Species

KNApSAcK Entry

Organism name Cryptocarya moschata
Genus Cryptocarya
Family Lauraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Cryptocarya
Linked NCBI taxonomy ID 22027
Linked level genus

Family

Family in NCBI taxonomy Lauraceae
ID 3433

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (13)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00010301 External link 512 Coriandrol
/ (S)-Linalool
/ S-(+)-Linalool
/ (+)-S-Linalool
/ (S)-3,7-Dimethyl-1,6-octadien-3-ol
CHEMBL25306
CHEMBL235672
6 / 8 / 2 No. 958 No. 34
C00036946 External link 512 Cryptofolione
/ (+)-Cryptofolione
/ Cryptomoscatone E2
CHEMBL2000309
No. 1591
C00036947 External link 512 Cryptomoscatone D2
No. 1591
C00036948 External link 512 Cryptomoscatone E1
CHEMBL2000309
No. 1591
C00036949 External link 512 Cryptomoscatone E3
No. 1591
C00036950 External link 512 Cryptomoscatone F1
No. 1591
C00036956 External link 512 Cryptopyranmoscatone B4
No. 1622
C00036952 External link 512 Cryptopyranmoscatone A2
No. 1622
C00036953 External link 512 Cryptopyranmoscatone A3
No. 1622
C00036954 External link 512 Cryptopyranmoscatone B1
No. 1622
C00036955 External link 512 Cryptopyranmoscatone B2
No. 1622
C00036951 External link 512 Cryptopyranmoscatone A1
No. 1622
C00037211 External link 512 Goniothalamin
/ (+)-Goniothalamin
CHEMBL464443
CHEMBL1170485
CHEMBL1240592
C103280
22 / 32 / 24 16 / 0 No. 3123 No. 63

Human Protein / Gene in interactions

27 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P83916 Chromobox protein homolog 1 Unclassified protein C00010301 C00037211 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00037211 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00037211 2 / 0
P02545 Prelamin-A/C Unclassified protein C00037211 11 / 10
P10828 Thyroid hormone receptor beta NR1A2 C00010301 3 / 1
P42858 Huntingtin Unclassified protein C00037211 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00037211 2 / 0
O75496 Geminin Unclassified protein C00037211 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00037211 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00037211 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00037211 1 / 2
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00010301 3 / 0
O60674 Tyrosine-protein kinase JAK2 Jakb C00037211 5 / 1
Q99700 Ataxin-2 Unclassified protein C00037211 1 / 1
Q9Y4X1 UDP-glucuronosyltransferase 2A1 Enzyme C00010301 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00010301 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00037211 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00037211 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00010301 5 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00037211 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00037211 0 / 0
O14980 Exportin-1 Unclassified protein C00037211 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00037211 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00037211 1 / 0
O00255 Menin Unclassified protein C00037211 2 / 5
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00037211 2 / 1
Q13148 TAR DNA-binding protein 43 Unclassified protein C00037211 1 / 1

16 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
306 ANXA3, ANX3 annexin A3 (EC:3.1.4.43) C00037211
581 BAX, BCL2L4 BCL2-associated X protein C00037211
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00037211
835 CASP2, CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57 caspase 2, apoptosis-related cysteine peptidase (EC:3.4.22.55) C00037211
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00037211
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00037211
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00037211
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00037211
4193 MDM2, ACTFS, HDMX, hdm2 MDM2 oncogene, E3 ubiquitin protein ligase C00037211
4842 NOS1, IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS nitric oxide synthase 1 (neuronal) (EC:1.14.13.39) C00037211
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00037211
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00037211
5366 PMAIP1, APR, NOXA phorbol-12-myristate-13-acetate-induced protein 1 C00037211
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00037211
7132 TNFRSF1A, CD120a, FPF, MS5, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, p55, p55-R, p60 tumor necrosis factor receptor superfamily, member 1A C00037211
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00037211

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (40)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#600880 Budd-chiari syndrome; bdchs O60674
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
Q14191
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#143500 Gilbert syndrome P22309
P22310
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#145000 Hyperparathyroidism 1; hrpt1 O00255
#601626 Leukemia, acute myeloid; aml O60674
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#254450 Myelofibrosis O60674
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#263300 Polycythemia vera; pv O60674
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#614521 Thrombocythemia 3; thcyt3 O60674
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277700 Werner syndrome; wrn Q14191

KEGG DISEASE (26)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00012 Polycythemia vera O60674 (related)
O60674 (marker)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)