PCIDB

KNApSAcK Metabolite C00003834

Metabolite

KNApSAcK Entry

id C00003834
Name Scutellarein / 6-Hydroxyapigenin
CAS RN 529-53-3
Standard InChI InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)11-5-9(17)13-12(21-11)6-10(18)14(19)15(13)20/h1-6,16,18-20H
Standard InChI (Main Layer) InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)11-5-9(17)13-12(21-11)6-10(18)14(19)15(13)20/h1-6,16,18-20H

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 71

Link

ChEMBL

By standard InChI CHEMBL55415
By standard InChI Main Layer CHEMBL55415

KEGG

By LinkDB C10184

CTD

By CAS RN C458179

Human Protein / Gene in interaction

21 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 CHEMBL55415 CHEMBL1780345 (1) CHEMBL1780385 (1)
0 / 0
Q9Y3R4 Sialidase-2 Enzyme CHEMBL55415 CHEMBL1100507 (1)
0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr CHEMBL55415 CHEMBL2342404 (1)
1 / 1
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 CHEMBL55415 CHEMBL1780346 (1)
4 / 4
P04745 Alpha-amylase 1 Enzyme CHEMBL55415 CHEMBL964479 (2)
0 / 0
Q9UN88 Gamma-aminobutyric acid receptor subunit theta GABA-A theta CHEMBL55415 CHEMBL877825 (1)
0 / 0
P28472 Gamma-aminobutyric acid receptor subunit beta-3 GABA-A beta CHEMBL55415 CHEMBL877825 (1)
1 / 0
P14867 Gamma-aminobutyric acid receptor subunit alpha-1 GABA-A alpha CHEMBL55415 CHEMBL877825 (1)
1 / 1
P48169 Gamma-aminobutyric acid receptor subunit alpha-4 GABA-A alpha CHEMBL55415 CHEMBL877825 (1)
0 / 0
O14764 Gamma-aminobutyric acid receptor subunit delta GABA-A delta CHEMBL55415 CHEMBL877825 (1)
1 / 1
P31644 Gamma-aminobutyric acid receptor subunit alpha-5 GABA-A alpha CHEMBL55415 CHEMBL877825 (1)
0 / 0
Q99928 Gamma-aminobutyric acid receptor subunit gamma-3 GABA-A gamma CHEMBL55415 CHEMBL877825 (1)
0 / 0
P78334 Gamma-aminobutyric acid receptor subunit epsilon GABA-A epsilon CHEMBL55415 CHEMBL877825 (1)
0 / 0
Q8N1C3 Gamma-aminobutyric acid receptor subunit gamma-1 GABA-A gamma CHEMBL55415 CHEMBL877825 (1)
0 / 0
P34903 Gamma-aminobutyric acid receptor subunit alpha-3 GABA-A alpha CHEMBL55415 CHEMBL877825 (1)
0 / 0
O00591 Gamma-aminobutyric acid receptor subunit pi GABA-A pi CHEMBL55415 CHEMBL877825 (1)
0 / 0
P47870 Gamma-aminobutyric acid receptor subunit beta-2 GABA-A beta CHEMBL55415 CHEMBL877825 (1)
0 / 0
P18507 Gamma-aminobutyric acid receptor subunit gamma-2 GABA-A gamma CHEMBL55415 CHEMBL877825 (1)
4 / 2
P18505 Gamma-aminobutyric acid receptor subunit beta-1 GABA-A beta CHEMBL55415 CHEMBL877825 (1)
0 / 0
Q16445 Gamma-aminobutyric acid receptor subunit alpha-6 GABA-A alpha CHEMBL55415 CHEMBL877825 (1)
0 / 0
P47869 Gamma-aminobutyric acid receptor subunit alpha-2 GABA-A alpha CHEMBL55415 CHEMBL877825 (1)
1 / 0

CTD interaction (7)

compound gene gene name gene description interaction interaction type form reference
pmid
C458179 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) CYP1A1 protein affects the metabolism of scutellarein affects metabolic processing
protein 19666078
C458179 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) [CYP1A1 protein affects the metabolism of scutellarein] which results in increased chemical synthesis of 6-hydroxyluteolin affects metabolic processing
/ increases chemical synthesis
protein 19666078
C458179 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) scutellarein results in decreased activity of CYP1A1 protein decreases activity
protein 21482471
C458179 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) CYP1A2 protein affects the metabolism of scutellarein affects metabolic processing
protein 19666078
C458179 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) CYP1B1 protein affects the metabolism of scutellarein affects metabolic processing
protein 19666078
C458179 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) [CYP1B1 protein affects the metabolism of scutellarein] which results in increased chemical synthesis of 6-hydroxyluteolin affects metabolic processing
/ increases chemical synthesis
protein 19666078
C458179 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) scutellarein results in decreased activity of CYP1B1 protein decreases activity
protein 21482471

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (13)

OMIM preferred title UniProt
#103780 Alcohol dependence P47869
#607208 Dravet syndrome P18507
#607681 Epilepsy, childhood absence, susceptibility to, 2; eca2 P18507
#612269 Epilepsy, childhood absence, susceptibility to, 5; eca5 P28472
#613060 Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 O14764
#611136 Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 P14867
#604233 Generalized epilepsy with febrile seizures plus, type 1; gefsp1 P18507
#611277 Generalized epilepsy with febrile seizures plus, type 3; gefsp3 P18507
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#601626 Leukemia, acute myeloid; aml P36888
#604229 Peters anomaly Q16678

KEGG DISEASE (7)

KEGG disease name UniProt
H00783 Febrile seizures O14764 (related)
P18507 (related)
H00808 Idiopathic generalized epilepsies (IGEs) P14867 (related)
P18507 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D020257 C458179 Ventricular Remodeling therapeutic
11940368