PCIDB

KNApSAcK Metabolite C00042390

Metabolite

KNApSAcK Entry

id C00042390
Name Cinnamyl alcohol
CAS RN 104-54-1
Standard InChI InChI=1S/C9H10O/c10-8-4-7-9-5-2-1-3-6-9/h1-7,10H,8H2/b7-4+
Standard InChI (Main Layer) InChI=1S/C9H10O/c10-8-4-7-9-5-2-1-3-6-9/h1-7,10H,8H2

Cluster

Phytochemical cluster No. 6
KCF-S cluster No. 2320

Link

ChEMBL

By standard InChI CHEMBL324794
By standard InChI Main Layer CHEMBL118958 CHEMBL324794

KEGG

By LinkDB C02394

CTD

By CAS RN C020722

Species

Summary

Plant class

class name count
asterids 1

Family

family name count
Araliaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Tetrapanax papyriferus 46417 Araliaceae asterids Viridiplantae

Human Protein / Gene in interaction

4 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase CHEMBL324794 CHEMBL2051343 (1) CHEMBL2051344 (1)
1 / 1
O60656 UDP-glucuronosyltransferase 1-9 Enzyme CHEMBL324794 CHEMBL1908086 (1)
0 / 0
O75762 Transient receptor potential cation channel subfamily A member 1 Unclassified protein CHEMBL324794 CHEMBL940160 (1)
1 / 0
Q9Y4X1 UDP-glucuronosyltransferase 2A1 Enzyme CHEMBL324794 CHEMBL1908088 (1)
0 / 0

CTD interaction (32)

compound gene gene name gene description interaction interaction type form reference
pmid
C020722 231 AKR1B1
ADR
ALDR1
ALR2
AR
aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21) cinnamyl alcohol results in increased expression of AKR1B1 mRNA increases expression
mRNA 20566472
C020722 57016 AKR1B10
AKR1B11
AKR1B12
ALDRLn
ARL-1
ARL1
HIS
HSI
aldo-keto reductase family 1, member B10 (aldose reductase) (EC:1.1.1.2) cinnamyl alcohol results in increased expression of AKR1B10 mRNA increases expression
mRNA 20566472
C020722 1645 AKR1C1
2-ALPHA-HSD
20-ALPHA-HSD
C9
DD1
DD1/DD2
DDH
DDH1
H-37
HAKRC
HBAB
MBAB
aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) cinnamyl alcohol results in increased expression of AKR1C1 mRNA increases expression
mRNA 20566472
C020722 1646 AKR1C2
AKR1C-pseudo
BABP
DD
DD2
DDH2
HAKRD
HBAB
MCDR2
SRXY8
aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) cinnamyl alcohol results in increased activity of AKR1C2 promoter increases activity
promoter 21195160
C020722 8644 AKR1C3
DD3
DDX
HA1753
HAKRB
HAKRe
HSD17B5
PGFS
hluPGFS
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) cinnamyl alcohol results in increased expression of AKR1C3 mRNA increases expression
mRNA 20566472
C020722 847 CAT
catalase (EC:1.11.1.6) cinnamyl alcohol results in increased expression of CAT mRNA increases expression
mRNA 20566472
C020722 2235 FECH
EPP
FCE
ferrochelatase (EC:4.99.1.1) cinnamyl alcohol results in increased expression of FECH mRNA increases expression
mRNA 20566472
C020722 2512 FTL
NBIA3
ferritin, light polypeptide cinnamyl alcohol results in increased expression of FTL mRNA increases expression
mRNA 20566472
C020722 2539 G6PD
G6PD1
glucose-6-phosphate dehydrogenase (EC:1.1.1.49) cinnamyl alcohol results in increased expression of G6PD mRNA increases expression
mRNA 20566472
C020722 2729 GCLC
GCL
GCS
GLCL
GLCLC
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) cinnamyl alcohol results in increased expression of GCLC mRNA increases expression
mRNA 20566472
C020722 2730 GCLM
GLCLR
glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) cinnamyl alcohol results in increased expression of GCLM mRNA increases expression
mRNA 20566472
C020722 2878 GPX3
GPx-P
GSHPx-3
GSHPx-P
glutathione peroxidase 3 (plasma) (EC:1.11.1.9) cinnamyl alcohol results in increased expression of GPX3 mRNA increases expression
mRNA 20566472
C020722 2936 GSR
glutathione reductase (EC:1.8.1.7) cinnamyl alcohol results in increased expression of GSR mRNA increases expression
mRNA 20566472
C020722 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) cinnamyl alcohol results in increased expression of HMOX1 mRNA increases expression
mRNA 20566472
C020722 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 cinnamyl alcohol results in increased expression of IL8 mRNA increases expression
mRNA 21920952
C020722 23764 MAFF
U-MAF
hMafF
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F cinnamyl alcohol results in increased expression of MAFF mRNA increases expression
mRNA 20566472
C020722 4097 MAFG
hMAF
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G cinnamyl alcohol results in increased expression of MAFG mRNA increases expression
mRNA 20566472
C020722 7975 MAFK
NFE2U
P18
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K cinnamyl alcohol results in increased expression of MAFK mRNA increases expression
mRNA 20566472
C020722 4199 ME1
HUMNDME
MES
malic enzyme 1, NADP(+)-dependent, cytosolic (EC:1.1.1.40) cinnamyl alcohol results in increased expression of ME1 mRNA increases expression
mRNA 20566472
C020722 4257 MGST1
GST12
MGST
MGST-I
microsomal glutathione S-transferase 1 (EC:2.5.1.18) cinnamyl alcohol results in increased expression of MGST1 mRNA increases expression
mRNA 20566472
C020722 4501 MT1X
MT-1l
MT1
metallothionein 1X cinnamyl alcohol results in increased expression of MT1X mRNA increases expression
mRNA 20566472
C020722 1728 NQO1
DHQU
DIA4
DTD
NMOR1
NMORI
QR1
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) cinnamyl alcohol results in increased expression of NQO1 mRNA increases expression
mRNA 20566472
C020722 5226 PGD
6PGD
phosphogluconate dehydrogenase (EC:1.1.1.44) cinnamyl alcohol results in increased expression of PGD mRNA increases expression
mRNA 20566472
C020722 22949 PTGR1
LTB4DH
PGR1
ZADH3
prostaglandin reductase 1 (EC:1.3.1.48 1.3.1.74) cinnamyl alcohol results in increased expression of PTGR1 mRNA increases expression
mRNA 20566472
C020722 6647 SOD1
ALS
ALS1
IPOA
SOD
hSod1
homodimer
superoxide dismutase 1, soluble (EC:1.15.1.1) cinnamyl alcohol results in increased expression of SOD1 mRNA increases expression
mRNA 20566472
C020722 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) cinnamyl alcohol results in increased expression of SOD2 mRNA increases expression
mRNA 20566472
C020722 6649 SOD3
EC-SOD
superoxide dismutase 3, extracellular (EC:1.15.1.1) cinnamyl alcohol results in increased expression of SOD3 mRNA increases expression
mRNA 20566472
C020722 140809 SRXN1
C20orf139
Npn3
SRX
SRX1
sulfiredoxin 1 (EC:1.8.98.2) cinnamyl alcohol results in increased expression of SRXN1 mRNA increases expression
mRNA 20566472
C020722 25828 TXN2
MT-TRX
MTRX
TRX2
thioredoxin 2 cinnamyl alcohol results in increased expression of TXN2 mRNA increases expression
mRNA 20566472
C020722 7296 TXNRD1
GRIM-12
TR
TR1
TRXR1
TXNR
thioredoxin reductase 1 (EC:1.8.1.9) cinnamyl alcohol results in increased expression of TXNRD1 mRNA increases expression
mRNA 20566472
C020722 10587 TXNRD2
SELZ
TR
TR-BETA
TR3
TRXR2
thioredoxin reductase 2 (EC:1.8.1.9) cinnamyl alcohol results in increased expression of TXNRD2 mRNA increases expression
mRNA 20566472
C020722 54578 UGT1A6
GNT1
HLUGP
HLUGP1
UDPGT
UDPGT_1-6
UGT1
UGT1A6S
UGT1F
UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17) cinnamyl alcohol results in increased expression of UGT1A6 mRNA increases expression
mRNA 20566472

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (2)

OMIM preferred title UniProt
#615040 Episodic pain syndrome, familial, 1; feps1 O75762
#278300 Xanthinuria, type i P47989

KEGG DISEASE (1)

KEGG disease name UniProt
H00192 Xanthinuria P47989 (related)

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D017449 C020722 Dermatitis, Allergic Contact marker/mechanism
11042091
22245253