Plant Species

Cumulative plant class count

class name count
Magnoliophyta 17
Liliopsida 5
asterids 2

Cumulative family count

class name count
Piperaceae 12
Zingiberaceae 5
Lauraceae 3
Gesneriaceae 2
Annonaceae 2

KCF-S cluster (3)

KCF-S ID # of metabolite
No. 1312 7
No. 2531 4
No. 3123 3

Metabolite list (14)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
C00002987 External link 512 p-Hydroxy-5,6-dehydrokawain
/ 4'-Hydroxy-5,6-dehydrokawain
No. 1312
C00045571 External link 512 Goniothalamin
/ (+)-Goniothalamin
22 / 32 / 24 16 / 0 No. 1312
C00043208 External link 512 Hydroxykavain
No. 1312
C00029551 External link 512 Methysticin
10 / 14 / 40 No. 1312
C00003024 External link 512 10-Methoxyyagonin
No. 1312
C00029373 External link 512 5,6-Dehydromethysticin
No. 1312
C00029550 External link 512 Dihydromethysticin
11 / 2 / 3 No. 1312
C00029378 External link 512 5,6-Dehydro-7,8-dihydromethysticin
3 / 0 / 0 No. 2531
C00003005 External link 512 5,6-Dehydrokawain
12 / 16 / 44 No. 2531
C00029583 External link 512 11-Hydroxy-12-methoxydihydrokavain
No. 2531
C00002988 External link 512 Yangonin
16 / 25 / 49 No. 2531
C00037211 External link 512 Kawain
18 / 11 / 7 No. 3123
C00003000 External link 512 5,6-Dehydrokawain
/ Desmethoxyyangonin
12 / 16 / 44 No. 3123
C00030497 External link 512 Marindinin
/ 7,8-Dihydrokavain
5 / 3 / 5 No. 3123

Human Protein / Gene in interactions

49 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00002987 C00002988 C00003000 C00003005 C00003024 C00029550 C00029583 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002987 C00002988 C00003000 C00003005 C00003024 C00029550 C00037211 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002987 C00002988 C00003000 C00003005 C00029550 C00029583 0 / 1
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00002987 C00002988 C00003000 C00003005 C00003024 C00029550 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002987 C00002988 C00003000 C00003005 C00003024 C00029550 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00002987 C00003000 C00003005 C00003024 C00029550 4 / 1
Q96RI1 Bile acid receptor NR1H4 C00002987 C00002988 C00003005 C00003024 C00029550 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00002987 C00002988 C00003000 C00029550 C00029583 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00002987 C00003005 C00003024 C00029550 7 / 37
P10636 Microtubule-associated protein tau Unclassified protein C00003000 C00003024 C00037211 4 / 3
O75496 Geminin Unclassified protein C00002988 C00003000 C00037211 0 / 0
P10275 Androgen receptor NR3C4 C00002987 C00029550 C00029583 3 / 4
P35869 Aryl hydrocarbon receptor Transcription Factor C00002987 C00003024 C00029550 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00003000 C00037211 C00043208 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00003000 C00037211 C00043208 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002987 C00003024 C00029550 2 / 2
Q13148 TAR DNA-binding protein 43 Unclassified protein C00003000 C00037211 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00002988 C00037211 0 / 0
P10145 Interleukin-8 Secreted protein C00003024 C00029583 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00037211 C00043208 0 / 0
O60674 Tyrosine-protein kinase JAK2 Jakb C00037211 5 / 1
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00037211 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00003024 0 / 1
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00003024 5 / 3
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00037211 1 / 2
P51151 Ras-related protein Rab-9A Unclassified protein C00037211 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003000 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00003024 3 / 3
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00037211 2 / 0
P42858 Huntingtin Unclassified protein C00037211 1 / 1
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00003000 0 / 0
P03372 Estrogen receptor NR3A1 C00002988 1 / 1
P55210 Caspase-7 C14 C00003024 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003000 1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003000 0 / 1
P16473 Thyrotropin receptor Glycohormone receptor C00003005 3 / 2
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00037211 0 / 0
P02545 Prelamin-A/C Unclassified protein C00037211 11 / 10
P29466 Caspase-1 C14 C00003024 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00037211 2 / 0
Q99700 Ataxin-2 Unclassified protein C00037211 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00003005 0 / 0
O14980 Exportin-1 Unclassified protein C00037211 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00003000 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002988 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00037211 1 / 0
O00255 Menin Unclassified protein C00037211 2 / 5
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00037211 2 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003000 1 / 0

16 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
306 ANXA3, ANX3 annexin A3 (EC: C00037211
581 BAX, BCL2L4 BCL2-associated X protein C00037211
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00037211
835 CASP2, CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57 caspase 2, apoptosis-related cysteine peptidase (EC: C00037211
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC: C00037211
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC: C00037211
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC: C00037211
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00037211
4193 MDM2, ACTFS, HDMX, hdm2 MDM2 oncogene, E3 ubiquitin protein ligase C00037211
4842 NOS1, IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS nitric oxide synthase 1 (neuronal) (EC: C00037211
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC: C00037211
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC: C00037211
5366 PMAIP1, APR, NOXA phorbol-12-myristate-13-acetate-induced protein 1 C00037211
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00037211
7132 TNFRSF1A, CD120a, FPF, MS5, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, p55, p55-R, p60 tumor necrosis factor receptor superfamily, member 1A C00037211
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00037211

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (62)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
%606641 Body mass index; bmi P37231
#600880 Budd-chiari syndrome; bdchs O60674
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#601626 Leukemia, acute myeloid; aml O60674
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#254450 Myelofibrosis O60674
#601665 Obesity P37231
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#263300 Polycythemia vera; pv O60674
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#614521 Thrombocythemia 3; thcyt3 O60674
#277700 Werner syndrome; wrn Q14191


KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00012 Polycythemia vera O60674 (related)
O60674 (marker)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)