Species

KNApSAcK Entry

Organism name Salvia pachyphylla
Genus Salvia
Family Labiatae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Salvia pachyphylla
Linked NCBI taxonomy ID 207759
Linked level species

Family

Family in NCBI taxonomy Lamiaceae
ID 4136

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (8)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00036880 External link 512 Carnosic acid
CHEMBL484853
CHEMBL1397655
C018381
17 / 23 / 55 6 / 4 No. 323 No. 41
C00031191 External link 512 Rosmanol
No. 734 No. 40
C00041292 External link 512 7-Methoxyrosmanol
/ (+)-7-Methoxyrosmanol
CHEMBL464376
CHEMBL1081338
No. 734 No. 40
C00037344 External link 512 Isorosmanol
CHEMBL494659
CHEMBL2333536
No. 734 No. 40
C00041281 External link 512 5,6-Didehydro-O-methylsugiol
CHEMBL494660
No. 1418
C00041258 External link 512 20-Deoxocarnosol
CHEMBL491879
No. 2253
C00041232 External link 512 11,12-Dioxoabieta-8,13-diene
/ (-)-11,12-Dioxoabieta-8,13-diene
No. 2951
C00041294 External link 512 8beta-Hydroxy-9(11),13-abietadien-12-one
/ (-)-8beta-Hydroxy-9(11),13-abietadien-12-one
CHEMBL243549
No. 5158

Human Protein / Gene in interactions

17 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P04637 Cellular tumor antigen p53 Transcription Factor C00036880 7 / 37
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00036880 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00036880 2 / 3
O15296 Arachidonate 15-lipoxygenase B Enzyme C00036880 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00036880 0 / 0
P16233 Pancreatic triacylglycerol lipase Hydrolase C00036880 0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00036880 2 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00036880 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00036880 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00036880 2 / 2
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00036880 0 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00036880 4 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00036880 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00036880 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00036880 1 / 1
O00255 Menin Unclassified protein C00036880 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00036880 1 / 2

6 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
100136148 C00036880
929 CD14 CD14 molecule C00036880
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00036880
5914 RARA, NR1B1, RAR retinoic acid receptor, alpha C00036880
6256 RXRA, NR2B1 retinoid X receptor, alpha C00036880
7421 VDR, NR1I1 vitamin D (1,25- dihydroxyvitamin D3) receptor C00036880

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (23)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#114500 Colorectal cancer; crc P18054
#119900 Digital clubbing, isolated congenital P15428
#133239 Esophageal cancer P04637
P18054
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#211980 Lung cancer P04637
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (55)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

4 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D002294 Carcinoma, Squamous Cell C00036880
D006965 Hyperplasia C00036880
D009062 Mouth Neoplasms C00036880
D009374 Neoplasms, Experimental C00036880