PCIDB

KNApSAcK Metabolite C00007366

Metabolite

KNApSAcK Entry

id C00007366
Name alpha-Tocopherol
CAS RN 59-02-9
Standard InChI InChI=1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3/t21-,22-,29-/m1/s1
Standard InChI (Main Layer) InChI=1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3

Cluster

Phytochemical cluster
KCF-S cluster No. 1290

Link

ChEMBL

By standard InChI CHEMBL47
By standard InChI Main Layer CHEMBL47 CHEMBL49563 CHEMBL442800

KEGG

By LinkDB C02477

CTD

By CAS RN D024502

Species

Summary

Plant class

class name count
rosids 9
Liliopsida 7
asterids 7
eudicotyledons 3
Magnoliophyta 2
Viridiplantae 1

Family (Top 10)

family name count
Poaceae 5
Apiaceae 3
Arecaceae 2
Solanaceae 1
Annonaceae 1
Myrtaceae 1
Proteaceae 1
Euphorbiaceae 1
Juglandaceae 1
Sapindaceae 1

List (29)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Aesculus hippocastanum Hort. 43363 Hippocastanaceae rosids Viridiplantae
Amaranthus hypochondriacus L. 28502 Amaranthaceae eudicotyledons Viridiplantae
Arabidopsis thaliana 3702 Brassicaceae rosids Viridiplantae
Avena sativa L. 4498 Poaceae Liliopsida Viridiplantae
Bixa orellana L. 66672 Bixaceae rosids Viridiplantae
Botryococcus braunii 38881 Botryococcaceae Viridiplantae Viridiplantae
Calophyllum inophyllum L. 158927 Calophyllaceae rosids Viridiplantae
Carum carvi L. 48032 Apiaceae asterids Viridiplantae
Cocos nucifera L. 13894 Arecaceae Liliopsida Viridiplantae
Coriandrum sativum L. 4047 Apiaceae asterids Viridiplantae
Delphinium ajacis L. 37494 Ranunculaceae eudicotyledons Viridiplantae
Elaeis guineensis Jacq. 51953 Arecaceae Liliopsida Viridiplantae
Feijoa sellowiana 260130 Myrtaceae rosids Viridiplantae
Foeniculum vulgare L. 48037 Apiaceae asterids Viridiplantae
Gevuina avellana Mol. 54938 Proteaceae eudicotyledons Viridiplantae
Hevea brasiliensis Mull.Arg. 3980 Euphorbiaceae rosids Viridiplantae
Hordeum vulgare L. 4513 Poaceae Liliopsida Viridiplantae
Juglans regia L. 51240 Juglandaceae rosids Viridiplantae
Litchi chinensis Sonn. 151069 Sapindaceae rosids Viridiplantae
Machilus zuihoensis 337466 Lauraceae Magnoliophyta Viridiplantae
Nicotiana tabacum L. 4097 Solanaceae asterids Viridiplantae
Oryza sativa L. 4530 Poaceae Liliopsida Viridiplantae
Rosmarinus officinalis L. 39177 Lamiaceae asterids Viridiplantae
Sebertia acuminata 280718 Sapotaceae asterids Viridiplantae
Secale cereale L. 4550 Poaceae Liliopsida Viridiplantae
Uvaria pandensis 673193 Annonaceae Magnoliophyta Viridiplantae
Vaccinium macrocarpon Aiton 13750 Ericaceae asterids Viridiplantae
Vitis vinifera L. 29760 Vitaceae rosids Viridiplantae
Zea mays L. 4577 Poaceae Liliopsida Viridiplantae

Human Protein / Gene in interaction

99 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL47 CHEMBL442800 CHEMBL1741321 (1) CHEMBL1909136 (2)
1 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL47 CHEMBL1909139 (2)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL47 CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL47 CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL47 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL47 CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL47 CHEMBL1909201 (2)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL47 CHEMBL1909176 (2)
0 / 0
P29466 Caspase-1 C14 CHEMBL47 CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL47 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL47 CHEMBL1909199 (2)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL47 CHEMBL1909197 (2)
2 / 2
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL442800 CHEMBL1614331 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL47 CHEMBL442800 CHEMBL1614544 (2)
11 / 10
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL442800 CHEMBL1613776 (1)
3 / 1
P00918 Carbonic anhydrase 2 Lyase CHEMBL47 CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL47 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL47 CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL47 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL47 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL47 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL47 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL47 CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL47 CHEMBL1909093 (2)
0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL47 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL47 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL47 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL47 CHEMBL442800 CHEMBL1614027 (1) CHEMBL1741325 (1)
CHEMBL1909135 (2)
0 / 1
P16662 UDP-glucuronosyltransferase 2B7 Enzyme CHEMBL47 CHEMBL1908093 (1)
0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL47 CHEMBL1909203 (2)
1 / 11
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL47 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL47 CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL47 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL47 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL47 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL47 CHEMBL1909214 (2)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL47 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL47 CHEMBL1909096 (2)
1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL47 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL47 CHEMBL1909166 (2)
1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL47 CHEMBL1909133 (2)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL47 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL47 CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL47 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL47 CHEMBL1909101 (2)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL47 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL47 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL47 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL47 CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL47 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL47 CHEMBL1909100 (2)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL47 CHEMBL1909167 (2)
1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL47 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL47 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL47 CHEMBL1909110 (2)
1 / 0
P03956 Interstitial collagenase M10A CHEMBL47 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL47 CHEMBL1909119 (2)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL47 CHEMBL49563 CHEMBL442800 CHEMBL1794467 (4)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL47 CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL47 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL47 CHEMBL1909170 (2)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL47 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL47 CHEMBL1909109 (2)
2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL47 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL47 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL47 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL47 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL47 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL47 CHEMBL1909108 (2)
0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL47 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL47 CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL47 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL47 CHEMBL442800 CHEMBL1741322 (1) CHEMBL1909132 (2)
0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL47 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL47 CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL47 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL47 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL47 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL47 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL47 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL47 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL47 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL47 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL47 CHEMBL1909168 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL47 CHEMBL442800 CHEMBL1613777 (1) CHEMBL1741323 (1)
CHEMBL1909134 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL47 CHEMBL442800 CHEMBL1741324 (1) CHEMBL1743290 (1)
CHEMBL1909138 (2)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL47 CHEMBL1909137 (2)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL442800 CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL47 CHEMBL49563 CHEMBL1614250 (1) CHEMBL1614502 (1)
4 / 3
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL47 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL47 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL47 CHEMBL1909213 (2)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL47 CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL47 CHEMBL1909116 (2)
1 / 1
P06239 Tyrosine-protein kinase Lck Src CHEMBL47 CHEMBL1909206 (2)
0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL47 CHEMBL1909128 (2)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL49563 CHEMBL1794536 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL47 CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL47 CHEMBL1614531 (1)
1 / 3

CTD interaction (111)

compound gene gene name gene description interaction interaction type form reference
pmid
D024502 335 APOA1
apolipoprotein A-I alpha-Tocopherol results in decreased expression of APOA1 mRNA decreases expression
mRNA 16423621
D024502 335 APOA1
apolipoprotein A-I alpha-Tocopherol results in decreased expression of APOA1 protein decreases expression
protein 16423621
D024502 338 APOB
FLDB
LDLCQ4
apolipoprotein B alpha-Tocopherol promotes the reaction [APOB protein results in increased reduction of Copper] increases reaction
/ increases reduction
protein 11368321
D024502 351 APP
AAA
ABETA
ABPP
AD1
APPI
CTFgamma
CVAP
PN-II
PN2
amyloid beta (A4) precursor protein alpha-Tocopherol inhibits the reaction [APP protein results in increased activity of MAPK14 protein] decreases reaction
/ increases activity
protein 12684028
D024502 351 APP
AAA
ABETA
ABPP
AD1
APPI
CTFgamma
CVAP
PN-II
PN2
amyloid beta (A4) precursor protein alpha-Tocopherol inhibits the reaction [APP protein results in increased activity of MAPK8 protein] decreases reaction
/ increases activity
protein 12684028
D024502 1386 ATF2
CRE-BP1
CREB2
HB16
TREB7
activating transcription factor 2 (EC:2.3.1.48) alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased phosphorylation of ATF2 protein] decreases reaction
/ increases phosphorylation
protein 14645110
D024502 23621 BACE1
ASP2
BACE
HSPC104
beta-site APP-cleaving enzyme 1 (EC:3.4.23.46) alpha-Tocopherol inhibits the reaction [Oxygen deficiency results in increased expression of BACE1 mRNA] decreases reaction
/ increases expression
mRNA 19196431
D024502 581 BAX
BCL2L4
BCL2-associated X protein alpha-Tocopherol affects the reaction [Lipopolysaccharides results in increased expression of BAX protein] affects reaction
/ increases expression
protein 11805214
D024502 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 alpha-Tocopherol affects the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein] affects reaction
/ decreases expression
protein 11805214
D024502 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 alpha-Tocopherol analog results in decreased expression of BCL2 mRNA decreases expression
mRNA 20686688
D024502 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 alpha-Tocopherol analog results in decreased expression of BCL2 protein decreases expression
protein 20686688
D024502 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein] decreases expression
/ decreases reaction
protein 20686688
D024502 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 DDIT3 mRNA affects the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein] affects reaction
/ decreases expression
protein 20686688
D024502 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 salubrinal inhibits the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein] decreases expression
/ decreases reaction
protein 20686688
D024502 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 TNFRSF10B mRNA affects the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein] affects reaction
/ decreases expression
protein 20686688
D024502 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) [alpha-Tocopherol co-treated with beta-ionone] results in increased activity of CASP3 protein affects cotreatment
/ increases activity
protein 17618090
D024502 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) [alpha-Tocopherol co-treated with Tretinoin] results in increased activity of CASP3 protein affects cotreatment
/ increases activity
protein 17874176
D024502 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) alpha-Tocopherol inhibits the reaction [7-ketocholesterol results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 12450566
D024502 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) alpha-Tocopherol inhibits the reaction [Acetaldehyde results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 14722101
D024502 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) alpha-Tocopherol inhibits the reaction [cholest-5-en-3 beta,7 alpha-diol results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 12450566
D024502 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) alpha-Tocopherol inhibits the reaction [Vitamin A results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 17618090
D024502 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) alpha-Tocopherol promotes the reaction [Amiodarone results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 23042730
D024502 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) alpha-Tocopherol promotes the reaction [beta Carotene metabolite results in decreased activity of CASP3 protein] decreases activity
/ increases reaction
protein 17618090
D024502 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) alpha-Tocopherol promotes the reaction [TNF protein promotes the reaction [Amiodarone results in increased activity of CASP3 protein]] increases activity
/ increases reaction
protein 23042730
D024502 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) alpha-Tocopherol results in decreased activity of CASP3 protein decreases activity
protein 15095415
17618090
D024502 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) alpha-Tocopherol promotes the reaction [Amiodarone results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 23042730
D024502 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) alpha-Tocopherol promotes the reaction [TNF protein promotes the reaction [Amiodarone results in increased activity of CASP7 protein]] increases activity
/ increases reaction
protein 23042730
D024502 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) alpha-Tocopherol analog results in increased cleavage of CASP8 protein increases cleavage
protein 20686688
D024502 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) alpha-Tocopherol analog results in increased cleavage of CASP9 protein increases cleavage
protein 20686688
D024502 847 CAT
catalase (EC:1.11.1.6) alpha-Tocopherol results in increased expression of CAT mRNA increases expression
mRNA 19083475
D024502 847 CAT
catalase (EC:1.11.1.6) alpha-Tocopherol results in increased expression of CAT protein increases expression
protein 19083475
D024502 1080 CFTR
ABC35
ABCC7
CF
CFTR/MRP
MRP7
TNR-CFTR
dJ760C5.1
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) alpha-Tocopherol inhibits the reaction [Cadmium results in decreased expression of CFTR protein] decreases expression
/ decreases reaction
protein 20363832
D024502 1382 CRABP2
CRABP-II
RBP6
cellular retinoic acid binding protein 2 [Tretinoin co-treated with alpha-Tocopherol] results in increased expression of CRABP2 mRNA affects cotreatment
/ increases expression
mRNA 15225641
D024502 1382 CRABP2
CRABP-II
RBP6
cellular retinoic acid binding protein 2 [Tretinoin co-treated with alpha-Tocopherol] results in increased expression of CRABP2 protein affects cotreatment
/ increases expression
protein 15225641
D024502 1401 CRP
PTX1
C-reactive protein, pentraxin-related [alpha-Tocopherol co-treated with gamma-Tocopherol] results in decreased expression of CRP protein affects cotreatment
/ decreases expression
protein 18191645
D024502 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 alpha-Tocopherol analog results in increased expression of DDIT3 protein increases expression
protein 20686688
D024502 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in increased expression of DDIT3 protein] decreases reaction
/ increases expression
protein 20686688
D024502 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 DDIT3 mRNA affects the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein] affects reaction
/ decreases expression
mRNA 20686688
D024502 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased expression of DDIT3 protein] decreases reaction
/ increases expression
protein 20686688
D024502 83939 EIF2A
EIF-2A
MST089
MSTP004
MSTP089
eukaryotic translation initiation factor 2A, 65kDa alpha-Tocopherol analog results in increased phosphorylation of EIF2A protein increases phosphorylation
protein 20686688
D024502 83939 EIF2A
EIF-2A
MST089
MSTP004
MSTP089
eukaryotic translation initiation factor 2A, 65kDa benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of EIF2A protein] decreases reaction
/ increases phosphorylation
protein 20686688
D024502 83939 EIF2A
EIF-2A
MST089
MSTP004
MSTP089
eukaryotic translation initiation factor 2A, 65kDa salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of EIF2A protein] decreases reaction
/ increases phosphorylation
protein 20686688
D024502 2335 FN1
CIG
ED-B
FINC
FN
FNZ
GFND
GFND2
LETS
MSF
fibronectin 1 alpha-Tocopherol inhibits the reaction [Glucose results in increased expression of and results in increased secretion of FN1 protein] decreases reaction
/ increases expression
/ increases secretion
protein 9225831
D024502 2534 FYN
SLK
SYN
p59-FYN
FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2) alpha-Tocopherol inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of FYN protein] decreases reaction
/ increases phosphorylation
protein 14572611
D024502 2534 FYN
SLK
SYN
p59-FYN
FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2) alpha-Tocopherol inhibits the reaction [Potassium Dichromate results in increased phosphorylation of FYN protein] decreases reaction
/ increases phosphorylation
protein 14572611
D024502 2879 GPX4
GPx-4
GSHPx-4
MCSP
PHGPx
snGPx
snPHGPx
glutathione peroxidase 4 (EC:1.11.1.12) alpha-Tocopherol inhibits the reaction [Sodium Selenite results in increased expression of GPX4 mRNA] decreases reaction
/ increases expression
mRNA 14642406
D024502 3048 HBG2
TNCY
hemoglobin, gamma G alpha-Tocopherol results in increased expression of HBG2 protein increases expression
protein 2606537
D024502 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) alpha-Tocopherol affects the expression of HMOX1 mRNA affects expression
mRNA 8743975
D024502 3162 HMOX1
HMOX1D
HO-1
HSP32
bK286B10
heme oxygenase (decycling) 1 (EC:1.14.99.3) alpha-Tocopherol inhibits the reaction [benzo(a)pyrene-7,8-dione results in increased expression of HMOX1 protein] decreases reaction
/ increases expression
protein 22053912
D024502 3240 HP
BP
HP2ALPHA2
HPA1S
haptoglobin alpha-Tocopherol affects the activity of HP protein polymorphism affects activity
protein 19769483
D024502 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 alpha-Tocopherol inhibits the reaction [Vehicle Emissions results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 22313677
D024502 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 alpha-Tocopherol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL8 protein] decreases reaction
/ increases secretion
protein 19135038
D024502 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased phosphorylation of JUN protein] decreases reaction
/ increases phosphorylation
protein 14645110
D024502 3932 LCK
LSK
YT16
p56lck
pp58lck
lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2) alpha-Tocopherol inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LCK protein] decreases reaction
/ increases phosphorylation
protein 14572611
D024502 3932 LCK
LSK
YT16
p56lck
pp58lck
lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2) alpha-Tocopherol inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LCK protein] decreases reaction
/ increases phosphorylation
protein 14572611
D024502 4067 LYN
JTK8
p53Lyn
p56Lyn
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2) alpha-Tocopherol inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LYN protein] decreases reaction
/ increases phosphorylation
protein 14572611
D024502 4067 LYN
JTK8
p53Lyn
p56Lyn
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2) alpha-Tocopherol inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LYN protein] decreases reaction
/ increases phosphorylation
protein 14572611
D024502 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) alpha-Tocopherol inhibits the reaction [Tamoxifen results in decreased phosphorylation of MAPK1 protein] decreases phosphorylation
/ decreases reaction
protein 17011908
D024502 1432 MAPK14
CSBP
CSBP1
CSBP2
CSPB1
EXIP
Mxi2
PRKM14
PRKM15
RK
SAPK2A
p38
p38ALPHA
mitogen-activated protein kinase 14 (EC:2.7.11.24) alpha-Tocopherol inhibits the reaction [[4-hydroxy-2-nonenal co-treated with Hydrogen Peroxide] results in increased activity of MAPK14 protein] affects cotreatment
/ decreases reaction
/ increases activity
protein 12684028
D024502 1432 MAPK14
CSBP
CSBP1
CSBP2
CSPB1
EXIP
Mxi2
PRKM14
PRKM15
RK
SAPK2A
p38
p38ALPHA
mitogen-activated protein kinase 14 (EC:2.7.11.24) alpha-Tocopherol inhibits the reaction [APP protein results in increased activity of MAPK14 protein] decreases reaction
/ increases activity
protein 12684028
D024502 1432 MAPK14
CSBP
CSBP1
CSBP2
CSPB1
EXIP
Mxi2
PRKM14
PRKM15
RK
SAPK2A
p38
p38ALPHA
mitogen-activated protein kinase 14 (EC:2.7.11.24) alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased activity of MAPK14 protein] decreases reaction
/ increases activity
protein 14645110
D024502 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) alpha-Tocopherol inhibits the reaction [Tamoxifen results in decreased phosphorylation of MAPK3 protein] decreases phosphorylation
/ decreases reaction
protein 17011908
D024502 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased activity of MAPK3 protein] decreases reaction
/ increases activity
protein 14645110
D024502 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) alpha-Tocopherol analog results in increased phosphorylation of MAPK8 protein increases phosphorylation
protein 20686688
D024502 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) alpha-Tocopherol inhibits the reaction [APP protein results in increased activity of MAPK8 protein] decreases reaction
/ increases activity
protein 12684028
D024502 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased activity of MAPK8 protein] decreases reaction
/ increases activity
protein 14645110
D024502 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK8 protein] decreases reaction
/ increases phosphorylation
protein 20686688
D024502 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK8 protein] decreases reaction
/ increases phosphorylation
protein 20686688
D024502 5601 MAPK9
JNK-55
JNK2
JNK2A
JNK2ALPHA
JNK2B
JNK2BETA
PRKM9
SAPK
SAPK1a
p54a
p54aSAPK
mitogen-activated protein kinase 9 (EC:2.7.11.24) alpha-Tocopherol analog results in increased phosphorylation of MAPK9 protein increases phosphorylation
protein 20686688
D024502 5601 MAPK9
JNK-55
JNK2
JNK2A
JNK2ALPHA
JNK2B
JNK2BETA
PRKM9
SAPK
SAPK1a
p54a
p54aSAPK
mitogen-activated protein kinase 9 (EC:2.7.11.24) benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK9 protein] decreases reaction
/ increases phosphorylation
protein 20686688
D024502 5601 MAPK9
JNK-55
JNK2
JNK2A
JNK2ALPHA
JNK2B
JNK2BETA
PRKM9
SAPK
SAPK1a
p54a
p54aSAPK
mitogen-activated protein kinase 9 (EC:2.7.11.24) salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased phosphorylation of MAPK9 protein] decreases reaction
/ increases phosphorylation
protein 20686688
D024502 4155 MBP
myelin basic protein alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased expression of MBP protein] decreases reaction
/ increases expression
protein 14645110
D024502 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 alpha-Tocopherol results in increased activity of NFKB1 protein increases activity
protein 19083475
D024502 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) alpha-Tocopherol results in increased expression of NOS3 mRNA increases expression
mRNA 16949522
D024502 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) alpha-Tocopherol results in increased expression of NOS3 protein increases expression
protein 16949522
D024502 11315 PARK7
DJ-1
DJ1
parkinson protein 7 alpha-Tocopherol inhibits the reaction [Rotenone affects the localization of PARK7 protein] affects localization
/ decreases reaction
protein 16439141
D024502 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) alpha-Tocopherol inhibits the reaction [Tamoxifen results in increased cleavage of PARP1 protein] decreases reaction
/ increases cleavage
protein 14645110
D024502 5230 PGK1
MIG10
PGKA
phosphoglycerate kinase 1 (EC:2.7.2.3) alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of PGK1 protein] decreases reaction
/ increases expression
protein 18603805
D024502 5340 PLG
plasminogen (EC:3.4.21.7) alpha-Tocopherol inhibits the reaction [Arsenic promotes the reaction [Humic Substances results in decreased activity of PLG protein]] decreases activity
/ decreases reaction
/ increases reaction
protein 11419606
D024502 5340 PLG
plasminogen (EC:3.4.21.7) alpha-Tocopherol inhibits the reaction [Humic Substances results in decreased activity of PLG protein] decreases activity
/ decreases reaction
protein 11419606
D024502 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma alpha-Tocopherol results in increased activity of PPARG protein increases activity
protein 19083475
D024502 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma alpha-Tocopherol results in increased expression of PPARG mRNA increases expression
mRNA 14521714
D024502 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma alpha-Tocopherol results in increased expression of PPARG protein increases expression
protein 14521714
D024502 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) alpha-Tocopherol metabolite results in decreased activity of PTGS2 protein decreases activity
protein 15225597
D024502 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) alpha-Tocopherol results in decreased activity of PTGS2 protein decreases activity
protein 15225597
D024502 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A alpha-Tocopherol affects the localization of RELA protein affects localization
protein 16882165
D024502 6256 RXRA
NR2B1
retinoid X receptor, alpha [Tretinoin co-treated with alpha-Tocopherol co-treated with Okadaic Acid] results in decreased phosphorylation of RXRA protein affects cotreatment
/ decreases phosphorylation
protein 15225641
D024502 6256 RXRA
NR2B1
retinoid X receptor, alpha [Tretinoin co-treated with alpha-Tocopherol] results in decreased phosphorylation of RXRA protein affects cotreatment
/ decreases phosphorylation
protein 15225641
D024502 6401 SELE
CD62E
ELAM
ELAM1
ESEL
LECAM2
selectin E alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of SELE protein] decreases reaction
/ increases expression
protein 12566129
D024502 4089 SMAD4
DPC4
JIP
MADH4
MYHRS
SMAD family member 4 SMAD4 results in decreased susceptibility to [Fluorouracil co-treated with alpha-Tocopherol] affects cotreatment
/ decreases response to substance
20562578
D024502 6622 SNCA
NACP
PARK1
PARK4
PD1
synuclein, alpha (non A4 component of amyloid precursor) alpha-Tocopherol inhibits the reaction [Rotenone results in increased expression of SNCA protein] decreases reaction
/ increases expression
protein 16439141
D024502 6647 SOD1
ALS
ALS1
IPOA
SOD
hSod1
homodimer
superoxide dismutase 1, soluble (EC:1.15.1.1) alpha-Tocopherol results in increased expression of SOD1 mRNA increases expression
mRNA 19083475
D024502 6647 SOD1
ALS
ALS1
IPOA
SOD
hSod1
homodimer
superoxide dismutase 1, soluble (EC:1.15.1.1) alpha-Tocopherol results in increased expression of SOD1 protein increases expression
protein 19083475
D024502 7015 TERT
CMM9
DKCA2
DKCB4
EST2
PFBMFT1
TCS1
TP2
TRT
hEST2
hTRT
telomerase reverse transcriptase (EC:2.7.7.49) alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in decreased activity of TERT protein] decreases activity
/ decreases reaction
protein 20112180
D024502 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor [alpha-Tocopherol co-treated with gamma-Tocopherol] results in decreased expression of TNF protein affects cotreatment
/ decreases expression
protein 18191645
D024502 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor alpha-Tocopherol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] decreases reaction
/ increases expression
protein 11805214
D024502 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor alpha-Tocopherol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein] decreases reaction
/ increases secretion
protein 19135038
D024502 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor alpha-Tocopherol inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species] decreases reaction
/ increases abundance
protein 16750838
D024502 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor alpha-Tocopherol promotes the reaction [TNF protein promotes the reaction [Amiodarone results in increased activity of CASP3 protein]] increases activity
/ increases reaction
protein 23042730
D024502 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor alpha-Tocopherol promotes the reaction [TNF protein promotes the reaction [Amiodarone results in increased activity of CASP7 protein]] increases activity
/ increases reaction
protein 23042730
D024502 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor alpha-Tocopherol results in decreased expression of TNF protein decreases expression
protein 18191645
D024502 8795 TNFRSF10B
CD262
DR5
KILLER
KILLER/DR5
TRAIL-R2
TRAILR2
TRICK2
TRICK2A
TRICK2B
TRICKB
ZTNFR9
tumor necrosis factor receptor superfamily, member 10b alpha-Tocopherol analog results in increased expression of TNFRSF10B mRNA increases expression
mRNA 20686688
D024502 8795 TNFRSF10B
CD262
DR5
KILLER
KILLER/DR5
TRAIL-R2
TRAILR2
TRICK2
TRICK2A
TRICK2B
TRICKB
ZTNFR9
tumor necrosis factor receptor superfamily, member 10b alpha-Tocopherol analog results in increased expression of TNFRSF10B protein increases expression
protein 20686688
D024502 8795 TNFRSF10B
CD262
DR5
KILLER
KILLER/DR5
TRAIL-R2
TRAILR2
TRICK2
TRICK2A
TRICK2B
TRICKB
ZTNFR9
tumor necrosis factor receptor superfamily, member 10b benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [alpha-Tocopherol analog results in increased expression of TNFRSF10B protein] decreases reaction
/ increases expression
protein 20686688
D024502 8795 TNFRSF10B
CD262
DR5
KILLER
KILLER/DR5
TRAIL-R2
TRAILR2
TRICK2
TRICK2A
TRICK2B
TRICKB
ZTNFR9
tumor necrosis factor receptor superfamily, member 10b salubrinal inhibits the reaction [alpha-Tocopherol analog results in increased expression of TNFRSF10B protein] decreases reaction
/ increases expression
protein 20686688
D024502 8795 TNFRSF10B
CD262
DR5
KILLER
KILLER/DR5
TRAIL-R2
TRAILR2
TRICK2
TRICK2A
TRICK2B
TRICKB
ZTNFR9
tumor necrosis factor receptor superfamily, member 10b TNFRSF10B mRNA affects the reaction [alpha-Tocopherol analog results in decreased expression of BCL2 protein] affects reaction
/ decreases expression
mRNA 20686688
D024502 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 alpha-Tocopherol inhibits the reaction [arsenite results in increased expression of TP53 mRNA] decreases reaction
/ increases expression
mRNA 12126965
D024502 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 alpha-Tocopherol inhibits the reaction [arsenite results in increased expression of TP53 protein] decreases reaction
/ increases expression
protein 12126965
D024502 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 12566129
D024502 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 alpha-Tocopherol inhibits the reaction [Vehicle Emissions results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 22313677
D024502 7494 XBP1
TREB5
XBP-1
XBP2
X-box binding protein 1 alpha-Tocopherol analog results in increased expression of XBP1 mRNA increases expression
mRNA 20686688

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (57)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (52)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)

Diseases related to CTD interactions

55 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D015746 D024502 Abdominal Pain marker/mechanism
16260695
D058186 D024502 Acute Kidney Injury therapeutic
8891671
19766176
D000755 D024502 Anemia, Sickle Cell therapeutic
15997260
D001247 D024502 Asthenia marker/mechanism
16260695
C535393 D024502 Ataxia with vitamin E deficiency therapeutic
10896705
D001284 D024502 Atrophy therapeutic
23633841
D001836 D024502 Body Weight Changes therapeutic
23633841
D001930 D024502 Brain Injuries therapeutic
14645467
19941068
D002279 D024502 Carcinoma 256, Walker therapeutic
19781538
D002318 D024502 Cardiovascular Diseases therapeutic
19769483
D002471 D024502 Cell Transformation, Neoplastic therapeutic
21344382
D002493 D024502 Central Nervous System Diseases marker/mechanism
18942769
D003072 D024502 Cognition Disorders therapeutic
19464315
21447382
D003556 D024502 Cystitis therapeutic
15232716
D003924 D024502 Diabetes Mellitus, Type 2 marker/mechanism
16506275
D056486 D024502 Drug-Induced Liver Injury therapeutic
3509882
D064420 D024502 Drug-Related Side Effects and Adverse Reactions therapeutic
7616398
9093712
D005334 D024502 Fever therapeutic
16844102
D005355 D024502 Fibrosis therapeutic
16260695
D005767 D024502 Gastrointestinal Diseases marker/mechanism
9199886
D005923 D024502 Glomerulosclerosis, Focal Segmental therapeutic
7838258
D006261 D024502 Headache marker/mechanism
16260695
D006461 D024502 Hemolysis therapeutic
10704919
D006949 D024502 Hyperlipidemias therapeutic
7838258
D006965 D024502 Hyperplasia therapeutic
23633841
D006973 D024502 Hypertension therapeutic
9880131
D007511 D024502 Ischemia therapeutic
8891671
D007674 D024502 Kidney Diseases therapeutic
18502357
D008113 D024502 Liver Neoplasms therapeutic
7852184
D008175 D024502 Lung Neoplasms therapeutic
16401635
D008569 D024502 Memory Disorders therapeutic
15364477
D009135 D024502 Muscular Diseases therapeutic
1566986
D009203 D024502 Myocardial Infarction therapeutic
9055097
16757080
19595682
20979156
D009325 D024502 Nausea marker/mechanism
16260695
D009336 D024502 Necrosis therapeutic
19066852
D009362 D024502 Neoplasm Metastasis therapeutic
19781538
D009410 D024502 Nerve Degeneration therapeutic
1806894
D009422 D024502 Nervous System Diseases therapeutic
11752462
15753152
16844102
D009436 D024502 Neural Tube Defects therapeutic
12739027
D010014 D024502 Osteolysis therapeutic
19781538
D010049 D024502 Ovarian Diseases therapeutic
23633841
D010146 D024502 Pain therapeutic
1566986
D011041 D024502 Poisoning therapeutic
16614824
D011230 D024502 Precancerous Conditions therapeutic
9093712
D011507 D024502 Proteinuria therapeutic
7919151
9608545
14714169
D011561 D024502 Pseudoxanthoma Elasticum therapeutic
17845175
D011657 D024502 Pulmonary Eosinophilia therapeutic
14606601
D011832 D024502 Radiation Injuries therapeutic
16260695
D051437 D024502 Renal Insufficiency therapeutic
11700016
D015427 D024502 Reperfusion Injury therapeutic
8891671
12910483
20609232
D012174 D024502 Retinitis Pigmentosa therapeutic
16849425
D012640 D024502 Seizures therapeutic
17543232
20602035
D014029 D024502 Tobacco Use Disorder marker/mechanism
9269585
D014591 D024502 Uterine Diseases therapeutic
23633841
D014717 D024502 Vertigo marker/mechanism
16260695