phytochemical cluster No. 63 (14 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• KCF-S cluster (3)
• Metabolite list (14)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
Magnoliophyta	17
Liliopsida	5
asterids	2

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Cumulative family count

class name	count
Piperaceae	12
Zingiberaceae	5
Lauraceae	3
Gesneriaceae	2
Annonaceae	2

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
alpha-Pyrones	5

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metabolites link (6)

br08003 Category	KEGG ID	KNApSAcK ID
alpha-Pyrones	C09925	C00002987
alpha-Pyrones	C09926	C00002988
alpha-Pyrones	C09947	C00003000
alpha-Pyrones	C09952	C00003005
alpha-Pyrones	C09980	C00003024
alpha-Pyrones	C09925	C00029550

KCF-S cluster (3)

KCF-S ID	# of metabolite
No. 1312	7
No. 2531	4
No. 3123	3

Metabolite list (14)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	figure
C00002987	p-Hydroxy-5,6-dehydrokawain / 4'-Hydroxy-5,6-dehydrokawain	CHEMBL464111				No. 1312
C00045571	Goniothalamin / (+)-Goniothalamin	CHEMBL464443 CHEMBL1170485 CHEMBL1240592	C103280	22 / 32 / 24	16 / 0	No. 1312
C00043208	Hydroxykavain					No. 1312
C00029551	Methysticin	CHEMBL579224 CHEMBL1883024	C076881	10 / 14 / 40		No. 1312
C00003024	10-Methoxyyagonin					No. 1312
C00029373	5,6-Dehydromethysticin	CHEMBL1946690				No. 1312
C00029550	Dihydromethysticin	CHEMBL576066 CHEMBL1510786		11 / 2 / 3		No. 1312
C00029378	5,6-Dehydro-7,8-dihydromethysticin	CHEMBL1376695		3 / 0 / 0		No. 2531
C00003005	5,6-Dehydrokawain	CHEMBL254218	C052297	12 / 16 / 44		No. 2531
C00029583	11-Hydroxy-12-methoxydihydrokavain					No. 2531
C00002988	Yangonin	CHEMBL1098658	C110481	16 / 25 / 49		No. 2531
C00037211	Kawain	CHEMBL578607 CHEMBL1473874 CHEMBL1482039		18 / 11 / 7		No. 3123
C00003000	5,6-Dehydrokawain / Desmethoxyyangonin	CHEMBL254218		12 / 16 / 44		No. 3123
C00030497	Marindinin / 7,8-Dihydrokavain	CHEMBL569329 CHEMBL1338909	C113859	5 / 3 / 5		No. 3123

Human Protein / Gene in interactions

49 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P19793	Retinoic acid receptor RXR-alpha	NR2B1	C00002987 C00002988 C00003000 C00003005 C00003024 C00029550 C00029583	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00002987 C00002988 C00003000 C00003005 C00003024 C00029550 C00037211	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002987 C00002988 C00003000 C00003005 C00029550 C00029583	0 / 1
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00002987 C00002988 C00003000 C00003005 C00003024 C00029550	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00002987 C00002988 C00003000 C00003005 C00003024 C00029550	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00002987 C00003000 C00003005 C00003024 C00029550	4 / 1
Q96RI1	Bile acid receptor	NR1H4	C00002987 C00002988 C00003005 C00003024 C00029550	0 / 0
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00002987 C00002988 C00003000 C00029550 C00029583	0 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00002987 C00003005 C00003024 C00029550	7 / 37
P10636	Microtubule-associated protein tau	Unclassified protein	C00003000 C00003024 C00037211	4 / 3
O75496	Geminin	Unclassified protein	C00002988 C00003000 C00037211	0 / 0
P10275	Androgen receptor	NR3C4	C00002987 C00029550 C00029583	3 / 4
P35869	Aryl hydrocarbon receptor	Transcription Factor	C00002987 C00003024 C00029550	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00003000 C00037211 C00043208	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00003000 C00037211 C00043208	0 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00002987 C00003024 C00029550	2 / 2
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00003000 C00037211	1 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00002988 C00037211	0 / 0
P10145	Interleukin-8	Secreted protein	C00003024 C00029583	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00037211 C00043208	0 / 0
O60674	Tyrosine-protein kinase JAK2	Jakb	C00037211	5 / 1
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00037211	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00003024	0 / 1
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00003024	5 / 3
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00037211	1 / 2
P51151	Ras-related protein Rab-9A	Unclassified protein	C00037211	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00003000	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00003024	3 / 3
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00037211	2 / 0
P42858	Huntingtin	Unclassified protein	C00037211	1 / 1
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00003000	0 / 0
P03372	Estrogen receptor	NR3A1	C00002988	1 / 1
P55210	Caspase-7	C14	C00003024	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00003000	1 / 1
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00003000	0 / 1
P16473	Thyrotropin receptor	Glycohormone receptor	C00003005	3 / 2
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00037211	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00037211	11 / 10
P29466	Caspase-1	C14	C00003024	0 / 0
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00037211	2 / 0
Q99700	Ataxin-2	Unclassified protein	C00037211	1 / 1
Q9UBT6	DNA polymerase kappa	Enzyme	C00003005	0 / 0
O14980	Exportin-1	Unclassified protein	C00037211	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00003000	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00002988	1 / 1
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00037211	1 / 0
O00255	Menin	Unclassified protein	C00037211	2 / 5
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00037211	2 / 1
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00003000	1 / 0

16 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
306	ANXA3, ANX3	annexin A3 (EC:3.1.4.43)	C00037211
581	BAX, BCL2L4	BCL2-associated X protein	C00037211
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00037211
835	CASP2, CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57	caspase 2, apoptosis-related cysteine peptidase (EC:3.4.22.55)	C00037211
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00037211
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00037211
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00037211
54205	CYCS, CYC, HCS, THC4	cytochrome c, somatic	C00037211
4193	MDM2, ACTFS, HDMX, hdm2	MDM2 oncogene, E3 ubiquitin protein ligase	C00037211
4842	NOS1, IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS	nitric oxide synthase 1 (neuronal) (EC:1.14.13.39)	C00037211
4846	NOS3, ECNOS, eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	C00037211
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00037211
5366	PMAIP1, APR, NOXA	phorbol-12-myristate-13-acetate-induced protein 1	C00037211
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00037211
7132	TNFRSF1A, CD120a, FPF, MS5, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, p55, p55-R, p60	tumor necrosis factor receptor superfamily, member 1A	C00037211
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00037211

Related Diseases

Diseases related to proteins in ChEMBL interactions