KNApSAcK Metabolite C00036880
Metabolite
KNApSAcK Entry
| id | C00036880 |
|---|---|
| Name | Carnosic acid |
| CAS RN | 3650-09-7 |
| Standard InChI | InChI=1S/C20H28O4/c1-11(2)13-10-12-6-7-14-19(3,4)8-5-9-20(14,18(23)24)15(12)17(22)16(13)21/h10-11,14,21-22H,5-9H2,1-4H3,(H,23,24)/t14-,20+/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C20H28O4/c1-11(2)13-10-12-6-7-14-19(3,4)8-5-9-20(14,18(23)24)15(12)17(22)16(13)21/h10-11,14,21-22H,5-9H2,1-4H3,(H,23,24) |
Cluster
| Phytochemical cluster | No. 41 |
|---|---|
| KCF-S cluster | No. 323 |
Link
ChEMBL
| By standard InChI | CHEMBL484853 |
|---|---|
| By standard InChI Main Layer | CHEMBL484853 CHEMBL1397655 |
KEGG
| By LinkDB |
|---|
CTD
| By CAS RN | C018381 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| asterids | 2 |
Family
| family name | count |
|---|---|
| Lamiaceae | 2 |
| Nocardiaceae | 1 |
List (4)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Hypis dilatata | ||||
| Nocardia sp. NRRL5646 | 1817 | Nocardiaceae | Bacteria | |
| Salvia officinalis | 38868 | Lamiaceae | asterids | Viridiplantae |
| Salvia pachyphylla | 207759 | Lamiaceae | asterids | Viridiplantae |
Human Protein / Gene in interaction
17 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P04637 | Cellular tumor antigen p53 | Transcription Factor | CHEMBL1397655 |
CHEMBL1613992
(1)
CHEMBL1613995
(1)
|
7 / 44 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | CHEMBL1397655 |
CHEMBL1614331
(1)
|
0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | CHEMBL484853 CHEMBL1397655 |
CHEMBL1794311
(2)
|
2 / 3 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | CHEMBL484853 CHEMBL1397655 |
CHEMBL1613800
(2)
|
0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL484853 CHEMBL1397655 |
CHEMBL1614458
(2)
|
0 / 0 |
| P16233 | Pancreatic triacylglycerol lipase | Hydrolase | CHEMBL484853 |
CHEMBL925170
(1)
|
0 / 0 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | CHEMBL484853 |
CHEMBL1614252
(1)
|
2 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | CHEMBL1397655 |
CHEMBL1614521
(1)
|
0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | CHEMBL1397655 |
CHEMBL1613910
(1)
|
3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | CHEMBL484853 CHEMBL1397655 |
CHEMBL1614038
(2)
|
2 / 2 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL1397655 |
CHEMBL1614108
(1)
CHEMBL1613886
(1)
|
0 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | CHEMBL484853 CHEMBL1397655 |
CHEMBL1614250
(2)
CHEMBL1614421
(2)
CHEMBL1614502 (2) |
4 / 3 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | CHEMBL1397655 |
CHEMBL1613914
(1)
|
0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL484853 |
CHEMBL1738442
(1)
|
0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | CHEMBL1397655 |
CHEMBL1614364
(1)
|
1 / 1 |
| O00255 | Menin | Unclassified protein | CHEMBL484853 |
CHEMBL1614257
(1)
|
2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | CHEMBL484853 |
CHEMBL1614257
(1)
|
1 / 3 |
CTD interaction (14)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C018381 | 100136148 | [salvin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD11B protein |
affects cotreatment
/ increases expression |
protein |
11504768
|
||
| C018381 | 100136148 | salvin promotes the reaction [Calcitriol results in increased expression of CD11B protein] |
increases expression
/ increases reaction |
protein |
11504768
|
||
| C018381 | 100136148 | salvin promotes the reaction [Tretinoin results in increased expression of CD11B protein] |
increases expression
/ increases reaction |
protein |
11504768
|
||
| C018381 | 929 |
CD14
|
CD14 molecule | [salvin co-treated with Tretinoin] results in increased expression of CD14 protein |
affects cotreatment
/ increases expression |
protein |
11504768
|
| C018381 | 929 |
CD14
|
CD14 molecule | salvin promotes the reaction [Calcitriol results in increased expression of CD14 protein] |
increases expression
/ increases reaction |
protein |
11504768
|
| C018381 | 5468 |
PPARG
CIMT1 GLM1 NR1C3 PPARG1 PPARG2 PPARgamma |
peroxisome proliferator-activated receptor gamma | salvin results in increased activity of PPARG protein |
increases activity
|
protein |
20696231
|
| C018381 | 5914 |
RARA
NR1B1 RAR |
retinoic acid receptor, alpha | [Tetradecanoylphorbol Acetate co-treated with salvin] results in increased expression of RARA protein |
affects cotreatment
/ increases expression |
protein |
11504768
|
| C018381 | 6256 |
RXRA
NR2B1 |
retinoid X receptor, alpha | Calcitriol promotes the reaction [salvin results in increased expression of RXRA protein] |
increases expression
/ increases reaction |
protein |
11504768
|
| C018381 | 6256 |
RXRA
NR2B1 |
retinoid X receptor, alpha | salvin results in increased expression of RXRA protein |
increases expression
|
protein |
11504768
|
| C018381 | 6256 |
RXRA
NR2B1 |
retinoid X receptor, alpha | Tretinoin promotes the reaction [salvin results in increased expression of RXRA protein] |
increases expression
/ increases reaction |
protein |
11504768
|
| C018381 | 7421 |
VDR
NR1I1 |
vitamin D (1,25- dihydroxyvitamin D3) receptor | Calcitriol promotes the reaction [salvin results in increased expression of VDR protein] |
increases expression
/ increases reaction |
protein |
11504768
|
| C018381 | 7421 |
VDR
NR1I1 |
vitamin D (1,25- dihydroxyvitamin D3) receptor | salvin results in increased expression of VDR protein |
increases expression
|
protein |
11504768
|
| C018381 | 7421 |
VDR
NR1I1 |
vitamin D (1,25- dihydroxyvitamin D3) receptor | Tetradecanoylphorbol Acetate promotes the reaction [salvin results in increased expression of VDR protein] |
increases expression
/ increases reaction |
protein |
11504768
|
| C018381 | 7421 |
VDR
NR1I1 |
vitamin D (1,25- dihydroxyvitamin D3) receptor | Tretinoin promotes the reaction [salvin results in increased expression of VDR protein] |
increases expression
/ increases reaction |
protein |
11504768
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (23)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #114500 | Colorectal cancer; crc |
P18054
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #133239 | Esophageal cancer |
P04637
P18054 |
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #211980 | Lung cancer |
P04637
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (55)
| KEGG | disease name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
4 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D002294 | C018381 | Carcinoma, Squamous Cell |
therapeutic
|
20816777
|
|
| D006965 | C018381 | Hyperplasia |
therapeutic
|
20816777
|
|
| D009062 | C018381 | Mouth Neoplasms |
therapeutic
|
20816777
|
|
| D009374 | C018381 | Neoplasms, Experimental |
therapeutic
|
20816777
|