PCIDB

KNApSAcK Metabolite C00042472

Metabolite

KNApSAcK Entry

id C00042472
Name DIethyl phthalate
CAS RN 84-66-2
Standard InChI InChI=1S/C12H14O4/c1-3-15-11(13)9-7-5-6-8-10(9)12(14)16-4-2/h5-8H,3-4H2,1-2H3
Standard InChI (Main Layer) InChI=1S/C12H14O4/c1-3-15-11(13)9-7-5-6-8-10(9)12(14)16-4-2/h5-8H,3-4H2,1-2H3

Cluster

Phytochemical cluster
KCF-S cluster No. 6057

Link

ChEMBL

By standard InChI CHEMBL388558
By standard InChI Main Layer CHEMBL388558

KEGG

By LinkDB C14175

CTD

By CAS RN C007379

Species

Summary

Plant class

class name count

Family

family name count

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Microcystis aeruginosa 1126 Bacteria

Human Protein / Gene in interaction

10 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL388558 CHEMBL1794585 (1)
0 / 0
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL388558 CHEMBL1614281 (1) CHEMBL1614361 (1)
3 / 2
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL388558 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL388558 CHEMBL2114780 (1)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL388558 CHEMBL1794401 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL388558 CHEMBL1794456 (1)
0 / 1
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL388558 CHEMBL2114890 (1)
0 / 0
P10275 Androgen receptor NR3C4 CHEMBL388558 CHEMBL1794560 (1)
3 / 4
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL388558 CHEMBL2354311 (1)
1 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL388558 CHEMBL2354287 (1)
1 / 1

CTD interaction (10)

compound gene gene name gene description interaction interaction type form reference
pmid
C007379 196 AHR
bHLHe76
aryl hydrocarbon receptor diethyl phthalate binds to and results in increased activity of AHR protein affects binding
/ increases activity
protein 23220035
C007379 367 AR
AIS
DHTR
HUMARA
HYSP1
KD
NR3C4
SBMA
SMAX1
TFM
androgen receptor diethyl phthalate inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein] affects binding
/ decreases reaction
/ increases activity
protein 20943248
C007379 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) diethyl phthalate results in increased expression of CASP3 protein alternative form increases expression
protein 23220035
C007379 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) diethyl phthalate results in increased expression of and results in increased activity of CYP1B1 protein increases activity
/ increases expression
protein 16040568
C007379 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) diethyl phthalate results in increased expression of CYP1B1 mRNA increases expression
mRNA 16040568
C007379 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 diethyl phthalate analog binds to ESR1 protein affects binding
protein 15464722
C007379 2100 ESR2
ER-BETA
ESR-BETA
ESRB
ESTRB
Erb
NR3A2
estrogen receptor 2 (ER beta) diethyl phthalate analog binds to ESR2 protein affects binding
protein 15464722
C007379 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 diethyl phthalate results in increased expression of IL8 mRNA increases expression
mRNA 21920952
C007379 8856 NR1I2
BXR
ONR1
PAR
PAR1
PAR2
PARq
PRR
PXR
SAR
SXR
nuclear receptor subfamily 1, group I, member 2 diethyl phthalate results in increased activity of NR1I2 protein increases activity
protein 21227907
C007379 9970 NR1I3
CAR
CAR1
MB67
nuclear receptor subfamily 1, group I, member 3 diethyl phthalate results in increased activity of NR1I3 protein alternative form increases activity
protein 21227907

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (10)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#114500 Colorectal cancer; crc P84022
#137800 Glioma susceptibility 1; glm1 O75874
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275

KEGG DISEASE (8)

KEGG disease name UniProt
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)

Diseases related to CTD interactions

7 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D018248 C007379 Adenoma, Liver Cell marker/mechanism
12616302
D001943 C007379 Breast Neoplasms marker/mechanism
20368132
D056486 C007379 Drug-Induced Liver Injury marker/mechanism
10837929
20674977
D005234 C007379 Fatty Liver marker/mechanism
21783644
D006529 C007379 Hepatomegaly marker/mechanism
21783644
D008548 C007379 Melanosis marker/mechanism
12616302
D011041 C007379 Poisoning marker/mechanism
23220035