PCIDB

KNApSAcK Metabolite C00007291

Metabolite

KNApSAcK Entry

id C00007291
Name Betaine
CAS RN 107-43-7
Standard InChI InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3
Standard InChI (Main Layer) InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3

Cluster

Phytochemical cluster
KCF-S cluster No. 5024

Link

ChEMBL

By standard InChI CHEMBL1182
By standard InChI Main Layer CHEMBL95889 CHEMBL1182

KEGG

By LinkDB C00719

CTD

By CAS RN D001622

Human Protein / Gene in interaction

10 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL95889 CHEMBL1741321 (1)
1 / 0
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL95889 CHEMBL1614281 (1) CHEMBL1614361 (1)
3 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL95889 CHEMBL1741325 (1)
0 / 1
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL95889 CHEMBL1738610 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL95889 CHEMBL1741322 (1)
0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL95889 CHEMBL1737868 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL95889 CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL95889 CHEMBL1741324 (1)
0 / 1
Q7Z2H8 Proton-coupled amino acid transporter 1 Unclassified protein CHEMBL95889 CHEMBL1919336 (2)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL95889 CHEMBL1738442 (1)
0 / 0

CTD interaction (7)

compound gene gene name gene description interaction interaction type form reference
pmid
D001622 635 BHMT
BHMT1
betaine--homocysteine S-methyltransferase (EC:2.1.1.5) BHMT protein results in increased metabolism of Betaine increases metabolic processing
protein 18230605
D001622 2157 F8
AHF
DXS1253E
F8B
F8C
FVIII
HEMA
coagulation factor VIII, procoagulant component Betaine affects the localization of and results in increased secretion of F8 protein affects localization
/ increases secretion
protein 22973456
D001622 2157 F8
AHF
DXS1253E
F8B
F8C
FVIII
HEMA
coagulation factor VIII, procoagulant component Betaine affects the localization of and results in increased secretion of F8 protein mutant form affects localization
/ increases secretion
protein 22973456
D001622 2157 F8
AHF
DXS1253E
F8B
F8C
FVIII
HEMA
coagulation factor VIII, procoagulant component Betaine results in increased secretion of F8 protein increases secretion
protein 22973456
D001622 2157 F8
AHF
DXS1253E
F8B
F8C
FVIII
HEMA
coagulation factor VIII, procoagulant component Betaine results in increased secretion of F8 protein mutant form increases secretion
protein 22973456
D001622 2158 F9
FIX
HEMB
P19
PTC
THPH8
coagulation factor IX (EC:3.4.21.22) Betaine results in increased secretion of F9 protein increases secretion
protein 22973456
D001622 6584 SLC22A5
CDSP
OCTN2
OCTN2VT
solute carrier family 22 (organic cation/carnitine transporter), member 5 Betaine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] decreases reaction
/ increases uptake
protein 16928358

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (5)

OMIM preferred title UniProt
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473

KEGG DISEASE (5)

KEGG disease name UniProt
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)

Diseases related to CTD interactions

11 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D003711 D001622 Demyelinating Diseases therapeutic
7527320
D056486 D001622 Drug-Induced Liver Injury therapeutic
18930038
D005235 D001622 Fatty Liver, Alcoholic therapeutic
20118189
D006712 D001622 Homocystinuria therapeutic
17413090
D008106 D001622 Liver Cirrhosis, Experimental therapeutic
18930038
D008113 D001622 Liver Neoplasms therapeutic
19642983
D008569 D001622 Memory Disorders therapeutic
22053950
D008661 D001622 Metabolism, Inborn Errors therapeutic
7527320
D009203 D001622 Myocardial Infarction therapeutic
19288277
D009436 D001622 Neural Tube Defects therapeutic
17413090
D013610 D001622 Tachycardia therapeutic
8834483