PCIDB

Orthosiphon spicatus

Species

KNApSAcK Entry

Organism name Orthosiphon spicatus
Genus Orthosiphon
Family Labiatae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Orthosiphon
Linked NCBI taxonomy ID 204150
Linked level genus

Family

Family in NCBI taxonomy Lamiaceae
ID 4136

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00003894 External link 512 Eupatorin
/ 3',5-Dihydroxy-4',6,7-trimethoxyflavone
/ 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-6,7-dimethoxy-4H-1-benzopyran-4-one
CHEMBL487402
C103110
5 / 5 / 4 5 / 0 No. 3 No. 15
C00004642 External link 512 Rhamnazin
/ 7,3'-Di-O-methylquercetin
/ 3,4',5-Trihydroxy-3',7-dimethoxyflavone
/ 3,5-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
CHEMBL457148
No. 3 No. 15
C00003868 External link 512 Pilloin
/ Luteolin 7,4'-dimethyl ether
/ 5,3'-Dihydroxy-7,4'-dimethoxyflavone
/ 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
CHEMBL483424
No. 3 No. 15
C00003841 External link 512 Tetramethylscutellarein
/ 5,6,7,4'-Tetramethoxyflavone
/ Scutellarein 5,6,7,4'-tetramethyl ether
/ 5,6,7-Trimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
CHEMBL75349
C072809
9 / 4 / 8 No. 8 No. 15
C00013596 External link 512 Sinensetin
/ Pedalitin permethyl ether
/ 5,6,7,3',4'-Pentamethoxyflavone
/ 2-(3,4-Dimethoxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one
CHEMBL226507
C059295
7 / 6 / 7 3 / 0 No. 8 No. 15
C00003871 External link 512 5,7,3',4'-Tetramethoxyflavone
/ Luteolin 5,7,3',4'-tetramethyl ether
CHEMBL327340
C103111
1 / 0 No. 8 No. 15
C00003821 External link 512 5,7,4'-Trimethoxyflavone
/ Apigenin 5,7,4'-trimethyl ether
CHEMBL1087720
C103112
1 / 1 / 0 1 / 0 No. 35 No. 15

Human Protein / Gene in interactions

18 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00003894 C00013596 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00003841 C00013596 1 / 2
O00255 Menin Unclassified protein C00003841 C00013596 2 / 5
P08183 Multidrug resistance protein 1 drug C00003821 C00013596 1 / 0
P35968 Vascular endothelial growth factor receptor 2 Vegfr C00003894 1 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00013596 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00003841 0 / 0
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00003894 4 / 4
Q96GD4 Aurora kinase B Aur C00003894 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00003841 0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00013596 2 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00003841 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00003841 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00003841 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00013596 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00003841 0 / 0
O14965 Aurora kinase A Aur C00003894 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00003841 1 / 1

7 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00003821 C00003894 C00013596
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00003894 C00013596
1557 CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00003894
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00013596
1565 CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) C00003894
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00003894
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00003871

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (12)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614490 Blood group, junior system; jr Q9UNQ0
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#602089 Hemangioma, capillary infantile P35968
#145000 Hyperparathyroidism 1; hrpt1 O00255
#612244 Inflammatory bowel disease 13; ibd13 P08183
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#604229 Peters anomaly Q16678
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0

KEGG DISEASE (12)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)