Cananga odorata

• Index
• Plant Species
• Metabolite list (14)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Cananga odorata
Genus	Cananga
Family	Annonaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Cananga odorata
Linked NCBI taxonomy ID	13393
Linked level	species

Family

Family in NCBI taxonomy	Annonaceae
ID	22140

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	Magnoliophyta
ID	3398

Metabolite list (14)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00027281	Anonaine	CHEMBL401798	C098138	1 / 0 / 0		No. 20	No. 4
C00025233	Coramine / Coreximin / Coreximine / (S)-Coreximine / (-)-Coreximine / Coramine(alkaloid)	CHEMBL1164087				No. 37	No. 4
C00000620	Isoeugenol	CHEMBL193598 CHEMBL445206 CHEMBL2135887	C036643	93 / 36 / 31	44 / 1	No. 310	No. 6
C00003203	alpha-Ylangene					No. 333	No. 38
C00001910	Reticuline / (+)-Reticuline	CHEMBL235212 CHEMBL401501 CHEMBL464734	C003298	1 / 0 / 0		No. 345	No. 4
C00025334	trans-Feruloyltyramine / N-trans-Feruloyltyramine / trans-N-Feruloyltyramine	CHEMBL206555 CHEMBL451720		1 / 4 / 2		No. 499
C00025258	Micheline A / (-)-Ushinsunine	CHEMBL221034 CHEMBL1617041 CHEMBL2009013		1 / 0 / 0		No. 553
C00025353	N-Oxyushinsunine / Ushinsunine N-oxide / (-)-Ushinsunine b-N-oxide	CHEMBL517632 CHEMBL517212				No. 553
C00000165	gamma-Eudesmol	CHEMBL477900				No. 613	No. 38
C00047091	Sampangine	CHEMBL435201		1 / 0 / 0		No. 1472
C00042398	Cleistopholine	CHEMBL444067				No. 3644
C00002753	Isosafrole	CHEMBL487603	C015959	10 / 6 / 10	2 / 0	No. 3773
C00045958	gamma-Eudesmol 11-alpha-L-rhamnoside / (-)-gamma-Eudesmol 11-alpha-L-rhamnoside	CHEMBL477899				No. 4164
C00045716	Cananodine	CHEMBL476684				No. 5427

Human Protein / Gene in interactions

104 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00000620 C00002753	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00000620 C00002753	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000620 C00002753	0 / 1
P35372	Mu-type opioid receptor	Opioid receptor	C00000620 C00001910	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00000620	0 / 0
P08246	Neutrophil elastase	S1A	C00000620	2 / 1
P33765	Adenosine receptor A3	Adenosine receptor	C00000620	0 / 0
Q16539	Mitogen-activated protein kinase 14	p38	C00000620	0 / 0
P49146	Neuropeptide Y receptor type 2	Neuropeptide Y receptor	C00000620	0 / 0
P29466	Caspase-1	C14	C00000620	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00000620	0 / 0
P27361	Mitogen-activated protein kinase 3	Erk	C00000620	0 / 0
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00002753	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00000620	2 / 2
O14757	Serine/threonine-protein kinase Chk1	Chk1	C00025258	0 / 0
Q13315	Serine-protein kinase ATM	Atypical serine/threonine protein kinase PIKK subfamily	C00002753	1 / 4
P00918	Carbonic anhydrase 2	Lyase	C00000620	1 / 2
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00000620	0 / 1
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00000620	1 / 1
P25021	Histamine H2 receptor	Histamine receptor	C00000620	0 / 0
P35367	Histamine H1 receptor	Histamine receptor	C00000620	0 / 0
Q01959	Sodium-dependent dopamine transporter	Dopamine	C00000620	1 / 0
P08912	Muscarinic acetylcholine receptor M5	Acetylcholine receptor	C00000620	0 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00000620	0 / 0
P13945	Beta-3 adrenergic receptor	Adrenergic receptor	C00000620	0 / 0
P08183	Multidrug resistance protein 1	drug	C00002753	1 / 0
P25024	C-X-C chemokine receptor type 1	CXC chemokine receptor	C00000620	0 / 0
P06241	Tyrosine-protein kinase Fyn	Src	C00000620	0 / 0
Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Ser_Thr	C00000620	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000620	0 / 1
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00000620	1 / 8
P14416	D(2) dopamine receptor	Dopamine receptor	C00000620	2 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00000620	0 / 0
P37288	Vasopressin V1a receptor	Vasopressin and oxytocin receptor	C00000620	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00000620	0 / 0
Q9Y271	Cysteinyl leukotriene receptor 1	Leukotriene receptor	C00000620	0 / 0
P20701	Integrin alpha-L	Membrane receptor	C00047091	0 / 0
P29274	Adenosine receptor A2a	Adenosine receptor	C00000620	0 / 0
P25929	Neuropeptide Y receptor type 1	Neuropeptide Y receptor	C00000620	0 / 0
P50052	Type-2 angiotensin II receptor	Angiotensin receptor	C00000620	1 / 1
Q14761	Protein tyrosine phosphatase receptor type C-associated protein	Enzyme	C00027281	0 / 0
P17948	Vascular endothelial growth factor receptor 1	Vegfr	C00000620	0 / 0
P41968	Melanocortin receptor 3	Melanocortin receptor	C00000620	1 / 0
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00000620	0 / 0
P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Oxidoreductase	C00000620	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00000620	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00000620	0 / 0
P30988	Calcitonin receptor	Calcitonin receptor	C00000620	0 / 0
P35462	D(3) dopamine receptor	Dopamine receptor	C00000620	1 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00000620	0 / 0
Q92731	Estrogen receptor beta	NR3A2	C00000620	0 / 1
P41595	5-hydroxytryptamine receptor 2B	Serotonin receptor	C00000620	0 / 0
P25101	Endothelin-1 receptor	Endothelin receptor	C00000620	0 / 0
P30411	B2 bradykinin receptor	Bradykinin receptor	C00000620	0 / 0
P32245	Melanocortin receptor 4	Melanocortin receptor	C00000620	1 / 0
P32238	Cholecystokinin receptor type A	Cholecystokinin receptor	C00000620	0 / 0
P08311	Cathepsin G	S1A	C00000620	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00000620	1 / 0
P03956	Interstitial collagenase	M10A	C00000620	0 / 1
P32241	Vasoactive intestinal polypeptide receptor 1	Vasoactive intestinal peptide receptor	C00000620	0 / 0
P11308	Transcriptional regulator ERG	Unclassified protein	C00002753	1 / 2
P83916	Chromobox protein homolog 1	Unclassified protein	C00000620	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00000620	0 / 1
P08172	Muscarinic acetylcholine receptor M2	Acetylcholine receptor	C00000620	2 / 0
P11229	Muscarinic acetylcholine receptor M1	Acetylcholine receptor	C00000620	0 / 0
P14679	Tyrosinase	Oxidoreductase	C00025334	4 / 2
P21554	Cannabinoid receptor 1	Cannabinoid receptor	C00000620	0 / 0
P31645	Sodium-dependent serotonin transporter	Serotonin	C00000620	2 / 0
P04626	Receptor tyrosine-protein kinase erbB-2	TK tyrosine-protein kinase EGFR subfamily	C00000620	5 / 9
P20309	Muscarinic acetylcholine receptor M3	Acetylcholine receptor	C00000620	1 / 0
P21452	Substance-K receptor	Neurokinin receptor	C00000620	0 / 0
P51679	C-C chemokine receptor type 4	CC chemokine receptor	C00000620	0 / 0
P51681	C-C chemokine receptor type 5	CC chemokine receptor	C00000620	3 / 0
P50406	5-hydroxytryptamine receptor 6	Serotonin receptor	C00000620	0 / 0
Q96RI1	Bile acid receptor	NR1H4	C00002753	0 / 0
P41597	C-C chemokine receptor type 2	CC chemokine receptor	C00000620	1 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00000620	0 / 0
P08575	Receptor-type tyrosine-protein phosphatase C	Enzyme	C00000620	2 / 1
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00000620	2 / 2
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00002753	0 / 0
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00000620	0 / 0
P03372	Estrogen receptor	NR3A1	C00000620	1 / 1
P08588	Beta-1 adrenergic receptor	Adrenergic receptor	C00000620	1 / 0
P22303	Acetylcholinesterase	Hydrolase	C00000620	1 / 0
P28223	5-hydroxytryptamine receptor 2A	Serotonin receptor	C00000620	0 / 0
P28335	5-hydroxytryptamine receptor 2C	Serotonin receptor	C00000620	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00000620	0 / 3
P08173	Muscarinic acetylcholine receptor M4	Acetylcholine receptor	C00000620	0 / 0
P25103	Substance-P receptor	Neurokinin receptor	C00000620	0 / 0
P25105	Platelet-activating factor receptor	PAF receptor	C00000620	0 / 0
P33032	Melanocortin receptor 5	Melanocortin receptor	C00000620	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000620	1 / 1
P21728	D(1A) dopamine receptor	Dopamine receptor	C00000620	0 / 0
P05181	Cytochrome P450 2E1	Cytochrome P450 2E1	C00000620	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000620	1 / 0
P10275	Androgen receptor	NR3C4	C00002753	3 / 4
P23975	Sodium-dependent noradrenaline transporter	Norepinephrine	C00000620	1 / 1
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00000620	0 / 0
P30542	Adenosine receptor A1	Adenosine receptor	C00000620	0 / 0
P18089	Alpha-2B adrenergic receptor	Adrenergic receptor	C00000620	0 / 0
P24557	Thromboxane-A synthase	Cytochrome P450 5A1	C00000620	1 / 1
P06239	Tyrosine-protein kinase Lck	Src	C00000620	0 / 1
P25025	C-X-C chemokine receptor type 2	CXC chemokine receptor	C00000620	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00000620	0 / 0

46 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
5243	ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1	ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44)	C00002753
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00002753
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00000620
231	AKR1B1, ADR, ALDR1, ALR2, AR	aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21)	C00000620
57016	AKR1B10, AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI	aldo-keto reductase family 1, member B10 (aldose reductase) (EC:1.1.1.2)	C00000620
1645	AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB	aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112)	C00000620
1646	AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8	aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357)	C00000620
8644	AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS	aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357)	C00000620
847	CAT	catalase (EC:1.11.1.6)	C00000620
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00000620
10850	CCL27, ALP, CTACK, CTAK, ESKINE, ILC, PESKY, SCYA27	chemokine (C-C motif) ligand 27	C00000620
29126	CD274, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1	CD274 molecule	C00000620
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00000620
2235	FECH, EPP, FCE	ferrochelatase (EC:4.99.1.1)	C00000620
2512	FTL, NBIA3	ferritin, light polypeptide	C00000620
2539	G6PD, G6PD1	glucose-6-phosphate dehydrogenase (EC:1.1.1.49)	C00000620
2729	GCLC, GCL, GCS, GLCL, GLCLC	glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2)	C00000620
2730	GCLM, GLCLR	glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2)	C00000620
2878	GPX3, GPx-P, GSHPx-3, GSHPx-P	glutathione peroxidase 3 (plasma) (EC:1.11.1.9)	C00000620
2936	GSR	glutathione reductase (EC:1.8.1.7)	C00000620
3162	HMOX1, HMOX1D, HO-1, HSP32, bK286B10	heme oxygenase (decycling) 1 (EC:1.14.99.3)	C00000620
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00000620
23764	MAFF, U-MAF, hMafF	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F	C00000620
4097	MAFG, hMAF	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G	C00000620
7975	MAFK, NFE2U, P18	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K	C00000620
4199	ME1, HUMNDME, MES	malic enzyme 1, NADP(+)-dependent, cytosolic (EC:1.1.1.40)	C00000620
4257	MGST1, GST12, MGST, MGST-I	microsomal glutathione S-transferase 1 (EC:2.5.1.18)	C00000620
4501	MT1X, MT-1l, MT1	metallothionein 1X	C00000620
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00000620
1728	NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1	NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2)	C00000620
5226	PGD, 6PGD	phosphogluconate dehydrogenase (EC:1.1.1.44)	C00000620
22949	PTGR1, LTB4DH, PGR1, ZADH3	prostaglandin reductase 1 (EC:1.3.1.48 1.3.1.74)	C00000620
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00000620
9021	SOCS3, ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3	suppressor of cytokine signaling 3	C00000620
6647	SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer	superoxide dismutase 1, soluble (EC:1.15.1.1)	C00000620
6648	SOD2, IPOB, MNSOD, MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	C00000620
6649	SOD3, EC-SOD	superoxide dismutase 3, extracellular (EC:1.15.1.1)	C00000620
140809	SRXN1, C20orf139, Npn3, SRX, SRX1	sulfiredoxin 1 (EC:1.8.98.2)	C00000620
7097	TLR2, CD282, TIL4	toll-like receptor 2	C00000620
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00000620
10626	TRIM16, EBBP	tripartite motif containing 16	C00000620
25828	TXN2, MT-TRX, MTRX, TRX2	thioredoxin 2	C00000620
7296	TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR	thioredoxin reductase 1 (EC:1.8.1.9)	C00000620
10587	TXNRD2, SELZ, TR, TR-BETA, TR3, TRXR2	thioredoxin reductase 2 (EC:1.8.1.9)	C00000620
54578	UGT1A6, GNT1, HLUGP, HLUGP1, UDPGT, UDPGT_1-6, UGT1, UGT1A6S, UGT1F	UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17)	C00000620
7538	ZFP36, G0S24, GOS24, NUP475, RNF162A, TIS11, TTP, zfp-36	ZFP36 ring finger protein	C00000620

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions