KCF-S cluster No. 3405 (3 metabolites)

Corresponding Phytochemical cluster No. 1

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (3)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
Liliopsida	3

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Cumulative family count

class name	count
Arecaceae	3

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Pyridine alkaloids	1

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metabolites link (1)

br08003 Category	KEGG ID	KNApSAcK ID
Pyridine alkaloids	C10129	C00002020

Metabolite list (3)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00002020	Arecoline	CHEMBL7303	D001115	15 / 22 / 18	64 / 21
C00044165	Ethyl N-methyl-1,2,5,6-tetrahydro-pyridine-3-carboxylate
C00044191	Guvacoline	CHEMBL268808	C094105	1 / 1 / 0

Human Protein / Gene in interactions

15 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P20309	Muscarinic acetylcholine receptor M3	Acetylcholine receptor	C00002020 C00044191	1 / 0
P11229	Muscarinic acetylcholine receptor M1	Acetylcholine receptor	C00002020	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00002020	11 / 10
P10828	Thyroid hormone receptor beta	NR1A2	C00002020	3 / 1
P08912	Muscarinic acetylcholine receptor M5	Acetylcholine receptor	C00002020	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00002020	0 / 1
P08172	Muscarinic acetylcholine receptor M2	Acetylcholine receptor	C00002020	2 / 0
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00002020	2 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00002020	1 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00002020	0 / 0
P08173	Muscarinic acetylcholine receptor M4	Acetylcholine receptor	C00002020	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00002020	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002020	0 / 1
Q13951	Core-binding factor subunit beta	Unclassified protein	C00002020	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00002020	1 / 4

64 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
57491	AHRR, AHH, AHHR, bHLHe77	aryl-hydrocarbon receptor repressor	C00002020
10327	AKR1A1, ALDR1, ALR, ARM, DD3	aldo-keto reductase family 1, member A1 (aldehyde reductase) (EC:1.1.1.2)	C00002020
223	ALDH9A1, ALDH4, ALDH7, ALDH9, E3, TMABADH	aldehyde dehydrogenase 9 family, member A1 (EC:1.2.1.3 1.2.1.19 1.2.1.47)	C00002020
328	APEX1, APE, APE1, APEN, APEX, APX, HAP1, REF1	APEX nuclease (multifunctional DNA repair enzyme) 1 (EC:4.2.99.18)	C00002020
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00002020
672	BRCA1, BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53	breast cancer 1, early onset	C00002020
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00002020
6352	CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP	chemokine (C-C motif) ligand 5	C00002020
902	CCNH, CAK, p34, p37	cyclin H	C00002020
995	CDC25C, CDC25, PPP1R60	cell division cycle 25C (EC:3.1.3.48)	C00002020
983	CDK1, CDC2, CDC28A, P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	C00002020
10036	CHAF1A, CAF-1, CAF1, CAF1B, CAF1P150, P150	chromatin assembly factor 1, subunit A (p150)	C00002020
8208	CHAF1B, CAF-1, CAF-IP60, CAF1, CAF1A, CAF1P60, MPHOSPH7, MPP7	chromatin assembly factor 1, subunit B (p60)	C00002020
1131	CHRM3, EGBRS, HM3	cholinergic receptor, muscarinic 3	C00002020
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00002020
56603	CYP26B1, CYP26A2, P450RAI-2, P450RAI2, RHFCA	cytochrome P450, family 26, subfamily B, polypeptide 1	C00002020
64858	DCLRE1B, APOLLO, SNM1B, SNMIB	DNA cross-link repair 1B	C00002020
54541	DDIT4, Dig2, REDD-1, REDD1	DNA-damage-inducible transcript 4	C00002020
3301	DNAJA1, DJ-2, DjA1, HDJ2, HSDJ, HSJ2, HSPF4, NEDD7, hDJ-2	DnaJ (Hsp40) homolog, subfamily A, member 1	C00002020
9521	EEF1E1, AIMP3, P18	eukaryotic translation elongation factor 1 epsilon 1	C00002020
2068	ERCC2, COFS2, EM9, TTD, XPD	excision repair cross-complementing rodent repair deficiency, complementation group 2 (EC:3.6.4.12)	C00002020
2189	FANCG, FAG, XRCC9	Fanconi anemia, complementation group G	C00002020
9518	GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB	growth differentiation factor 15	C00002020
2937	GSS, GSHS	glutathione synthetase (EC:6.3.2.3)	C00002020
2966	GTF2H2, BTF2, BTF2P44, T-BTF2P44, TFIIH, p44	general transcription factor IIH, polypeptide 2, 44kDa	C00002020
404672	GTF2H5, C6orf175, TFB5, TFIIH, TGF2H5, TTD, TTD-A, TTDA, bA120J8.2	general transcription factor IIH, polypeptide 5	C00002020
51182	HSPA14, HSP70-4, HSP70L1	heat shock 70kDa protein 14	C00002020
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00002020
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00002020
51451	LCMT1, LCMT, PPMT1	leucine carboxyl methyltransferase 1 (EC:2.1.1.233)	C00002020
4128	MAOA, MAO-A	monoamine oxidase A (EC:1.4.3.4)	C00002020
100302175	MIR1207, MIRN1207, hsa-mir-1207	microRNA 1207	C00002020
100188847	MIR1225, MIRN1225	microRNA 1225	C00002020
100302142	MIR1246, MIRN1246, hsa-mir-1246	microRNA 1246	C00002020
100302233	MIR1268A, MIR1268, MIRN1268, hsa-mir-1268, hsa-mir-1268a	microRNA 1268a	C00002020
100302276	MIR1290, MIRN1290, hsa-mir-1290	microRNA 1290	C00002020
100302270	MIR1305, MIRN1305, hsa-mir-1305	microRNA 1305	C00002020
406927	MIR136, MIRN136, miRNA136	microRNA 136	C00002020
406935	MIR143, MIRN143	microRNA 143	C00002020
406937	MIR145, MIRN145, miR-145, miRNA145	microRNA 145	C00002020
100302137	MIR1914, MIRN1914, hsa-mir-1914	microRNA 1914	C00002020
100302129	MIR1915, MIRN1915, hsa-mir-1915	microRNA 1915	C00002020
406978	MIR199B, MIRN199B, mir-199b	microRNA 199b	C00002020
407010	MIR23A, MIRN23A, hsa-mir-23a, miRNA23A	microRNA 23a	C00002020
407015	MIR26A1, MIR26A, MIRN26A1	microRNA 26a-1	C00002020
407017	MIR26B, MIRN26B, hsa-mir-26b, miR-26b	microRNA 26b	C00002020
407026	MIR29C, MIRN29C, miRNA29C	microRNA 29c	C00002020
407029	MIR30A, MIRN30A	microRNA 30a	C00002020
693215	MIR630, MIRN630, hsa-mir-630	microRNA 630	C00002020
4292	MLH1, COCA2, FCC2, HNPCC, HNPCC2, hMLH1	mutL homolog 1	C00002020
4313	MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24)	C00002020
4436	MSH2, COCA1, FCC1, HNPCC, HNPCC1, LCFS2	mutS homolog 2	C00002020
4489	MT1A, MT1, MT1S, MTC	metallothionein 1A	C00002020
9027	NAT8, ATase2, CML1, GLA, Hcml1, TSC501, TSC510	N-acetyltransferase 8 (GCN5-related, putative)	C00002020
5591	PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350	protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1)	C00002020
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00002020
5810	RAD1, HRAD1, REC1	RAD1 homolog (S. pombe) (EC:3.1.11.2)	C00002020
10111	RAD50, NBSLD, RAD502, hRad50	RAD50 homolog (S. cerevisiae)	C00002020
6283	S100A12, CAAF1, CAGC, CGRP, ENRAGE, MRP-6, MRP6, p6	S100 calcium binding protein A12	C00002020
8243	SMC1A, CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB	structural maintenance of chromosomes 1A	C00002020
7076	TIMP1, CLGI, EPA, EPO, HCI, TIMP	TIMP metallopeptidase inhibitor 1	C00002020
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00002020
56886	UGGT1, HUGT1, UGCGL1, UGT1	UDP-glucose glycoprotein glucosyltransferase 1	C00002020
100126299	VTRNA2-1, CBL-3, CBL3, MIR886, MIRN886, VTRNA2, hsa-mir-886, hvg-5, nc886	vault RNA 2-1	C00002020

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions