KNApSAcK Metabolite C00037211
Metabolite
KNApSAcK Entry
| id | C00037211 |
|---|---|
| Name | Goniothalamin / (+)-Goniothalamin |
| CAS RN | 17303-67-2 |
| Standard InChI | InChI=1S/C13H12O2/c14-13-8-4-7-12(15-13)10-9-11-5-2-1-3-6-11/h1-6,8-10,12H,7H2/b10-9+/t12-/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C13H12O2/c14-13-8-4-7-12(15-13)10-9-11-5-2-1-3-6-11/h1-6,8-10,12H,7H2 |
Cluster
| Phytochemical cluster | No. 63 |
|---|---|
| KCF-S cluster | No. 3123 |
Link
ChEMBL
| By standard InChI | CHEMBL464443 |
|---|---|
| By standard InChI Main Layer | CHEMBL464443 CHEMBL1170485 CHEMBL1240592 |
KEGG
| By LinkDB |
|---|
CTD
| By CAS RN | C103280 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| Magnoliophyta | 3 |
Family
| family name | count |
|---|---|
| Annonaceae | 2 |
| Lauraceae | 1 |
List (3)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Cryptocarya moschata | 22027 | Lauraceae | Magnoliophyta | Viridiplantae |
| Goniothalamus cardiopetalus | 261082 | Annonaceae | Magnoliophyta | Viridiplantae |
| Goniothalamus macrophyllus | 261089 | Annonaceae | Magnoliophyta | Viridiplantae |
Human Protein / Gene in interaction
22 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| Q99700 | Ataxin-2 | Unclassified protein | CHEMBL1170485 |
CHEMBL2114784
(1)
|
1 / 1 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | CHEMBL1170485 |
CHEMBL1794499
(1)
|
2 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | CHEMBL1170485 |
CHEMBL1614544
(1)
|
11 / 10 |
| P42858 | Huntingtin | Unclassified protein | CHEMBL1170485 |
CHEMBL1613918
(1)
|
1 / 1 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | CHEMBL1170485 |
CHEMBL1794584
(1)
|
2 / 0 |
| O75496 | Geminin | Unclassified protein | CHEMBL1170485 |
CHEMBL2114843
(1)
CHEMBL2114780
(1)
|
0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | CHEMBL1170485 |
CHEMBL1613838
(1)
|
0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | CHEMBL1170485 |
CHEMBL2114788
(1)
|
0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | CHEMBL1170485 |
CHEMBL1614257
(1)
CHEMBL1614410
(1)
|
1 / 3 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | CHEMBL1170485 |
CHEMBL1794401
(1)
|
0 / 0 |
| O60674 | Tyrosine-protein kinase JAK2 | Jakb | CHEMBL1170485 |
CHEMBL1613998
(1)
CHEMBL1738019
(1)
CHEMBL1738021 (1) |
5 / 2 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | CHEMBL1170485 |
CHEMBL1738588
(1)
|
0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | CHEMBL1170485 |
CHEMBL1794483
(1)
|
0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | CHEMBL1170485 |
CHEMBL1614211
(1)
|
0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | CHEMBL1170485 |
CHEMBL1614421
(1)
|
4 / 3 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL1170485 |
CHEMBL1738184
(1)
|
0 / 0 |
| O14980 | Exportin-1 | Unclassified protein | CHEMBL464443 |
CHEMBL1110148
(1)
|
0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL1170485 |
CHEMBL1738442
(1)
|
0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | CHEMBL1170485 |
CHEMBL2354311
(1)
|
1 / 0 |
| O00255 | Menin | Unclassified protein | CHEMBL1170485 |
CHEMBL1614257
(1)
|
2 / 5 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | CHEMBL1170485 |
CHEMBL2114796
(1)
|
2 / 1 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | CHEMBL1170485 |
CHEMBL2354287
(1)
|
1 / 1 |
CTD interaction (33)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C103280 | 306 |
ANXA3
ANX3 |
annexin A3 (EC:3.1.4.43) | goniothalamin results in increased cleavage of ANXA3 protein |
increases cleavage
|
protein |
18771661
|
| C103280 | 581 |
BAX
BCL2L4 |
BCL2-associated X protein | goniothalamin results in decreased expression of BAX protein |
decreases expression
|
protein |
18771661
|
| C103280 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | goniothalamin results in decreased expression of BCL2 protein |
decreases expression
|
protein |
18771661
|
| C103280 | 835 |
CASP2
CASP-2 ICH1 NEDD-2 NEDD2 PPP1R57 |
caspase 2, apoptosis-related cysteine peptidase (EC:3.4.22.55) | goniothalamin results in increased activity of CASP2 protein |
increases activity
|
protein |
20026395
20498002 |
| C103280 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | goniothalamin results in increased activity of CASP3 protein |
increases activity
|
protein |
20498002
|
| C103280 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | goniothalamin results in increased cleavage of CASP3 protein |
increases cleavage
|
protein |
21810437
|
| C103280 | 841 |
CASP8
ALPS2B CAP4 Casp-8 FLICE MACH MCH5 |
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) | goniothalamin results in increased cleavage of CASP8 protein |
increases cleavage
|
protein |
21810437
|
| C103280 | 842 |
CASP9
APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56 |
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | goniothalamin results in increased activity of CASP9 protein |
increases activity
|
protein |
20498002
|
| C103280 | 842 |
CASP9
APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56 |
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | goniothalamin results in increased cleavage of CASP9 protein |
increases cleavage
|
protein |
21810437
|
| C103280 | 54205 |
CYCS
CYC HCS THC4 |
cytochrome c, somatic | goniothalamin affects the localization of CYCS protein |
affects localization
|
protein |
20498002
21810437 |
| C103280 | 4193 |
MDM2
ACTFS HDMX hdm2 |
MDM2 oncogene, E3 ubiquitin protein ligase | goniothalamin results in increased expression of MDM2 protein |
increases expression
|
protein |
20498002
|
| C103280 | 4842 |
NOS1
IHPS1 N-NOS NC-NOS NOS bNOS nNOS |
nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) | goniothalamin results in decreased expression of NOS1 protein |
decreases expression
|
protein |
18771661
|
| C103280 | 4846 |
NOS3
ECNOS eNOS |
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | goniothalamin results in decreased expression of NOS3 protein |
decreases expression
|
protein |
18771661
|
| C103280 | 142 |
PARP1
ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1 |
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) | goniothalamin results in increased cleavage of PARP1 protein |
increases cleavage
|
protein |
18771661
21810437 |
| C103280 | 142 |
PARP1
ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1 |
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) | pifithrin inhibits the reaction [goniothalamin results in increased cleavage of PARP1 protein] |
decreases reaction
/ increases cleavage |
protein |
21810437
|
| C103280 | 142 |
PARP1
ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1 |
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) | TP53 mutant form inhibits the reaction [goniothalamin results in increased cleavage of PARP1 protein] |
decreases reaction
/ increases cleavage |
protein |
21810437
|
| C103280 | 5366 |
PMAIP1
APR NOXA |
phorbol-12-myristate-13-acetate-induced protein 1 | goniothalamin results in increased activity of PMAIP1 protein |
increases activity
|
protein |
21810437
|
| C103280 | 5366 |
PMAIP1
APR NOXA |
phorbol-12-myristate-13-acetate-induced protein 1 | goniothalamin results in increased expression of PMAIP1 mRNA |
increases expression
|
mRNA |
21810437
|
| C103280 | 5366 |
PMAIP1
APR NOXA |
phorbol-12-myristate-13-acetate-induced protein 1 | goniothalamin results in increased expression of PMAIP1 protein |
increases expression
|
protein |
21810437
|
| C103280 | 5366 |
PMAIP1
APR NOXA |
phorbol-12-myristate-13-acetate-induced protein 1 | goniothalamin results in increased localization of PMAIP1 protein |
increases localization
|
protein |
21810437
|
| C103280 | 5366 |
PMAIP1
APR NOXA |
phorbol-12-myristate-13-acetate-induced protein 1 | pifithrin inhibits the reaction [goniothalamin results in increased expression of PMAIP1 protein] |
decreases reaction
/ increases expression |
protein |
21810437
|
| C103280 | 5366 |
PMAIP1
APR NOXA |
phorbol-12-myristate-13-acetate-induced protein 1 | TP53 mutant form inhibits the reaction [goniothalamin results in increased expression of PMAIP1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21810437
|
| C103280 | 5366 |
PMAIP1
APR NOXA |
phorbol-12-myristate-13-acetate-induced protein 1 | TP53 mutant form inhibits the reaction [goniothalamin results in increased expression of PMAIP1 protein] |
decreases reaction
/ increases expression |
protein |
21810437
|
| C103280 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | goniothalamin results in decreased expression of RELA protein |
decreases expression
|
protein |
18771661
|
| C103280 | 7132 |
TNFRSF1A
CD120a FPF MS5 TBP1 TNF-R TNF-R-I TNF-R55 TNFAR TNFR1 TNFR1-d2 TNFR55 TNFR60 p55 p55-R p60 |
tumor necrosis factor receptor superfamily, member 1A | goniothalamin results in decreased expression of TNFRSF1A protein |
decreases expression
|
protein |
18771661
|
| C103280 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | goniothalamin results in increased activity of TP53 protein |
increases activity
|
protein |
21810437
|
| C103280 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | goniothalamin results in increased expression of TP53 protein |
increases expression
|
protein |
20498002
|
| C103280 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | goniothalamin results in increased localization of TP53 protein |
increases localization
|
protein |
21810437
|
| C103280 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | goniothalamin results in increased phosphorylation of and results in increased expression of TP53 protein |
increases expression
/ increases phosphorylation |
protein |
21810437
|
| C103280 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | pifithrin inhibits the reaction [goniothalamin results in increased phosphorylation of and results in increased expression of TP53 protein] |
decreases reaction
/ increases expression / increases phosphorylation |
protein |
21810437
|
| C103280 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | TP53 mutant form inhibits the reaction [goniothalamin results in increased cleavage of PARP1 protein] |
decreases reaction
/ increases cleavage |
mutant form |
21810437
|
| C103280 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | TP53 mutant form inhibits the reaction [goniothalamin results in increased expression of PMAIP1 mRNA] |
decreases reaction
/ increases expression |
mutant form |
21810437
|
| C103280 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | TP53 mutant form inhibits the reaction [goniothalamin results in increased expression of PMAIP1 protein] |
decreases reaction
/ increases expression |
mutant form |
21810437
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (32)
| OMIM | preferred title | UniProt |
|---|---|---|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #600880 | Budd-chiari syndrome; bdchs |
O60674
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
Q14191 |
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #601626 | Leukemia, acute myeloid; aml |
O60674
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #254450 | Myelofibrosis |
O60674
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #263300 | Polycythemia vera; pv |
O60674
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #614521 | Thrombocythemia 3; thcyt3 |
O60674
|
| #277700 | Werner syndrome; wrn |
Q14191
|
KEGG DISEASE (24)
| KEGG | disease name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00012 | Polycythemia vera |
O60674
(related)
O60674 (marker) |
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00296 | Defects in RecQ helicases |
Q14191
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|