PCIDB

KNApSAcK Metabolite C00044432

Metabolite

KNApSAcK Entry

id C00044432
Name 2-Quinolone
CAS RN 59-31-4
Standard InChI InChI=1S/C9H7NO/c11-9-6-5-7-3-1-2-4-8(7)10-9/h1-6H,(H,10,11)
Standard InChI (Main Layer) InChI=1S/C9H7NO/c11-9-6-5-7-3-1-2-4-8(7)10-9/h1-6H,(H,10,11)

Cluster

Phytochemical cluster
KCF-S cluster No. 3673

Link

ChEMBL

By standard InChI CHEMBL186422
By standard InChI Main Layer CHEMBL186422

KEGG

By LinkDB C06415

CTD

By CAS RN C107724

Species

Summary

Plant class

class name count
rosids 1

Family

family name count
Rutaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Glycosmis arborea 68543 Rutaceae rosids Viridiplantae

Human Protein / Gene in interaction

19 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P09917 Arachidonate 5-lipoxygenase Oxidoreductase CHEMBL186422 CHEMBL1664429 (1)
0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase CHEMBL186422 CHEMBL1960502 (1) CHEMBL1960514 (1)
0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase CHEMBL186422 CHEMBL1960503 (1) CHEMBL1960515 (1)
0 / 0
P43166 Carbonic anhydrase 7 Lyase CHEMBL186422 CHEMBL1960500 (1) CHEMBL1960512 (1)
0 / 0
P22894 Neutrophil collagenase M10A CHEMBL186422 CHEMBL1664434 (1)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL186422 CHEMBL1664435 (1)
2 / 2
Q8N1Q1 Carbonic anhydrase 13 Lyase CHEMBL186422 CHEMBL1960497 (1) CHEMBL1960509 (1)
0 / 0
P00918 Carbonic anhydrase 2 Lyase CHEMBL186422 CHEMBL1960506 (1) CHEMBL1960518 (1)
1 / 2
P23280 Carbonic anhydrase 6 Lyase CHEMBL186422 CHEMBL1960501 (1) CHEMBL1960513 (1)
0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase CHEMBL186422 CHEMBL1960496 (1) CHEMBL1960508 (1)
0 / 0
O43570 Carbonic anhydrase 12 Lyase CHEMBL186422 CHEMBL1960498 (1) CHEMBL1960510 (1)
1 / 2
P00915 Carbonic anhydrase 1 Lyase CHEMBL186422 CHEMBL1960507 (1) CHEMBL1960519 (1)
0 / 0
P03956 Interstitial collagenase M10A CHEMBL186422 CHEMBL1664431 (1)
0 / 1
Q16790 Carbonic anhydrase 9 Lyase CHEMBL186422 CHEMBL1960499 (1) CHEMBL1960511 (1)
0 / 1
P08253 72 kDa type IV collagenase M10A CHEMBL186422 CHEMBL1664432 (1)
1 / 3
P07451 Carbonic anhydrase 3 Lyase CHEMBL186422 CHEMBL1960505 (1) CHEMBL1960517 (1)
0 / 0
P08254 Stromelysin-1 M10A CHEMBL186422 CHEMBL1664433 (1)
1 / 0
P22748 Carbonic anhydrase 4 Lyase CHEMBL186422 CHEMBL1960504 (1) CHEMBL1960516 (1)
1 / 1
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL186422 CHEMBL1794536 (1)
0 / 0

CTD interaction (2)

compound gene gene name gene description interaction interaction type form reference
pmid
C107724 5444 PON1
ESA
MVCD5
PON
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) 2-hydroxyquinoline inhibits the reaction [PON1 protein results in increased hydrolysis of Isoflurophate] decreases reaction
/ increases hydrolysis
protein 21382471
C107724 5444 PON1
ESA
MVCD5
PON
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) 2-hydroxyquinoline inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] decreases reaction
/ increases hydrolysis
protein 21382471

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (7)

OMIM preferred title UniProt
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#143860 Hyperchlorhidrosis, isolated O43570
#603932 Intervertebral disc disease; idd P14780
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#600852 Retinitis pigmentosa 17; rp17 P22748

KEGG DISEASE (9)

KEGG disease name UniProt
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)