PCIDB

KNApSAcK Metabolite C00000620

Metabolite

KNApSAcK Entry

id C00000620
Name Isoeugenol
CAS RN 97-54-1
Standard InChI InChI=1S/C10H12O2/c1-3-4-8-5-6-9(11)10(7-8)12-2/h3-7,11H,1-2H3/b4-3+
Standard InChI (Main Layer) InChI=1S/C10H12O2/c1-3-4-8-5-6-9(11)10(7-8)12-2/h3-7,11H,1-2H3

Cluster

Phytochemical cluster No. 6
KCF-S cluster No. 310

Link

ChEMBL

By standard InChI CHEMBL193598
By standard InChI Main Layer CHEMBL193598 CHEMBL445206 CHEMBL2135887

KEGG

By LinkDB C10469

CTD

By CAS RN C036643

Human Protein / Gene in interaction

93 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL445206 CHEMBL1909136 (2)
1 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL193598 CHEMBL1738312 (1)
0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL445206 CHEMBL1909139 (2)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL445206 CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL445206 CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL445206 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL445206 CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL445206 CHEMBL1909201 (2)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL445206 CHEMBL1909176 (2)
0 / 0
P29466 Caspase-1 C14 CHEMBL445206 CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL445206 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL445206 CHEMBL1909199 (2)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL445206 CHEMBL1909197 (2)
2 / 2
P00918 Carbonic anhydrase 2 Lyase CHEMBL445206 CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL445206 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL445206 CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL445206 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL445206 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL445206 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL445206 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL445206 CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL445206 CHEMBL1909093 (2)
0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL445206 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL445206 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL445206 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL445206 CHEMBL1909135 (2)
0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL445206 CHEMBL1909203 (2)
1 / 11
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL445206 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL445206 CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL445206 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL445206 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL445206 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL445206 CHEMBL1909214 (2)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL445206 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL445206 CHEMBL1909096 (2)
1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL445206 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL445206 CHEMBL1909166 (2)
1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL445206 CHEMBL1909133 (2)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL445206 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL445206 CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL445206 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL445206 CHEMBL1909101 (2)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL445206 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL445206 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL445206 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL445206 CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL445206 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL445206 CHEMBL1909100 (2)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL445206 CHEMBL1909167 (2)
1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL445206 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL445206 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL445206 CHEMBL1909110 (2)
1 / 0
P03956 Interstitial collagenase M10A CHEMBL445206 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL445206 CHEMBL1909119 (2)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL193598 CHEMBL1794401 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL445206 CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL445206 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL445206 CHEMBL1909170 (2)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL445206 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL445206 CHEMBL1909109 (2)
2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL445206 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL445206 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL445206 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL445206 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL445206 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL445206 CHEMBL1909108 (2)
0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL445206 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL445206 CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL445206 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL445206 CHEMBL1909132 (2)
0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL445206 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL445206 CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL445206 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL445206 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL445206 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL445206 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL445206 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL445206 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL445206 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL445206 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL445206 CHEMBL1909168 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL445206 CHEMBL1909134 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL445206 CHEMBL1909138 (2)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL445206 CHEMBL1909137 (2)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL193598 CHEMBL2135887 CHEMBL2114890 (2)
0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL445206 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL445206 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL445206 CHEMBL1909213 (2)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL445206 CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL445206 CHEMBL1909116 (2)
1 / 1
P06239 Tyrosine-protein kinase Lck Src CHEMBL445206 CHEMBL1909206 (2)
0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL445206 CHEMBL1909128 (2)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL193598 CHEMBL1738442 (1)
0 / 0

CTD interaction (54)

compound gene gene name gene description interaction interaction type form reference
pmid
C036643 196 AHR
bHLHe76
aryl hydrocarbon receptor 3'-methoxy-4'-nitroflavone inhibits the reaction [isoeugenol results in increased activity of AHR protein] decreases reaction
/ increases activity
protein 16972787
C036643 196 AHR
bHLHe76
aryl hydrocarbon receptor isoeugenol results in increased activity of AHR protein increases activity
protein 16972787
C036643 231 AKR1B1
ADR
ALDR1
ALR2
AR
aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21) isoeugenol results in increased expression of AKR1B1 mRNA increases expression
mRNA 20566472
C036643 57016 AKR1B10
AKR1B11
AKR1B12
ALDRLn
ARL-1
ARL1
HIS
HSI
aldo-keto reductase family 1, member B10 (aldose reductase) (EC:1.1.1.2) isoeugenol results in increased expression of AKR1B10 mRNA increases expression
mRNA 20566472
C036643 1645 AKR1C1
2-ALPHA-HSD
20-ALPHA-HSD
C9
DD1
DD1/DD2
DDH
DDH1
H-37
HAKRC
HBAB
MBAB
aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) isoeugenol results in increased expression of AKR1C1 mRNA increases expression
mRNA 20566472
C036643 1646 AKR1C2
AKR1C-pseudo
BABP
DD
DD2
DDH2
HAKRD
HBAB
MCDR2
SRXY8
aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) isoeugenol results in increased activity of AKR1C2 promoter increases activity
promoter 21195160
C036643 1646 AKR1C2
AKR1C-pseudo
BABP
DD
DD2
DDH2
HAKRD
HBAB
MCDR2
SRXY8
aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) isoeugenol results in increased expression of AKR1C2 mRNA increases expression
mRNA 20491607
C036643 8644 AKR1C3
DD3
DDX
HA1753
HAKRB
HAKRe
HSD17B5
PGFS
hluPGFS
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) isoeugenol results in increased expression of AKR1C3 mRNA increases expression
mRNA 20566472
C036643 847 CAT
catalase (EC:1.11.1.6) isoeugenol results in increased expression of CAT mRNA increases expression
mRNA 20566472
C036643 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 isoeugenol results in decreased secretion of CCL2 protein decreases secretion
protein 20488241
C036643 10850 CCL27
ALP
CTACK
CTAK
ESKINE
ILC
PESKY
SCYA27
chemokine (C-C motif) ligand 27 isoeugenol results in increased expression of CCL27 mRNA increases expression
mRNA 17936526
C036643 29126 CD274
B7-H
B7H1
PD-L1
PDCD1L1
PDCD1LG1
PDL1
CD274 molecule isoeugenol results in increased expression of CD274 protein increases expression
protein 20488241
C036643 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) isoeugenol results in increased expression of CYP1A1 mRNA increases expression
mRNA 20491607
C036643 2235 FECH
EPP
FCE
ferrochelatase (EC:4.99.1.1) isoeugenol results in increased expression of FECH mRNA increases expression
mRNA 20566472
C036643 2512 FTL
NBIA3
ferritin, light polypeptide isoeugenol results in increased expression of FTL mRNA increases expression
mRNA 20566472
C036643 2539 G6PD
G6PD1
glucose-6-phosphate dehydrogenase (EC:1.1.1.49) isoeugenol results in increased expression of G6PD mRNA increases expression
mRNA 20566472
C036643 2729 GCLC
GCL
GCS
GLCL
GLCLC
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) isoeugenol results in increased expression of GCLC mRNA increases expression
mRNA 20566472
C036643 2730 GCLM
GLCLR
glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) isoeugenol results in increased expression of GCLM mRNA increases expression
mRNA 20566472
C036643 2878 GPX3
GPx-P
GSHPx-3
GSHPx-P
glutathione peroxidase 3 (plasma) (EC:1.11.1.9) isoeugenol results in increased expression of GPX3 mRNA increases expression
mRNA 20566472
C036643 2936 GSR
glutathione reductase (EC:1.8.1.7) isoeugenol results in increased expression of GSR mRNA increases expression
mRNA 20566472
C036643 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) isoeugenol results in increased expression of HMOX1 mRNA increases expression
mRNA 20491607
20566472
C036643 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 [Indomethacin co-treated with isoeugenol] results in increased expression of IL8 mRNA affects cotreatment
/ increases expression
mRNA 21284934
C036643 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 isoeugenol results in increased expression of IL8 mRNA increases expression
mRNA 21284934
21920952
21969073
C036643 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 KT 5720 inhibits the reaction [isoeugenol results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 21969073
C036643 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 SB 203580 inhibits the reaction [isoeugenol results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 21969073
C036643 23764 MAFF
U-MAF
hMafF
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F isoeugenol results in increased expression of MAFF mRNA increases expression
mRNA 20491607
20566472
C036643 4097 MAFG
hMAF
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G isoeugenol results in increased expression of MAFG mRNA increases expression
mRNA 20566472
C036643 7975 MAFK
NFE2U
P18
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K isoeugenol results in increased expression of MAFK mRNA increases expression
mRNA 20566472
C036643 4199 ME1
HUMNDME
MES
malic enzyme 1, NADP(+)-dependent, cytosolic (EC:1.1.1.40) isoeugenol results in increased expression of ME1 mRNA increases expression
mRNA 20566472
C036643 4257 MGST1
GST12
MGST
MGST-I
microsomal glutathione S-transferase 1 (EC:2.5.1.18) isoeugenol results in increased expression of MGST1 mRNA increases expression
mRNA 20566472
C036643 4501 MT1X
MT-1l
MT1
metallothionein 1X isoeugenol results in increased expression of MT1X mRNA increases expression
mRNA 20566472
C036643 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]] affects binding
/ decreases reaction
/ increases activity
protein 10871845
C036643 1728 NQO1
DHQU
DIA4
DTD
NMOR1
NMORI
QR1
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) isoeugenol results in increased expression of NQO1 mRNA increases expression
mRNA 20491607
20566472
C036643 5226 PGD
6PGD
phosphogluconate dehydrogenase (EC:1.1.1.44) isoeugenol results in increased expression of PGD mRNA increases expression
mRNA 20566472
C036643 22949 PTGR1
LTB4DH
PGR1
ZADH3
prostaglandin reductase 1 (EC:1.3.1.48 1.3.1.74) isoeugenol results in increased expression of PTGR1 mRNA increases expression
mRNA 20566472
C036643 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]] affects binding
/ decreases reaction
/ increases activity
protein 10871845
C036643 9021 SOCS3
ATOD4
CIS3
Cish3
SOCS-3
SSI-3
SSI3
suppressor of cytokine signaling 3 isoeugenol results in increased expression of SOCS3 mRNA increases expression
mRNA 21969073
C036643 9021 SOCS3
ATOD4
CIS3
Cish3
SOCS-3
SSI-3
SSI3
suppressor of cytokine signaling 3 isoeugenol results in increased expression of SOCS3 protein increases expression
protein 21969073
C036643 9021 SOCS3
ATOD4
CIS3
Cish3
SOCS-3
SSI-3
SSI3
suppressor of cytokine signaling 3 KT 5720 inhibits the reaction [isoeugenol results in increased expression of SOCS3 mRNA] decreases reaction
/ increases expression
mRNA 21969073
C036643 6647 SOD1
ALS
ALS1
IPOA
SOD
hSod1
homodimer
superoxide dismutase 1, soluble (EC:1.15.1.1) isoeugenol results in increased expression of SOD1 mRNA increases expression
mRNA 20566472
C036643 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) isoeugenol results in increased expression of SOD2 mRNA increases expression
mRNA 20566472
C036643 6649 SOD3
EC-SOD
superoxide dismutase 3, extracellular (EC:1.15.1.1) isoeugenol results in increased expression of SOD3 mRNA increases expression
mRNA 20566472
C036643 140809 SRXN1
C20orf139
Npn3
SRX
SRX1
sulfiredoxin 1 (EC:1.8.98.2) isoeugenol results in increased expression of SRXN1 mRNA increases expression
mRNA 20566472
C036643 7097 TLR2
CD282
TIL4
toll-like receptor 2 isoeugenol results in increased expression of TLR2 mRNA increases expression
mRNA 17936526
C036643 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor isoeugenol inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]] affects binding
/ decreases reaction
/ increases activity
protein 10871845
C036643 10626 TRIM16
EBBP
tripartite motif containing 16 [Indomethacin co-treated with isoeugenol] results in increased expression of TRIM16 mRNA affects cotreatment
/ increases expression
mRNA 21284934
C036643 10626 TRIM16
EBBP
tripartite motif containing 16 isoeugenol results in increased expression of TRIM16 mRNA increases expression
mRNA 21284934
C036643 25828 TXN2
MT-TRX
MTRX
TRX2
thioredoxin 2 isoeugenol results in increased expression of TXN2 mRNA increases expression
mRNA 20566472
C036643 7296 TXNRD1
GRIM-12
TR
TR1
TRXR1
TXNR
thioredoxin reductase 1 (EC:1.8.1.9) isoeugenol results in increased expression of TXNRD1 mRNA increases expression
mRNA 20566472
C036643 10587 TXNRD2
SELZ
TR
TR-BETA
TR3
TRXR2
thioredoxin reductase 2 (EC:1.8.1.9) isoeugenol results in increased expression of TXNRD2 mRNA increases expression
mRNA 20566472
C036643 54578 UGT1A6
GNT1
HLUGP
HLUGP1
UDPGT
UDPGT_1-6
UGT1
UGT1A6S
UGT1F
UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17) isoeugenol results in increased expression of UGT1A6 mRNA increases expression
mRNA 20566472
C036643 7538 ZFP36
G0S24
GOS24
NUP475
RNF162A
TIS11
TTP
zfp-36
ZFP36 ring finger protein isoeugenol results in increased expression of ZFP36 protein increases expression
protein 21969073
C036643 7538 ZFP36
G0S24
GOS24
NUP475
RNF162A
TIS11
TTP
zfp-36
ZFP36 ring finger protein KT 5720 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein] decreases reaction
/ increases expression
protein 21969073
C036643 7538 ZFP36
G0S24
GOS24
NUP475
RNF162A
TIS11
TTP
zfp-36
ZFP36 ring finger protein SB 203580 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein] decreases reaction
/ increases expression
protein 21969073

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (36)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#603932 Intervertebral disc disease; idd P14780
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#126200 Multiple sclerosis, susceptibility to; ms P08575
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#607276 Resting heart rate, variation in P08588
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (31)

KEGG disease name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D017449 C036643 Dermatitis, Allergic Contact marker/mechanism
22245253