KCF-S cluster No. 1312 (7 metabolites)

Corresponding Phytochemical cluster No. 63

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (7)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
Magnoliophyta	8
Liliopsida	5
asterids	2

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Cumulative family count

class name	count
Piperaceae	6
Zingiberaceae	5
Lauraceae	2
Gesneriaceae	2

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
alpha-Pyrones	2

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metabolites link (3)

br08003 Category	KEGG ID	KNApSAcK ID
alpha-Pyrones	C09925	C00002987
alpha-Pyrones	C09980	C00003024
alpha-Pyrones	C09925	C00029550

Metabolite list (7)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00002987	5,6-Dehydrokawain	CHEMBL254218	C052297	12 / 16 / 44
C00003024	Yangonin	CHEMBL1098658	C110481	16 / 25 / 49
C00029373	10-Methoxyyagonin
C00029550	5,6-Dehydrokawain / Desmethoxyyangonin	CHEMBL254218		12 / 16 / 44
C00029551	5,6-Dehydromethysticin	CHEMBL1946690
C00043208	5,6-Dehydro-7,8-dihydromethysticin	CHEMBL1376695		3 / 0 / 0
C00045571	p-Hydroxy-5,6-dehydrokawain / 4'-Hydroxy-5,6-dehydrokawain	CHEMBL464111

Human Protein / Gene in interactions

22 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P04637	Cellular tumor antigen p53	Transcription Factor	C00002987 C00003024 C00029550	7 / 37
Q16637	Survival motor neuron protein	Unclassified protein	C00002987 C00003024 C00029550	4 / 1
P35869	Aryl hydrocarbon receptor	Transcription Factor	C00002987 C00003024 C00029550	0 / 0
Q96RI1	Bile acid receptor	NR1H4	C00002987 C00003024 C00029550	0 / 0
P19793	Retinoic acid receptor RXR-alpha	NR2B1	C00002987 C00003024 C00029550	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00002987 C00003024 C00029550	0 / 0
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00002987 C00003024 C00029550	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00002987 C00003024 C00029550	0 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00002987 C00003024 C00029550	2 / 2
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002987 C00029550	0 / 1
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00002987 C00029550	0 / 0
P10275	Androgen receptor	NR3C4	C00002987 C00029550	3 / 4
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00003024	3 / 3
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00003024	5 / 3
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00043208	0 / 0
P55210	Caspase-7	C14	C00003024	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00003024	0 / 1
P10636	Microtubule-associated protein tau	Unclassified protein	C00003024	4 / 3
P83916	Chromobox protein homolog 1	Unclassified protein	C00043208	0 / 0
P10145	Interleukin-8	Secreted protein	C00003024	0 / 0
P29466	Caspase-1	C14	C00003024	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00043208	0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions