
CHEMBL471274
No. 700 No. 21

Human Protein / Gene in interactions

126 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00003633 C00007190 0 / 3
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00003633 C00007190 0 / 0
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00003633 0 / 0
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter C00003633 1 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00003633 0 / 0
Q99700 Ataxin-2 Unclassified protein C00003633 1 / 1
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00007190 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00003633 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003633 1 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00003633 2 / 2
P08246 Neutrophil elastase S1A C00003633 2 / 1
P33765 Adenosine receptor A3 Adenosine receptor C00003633 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00003633 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00003633 0 / 0
P29466 Caspase-1 C14 C00003633 0 / 0
P17252 Protein kinase C alpha type Alpha C00003633 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00003633 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00007190 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00003633 2 / 2
P02545 Prelamin-A/C Unclassified protein C00003633 11 / 10
A2TJX0 Krueppel-like factor 5 Unclassified protein C00003633 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00003633 3 / 2
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00000682 1 / 1
P00918 Carbonic anhydrase 2 Lyase C00003633 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00003633 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00003633 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00003633 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00003633 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00003633 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00003633 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00003633 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00003633 0 / 0
P02768 Serum albumin Secreted protein C00003633 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00003633 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00003633 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00003633 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003633 0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00003633 1 / 8
P14416 D(2) dopamine receptor Dopamine receptor C00003633 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00003633 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00003633 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00003633 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00003633 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00003633 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00003633 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00003633 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00003633 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00003633 1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00003633 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00003633 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00003633 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00003633 2 / 0
O75496 Geminin Unclassified protein C00003633 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00003633 0 / 0
Q8TCC7 Solute carrier family 22 member 8 Antiporter C00003633 0 / 0
P46721 Solute carrier organic anion transporter family member 1A2 Unclassified protein C00003633 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00003633 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00003633 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00003633 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00003633 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00003633 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00003633 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00003633 0 / 1
Q16637 Survival motor neuron protein Unclassified protein C00003633 4 / 1
P25101 Endothelin-1 receptor Endothelin receptor C00003633 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00003633 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00003633 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00003633 0 / 0
P08311 Cathepsin G S1A C00003633 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00003633 1 / 0
P40763 Signal transducer and activator of transcription 3 Transcription Factor C00003633 1 / 2
P03956 Interstitial collagenase M10A C00003633 0 / 1
P54707 Potassium-transporting ATPase alpha chain 2 Potassium-transporting P-type ATPase alpha subunit C00003633 0 / 0
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00003633 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00003633 7 / 3
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter C00003633 1 / 0
P04150 Glucocorticoid receptor NR3C1 C00003633 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00003633 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00003633 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00003633 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00003633 2 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00007190 5 / 3
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00003633 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00003633 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00003633 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00003633 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00003633 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00003633 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00003633 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00003633 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00003633 2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003633 0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00003633 1 / 1
Q01453 Peripheral myelin protein 22 Unclassified protein C00003633 5 / 2
P04637 Cellular tumor antigen p53 Transcription Factor C00003633 7 / 37
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00003633 0 / 0
P03372 Estrogen receptor NR3A1 C00003633 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00003633 1 / 0
P22303 Acetylcholinesterase Hydrolase C00003633 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00003633 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00003633 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00003633 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00003633 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00003633 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00003633 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00003633 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00003633 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003633 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003633 0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00003633 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00003633 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00003633 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00003633 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00003633 0 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00007190 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00003633 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00003633 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00003633 0 / 1
P31939 Bifunctional purine biosynthesis protein PURH Enzyme C00003633 1 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00003633 0 / 0
P42224 Signal transducer and activator of transcription 1-alpha/beta Unclassified protein C00003633 3 / 3
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00003633 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00003633 1 / 0
Q6ZQN7 Solute carrier organic anion transporter family member 4C1 Unclassified protein C00003633 0 / 0
Q9NYB5 Solute carrier organic anion transporter family member 1C1 Unclassified protein C00003633 0 / 0
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00007190 0 / 0

83 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
2 A2M, A2MD, CPAMD5, FWP007, S863-7 alpha-2-macroglobulin C00003633
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00003633
10449 ACAA2, DSAEC acetyl-CoA acyltransferase 2 (EC:2.3.1.16) C00003633
59 ACTA2, AAT6, ACTSA, MYMY5 actin, alpha 2, smooth muscle, aorta C00003633
126 ADH1C, ADH3 alcohol dehydrogenase 1C (class I), gamma polypeptide (EC:1.1.1.1) C00003633
301 ANXA1, ANX1, LPC1 annexin A1 C00003633
302 ANXA2, ANX2, ANX2L4, CAL1H, LIP2, LPC2, LPC2D, P36, PAP-IV annexin A2 C00003633
369 ARAF, A-RAF, ARAF1, PKS2, RAFA1 v-raf murine sarcoma 3611 viral oncogene homolog (EC:2.7.11.1) C00003633
25820 ARIH1, ARI, HARI, HHARI, UBCH7BP ariadne RBR E3 ubiquitin protein ligase 1 C00003633
10092 ARPC5, ARC16, dJ127C7.3, p16-Arc actin related protein 2/3 complex, subunit 5, 16kDa C00003633
408 ARRB1, ARB1, ARR1 arrestin, beta 1 C00003633
427 ASAH1, AC, ACDase, ASAH, PHP, PHP32, SMAPME N-acylsphingosine amidohydrolase (acid ceramidase) 1 (EC:3.5.1.23) C00003633
479 ATP12A, ATP1AL1 ATPase, H+/K+ transporting, nongastric, alpha polypeptide (EC:3.6.3.10) C00003633
476 ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide (EC:3.6.3.9) C00003633
477 ATP1A2, FHM2, MHP2 ATPase, Na+/K+ transporting, alpha 2 polypeptide (EC:3.6.3.9) C00003633
478 ATP1A3, AHC2, DYT12, RDP ATPase, Na+/K+ transporting, alpha 3 polypeptide (EC:3.6.3.9) C00003633
496 ATP4B, ATP6B ATPase, H+/K+ exchanging, beta polypeptide C00003633
498 ATP5A1, ATP5A, ATP5AL2, ATPM, MC5DN4, MOM2, OMR, ORM, hATP1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle C00003633
22893 BAHD1 bromo adjacent homology domain containing 1 C00003633
581 BAX, BCL2L4 BCL2-associated X protein C00003633
51806 CALML5, CLSP calmodulin-like 5 C00003633
821 CANX, CNX, IP90, P90 calnexin C00003633
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00003633
64770 CCDC14 coiled-coil domain containing 14 C00003633
8900 CCNA1 cyclin A1 C00003633
890 CCNA2, CCN1, CCNA cyclin A2 C00003633
1017 CDK2, p33(CDK2) cyclin-dependent kinase 2 (EC:2.7.11.22) C00003633
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00003633
9076 CLDN1, CLD1, ILVASC, SEMP1 claudin 1 C00003633
10330 CNPY2, HP10390, MSAP, TMEM4, ZSIG9 canopy FGF signaling regulator 2 C00003633
1537 CYC1, MC3DN6, UQCR4 cytochrome c-1 C00003633
1650 DDOST, AGER1, CDG1R, OKSWcl45, OST, OST48, WBP1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) (EC:2.4.99.18) C00003633
1812 DRD1, DADR, DRD1A dopamine receptor D1 C00003633
1828 DSG1, CDHF4, DG1, DSG, EPKHIA, PPKS1, SPPK1 desmoglein 1 C00003633
1854 DUT, dUTPase deoxyuridine triphosphatase (EC:3.6.1.23) C00003633
1889 ECE1, ECE endothelin converting enzyme 1 (EC:3.4.24.71) C00003633
1892 ECHS1, SCEH enoyl CoA hydratase, short chain, 1, mitochondrial (EC:4.2.1.17) C00003633
27335 EIF3K, EIF3-p28, EIF3S12, HSPC029, M9, MSTP001, PLAC-24, PLAC24, PRO1474, PTD001 eukaryotic translation initiation factor 3, subunit K C00003633
10667 FARS2, COXPD14, FARS1, HSPC320, PheRS, dJ520B18.2 phenylalanyl-tRNA synthetase 2, mitochondrial (EC:6.1.1.20) C00003633
2271 FH, HLRCC, LRCC, MCL, MCUL1 fumarate hydratase (EC:4.2.1.2) C00003633
51661 FKBP7, FKBP23, PPIase FK506 binding protein 7 (EC:5.2.1.8) C00003633
2638 GC, DBP, DBP/GC, GRD3, VDBG, VDBP group-specific component (vitamin D binding protein) (EC:6.4.-.-) C00003633
2743 GLRB, HKPX2 glycine receptor, beta C00003633
8225 GTPBP6, PGPL GTP binding protein 6 (putative) C00003633
3091 HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) C00003633
3181 HNRNPA2B1, HNRNPA2, HNRNPB1, HNRPA2, HNRPA2B1, HNRPB1, IBMPFD2, RNPA2, SNRPB1 heterogeneous nuclear ribonucleoprotein A2/B1 C00003633
9987 HNRNPDL, HNRNP, HNRPDL, JKTBP, JKTBP2, laAUF1 heterogeneous nuclear ribonucleoprotein D-like C00003633
3241 HPCAL1, BDR1, HLP2, VILIP-3 hippocalcin-like 1 C00003633
3273 HRG, HPRG, HRGP, THPH11 histidine-rich glycoprotein C00003633
3329 HSPD1, CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13 heat shock 60kDa protein 1 (chaperonin) C00003633
3559 IL2RA, CD25, IDDM10, IL2R, TCGFR interleukin 2 receptor, alpha C00003633
3560 IL2RB, CD122, IL15RB, P70-75 interleukin 2 receptor, beta C00003633
3751 KCND2, KV4.2, RK5 potassium voltage-gated channel, Shal-related subfamily, member 2 C00003633
3757 KCNH2, ERG1, HERG, HERG1, Kv11.1, LQT2, SQT1 potassium voltage-gated channel, subfamily H (eag-related), member 2 C00003633
3956 LGALS1, GAL1, GBP lectin, galactoside-binding, soluble, 1 C00003633
4047 LSS, OSC lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) (EC:5.4.99.7) C00003633
5598 MAPK7, BMK1, ERK4, ERK5, PRKM7 mitogen-activated protein kinase 7 (EC:2.7.11.24) C00003633
4191 MDH2, M-MDH, MDH, MGC:3559, MOR1 malate dehydrogenase 2, NAD (mitochondrial) (EC:1.1.1.37) C00003633
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00003633
10627 MYL12A, MLCB, MRCL3, MRLC3, MYL2B myosin, light chain 12A, regulatory, non-sarcomeric C00003633
10577 NPC2, EDDM1, HE1 Niemann-Pick disease, type C2 C00003633
5111 PCNA proliferating cell nuclear antigen C00003633
10016 PDCD6, ALG-2, PEF1B programmed cell death 6 C00003633
5204 PFDN5, MM-1, MM1, PFD5 prefoldin subunit 5 C00003633
5216 PFN1, ALS18 profilin 1 C00003633
9374 PPT2, C6orf8, G14, PPT-2 palmitoyl-protein thioesterase 2 (EC:3.1.2.22) C00003633
5694 PSMB6, DELTA, LMPY, Y proteasome (prosome, macropain) subunit, beta type, 6 (EC:3.4.25.1) C00003633
5771 PTPN2, PTN2, PTPT, TC-PTP, TCELLPTP, TCPTP protein tyrosine phosphatase, non-receptor type 2 (EC:3.1.3.48) C00003633
9230 RAB11B, H-YPT3 RAB11B, member RAS oncogene family C00003633
6093 ROCK1, P160ROCK, ROCK-I Rho-associated, coiled-coil containing protein kinase 1 (EC:2.7.11.1) C00003633
9475 ROCK2, ROCK-II Rho-associated, coiled-coil containing protein kinase 2 (EC:2.7.11.1) C00003633
6119 RPA3, REPA3 replication protein A3, 14kDa C00003633
23322 RPGRIP1L, CORS3, FTM, JBTS7, MKS5, NPHP8 RPGRIP1-like C00003633
6284 S100A13 S100 calcium binding protein A13 C00003633
6446 SGK1, SGK serum/glucocorticoid regulated kinase 1 (EC:2.7.11.1) C00003633
10110 SGK2, H-SGK2, dJ138B7.2 serum/glucocorticoid regulated kinase 2 (EC:2.7.11.1) C00003633
23678 SGK3, CISK, SGK2, SGKL serum/glucocorticoid regulated kinase family, member 3 (EC:2.7.11.1) C00003633
6528 SLC5A5, NIS, TDH1 solute carrier family 5 (sodium/iodide cotransporter), member 5 C00003633
8884 SLC5A6, SMVT solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 C00003633
7167 TPI1, TIM, TPI, TPID triosephosphate isomerase 1 (EC:5.3.1.1) C00003633
7178 TPT1, HRF, TCTP, p02, p23 tumor protein, translationally-controlled 1 C00003633
7295 TXN, TRDX, TRX, TRX1 thioredoxin C00003633
463 ZFHX3, ATBF1, ATBT, ZNF927 zinc finger homeobox 3 C00003633

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (86)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#608688 Aicar transformylase/imp cyclohydrolase deficiency P31939
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#209950 Atypical mycobacteriosis, familial P42224
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
%606641 Body mass index; bmi P37231
#300615 Brunner syndrome P21397
#614162 Candidiasis, familial, 7; candf7 P42224
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P84022
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 O75874
P04626
P37231
#139393 Guillain-barre syndrome, familial; gbs Q01453
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#147060 Hyper-ige recurrent infection syndrome, autosomal dominant P40763
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#613796 Mycobacterial and viral infections, susceptibility to, autosomal recessive P42224
#159900 Myoclonic dystonia P14416
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P32245
P37231
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260500 Papilloma of choroid plexus; cpp P04637
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#278300 Xanthinuria, type i P47989
#112100 Yt blood group antigen P22303

KEGG DISEASE (80)

KEGG name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
P40763 (related)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H00966 AICA-ribosiduria P31939 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00107 Other well-defined immunodeficiency syndromes P40763 (related)
H00089 IFN-gamma/IL-12 axis P42224 (related)
H00363 Candidiasis P42224 (related)
H01109 Chronic mucocutaneous candidiasis (CMC) P42224 (related)
H00192 Xanthinuria P47989 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

33 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000014 Abnormalities, Drug-Induced C00003633
D000647 Amnesia C00003633
D001145 Arrhythmias, Cardiac C00003633
D001281 Atrial Fibrillation C00003633
D001714 Bipolar Disorder C00003633
D001919 Bradycardia C00003633
D001927 Brain Diseases C00003633
D001929 Brain Edema C00003633
D020520 Brain Infarction C00003633
D001930 Brain Injuries C00003633
D002303 Cardiac Output, Low C00003633
D006332 Cardiomegaly C00003633
D003251 Constriction, Pathologic C00003633
D064420 Drug-Related Side Effects and Adverse Reactions C00003633
D006323 Heart Arrest C00003633
D006327 Heart Block C00003633
D006331 Heart Diseases C00003633
D006948 Hyperkinesis C00003633
D006973 Hypertension C00003633
D020925 Hypoxia-Ischemia, Brain C00003633
D009336 Necrosis C00003633
D009410 Nerve Degeneration C00003633
D010243 Paralysis C00003633
D012164 Retinal Diseases C00003633
D012640 Seizures C00003633
D020182 Sleep Apnea, Central C00003633
D013610 Tachycardia C00003633
D013616 Tachycardia, Sinus C00003633
D017180 Tachycardia, Ventricular C00003633
D014570 Urologic Diseases C00003633
D014693 Ventricular Fibrillation C00003633
D018879 Ventricular Premature Complexes C00003633
D015837 Vestibular Diseases C00003633