Polygonum hydropiper L.
Species
KNApSAcK Entry
| Organism name | Polygonum hydropiper L. |
|---|---|
| Genus | Polygonum |
| Family | Polygonaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Persicaria hydropiper |
|---|---|
| Linked NCBI taxonomy ID | 46901 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Polygonaceae |
|---|---|
| ID | 3615 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
Natural Activity
List (28)
| Species | Activity |
|---|---|
| Polygonum hydropiper L. | Allergenic |
| Polygonum hydropiper L. | Analgesic |
| Polygonum hydropiper L. | Anti-implantation |
| Polygonum hydropiper L. | Antibacterial |
| Polygonum hydropiper L. | Anticapillary Fragility |
| Polygonum hydropiper L. | Antifertility |
| Polygonum hydropiper L. | Antimutagenic |
| Polygonum hydropiper L. | Antirheumatic |
| Polygonum hydropiper L. | Antiseptic |
| Polygonum hydropiper L. | Carminative |
| Polygonum hydropiper L. | Contraceptive |
| Polygonum hydropiper L. | Diaphoretic |
| Polygonum hydropiper L. | Diuretic |
| Polygonum hydropiper L. | Emmenagogue |
| Polygonum hydropiper L. | Hemostat |
| Polygonum hydropiper L. | Hypotensive |
| Polygonum hydropiper L. | Insectifuge |
| Polygonum hydropiper L. | Irritant |
| Polygonum hydropiper L. | Larvicide |
| Polygonum hydropiper L. | Litholytic |
| Polygonum hydropiper L. | Myorelaxant |
| Polygonum hydropiper L. | Piscicide |
| Polygonum hydropiper L. | Rubefacient |
| Polygonum hydropiper L. | Sedative |
| Polygonum hydropiper L. | Stimulant |
| Polygonum hydropiper L. | Uterotonic |
| Polygonum hydropiper L. | Vasoconstrictor |
| Polygonum hydropiper L. | Vermifuge |
Metabolite list (5)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00004386
|
6-Hydroxyluteolin 7-O-beta-glucopyranoside:6-Hydroxyluteolin 7-glucoside
|
CHEMBL469621
|
No. 2 | No. 15 |
|
|||
|
C00005376
|
Miquelianin
/ Quercetin 3-O-beta-D-glucuronide |
CHEMBL520546
CHEMBL1506682 |
23 / 30 / 21 | No. 2 | No. 15 |
|
||
|
C00003884
|
Nornepetin
/ 6-Hydroxyluteolin / Demethylpedalitin / 2-(3,4-Dihydroxyphenyl)-5,6,7-trihydroxy-4H-1-benzopyran-4-one |
CHEMBL464107
|
C057617
|
2 / 0 | No. 3 | No. 15 |
|
|
|
C00003834
|
Scutellarein
/ 6-Hydroxyapigenin |
CHEMBL55415
|
C458179
|
21 / 13 / 7 | 3 / 1 | No. 71 | No. 15 |
|
|
C00035906
|
3',4',5,6,7-Pentahydroxyflavone
|
No. 4656 |
|
Human Protein / Gene in interactions
44 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00005376 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00005376 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00005376 | 1 / 1 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00005376 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00005376 | 11 / 10 |
| P04798 | Cytochrome P450 1A1 | Cytochrome P450 1A1 | C00003834 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00005376 | 1 / 0 |
| Q9Y3R4 | Sialidase-2 | Enzyme | C00003834 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00005376 | 0 / 0 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00003834 | 1 / 1 |
| P39748 | Flap endonuclease 1 | Enzyme | C00005376 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00005376 | 7 / 3 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00005376 | 1 / 1 |
| P09923 | Intestinal-type alkaline phosphatase | Enzyme | C00005376 | 0 / 0 |
| P05186 | Alkaline phosphatase, tissue-nonspecific isozyme | Enzyme | C00005376 | 3 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00005376 | 0 / 0 |
| Q16678 | Cytochrome P450 1B1 | Cytochrome P450 1B1 | C00003834 | 4 / 4 |
| P04745 | Alpha-amylase 1 | Enzyme | C00003834 | 0 / 0 |
| P10696 | Alkaline phosphatase, placental-like | Enzyme | C00005376 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00005376 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00005376 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00005376 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00005376 | 4 / 3 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00005376 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00005376 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00005376 | 0 / 0 |
| Q9UN88 | Gamma-aminobutyric acid receptor subunit theta | GABA-A theta | C00003834 | 0 / 0 |
| P28472 | Gamma-aminobutyric acid receptor subunit beta-3 | GABA-A beta | C00003834 | 1 / 0 |
| P14867 | Gamma-aminobutyric acid receptor subunit alpha-1 | GABA-A alpha | C00003834 | 1 / 1 |
| P48169 | Gamma-aminobutyric acid receptor subunit alpha-4 | GABA-A alpha | C00003834 | 0 / 0 |
| O14764 | Gamma-aminobutyric acid receptor subunit delta | GABA-A delta | C00003834 | 1 / 1 |
| P31644 | Gamma-aminobutyric acid receptor subunit alpha-5 | GABA-A alpha | C00003834 | 0 / 0 |
| Q99928 | Gamma-aminobutyric acid receptor subunit gamma-3 | GABA-A gamma | C00003834 | 0 / 0 |
| P78334 | Gamma-aminobutyric acid receptor subunit epsilon | GABA-A epsilon | C00003834 | 0 / 0 |
| Q8N1C3 | Gamma-aminobutyric acid receptor subunit gamma-1 | GABA-A gamma | C00003834 | 0 / 0 |
| P34903 | Gamma-aminobutyric acid receptor subunit alpha-3 | GABA-A alpha | C00003834 | 0 / 0 |
| O00591 | Gamma-aminobutyric acid receptor subunit pi | GABA-A pi | C00003834 | 0 / 0 |
| P47870 | Gamma-aminobutyric acid receptor subunit beta-2 | GABA-A beta | C00003834 | 0 / 0 |
| P18507 | Gamma-aminobutyric acid receptor subunit gamma-2 | GABA-A gamma | C00003834 | 4 / 2 |
| P18505 | Gamma-aminobutyric acid receptor subunit beta-1 | GABA-A beta | C00003834 | 0 / 0 |
| Q16445 | Gamma-aminobutyric acid receptor subunit alpha-6 | GABA-A alpha | C00003834 | 0 / 0 |
| P47869 | Gamma-aminobutyric acid receptor subunit alpha-2 | GABA-A alpha | C00003834 | 1 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00005376 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00005376 | 2 / 1 |
3 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00003834
C00003884
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00003834
C00003884
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00003834
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (43)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #103780 | Alcohol dependence |
P47869
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
Q14191
|
| #607208 | Dravet syndrome |
P18507
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #607681 | Epilepsy, childhood absence, susceptibility to, 2; eca2 |
P18507
|
| #612269 | Epilepsy, childhood absence, susceptibility to, 5; eca5 |
P28472
|
| #613060 | Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 |
O14764
|
| #611136 | Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 |
P14867
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #604233 | Generalized epilepsy with febrile seizures plus, type 1; gefsp1 |
P18507
|
| #611277 | Generalized epilepsy with febrile seizures plus, type 3; gefsp3 |
P18507
|
| #137750 | Glaucoma 1, open angle, a; glc1a |
Q16678
|
| #231300 | Glaucoma 3, primary congenital, a; glc3a |
Q16678
|
| #137760 | Glaucoma, primary open angle; poag |
Q16678
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #146300 | Hypophosphatasia, adult |
P05186
|
| #241510 | Hypophosphatasia, childhood |
P05186
|
| #241500 | Hypophosphatasia, infantile |
P05186
|
| #601626 | Leukemia, acute myeloid; aml |
P36888
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #604229 | Peters anomaly |
Q16678
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (28)
| KEGG | name | UniProt |
|---|---|---|
| H00783 | Febrile seizures |
O14764
(related)
P18507 (related) |
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00213 | Hypophosphatasia |
P05186
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00023 | Testicular cancer |
P10696
(marker)
|
| H00808 | Idiopathic generalized epilepsies (IGEs) |
P14867
(related)
P18507 (related) |
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00296 | Defects in RecQ helicases |
Q14191
(related)
|
| H00612 | Primary open angle glaucoma |
Q16678
(related)
|
| H01075 | Peters anomaly |
Q16678
(related)
|
| H01159 | Anterior segment dysgenesis (ASD) |
Q16678
(related)
|
| H01203 | Primary congenital glaucoma (PCG) |
Q16678
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|