KCF-S cluster No. 1523 (7 metabolites)
Corresponding Phytochemical cluster No. 1
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| rosids | 8 |
| Liliopsida | 5 |
| eudicotyledons | 1 |
Cumulative family count
| class name | count |
|---|---|
| Fabaceae | 6 |
| Araceae | 2 |
| Asparagaceae | 2 |
| Brassicaceae | 2 |
| Hyacinthaceae | 1 |
| Amaranthaceae | 1 |
| Enterobacteriaceae | 1 |
KEGG BRITE br08003
Categories (1)
| br08003 Category | # of metabolite |
|---|---|
| Piperidine alkaloids | 1 |
metabolites link (2)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|---|---|
| Piperidine alkaloids | C00408 | C00000210 |
| Piperidine alkaloids | C00408 | C00001387 |
Metabolite list (7)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00000210
|
L-Pepecolic acid
|
CHEMBL308408
CHEMBL322883 CHEMBL1231898 |
3 / 0 / 3 |
|
||
|
C00001343
|
L-Azetidine 2-carboxylic acid
|
CHEMBL33592
CHEMBL1165239 CHEMBL1599178 |
C089382
|
8 / 14 / 15 |
|
|
|
C00001370
|
trans-4-Hydroxy-L-proline
|
CHEMBL352418
CHEMBL1213475 CHEMBL1229563 CHEMBL1233477 |
2 / 1 / 1 |
|
||
|
C00001387
|
L-Pipecolic acid
|
CHEMBL308408
CHEMBL322883 CHEMBL1231898 |
C031345
|
3 / 0 / 3 | 1 / 1 |
|
|
C00001388
|
L-Proline
|
CHEMBL54922
CHEMBL72275 CHEMBL80257 |
10 / 14 / 17 |
|
||
|
C00037000
|
trans-5-Hydroxypipecolic acid
|
|
||||
|
C00037104
|
cis-5-Hydroxypipecolic acid
|
|
Human Protein / Gene in interactions
14 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q7Z2H8 | Proton-coupled amino acid transporter 1 | Unclassified protein | C00000210 C00001343 C00001370 C00001387 C00001388 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001343 C00001388 | 1 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001343 C00001388 | 11 / 10 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001343 C00001388 | 0 / 1 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000210 C00001387 | 0 / 3 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001343 C00001388 | 0 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001343 C00001388 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001343 C00001388 | 1 / 1 |
| Q9P0Z9 | Peroxisomal sarcosine oxidase | Enzyme | C00000210 C00001387 | 0 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00001343 | 1 / 2 |
| Q9GZT9 | Egl nine homolog 1 | Enzyme | C00001370 | 1 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001388 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00001388 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00001388 | 1 / 4 |
1 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 51268 | PIPOX, LPIPOX | pipecolic acid oxidase (EC:1.5.3.1 1.5.3.7) |
C00001387
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (16)
| OMIM | preferred title | UniProt |
|---|---|---|
| #210900 | Bloom syndrome; blm |
P54132
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #609820 | Erythrocytosis, familial, 3; ecyt3 |
Q9GZT9
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
KEGG DISEASE (23)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00025 | Penile cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00236 | Congenital polycythemia |
Q9GZT9
(related)
|